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Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
Circio and GenAssist Collaborate on Gene Therapy for Muscle Disease and In Vivo Cell Therapy
An official at Circio says that by integrating Circio's and GenAssist's complementary technologies, the parties aim to focus on the development of a joint next generation of AAV gene therapy candidates. The post Circio…
Detection of Self-Harm in Electronic Mental Health Records Using Privacy-Preserving Local Language Models: Methodological Study
Background: Self-harm is the strongest risk factor for suicide and an important outcome for mental health care. Although prevalent in clinical populations, it is often imprecisely captured in routinely collected clinical data, where it…
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Detection of Self-Harm in Electronic Mental Health Records Using Privacy-Preserving Local Language Models: Methodological Study
Background: Self-harm is the strongest risk factor for suicide and an important outcome for mental health care. Although prevalent in clinical populations, it is often imprecisely captured in routinely collected clinical data, where it is often recorded and stored as…
Chemotherapy-related cognitive impairment and non-pharmacological interventions targeting the nervous system: a systematic review
BackgroundChemotherapy-related cognitive impairment (CRCI) represents an increasingly recognized problem in the growing cancer survivor population within the US and worldwide. CRCI is characterized by deficits in memory, sustained attention, and executive function, which significantly worsens the cancer survivors’ quality of…
Platform shift in mental health support among undergraduates: from campus counselors to GenAI-based consultation
China is advancing the implementation of the “AI+” initiative and exploring the promotion of AI technology in scenarios such as health management and assisted diagnosis. Against this backdrop, universities are accelerating the adoption of GenAI virtual counseling tools to address…
Determinants of mental health distress among health workers in Abu Dhabi, United Arab Emirates
Healthcare workers (HCWs) remain at elevated risk of psychological distress, yet post-pandemic evidence from the United Arab Emirates is scarce. This cross-sectional electronic survey assessed depression, anxiety, and stress among physicians and nurses providing direct clinical care across Abu Dhabi…
Suicide risk assessment: clinical implications of the unpredictability of suicidal behavior
Risk assessment in the context of suicidal ideation and behavior cannot be conducted with certainty. Recent meta-analyses demonstrate that neither individual risk factors, composite risk scores, clinical judgment, nor adherence to theoretical models or artificial intelligence enables sufficiently accurate prediction…
Reduced left dorsolateral prefrontal activation and right inferior frontal de-oxygenation differ between psychotic and non−psychotic adolescent depression during verbal fluency
BackgroundAdolescents with major depressive disorder (MDD) who exhibit psychotic symptoms (MDD-Psy) often show greater clinical severity and higher suicide risk than those without psychosis (MDD-NonPsy). It remains unclear whether prefrontal hemodynamic responses during cognitive challenge can differ between these subgroups.MethodsWe…
Programmable, multiplexed and orthogonal gene control in bacteria with attenuated Cas13d systems
Nature Biotechnology, Published online: 02 June 2026; doi:10.1038/s41587-026-03160-xA Cas13-based gene switch allows multiplexed RNA regulation in bacteria.
Translating ‘food is medicine’ from concept to reality
Nature Medicine, Published online: 02 June 2026; doi:10.1038/s41591-026-04420-8An ancient concept gathers scientific evidence as medically tailored meals show potential to lower healthcare utilization and costs — but larger studies are needed alongside policies to scale and sustain evidence-based approaches.
Medically tailored meals receipt and healthcare utilization and costs in Massachusetts’ Medicaid demonstration
Nature Medicine, Published online: 02 June 2026; doi:10.1038/s41591-026-04407-5Between 2020 and 2023, in Massachusetts, receiving medically tailored meals was associated with reductions in hospitalizations and emergency department visits and lower healthcare costs.
15-strain live biotherapeutic product or same donor fecal microbiota transplant for recurrent Clostridioides difficile infection: a randomized phase 1b trial
Nature Medicine, Published online: 02 June 2026; doi:10.1038/s41591-026-04442-2A randomized, single-blind, parallel-group, phase 1b clinical trial compared fecal microbiota transplant or a 15-strain live biotherapeutic product (MTC01) derived from the same donor and found similar efficacy and engraftment between treatments.
Microbial reactivation of host androgens directs enteric neuronal regulation of gut motility
Nature Neuroscience, Published online: 02 June 2026; doi:10.1038/s41593-026-02321-0This study shows that androgens signal to specific enteric neurons to stimulate gut motility. Bacterial metabolism of host-derived steroids generates the ligands, revealing a dynamic host–microbe interaction that influences nervous system function.
Rehumanizing global health care with agentic AI
The global health care sector is under increasing strain. Decades of chronic underinvestment and constraints in recruitment have coincided with a surge in demand for services for aging populations. Gaps in provision are already taking a toll, with fragmented access…
How small businesses can leverage AI
This article is from Making AI Work, MIT Technology Review’s limited-run newsletter examining how to apply LLMs across industries. To receive it in your inbox,sign up here. From accounting to design to market research and product development, there’s a staggering…
Opinion: The virtual end of the doctor’s office waiting room
It’s time to rethink and redesign how patients enter the health care system altogether, writes emergency physician Iyesatta Massaquoi Emeli.
STAT+: Online care is caught in the crossfire as states crack down on corporate medicine
Growing legislative scrutiny across multiple states targets the corporate structure underlying most direct-to-consumer telehealth businesses.
The Download: China’s brain implant ambitions
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. China has approved the world’s first invasive brain-computer chip—here’s what’s next Sitting in the courtyard of…
STAT+: Trump administration releases rules for new Medicaid work requirements
States are racing to implement the new requirements by the start of next year.
STAT+: Eli Lilly warns hospitals to submit claims data in the next five days or lose their 340B drug discounts
Eli Lilly has told more than 1,000 hospitals participating in the 340B drug discount program to submit claims data over the next five days — or lose price breaks.
STAT+: Global coalition to fast-track three vaccines targeting Ebola outbreak with $62 million in funding
With no licensed vaccines available to protect against the Ebola virus currently spreading in the Congo, efforts are underway to fast-track development of at least three vaccines.
STAT+: Abivax ulcerative colitis drug shows strong efficacy, but cases of cancer raise concerns
Abivax said its experimental treatment for ulcerative colitis showed significant efficacy in a closely watched trial, but shares of the company tanked on safety concerns.