STAT+: Cell therapy primed liver transplant patients to avoid organ rejection, small study shows

Immune tolerance has long been the holy grail in transplant medicine, a hoped-for end to the downsides of anti-rejection regimens for patients after they receive lifesaving organ transplants. A small, early-stage study now shows promise in taking cells from living donors — people giving a portion of their livers — to teach recipients’ immune systems to accept the foreign organs as their own and achieve the ultimate healthy outcome. 

Living donations take advantage of the liver’s ability to regenerate, meaning donors can part with a piece of their liver and later see it grow back. Recipients can regain enough liver function from the partial organs that also grow, replacing livers damaged by alcohol-associated liver disease, metabolic-associated liver disease, liver cancer, or other causes. Immunosuppression keeps their bodies from rejecting the new organs, but it also raises their vulnerability to infectious diseases and certain cancers. Serious side effects from the drugs include developing diabetes and kidney damage.

Cell therapy has been tried before to disarm the immune system’s attack by recruiting regulatory T immune cells taken from the donor. In the new study, whose results were published Friday in Nature Communications, different immune cells known as regulatory dendritic cells were obtained from donors’ white blood cells and generated in a lab. The idea behind both cell therapies is the same: to teach immune cells in the recipient’s body to treat the donated liver fragment as familiar tissue, not an invader be attacked.

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Opinion: Don’t believe headlines saying that vaccine skepticism is widespread

Two years ago, I wrote in the New England Journal of Medicine that one of the greatest threats to childhood vaccination is the normalization of skepticism, even though it isn’t actually the norm. When credible outlets, trusted voices, and social media algorithms tell the public that most Americans doubt vaccines, some may start to wonder if they should, too. I watched that play out this week.

On Monday, Politico published a poll on vaccine attitudes titled, “More Americans doubt vaccine safety than trust it, Politico Poll finds,” followed by the subhead, “Health Secretary Robert F. Kennedy Jr.’s views are commonplace across the land.” I consider Politico a reputable news outlet, so this headline stopped me in my tracks.

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Opinion: Health care is not ready for the new era of AI-enabled cyberattacks

On April 6, cancer patients at Brockton Hospital in Massachusetts showed up for chemotherapy infusions and were told to go home. The hospital’s information systems had been hit by a cyberattack. The ER closed. Ambulances were diverted. Staff switched to paper records. Patients were told to call back later to reschedule their treatment.

This wasn’t the first time that this kind of incident has happened. In May 2024, the Ascension ransomware attack took down systems across 136 hospitals for six weeks. That same year, the Change Healthcare breach compromised the personal health information of 100 million Americans, roughly one in three people in the country, and disrupted billing and authorization systems so severely that physician practices warned they might have to close their doors. After the Change breach, an AHA survey of nearly 1,000 hospitals found that 74% reported direct impact on patient care.

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Why having “humans in the loop” in an AI war is an illusion

The availability of artificial intelligence for use in warfare is at the center of a legal battle between Anthropic and the Pentagon. This debate has become urgent, with AI playing a bigger role than ever before in the current conflict with Iran. AI is no longer just helping humans analyze intelligence. It is now an active player—generating targets in real time, controlling and coordinating missile interceptions, and guiding lethal swarms of autonomous drones.

Most of the public conversation regarding the use of AI-driven autonomous lethal weapons centers on how much humans should remain “in the loop.” Under the Pentagon’s current guidelines, human oversight supposedly provides accountability, context, and nuance while reducing the risk of hacking.

AI systems are opaque “black boxes”

But the debate over “humans in the loop” is a comforting distraction. The immediate danger is not that machines will act without human oversight; it is that human overseers have no idea what the machines are actually “thinking.” The Pentagon’s guidelines are fundamentally flawed because they rest on the dangerous assumption that humans understand how AI systems work.

Having studied intentions in the human brain for decades and in AI systems more recently, I can attest that state-of-the-art AI systems are essentially “black boxes.” We know the inputs and outputs, but the artificial “brain” processing them remains opaque. Even their creators cannot fully interpret them or understand how they work. And when AIs do provide reasons, they are not always trustworthy.

The illusion of human oversight in autonomous systems

In the debate over human oversight, a fundamental question is going unasked: Can we understand what an AI system intends to do before it acts?

Imagine an autonomous drone tasked with destroying an enemy munitions factory. The automated command and control system determines that the optimal target is a munitions storage building. It reports a 92% probability of mission success because secondary explosions of the munitions in the building will thoroughly destroy the facility. A human operator reviews the legitimate military objective, sees the high success rate, and approves the strike.

