Three things to watch amid Anthropic’s latest feud with the government

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For those of you enjoying your summer unaware of Anthropic’s latest feud with the US government, here’s a recap: In April the company said it had built an AI model called Mythos that was so good at working with code it could pose a global cybersecurity threat. Anthropic gave access to a small group of cybersecurity experts so they could see what they were up against. Then it released a modified version called Fable which it said was safer to the public on Tuesday, June 9. That Friday, the federal government told the company it was a threat to national security and placed export controls on the new release. Anthropic revoked access to both models hours later.

People worried about catastrophic effects of AI—broadly labeled “doomers”—have said for years that the technology poses a threat to humanity and published proposals for how the government should intervene in its development. The doomers just got their government intervention—not over a bioweapon or rogue AI, but in response to an AI model that’s basically just really good at coding. And the result so far looks less like a safety plan than like a superficial reaction.

There’s plenty to dissect about what happened in those few days that led to such drastic action from the government, and it’s notable that Amazon CEO Andy Jassy was the one who told government officials that Fable would be dangerous (Amazon is both invested in Anthropic and building its own competing AI models). It’s also possible this will be a short-lived ban from the government that doesn’t survive legal scrutiny (it’s not clear that Anthropic’s offering access to Fable really counts as “exporting” it, for example). 

But there are ripple effects happening already. 

For one, this is making a whole lot of people not want to rely on American AI companies. TheFrench politician Bruno Retailleau described it as a “wake-up call” that should motivate Europe to build more AI. But any vision of turning Paris into Silicon Valley—touted by many other European leaders following the shutdown of Anthropic’s models—is complicated by one big thing: China. 

Open-source models from China are very capable and incredibly cheap, and they can be downloaded to run on anyone’s servers with no rules or guardrails. (This makes them attractive to companies that don’t want access turned off on the basis of a decision from the White House—but equally attractive to cybercriminals, the type that Anthropic hoped to fend off by building safety guardrails into its models.) 

It’s possible that companies, including those in the US and Europe, will decide that working with Chinese models is just easier, as the skyrocketing of shares in the Chinese startup Zhipu suggests. Playing this forward, is it possible the government’s next drastic decision will be to say that US companies using models from China pose a threat to national security? I wouldn’t write it off. 

Second, it’s possible that shutting off access to Anthropic’s models will leave the country morevulnerable to cybersecurity attacks, not less. Leading cybersecurity experts have said as much in an open letter to the government, writing that access to Anthropic’s models was helping researchers prepare defenses, and that the company’s models are no more dangerous than other leading models that are widely available. Such is the risk of applying the concept of nonproliferation to software—trying to control and restrict dangerous AI models in the manner of the uranium used for nuclear weapons. 

The third thing worth watching is how US lawmakers will react. Remember that following Anthropic’s last feud with the government over how the Pentagon could or could not use its models, a slate of new bills was introduced that would define the limits of military AI.

Right now, the biggest players shaping how AI gets used are the companies and the White House. There’s been much talk about more federal AI regulation, and polling suggests most Americans want it. Lawmakers are still figuring out whether to form rules on how kids use chatbots and are far from a clear answer on the extent to which the government should vet the safety of AI models. But with every drastic action from the White House, the pressure for regulations rises.

To state the obvious, predictions are hard when the administration’s attitudes toward AI  change with the wind. When President Trump took office, he threw out the restrictive rulebook for how to make AI safe and promised to get out of the way of tech companies. The White House has now called the most valuable AI startup a risk to national security once in the spring, and again in summer. What will fall bring?

Brain-Infiltrating T Cells Linked to Social Deficits in Autism Mouse Model

The prevalence of autism spectrum disorder (ASD) is roughly one in 36 people, with a male-to-female ratio of 4:1. The disorder is known to be influenced by multiple factors, both genetic (gene mutations and copy number variations) and environmental, such as infections during pregnancy. However, the role of immunity in genetic ASD remains unclear.

