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Maternal Blood Test Allows Comprehensive Genetic Fetal Screening
Non-invasive fetal sequencing (NIFS), a test developed by scientists at Harvard University, allows comprehensive genetic screening of a fetus using only a blood test from the expectant mother. The post Maternal Blood Test Allows…
Breaking Barriers in Student Mental Health Care With AI-Enhanced Group Cognitive Behavioral Therapy: Pilot Feasibility Study
Background: University students experience elevated psychological distress, with limited access to mental health services. While cognitive behavioral therapy (CBT) demonstrates efficacy for anxiety and depression, treatment gaps persist due to access barriers and insufficient…
Using a Virtual Reality CAVE–Based Mindfulness Intervention to Promote Mental Well-Being in Adolescents With Anxiety Symptoms: Pre-Post Mixed Methods Pilot Study
Background: Adolescent anxiety is a growing public health concern associated with significant social and emotional impairment. Mindfulness-based interventions (MBIs) have shown promise in reducing anxiety and improving well-being; however, engagement remains challenging. Virtual reality…
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Breaking Barriers in Student Mental Health Care With AI-Enhanced Group Cognitive Behavioral Therapy: Pilot Feasibility Study
Background: University students experience elevated psychological distress, with limited access to mental health services. While cognitive behavioral therapy (CBT) demonstrates efficacy for anxiety and depression, treatment gaps persist due to access barriers and insufficient between-session support. Large language model (LLM)…
Using a Virtual Reality CAVE–Based Mindfulness Intervention to Promote Mental Well-Being in Adolescents With Anxiety Symptoms: Pre-Post Mixed Methods Pilot Study
Background: Adolescent anxiety is a growing public health concern associated with significant social and emotional impairment. Mindfulness-based interventions (MBIs) have shown promise in reducing anxiety and improving well-being; however, engagement remains challenging. Virtual reality (VR)–based delivery may enhance immersion and…
Prevalence and Predictors of Self-Reported Adverse Experiences in Digital Meditation Training: 2 Randomized Controlled Trials
Background: Digital meditation-based interventions (MBIs) reach vast global audiences with millions of active users, yet concerns persist about the frequency and nature of adverse experiences (ie, AExs) occurring during meditation training. Some researchers have argued that AExs are substantially underdetected…
STAT+: Trump administration revisits policy to close Medicare drug price negotiation loophole
Trump administration revisits policy to plug Medicare drug price negotiation loophole.
Passive Smart Home Monitoring for Delirium-Relevant Anomaly Detection in People Living With Dementia: Proof-of-Concept Study
Background: Delirium superimposed on dementia is associated with poor outcomes yet remains underdetected in home settings. Current detection relies on face-to-face clinical assessment (eg, the Confusion Assessment Method criteria), which is rarely applied outside hospitals. Objective: This proof-of-concept study developed…
The Download: “reprogramming” aging, and the hidden sense of interoception
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Why “reprogramming” is the buzziest approach to reversing aging right now Earlier this week, Life Biosciences,…
Distribution of bladder afferent activity across the sacral roots in sheep shows marked individual variation: implications for neuroprosthesis design
ObjectiveImplantable sacral anterior root stimulators enable bladder emptying after spinal cord injury but do not prevent reflex incontinence. A closed-loop neuroprosthesis that detects and inhibits reflex bladder contractions could address this, but first, reliable detection of bladder fullness from the…
Artificial intelligence for autism spectrum disorder: advances in diagnosis, behavior analysis and educational support
IntroductionArtificial intelligence has become an increasingly relevant field of research in the study of Autism Spectrum Disorder (ASD), offering novel technological approaches for the analysis, detection, and support of individuals on the autism spectrum. The aim of this study was…
Head circumference assessment in pediatric MRI: a pilot study of manual measurement methods and automated segmentation-based alternatives
PurposeHead circumference (HC) is an important clinical parameter in neuropediatrics, but it is often missing or outdated in referral information. This can lead to subjective, reader-dependent estimation during MRI interpretation. We first aimed to compare magnetic resonance imaging (MRI)-based methods…
Problematic social media use, everyday memory failures, and prospective and retrospective lapses: evidence from a large sample of young adults
IntroductionProblematic social media use (PSMU) has become a growing research topic due to its potential psychological and cognitive consequences. However, little research has examined its relationship with everyday memory functioning, particularly specific forms of memory.MethodsA sample of 943 Spanish young…
Affect before diagnosis: applying affective neuroscience to psychiatry
Jaak Panksepp spent nearly five decades mapping the primary-process affective systems of the mammalian brain across different species, producing a framework of considerable empirical power that is functionally invisible within psychiatry. Psychiatry has not built upon that literature in human…
Comparison of the therapeutic effects of open psychiatric wards for patients with depression: a meta-analysis
ObjectiveTo systematically evaluate and compare the differences in treatment outcomes between open and closed psychiatric wards for hospitalized patients with depression, and to provide evidence-based support for optimizing psychiatric ward management models.MethodsPubMed, Web of Science, China National Knowledge Infrastructure (CNKI),…
Sexual function in women with complex PTSD: a comparative study
BackgroundPosttraumatic stress disorder (PTSD) is associated with impaired sexual functioning in women, but the effects of complex PTSD (CPTSD) remain unclear. This study tested three hypotheses: (1) women with CPTSD would report lower overall sexual function than women with PTSD…
Logotherapy techniques to unlock resilience among Ukrainian refugees: a pre-post quasi-experimental design
The ongoing Russian-Ukrainian war has triggered a significant refugee crisis, resulting in widespread trauma, displacement, and mental health challenges among affected populations. This study aimed to explore the potential usefulness of logotherapy, a meaning-centered therapy, in addressing the mental health…
The Hong Kong Genome Project is a flagship initiative for precision medicine in Chinese populations
Nature Medicine, Published online: 12 June 2026; doi:10.1038/s41591-026-04421-7The Hong Kong Genome Project established a genome sequencing database that provides improved diagnoses for patients and more efficient, population-tailored carrier status screening. Actionable pharmacogenomic variants were identified in almost all participants, informing…
Efficacy and target engagement of dopamine agonist pramipexole for anhedonic depression: a randomized placebo-controlled trial
Nature Medicine, Published online: 12 June 2026; doi:10.1038/s41591-026-04465-9Pramipexole, in patients with major depressive disorder, dysthymia or bipolar depression, reduced Snaith−Hamilton Pleasure Scale scores significantly compared to placebo.
General-purpose large language models outperform specialized clinical AI tools on medical benchmarks
Nature Medicine, Published online: 12 June 2026; doi:10.1038/s41591-026-04431-5In an independent evaluation, frontier large language models outperformed specialized clinical artificial intelligence tools on medical knowledge, clinician alignment and real-world clinical queries.
Striatal pathways dissociably control action counting and goal-directed steering
Nature Neuroscience, Published online: 12 June 2026; doi:10.1038/s41593-026-02330-zStriatal direct and indirect pathways jointly control how many actions are performed during counting, and how animals move toward specific goals. These pathways implement a push–pull controller for discrete action counting as well…
Chile offers new data on food warning label efficacy
Kennedy's "publicly" "available" "calendar," drinking during pregnancy, and more health news from Morning Rounds