But what the operator does not know is that the AI system’s calculation included a hidden factor: Beyond devastating the munitions factory, the secondary explosions would also severely damage a nearby children’s hospital. The emergency response would then focus on the hospital, ensuring the factory burns down. To the AI, maximizing disruption in this way meets its given objective. But to a human, it is potentially committing a war crime by violating the rules regarding civilian life. 

Keeping a human in the loop may not provide the safeguard people imagine, because the human cannot know the AI’s intention before it acts. Advanced AI systems do not simply execute instructions; they interpret them. If operators fail to define their objectives carefully enough—a highly likely scenario in high-pressure situations—the “black box” system could be doing exactly what it was told and still not acting as humans intended.

This “intention gap” between AI systems and human operators is precisely why we hesitate to deploy frontier black-box AI in civilian health care or air traffic control, and why its integration into the workplace remains fraught—yet we are rushing to deploy it on the battlefield.

To make matters worse, if one side in a conflict deploys fully autonomous weapons, which operate at machine speed and scale, the pressure to remain competitive would push the other side to rely on such weapons too. This means the use of increasingly autonomous—and opaque—AI decision-making in war is only likely to grow.

The solution: Advance the science of AI intentions

The science of AI must comprise both building highly capable AI technology and understanding how this technology works. Huge advances have been made in developing and building more capable models, driven by record investments—forecast by Gartner to grow to around $2.5 trillion in 2026 alone. In contrast, the investment in understanding how the technology works has been minuscule.

We need a massive paradigm shift. Engineers are building increasingly capable systems. But understanding how these systems work is not just an engineering problem—it requires an interdisciplinary effort. We must build the tools to characterize, measure, and intervene in the intentions of AI agents before they act. We need to map the internal pathways of the neural networks that drive these agents so that we can build a true causal understanding of their decision-making, moving beyond merely observing inputs and outputs. 

A promising way forward is to combine techniques from mechanistic interpretability (breaking neural networks down into human-understandable components) with insights, tools, and models from the neuroscience of intentions. Another idea is to develop transparent, interpretable “auditor” AIs designed to monitor the behavior and emergent goals of more capable black-box systems in real time.  

Developing a better understanding of how AI functions will enable us to rely on AI systems for mission-critical applications. It will also make it easier to build more efficient, more capable, and safer systems.

Colleagues and I are exploring how ideas from neuroscience, cognitive science, and philosophy—fields that study how intentions arise in human decision-making—might help us understand the intentions of artificial systems. We must prioritize these kinds of interdisciplinary efforts, including collaborations between academia, government, and industry.

However, we need more than just academic exploration. The tech industry—and the philanthropists funding AI alignment, which strives to encode human values and goals into these models—must direct substantial investments toward interdisciplinary interpretability research. Furthermore, as the Pentagon pursues increasingly autonomous systems, Congress must mandate rigorous testing of AI systems’ intentions, not just their performance.

Until we achieve that, human oversight over AI may be more illusion than safeguard.

Uri Maoz is a cognitive and computational neuroscientist specializing in how the brain transforms intentions into actions. A professor at Chapman University with appointments at UCLA and Caltech, he leads an interdisciplinary initiative focused on understanding and measuring intentions in artificial intelligence systems (ai-intentions.org).

Transcutaneous auricular vagus nerve stimulation to alleviate metformin-associated gastrointestinal adverse events and optimize glycaemic control: a randomized, sham-controlled pilot trial protocol

BackgroundGastrointestinal adverse events (GI AEs) are the main dose-limiting side effects of metformin in type 2 diabetes mellitus (T2DM), reducing adherence and compromising long-term glycaemic control. Current strategies (dose adjustment or combination therapy) seldom address both tolerability and sustained metabolic efficacy. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive neuromodulation technique that may modulate gut–brain–metabolic pathways—vagal reflexes, inflammation, intestinal barrier function, and enteroendocrine signaling—and thus improve drug tolerance while preserving glycaemic control.MethodsThis single-center, randomized, sham-controlled pilot trial will enroll 60 T2DM patients with metformin-associated GI AEs, randomized 1:1 to either the taVNS group or the sham control group. The intervention lasts 2 weeks with a follow-up at week 4. Assessments at baseline and follow-up include a validated Metformin Symptom Severity Score (total score 0–50; primary outcome), Bristol Stool Form Scale, bowel urgency, glycaemic/metabolic indices [fasting blood glucose (FBG), 2-h postprandial glucose (PG2h), glycated albumin (GA), fasting C-peptide, fasting insulin, HOMA-IR, ISI], and mechanistic biomarkers (GLP-1, 5-HT, IL-6, IL-10, TNF-α, D-lactate, DAO, bile acids). Safety monitoring includes routine hematology, liver and renal function tests.DiscussionBy combining clinical outcomes with targeted biomarker analyses in a randomized design, this pilot study will assess whether taVNS alleviates metformin-associated GI intolerance without impairing glycaemic efficacy, and will provide feasibility data, effect-size estimates, and biomarker selection for future confirmatory trials.Clinical trial registrationTrial registration International Traditional Medicine Clinical Trial Registry (ITMCTR) http://itmctr.ccebtcm.org.cn/, Identifier: ITMCTR2025001086.

