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Is the oxytocin system a keystone in human wellbeing?
It has also taken over a century for science to fully realize that oxytocin is far more than a “female reproductive hormone.” Both the measurement and interpretation of the biochemical and functional properties of…
Asymmetric encoder-decoder U-net with hybrid attention and residual dilated convolution for brain tumor segmentation
InroductionThe accurate and automatic segmentation of brain tumors from magnetic resonance imaging is regarded as essential for clinical diagnosis and surgical planning. Nevertheless, the concurrent extraction of both local fine details and global contextual…
News
3048 results
Social cognitive deficits and altered multi-brain dynamics during problem-solving in heroin abstainers: An fNIRS hyperscanning study
Despite extensive research on the neurobiology of addiction, little is known about how repeated drug use and withdrawal are related to social functioning impairments in humans, a highly social species. This obscures the broader societal impact of drug addiction and…
Long Term Follow-up of Mentalization-Based Treatment: Exploring Variability in Outcomes, Long-term Value and Experiences 10+ Year After Receiving MBT Day Hospital or MBT Intensive Outpatient
Conditions: Borderline Personality Disorder Sponsors: De Viersprong; Arkin Not yet recruiting
Transcranial Photobiomodulation for Bipolar Depression
Conditions: Bipolar; Bipolar Disorder (BD); Bipolar Disorder Depression Interventions: Device: Vielight Neuro Rx Gamma; Device: Sham Device Sponsors: Vielight Inc. Not yet recruiting
Research on the Molecular Mechanism of Cognitive Differences Between Williams Syndrome and Autism Spectrum Disorder
Conditions: Williams Syndrome; Autism Disorder Sponsors: Qilu Hospital of Shandong University Not yet recruiting
The Unspoken Toll: Why Exam Pressure Must Be Part of the Youth Mental Health Discussion
A Conversation with Tatum Redmond and Amanda van der Vyver-Anderson from Community Keepers, South Africa By Mai El Shoush, Partnerships Campaign Manager, Stavros Niarchos Foundation (SNF) Global Center for Child and Adolescent Mental Health at the Child Mind Institute Community…
Beyond dopamine blockade: mechanistic humility and the rise of muscarinic, TAAR1, and glutamatergic pathways in schizophrenia
The approval of the first non–dopamine-blocking therapy for schizophrenia marks a defining moment in psychiatry. Muscarinic M1/M4 modulation, alongside emerging TAAR1 and glutamatergic pathways, signals a shift beyond dopamine dominance toward circuit-level integration. These advances embody mechanistic humility: the scientific…
Associations between adult ADHD core symptoms, cognitive flexibility, and emotional eating: a case-control study
IntroductionAttention-deficit/hyperactivity disorder (ADHD) in adults often co-occurs with eating disorders (EDs), potentially through shared difficulties in emotional regulation, and executive functions. This study explored the associations between cognitive flexibility as a component of executive functions, core adult ADHD symptom dimensions…
Narcolepsy as an immune-associated hypothalamic encephalopathy: orexin dysfunction and implications for precision sleep medicine
Narcolepsy can no longer be adequately conceptualized by excessive sleepiness and cataplexy. It is increasingly recognized as a multisystem hypothalamic encephalopathy, rooted in the selective loss or dysfunction of orexin neurons, yet extending across motor, psychiatric, metabolic, and autonomic domains.…
CABG-AI-Supported Discharge Education
Conditions: Coronary Artery Disease; Postoperative Care; Patient Discharge; Recovery of Function; Anxiety; Pain; Stress, Physiological; Surgical Nursing; Nursing; Discharge Education Interventions: Behavioral: AI-Supported Individualized Discharge Education; Behavioral: Standard Discharge Education Sponsors: Hasan Kalyoncu University Not yet recruiting
Evidence of monkeypox virus clade IIb lineage A.2.2 in the Republic of the Congo and co-circulation of clade Ia, Ib and clade IIb
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04256-2Whole-genome phylogenetic analyses have identified a case of monkeypox virus clade IIb lineage in the Republic of the Congo and co-circulation of three clade lineages, emphasizing the importance of improved surveillance given the risk…
The exposome of brain aging across 34 countries
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04302-zExposome analyses across 34 countries showed that social exposures were associated with faster functional brain aging and physical exposures with faster structural brain aging.
Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion
Conditions: Concussion; Depression Interventions: Device: ONE-D TMS protocol and d-cycloserine (125 mg) Sponsors: University of Florida Not yet recruiting
CARED : A Novel Rapid Treatment Paradigm for Depression
Conditions: Major Depressive Disorder Interventions: Device: Intermittent Theta Burst Stimulation (iTBS); Device: Transcranial Alternating Current Stimulation (tACS); Behavioral: Psychotherapy; Device: Sham (Placebo) Transcranial Alternating Current Stimulation (tACS) Sponsors: University of North Carolina, Chapel Hill; Foundation of Hope for the Research…
Efficacy of Spectrally Optimized Light on Cognitive Impairment in Major Depressive Disorder and Its Neuroimaging Mechanisms
Conditions: Major Depressive Disorder (MDD); Neuroimaging; Bright Light Treatment; Cognitive Impairment Interventions: Device: bright light; Device: dim red light(placebo) Sponsors: Peking University Sixth Hospital Not yet recruiting
Target product profiles for treatments to delay or prevent symptomatic Alzheimer’s disease
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04305-wTo accelerate therapeutic development and equip stakeholders with clear benchmarks, the authors outline target product profiles for therapies designed to delay or prevent the onset of clinical symptoms of Alzheimer’s disease.