One area of interest lies in lymphocytes—cells that are known to shape neurodevelopment and behavior. But their roles in neurodevelopmental disorders are not well defined.

Now, new research shows that a subset of T cells—γδ T cells—can infiltrate the brain and contribute to changes in social behavior in a genetic mouse model that mimics behavioral features of ASD. Depleting these cells from the brain increased sociability, suggesting that targeting abnormal immune function during neurodevelopment may offer interventions for ASD.

This work is published in Science Immunology in the paper, “CXCL16-mediated recruitment of γδ T cells to the brain reduces sociability in mice.”

Infections during pregnancy can induce the release of interleukin-17A (IL-17A) from T helper 17 cells and γδ T cells. Prior research has linked this type of maternal immune activation to neurodevelopmental disorders, but there is a lack of evidence connecting IL-17A and social behaviors in genetic mouse models.

To investigate this further, a team of researchers from the Division of Allergy and Immunology in the Medical Institute of Bioregulation at Kyushu University, in Fukuoka, Japan, studied 15q11-13 duplication (15q dup) mice—a mouse model that mimics a chromosome duplication found in some humans with ASD. These mice also demonstrate reduced social interactions, behavioral inflexibility, and increased anxiety-like behaviors.

The team analyzed immune cell populations in the brains of the 15q dup mice. Their findings suggest an increase in γδ T cells in the developing brains when compared with wild-type mice.

Using single-cell RNA sequencing (scRNA-seq), the team uncovered that this was most likely due to microglia in the brain expressing the chemokine CXCL16, which promotes immune cell migration. CXCL16 was highly expressed in the brains of 15q dup mice and contributed to increased infiltration of γδ T cells.

In addition, experiments revealed that deleting IL-17A–producing γδ T cells or blocking them with antibodies after birth increased sociability and reduced anxiety-like behaviors in the 15q dup mice.

Taken together, the authors note that these findings suggest that “immune dysregulation contributes to social behavior deficits in 15q dup mice, consistent with observations in maternal immune activation models, and may represent a potential target for interventions for ASD-associated differences in social behavior.”

The post Brain-Infiltrating T Cells Linked to Social Deficits in Autism Mouse Model appeared first on GEN – Genetic Engineering and Biotechnology News.

Breast Milk Fatty Acid Shapes Immune Development in Mice

In a new study published in Science titled, “Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting,” researchers from the University of Chicago have found that trans-vaccenic acid (TVA), the most abundant trans fatty acid in human breast milk, helps boost immune system development in mice. 

Nursing female mice that were fed a diet enriched with TVA passed the nutrient to their pups, leading to increased production of immune cells during early development. Genetic analyses showed that TVA exposure during breastfeeding reprogrammed immune cells to improve responses to pathogens. Mice that were nursed on TVA-enriched milk responded faster to infections with viruses or common bacteria, even into adulthood. 

“It’s common knowledge that breastfeeding is important for neonatal immune development and overall health, but breast milk is so complex that it seems almost impossible that one single molecule would be sufficient to change a baby’s immune development,” said Jing Chen, PhD, professor of medicine at UChicago and co-corresponding author on the study. “So, it was very surprising to see that during this crucial stage of development, one nutrient derived from the mother’s diet and delivered through breastfeeding has such a tremendous effect.” 

TVA is a long-chain fatty acid found in meat and dairy products from grazing animals such as cows and sheep. The human and mouse body must obtain TVA through diet.  

Pups who were nursed by mothers with a diet enriched with TVA demonstrated a broader and more effective immune cell population, particularly CD4+ T cells that are important for adaptive immunity. Mice raised on TVA-enriched breast milk responded more quickly and had higher survival rates when exposed to the flu virus or Salmonella. 

