Coproduction Without Youth? Closing the Participation Gap in Digital Mental Health Research

Young people are among the most intensive users of digital and generative artificial intelligence (GenAI)–enabled mental health tools, yet they remain underrepresented in the research and design processes that shape these technologies. Although participatory approaches such as co-design and patient and public involvement are widely endorsed as best practices, youth involvement in digital youth mental health (DYMH) research is often inconsistent, superficial, or limited to late-stage consultation. This participation gap risks producing interventions that are misaligned with young people’s lived experiences, priorities, and vulnerabilities, particularly in the context of rapidly evolving and scalable GenAI systems. This Viewpoint aims to reexamine the underlying drivers of the participation gap in DYMH research; clarify how participation is conceptualized and implemented across disciplines; and propose concrete, actionable recommendations to support more meaningful and consistent youth involvement across the research life cycle. We draw on interdisciplinary literature from digital mental health, human-computer interaction, child-computer interaction, and health research policy. Our Viewpoint integrates conceptual frameworks (eg, Lundy’s model of participation), existing reviews of co-design practices, and emerging evidence on GenAI in mental health. We adopt a life cycle–oriented perspective to examine how youth participation is distributed across stages of research and development, including problem formulation, design, implementation, and evaluation. We identify 3 interrelated drivers of the participation gap. First, conceptual and linguistic fragmentation obscures what participation entails in practice, with terms such as co-design, participatory design, user-centered design, and patient and public involvement used inconsistently across disciplines. Second, youth involvement is uneven across the research life cycle, with participation often concentrated in early ideation or usability testing but largely absent from upstream decision-making and downstream evaluation. Third, institutional barriers—including ethics review processes, consent requirements, funding constraints, and adult-centric research norms—systematically limit meaningful youth partnership. These challenges are amplified in the context of GenAI, where opaque “black box” systems, simulated therapeutic interactions, and rapid deployment cycles introduce distinct risks if youth perspectives are not integrated. We propose a set of minimum expectations to address these gaps, including explicit specification of participatory models, life cycle mapping of youth involvement, reporting of youth influence on decisions, dedicated funding for participation, proportional ethics frameworks, and mechanisms for youth-informed governance of GenAI systems. Closing the participation gap in DYMH research is both an ethical imperative and a practical necessity. Moving beyond aspirational commitments requires embedding youth participation as a standard, resourced, and accountable component of research, design, and governance. In the context of rapidly evolving digital and GenAI technologies, failure to do so risks producing interventions that are scalable but not safe, credible, or responsive to the needs of young people.
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Supporting Student Mental Health With the Safespace Generative AI Chatbot: Mixed Methods Feasibility Study

Background: Generative artificial intelligence (GenAI) chatbots have the potential to provide personalized mental health support to individuals at scale. Objective: This study evaluates the feasibility and usage patterns of the Safespace GenAI chatbot, an artificial intelligence (AI)–driven smartphone app that offers a large language model–powered interactive chatbot to support mental health. Methods: Using a mixed methods approach, we explored baseline attitudes toward GenAI chatbots and chatbot usage patterns, conducted a qualitative content analysis of participants’ experiences, and descriptively assessed patterns related to preintervention depressive symptoms. The study included an initial sample of 42 university students, 20 of whom actively used the chatbot over 2 to 4 weeks, generating 286 user-chatbot interactions. Results: Preintervention surveys indicated that the majority of participants anticipated that the chatbot would be helpful (27/42, 64%) and that they trusted its privacy safeguards (39/42, 93%). Usage patterns suggested that the highest levels of interaction occurred early in the morning and late at night, when peer and professional support may be inaccessible. The qualitative analysis indicated that participants appreciated using the chatbot for reflection as a blended-care tool between their counseling sessions, while also naming technical barriers and specific design needs required to sustain engagement. In addition, our exploratory analyses descriptively showed that participants with elevated depression scores engaged in emotional disclosure during 99% (38 sessions with 8 participants) of their sessions, compared to 84% (26 sessions of 12 participants) of those with low symptoms. Due to the small sample size, future adequately powered studies are needed to inferentially examine these observed patterns. Conclusions: These findings provide initial insights into the usage and engagement dynamics of the Safespace GenAI chatbot and highlight directions for future research to optimize GenAI-driven mental health interventions. Trial Registration: AEA Registry AEARCTR-0013291; https://doi.org/10.1257/rct.13291-1.0
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Context Memory Discrimination and Recognition in Humans: Development of a Novel Cognitive Task