Efficacy and Influencing Factors of Mindfulness-Based Exposure Group Therapy for OCD
Conditions: Obessive-Compulsive Disorder Interventions: Behavioral: mindfulness based exposure therapy; Other: Treatment as Usual (TAU) Sponsors: Shanghai Mental Health Center Recruiting
Improving Caregiver Engagement in Early Interventions
Conditions: Autism Interventions: Behavioral: FANS-EI; Behavioral: Early Intervention Sponsors: University of California, Davis; National Institute of Mental Health (NIMH) Not yet recruiting
Implementing Action-Based Cognitive Remediation for Transdiagnostic Cognitive Difficulties in a Tertiary Mental Health Hospital
Conditions: Psychiatric Disorders; Depression - Major Depressive Disorder; Schizophrenia and Other Psychotic Disorders; Anxiety and Mood Disorders; Bipolar and Related Disorders; PTSD - Post Traumatic Stress Disorder; Autism Spectrum Disorder Interventions: Behavioral: Action-Based Cognitive Remediation Sponsors: The Royal Ottawa Mental…
Safety Planning Intervention for Autistic Youth: A Randomized Controlled Trial With Providers in Developmental-Behavioral Pediatric Clinics
Conditions: Autism; Suicide Prevention Interventions: Behavioral: Safety Planning Intervention; Behavioral: Crisis Interventions for Pediatric Providers - Autism version (CIPP-A) Sponsors: Children's Hospital Los Angeles; Children's Hospital of Philadelphia Not yet recruiting
CFT Guided Self-help Intervention: Parents of Autistic Children
Conditions: Autism Disorders and Maternal Stress; Autism; Autism Disorder; Autism Spectrum Disorder; Autism in Children; Parent; Parent Mental Health; Parent Stress; Parent Support Interventions: Other: Guided, self-help compassion-focused intervention for parents of autistic children Sponsors: University of Nottingham; University Hospitals…
News Feed
Is the oxytocin system a keystone in human wellbeing?
It has also taken over a century for science to fully realize that oxytocin is far more than a “female reproductive hormone.” Both the measurement and interpretation of the biochemical and functional properties of…
Asymmetric encoder-decoder U-net with hybrid attention and residual dilated convolution for brain tumor segmentation
InroductionThe accurate and automatic segmentation of brain tumors from magnetic resonance imaging is regarded as essential for clinical diagnosis and surgical planning. Nevertheless, the concurrent extraction of both local fine details and global contextual…
News
3048 results
Social cognitive deficits and altered multi-brain dynamics during problem-solving in heroin abstainers: An fNIRS hyperscanning study
Despite extensive research on the neurobiology of addiction, little is known about how repeated drug use and withdrawal are related to social functioning impairments in humans, a highly social species. This obscures the broader societal impact of drug addiction and…
Long Term Follow-up of Mentalization-Based Treatment: Exploring Variability in Outcomes, Long-term Value and Experiences 10+ Year After Receiving MBT Day Hospital or MBT Intensive Outpatient
Conditions: Borderline Personality Disorder Sponsors: De Viersprong; Arkin Not yet recruiting
Transcranial Photobiomodulation for Bipolar Depression
Conditions: Bipolar; Bipolar Disorder (BD); Bipolar Disorder Depression Interventions: Device: Vielight Neuro Rx Gamma; Device: Sham Device Sponsors: Vielight Inc. Not yet recruiting
Research on the Molecular Mechanism of Cognitive Differences Between Williams Syndrome and Autism Spectrum Disorder
Conditions: Williams Syndrome; Autism Disorder Sponsors: Qilu Hospital of Shandong University Not yet recruiting
The Unspoken Toll: Why Exam Pressure Must Be Part of the Youth Mental Health Discussion
A Conversation with Tatum Redmond and Amanda van der Vyver-Anderson from Community Keepers, South Africa By Mai El Shoush, Partnerships Campaign Manager, Stavros Niarchos Foundation (SNF) Global Center for Child and Adolescent Mental Health at the Child Mind Institute Community…
Beyond dopamine blockade: mechanistic humility and the rise of muscarinic, TAAR1, and glutamatergic pathways in schizophrenia
The approval of the first non–dopamine-blocking therapy for schizophrenia marks a defining moment in psychiatry. Muscarinic M1/M4 modulation, alongside emerging TAAR1 and glutamatergic pathways, signals a shift beyond dopamine dominance toward circuit-level integration. These advances embody mechanistic humility: the scientific…
Associations between adult ADHD core symptoms, cognitive flexibility, and emotional eating: a case-control study
IntroductionAttention-deficit/hyperactivity disorder (ADHD) in adults often co-occurs with eating disorders (EDs), potentially through shared difficulties in emotional regulation, and executive functions. This study explored the associations between cognitive flexibility as a component of executive functions, core adult ADHD symptom dimensions…