“We saw that only postnatal exposure to TVA through breastfeeding is important to train the neonatal T cells, and this can have long-lasting imprinting effects,” Chen said. “Even in adulthood, when we challenged the mice with influenza, the ones that were exposed to higher TVA levels during breastfeeding responded better when battling the infection.” 

The team also analyzed TVA levels in breast milk and blood samples from human nursing mothers and infants. They found that higher TVA levels in breast milk were closely linked to higher TVA levels in infants’ blood. In preterm infants, levels of circulating TVA correlated with similar shifts in immune responses seen in mice.

Higher TVA levels in human breast milk were also associated with reduced risk of bronchopulmonary dysplasia, a chronic inflammatory lung disease that affects premature infants with underdeveloped lungs and increased susceptibility to respiratory infection. 

Chen hopes for more research on the possibilities for supplementing diets with TVA during pregnancy and breastfeeding, or infant formula. The team will also investigate additional fatty acids and nutrients found in breast milk to understand their benefits. 

“There are close to 40 fatty acids in total in breast milk, along with hundreds of other components,” Chen said. “So, I think it’s safe for us to say that we believe there could be additional fatty acids and nutrients that can do something similar.” 

The post Breast Milk Fatty Acid Shapes Immune Development in Mice appeared first on GEN – Genetic Engineering and Biotechnology News.

STAT+: Another big deal, another sign biotech M&A is back

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Good morning! Pharma companies are on a biotech buying spree, an LSD pill just delivered unusually strong late-stage depression data, and the FDA reverses course of Regenxbio’s treatment.

Also: Today, thousands of industry players (and me!) are gathering in San Diego for BIO to talk deals, science, and whatever comes next. Check out the last item for a jaunt down memory lane about the conference.

Continue to STAT+ to read the full story…

Affordable centimeter-scale 3D microscopy with submicrometer resolution

Nature Biotechnology, Published online: 22 June 2026; doi:10.1038/s41587-026-03209-x

Submicrometer-resolution three-dimensional (3D) imaging of large samples has been constrained by the short working distance, high cost and inflexible design of immersion objectives. We developed hybrid solid–liquid optics (HySIL) — a refractive framework with index-matched components — for submicrometer-resolution 3D imaging of centimeter-scale samples in various immersion media using inexpensive air objectives.

STAT+: Pharma goes on a spending spree, snapping up biotechs in a hurry

Pharmaceutical companies are hungry to make deals, and they’re making more than they have in years. 

In the past six months, there have been 32 biotech acquisitions valued at $1 billion or more. Pharmaceutical companies and even some large biotech companies have spent around $123 billion on these deals.

They’ve blown past last year’s totals in roughly half the amount of time. Pharma companies struck 26 blockbuster M&A deals in 2025, spending $112 billion altogether. 

Continue to STAT+ to read the full story…

Opinion: STAT readers debate blue zones, open-access publishing fees, and more

First Opinion is STAT’s platform for interesting, illuminating, and provocative articles about the life sciences writ large, written by biotech insiders, health care workers, researchers, and others.

To encourage robust, good-faith discussion about issues raised in First Opinion essays, STAT publishes selected Letters to the Editor received in response to them. You can submit a Letter to the Editor here, or find the submission form at the end of any First Opinion essay.

Read the rest…

The Download: AI bottleneck debates, and BCI trials take off

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

A startup claims it broke through a bottleneck that’s holding back LLMs

AI startup Subquadratic came out of stealth last month with a huge claim: it had solved a mathematical bottleneck that had held back large language models for almost a decade.

The purported breakthrough comes from slashing the number of computations transformers need to carry out to generate answers. The result is a faster and cheaper LLM that uses far less energy than any other model on the market.

Many experts remained skeptical—but Subquadratic has started to share the receipts. They suggest that their approach might be worth paying attention to.

Here’s how the system works—and why some researchers still aren’t convinced.