Background: When confronted with ambiguous stimuli, the ability to utilize contextual information is crucial for survival. Context processing involves the ability to discriminate new information from previously encountered information and to recognize something as previously encountered, even briefly or partially. Deficits in context processing are a key feature across a number of psychiatric conditions. Existing tasks only examine the discrimination and recognition of cues as opposed to contextual information. Thus, new tasks using complex scenes are urgently needed. Objective: We developed the Context Discrimination and Recognition Task (CDRT) and established baseline performance in healthy adults. Methods: Final analyses included 44 participants (mean age 30.27, SD 11.78) who completed the CDRT to characterize memory performance for (1) discrimination between previously viewed and never viewed complex scenes (Discrete Discrimination Score [DDS]), (2) recognition of previously viewed complex scenes (Discrete Recognition Score [DRS]), (3) sensitivity to distinctions across a gradient of complex scenes (width), and (4) bias in recognition of complex scenes (bias). Pearson correlations were conducted to examine associations between these scores. Results: The results revealed a significant positive relationship between DDS and DRS scores, (41)=0.71, <.001, and between DDS and modified recognition scores, (41)=0.71, <.001. Width was also negatively correlated with DDS, (41)=−0.31, =.04; DRS, (41)=−0.47, =.001; and DRSmid, (41)=−0.35, =.02 Conclusions: We found that the CDRT is sensitive to a range of discrimination and recognition levels and is uniquely positioned to probe context processing. Additionally, both recognition and discrimination scores increased with decreased ambiguity of complex scenes, demonstrating the sensitivity of the task in detecting variability of performance across participants. Better recognition of complex scenes was associated with greater sensitivity to differences between contexts. This novel task can be used to assess memory-associated processes for complex scenes in future studies aiming to elucidate neural functions underlying context processing in psychiatric conditions.

Shared reading is associated with fewer emotional/behavioral problems and better prosocial behavior in preschool children: a cross-sectional study in western China

BackgroundThe home literacy environment, particularly shared reading, plays a critical role in preschool children’s cognitive and socioemotional development. However, its associations with emotional and behavioral problems remain underexplored in large-scale studies. This study examined the relationship between shared reading and emotional/behavioral problems as well as prosocial behavior in preschool children.MethodsA cross-sectional study was conducted using stratified cluster sampling across 189 kindergartens in a major city in western China. A total of 21,366 parent-child pairs were included. Shared reading was assessed with the reading subscale of the StimQ-P (score range 0–22), which evaluates quantity, diversity of concepts and content, and interactivity quality. Emotional and behavioral problems were measured using the parent-reported Strengths and Difficulties Questionnaire (SDQ). Multivariate logistic regression and generalized additive models were employed to examine associations, adjusting for child age, gender, parental socioeconomic factors, lifestyle variables, and parental mental health (CES-D).ResultsHigher shared reading scores were significantly associated with lower odds of emotional/behavioral problems (adjusted OR = 0.96 per point increase, 95% CI: 0.95–0.97, P < 0.0001) and higher odds of adequate prosocial behavior (adjusted OR = 1.09, 95% CI: 1.08–1.10, P < 0.0001) in fully adjusted models. All four dimensions of shared reading showed independent associations. Nonlinear analyses revealed threshold effects, with associations becoming stronger above approximately 18 points for total difficulties and 15 points for prosocial behavior. These associations were largely consistent across subgroups after correction for multiple testing.ConclusionIn this large cross-sectional study conducted in western China, higher levels of shared reading were associated with lower odds of emotional/behavioral problems and higher odds of prosocial behaviors among preschool children. The results suggest possible threshold patterns in these associations. However, given the cross-sectional nature of the study, causality cannot be established.

Justice Department announces hundreds of charges in multibillion-dollar health care fraud crackdown

WASHINGTON — The Justice Department on Tuesday announced criminal charges against 455 people as part of a two-week health care fraud crackdown that officials say involved more than $6.5 billion in false claims submitted to insurers.

Among those charged is a nurse practitioner accused in Texas of billing Medicaid for medically unnecessary wound-care procedures and using the proceeds for fancy jewelry and luxury cars; a mental health company owner who prosecutors say exploited the homeless by billing for crisis stabilization services they did not need; and a hospice owner alleged to have paid kickbacks to a funeral home employee for information about Medicare beneficiaries.

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Dynamic changes of gut microbiota during progression of three Alzheimer’s disease mice models

IntroductionAlzheimer’s disease (AD) is an age-related and progressive neurodegenerative disorder characterized by cognitive impairment and irreversible neuronal degeneration, affecting approximately 55 million individuals worldwide. Despite extensive research efforts, the underlying pathogenic mechanisms of AD remain incompletely understood, and effective therapeutic strategies for preventing or delaying disease progression are still lacking. Increasing evidence suggests that the microbiota-gut-brain axis plays an important role in neurodegenerative diseases, including AD. However, the dynamic alterations of gut microbiota during AD progression across different transgenic mouse models remain poorly characterized.MethodsIn the present study, we investigated age-dependent changes in gut microbiota composition in three commonly used AD mouse models, including APP/PS1, 3xTg, and 5xFAD mice, using 16S rRNA gene sequencing. Fecal samples were collected longitudinally at 2, 4, 6, and 8 months of age to evaluate microbial diversity, community structure, and differential bacterial taxa during aging and disease progression.ResultsOur results demonstrated distinct and model-dependent alterations in gut microbiota composition across different stages of AD progression. Significant changes in microbial diversity and bacterial community structure were observed among the three AD mouse models and wild-type controls. In particular, dynamic alterations in Verrucomicrobiota, Proteobacteria, and Actinobacteriota were consistently identified during aging in AD mice. In addition, β-diversity, Linear discriminant analysis effect size (LEfSe), and correlation network analyses further revealed differential microbial signatures associated with different AD mouse models and age stages.DiscussionOverall, our findings provide additional evidence that gut microbiota composition undergoes dynamic alterations during aging in multiple AD mouse models and may be associated with AD-related progression. This study may contribute to a better understanding of microbiota-associated changes during AD development and provide a basis for future mechanistic studies targeting the microbiota-gutbrain axis in AD.