Narcolepsy as an immune-associated hypothalamic encephalopathy: orexin dysfunction and implications for precision sleep medicine
Narcolepsy can no longer be adequately conceptualized by excessive sleepiness and cataplexy. It is increasingly recognized as a multisystem hypothalamic encephalopathy, rooted in the selective loss or dysfunction of orexin neurons, yet extending across motor, psychiatric, metabolic, and autonomic domains.…
CABG-AI-Supported Discharge Education
Conditions: Coronary Artery Disease; Postoperative Care; Patient Discharge; Recovery of Function; Anxiety; Pain; Stress, Physiological; Surgical Nursing; Nursing; Discharge Education Interventions: Behavioral: AI-Supported Individualized Discharge Education; Behavioral: Standard Discharge Education Sponsors: Hasan Kalyoncu University Not yet recruiting
Evidence of monkeypox virus clade IIb lineage A.2.2 in the Republic of the Congo and co-circulation of clade Ia, Ib and clade IIb
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04256-2Whole-genome phylogenetic analyses have identified a case of monkeypox virus clade IIb lineage in the Republic of the Congo and co-circulation of three clade lineages, emphasizing the importance of improved surveillance given the risk…
The exposome of brain aging across 34 countries
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04302-zExposome analyses across 34 countries showed that social exposures were associated with faster functional brain aging and physical exposures with faster structural brain aging.
Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion
Conditions: Concussion; Depression Interventions: Device: ONE-D TMS protocol and d-cycloserine (125 mg) Sponsors: University of Florida Not yet recruiting
CARED : A Novel Rapid Treatment Paradigm for Depression
Conditions: Major Depressive Disorder Interventions: Device: Intermittent Theta Burst Stimulation (iTBS); Device: Transcranial Alternating Current Stimulation (tACS); Behavioral: Psychotherapy; Device: Sham (Placebo) Transcranial Alternating Current Stimulation (tACS) Sponsors: University of North Carolina, Chapel Hill; Foundation of Hope for the Research…
Efficacy of Spectrally Optimized Light on Cognitive Impairment in Major Depressive Disorder and Its Neuroimaging Mechanisms
Conditions: Major Depressive Disorder (MDD); Neuroimaging; Bright Light Treatment; Cognitive Impairment Interventions: Device: bright light; Device: dim red light(placebo) Sponsors: Peking University Sixth Hospital Not yet recruiting
Target product profiles for treatments to delay or prevent symptomatic Alzheimer’s disease
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04305-wTo accelerate therapeutic development and equip stakeholders with clear benchmarks, the authors outline target product profiles for therapies designed to delay or prevent the onset of clinical symptoms of Alzheimer’s disease.
Efficacy and Influencing Factors of Mindfulness-Based Exposure Group Therapy for OCD
Conditions: Obessive-Compulsive Disorder Interventions: Behavioral: mindfulness based exposure therapy; Other: Treatment as Usual (TAU) Sponsors: Shanghai Mental Health Center Recruiting
Improving Caregiver Engagement in Early Interventions
Conditions: Autism Interventions: Behavioral: FANS-EI; Behavioral: Early Intervention Sponsors: University of California, Davis; National Institute of Mental Health (NIMH) Not yet recruiting
Implementing Action-Based Cognitive Remediation for Transdiagnostic Cognitive Difficulties in a Tertiary Mental Health Hospital
Conditions: Psychiatric Disorders; Depression - Major Depressive Disorder; Schizophrenia and Other Psychotic Disorders; Anxiety and Mood Disorders; Bipolar and Related Disorders; PTSD - Post Traumatic Stress Disorder; Autism Spectrum Disorder Interventions: Behavioral: Action-Based Cognitive Remediation Sponsors: The Royal Ottawa Mental…
Safety Planning Intervention for Autistic Youth: A Randomized Controlled Trial With Providers in Developmental-Behavioral Pediatric Clinics
Conditions: Autism; Suicide Prevention Interventions: Behavioral: Safety Planning Intervention; Behavioral: Crisis Interventions for Pediatric Providers - Autism version (CIPP-A) Sponsors: Children's Hospital Los Angeles; Children's Hospital of Philadelphia Not yet recruiting
CFT Guided Self-help Intervention: Parents of Autistic Children
Conditions: Autism Disorders and Maternal Stress; Autism; Autism Disorder; Autism Spectrum Disorder; Autism in Children; Parent; Parent Mental Health; Parent Stress; Parent Support Interventions: Other: Guided, self-help compassion-focused intervention for parents of autistic children Sponsors: University of Nottingham; University Hospitals…