Radically different
Nature Biotechnology, Published online: 22 July 2026; doi:10.1038/s41587-026-03203-3
The cell-by-cell interactions between neoantigen-expressing tumor cells and tumor-specific T cells remained largely unexplored. A single-cell spatial transcriptomics framework enables mapping of neoantigen-expressing tumor cells and tumor-infiltrating T cells, as well as T cell receptor sequencing. This approach reveals distinct immune niches in the tumor microenvironment and their properties that determine tumor-specific responses.
Nature Biotechnology, Published online: 22 July 2026; doi:10.1038/s41587-026-03194-1
Spatial relationships between tumor neoantigens and cognate T cells are studied.
Nature Medicine, Published online: 22 July 2026; doi:10.1038/s41591-026-04593-2
Author Correction: Multi-antigen-targeting T cells in pediatric central nervous system tumors: a phase 1 trial