—Will Douglas Heaven

Brain-computer interface trials are taking off

—Jessica Hamzelou

This week, I covered the story of Casey Harrell—a man with ALS who is “the first power user” of a brain implant. The device has enabled him to maintain an income, reconnect with friends and family, and read to his daughter. He told me that it’s “nothing short of revolutionary.” 

Over the past couple of years, the number of BCI trial volunteers has soared. This year, China became the first country to approve a BCI for medical use. Advances in technology are allowing engineers to provide more features than ever. BCI research is properly taking off.

Find out how the technology is edging from the lab towards the market.

This story is from The Checkup, our weekly newsletter giving you the inside track on all things biotech. Sign up to receive it in your inbox every Thursday.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Amazon workers who backed data center limits may face termination
The engineers say they’re under investigation by the company. (NYT $)
+ And could face discipline, including potential termination. (The Verge)
+They had testified at meetings about pausing data centers. (CNBC)
+ They’ve filed a joint complaint to Seattle’s Office for Civil Rights. (Wired $)

2 A new fossil discovery has rewritten 150 years of evolutionary theory
It suggests early land vertebrates skipped the tadpole stage. (New Scientist $)
+ And raises questions about how vertebrates adapted to land. (404 Media)
+ Sponges may have been the first animals. (MIT Technology Review)
 
3 Bernie Sanders plans to give the public direct ownership of AI firms
He’s unveiled new legislation to create an AI sovereign wealth fund. (AP News)
+ It would be funded through a one-time tax on AI companies’ stock. (Quartz)
+ And make annual payments directly to Americans. (Washington Post $) 
 
4 Investors in China secretly acquired stakes in SpaceX before its IPO
One had ties to Chinese military contractors. (ProPublica)
+ The US fears China has got one of ASML’s top machines. (Reuters $)
 
5 Researchers have figured out Russia’s nuclear-powered missile
They call it “a terrible idea”—but not an impossible one. (NPR)
+ NASA is building a nuclear reactor-powered spacecraft. (MIT Technology Review)
 
6 Longevity medicine faces a do-or-die moment in a landmark trial
It will test whether cellular aging can be safely reversed in humans. (Axios)
+ The next step is “chemical reprogramming.” (MIT Technology Review)
 
7 Studies suggest AI may already be deskilling professionals
Over-reliance appears to weaken doctors’ and engineers’ abilities. (Nature)
 
8 Tech workers who maxed out their AI use are now trying to minimize it
Spiralling costs mean “tokenminning” has replaced “tokenmaxxing.” (NYT $)
 
9 Scientists say the human genome’s structure may confound AI models
Which would constrain AI-based models of biology and disease. (Quanta)

10 A new robotic self-driving toilet brings the bathroom to you
The Xiaoban also cleans up and empties itself all on its own. (The Verge)

Quote of the day

“They hated me. They were doing everything they could to knock me down. And look at them now.” 

—Donald Trump mocks Mark Zuckerberg and Jeff Bezos in a conversation with Elon Musk that’s recounted in a new book, Wired reports. 

One More Thing

chicken network

PABLO DELCAN


Technology can help us feed the world, if we look beyond profit

The pandemic exposed the weak spots in our interconnected food system. They’re the result of decades’ worth of technological advances, from globe-spanning shipping to refrigeration networks. But technology is not inherently opposed to sustainable and resilient food systems.

Powerful technologies like genetic modification can create stronger local agriculture and a healthier food system—but they normally aren’t. The challenge is ensuring they serve food security and human well-being, rather than simply maximizing profits.

Dive into our food system’s problems and the solutions that technology can provide.

—Fabio Parasecoli

We can still have nice things

A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.)

+ This intriguing video tracks the covert reality of Japan’s shinobi.
+ Dive into this admirably obsessive archive covering over 100 different ways to tie your shoes.
+ One of the world’s largest digital collections of plants and fungi is now available for free to everyone.
+ A grand orchestra has beautifully covered Michael Jackson’s “Human Nature” at Abbey Road Studios.