In conclusion, the presynaptic protein BSN can be quantified in plasma and CSF to assess synaptic pathologies. BSN elevation was already detectable at the earliest disease stages and persisted in progressive MS, underscoring continuous neurodegeneration in MS. Measuring synaptic proteins may complement established biomarkers of neuronal injury to enhance our understanding of neurodegeneration in MS.
Project Independence: Randomized Controlled Trial
Conditions: Accommodation; Daily Activities; Independence; Autism
Interventions: Behavioral: Project Independence
Sponsors: University of Miami
Not yet recruiting
Interventions: Behavioral: Project Independence
Sponsors: University of Miami
Not yet recruiting
An Exploratory Study on the Prediction of Recurrence Risk of Bipolar Disorder Using Sentiment Analysis Technology Based on Multi-modal Feature Fusion
Conditions: Bipolar Disorder (BD); Healthy Control
Interventions: Other: This is an observational study with no intervention.
Sponsors: Shanghai Mental Health Center
Recruiting
Interventions: Other: This is an observational study with no intervention.
Sponsors: Shanghai Mental Health Center
Recruiting
Effects of CO Level on Pain, Sensory Function, and Subjective Health
Conditions: Carbon Monoxide, Pain Perception, Sensory Thresholds, Anxiety, Depression, Tobacco Smoking
Sponsors: Izmir Democracy University
Not yet recruiting
Sponsors: Izmir Democracy University
Not yet recruiting
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
Conditions: Depressive Disorder, Major
Interventions: Drug: Seltorexant; Drug: Placebo
Sponsors: Janssen Research & Development, LLC
Not yet recruiting
Interventions: Drug: Seltorexant; Drug: Placebo
Sponsors: Janssen Research & Development, LLC
Not yet recruiting
Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillectomy
Conditions: Opioid-Induced Respiratory Depression; Postoperative Complications (Cardiopulmonary); Respiratory Complications Due to Anesthesia
Interventions: Device: Infrared Pupillometry
Sponsors: NeurOptics Inc; National Institute on Drug Abuse (NIDA); University of Pittsburgh Medical Center; University of California, San Francisco
Not yet recruiting
Interventions: Device: Infrared Pupillometry
Sponsors: NeurOptics Inc; National Institute on Drug Abuse (NIDA); University of Pittsburgh Medical Center; University of California, San Francisco
Not yet recruiting
Allopurinol in Depression
Conditions: Depression
Interventions: Drug: Sertraline 50 MG; Drug: Allopurinol 300 MG
Sponsors: Tanta University
Not yet recruiting
Interventions: Drug: Sertraline 50 MG; Drug: Allopurinol 300 MG
Sponsors: Tanta University
Not yet recruiting
tDCS: Sleep to Mood in Depression (S2M-D)
Conditions: Major Depressive Disorder; MDD; Depression; Major Depressive Episode
Interventions: Device: transcranial direct current stimulation (tDCS)
Sponsors: NYU Langone Health; Zabara Foundation
Not yet recruiting
Interventions: Device: transcranial direct current stimulation (tDCS)
Sponsors: NYU Langone Health; Zabara Foundation
Not yet recruiting
AI-Assisted Camera-Based Progressive Muscle Relaxation for Office Workers
Conditions: Musculoskeletal Pain; Neck Pain; Stress, Physiological; Work Related Musculoskeletal Disorders
Interventions: Behavioral: AI-Assisted Camera-Based Progressive Muscle Relaxation Program
Sponsors: Istanbul Medipol University Hospital
Recruiting
Interventions: Behavioral: AI-Assisted Camera-Based Progressive Muscle Relaxation Program
Sponsors: Istanbul Medipol University Hospital
Recruiting
Validation of Artificial Intelligence-Based Facial Paralysis Assessment in Patients With Bell’s Palsy
Conditions: Bell’s Palsy; Facial Nerve Paralysis
Interventions: Other: Sunnybrook Facial Grading System (FGS); Other: AI-Based Facial Assessment
Sponsors: Cairo University
Not yet recruiting
Interventions: Other: Sunnybrook Facial Grading System (FGS); Other: AI-Based Facial Assessment
Sponsors: Cairo University
Not yet recruiting