Cerebral blood flow and functional connectivity immediate changes following intradermal acupuncture in major depressive disorder

BackgroundAcupuncture has been increasingly applied as an adjunctive treatment for major depressive disorder (MDD), yet its central neurobiological mechanisms remain insufficiently understood. Cerebral blood flow (CBF) and functional connectivity strength (FCS) provide complementary perspectives on regional metabolic activity and large-scale functional integration, and their coupling may reflect neurovascular coordination relevant to depression.MethodsTwenty patients with MDD and twenty matched healthy controls (HC) underwent resting-state MRI. Patients received intradermal acupuncture (IA) and were scanned before and immediately after stimulation, while healthy controls were scanned once. Voxel-wise analyses of CBF, FCS, and their ratio (CBF/FCS) were performed to characterize acupuncture-related changes in neurovascular coupling. Group comparisons and pre–post acupuncture effects were assessed at the whole gray matter level.ResultsAcupuncture induced significant alterations in CBF/FCS coupling across widespread brain regions, including the bilateral precuneus, postcentral gyrus, superior temporal pole, superior frontal gyrus, occipital cortex, and cerebellum. These regions are primarily involved in sensorimotor processing, cognitive control, and emotional regulation. Overall, IA was associated with an immediate increase in CBF/FCS coupling, suggesting enhanced coordination between cerebral perfusion and functional network integration.ConclusionThis study provides evidence that intradermal acupuncture modulates neurovascular coupling in patients with MDD, offering neuroimaging-based insights into its antidepressant mechanisms. The findings support the notion that acupuncture may facilitate more efficient brain function by optimizing the balance between neural activity and metabolic supply.

Effect of low-intensity focused ultrasound on hippocampus of alcohol addicted mice: a preliminary study

Alcohol addiction is a chronic relapsing brain disorder characterized by significant neurobiological changes, particularly within the hippocampus, which mediates emotional regulation and reward-seeking behavior. Previous studies have shown that alcohol-induced neuronal injury contributes to withdrawal-associated anxiety and persistent alcohol preference. This study investigated the therapeutic effects of low-intensity focused ultrasound (LIFU) on the hippocampus in a mouse model of alcohol addiction. Twenty-six male C57BL/6 mice were allocated to an alcohol-exposed group (n = 20) and a control group (n = 6). Following a 28-day modeling period, the alcohol group was randomly subdivided into a therapy group and a sham group. The therapy group received LIFU treatment, while the sham group underwent an identical procedure with the ultrasound transducer powered off. After seven days of treatment, the therapy group exhibited less severe anxiety symptoms upon alcohol withdrawal and a reduced preference for alcohol compared to the sham group. The brain-derived neurotrophic factor (BDNF) concentration was significantly lower in the therapy group than in the sham group, but did not differ significantly from the control group. Hippocampal HE staining revealed more pronounced degeneration and apoptosis of granule cells in the dentate gyrus (DG) region in the sham group relative to the therapy group. These preliminary findings suggest that LIFU may modulate alcohol addiction by mitigating hippocampal neuronal injury.

Interoceptive dysfunction and its neural correlates in schizophrenia: protocol for a cross-sectional multimodal MRI study

BackgroundInteroception—the perception and integration of internal bodily signals—is fundamental to emotion regulation, bodily self-awareness, and predictive coding. Emerging evidence suggests that interoceptive disturbances may contribute to core psychopathological features of schizophrenia. Our research group recently conducted a systematic review and meta-analysis demonstrating significant impairments in interoceptive accuracy and sensitivity among individuals with schizophrenia. However, the neural mechanisms underlying these deficits remain unclear.MethodsThis cross-sectional protocol will recruit 30 individuals with schizophrenia and 30 age- and sex-matched healthy controls. Participants will complete (1) behavioral interoceptive assessment using the heartbeat counting task; (2) subjective interoceptive questionnaires, including the Multidimensional Assessment of Interoceptive Awareness (MAIA) and the Body Perception Questionnaire (BPQ); (3) clinical symptom ratings (PANSS, HAM-A, HAM-D); and (4) cognitive testing (TMT, animal fluency, DSST). All participants will undergo multimodal MRI scanning, including structural T1-weighted imaging, resting-state fMRI, and diffusion tensor imaging. Neuroimaging data will be preprocessed and analyzed using DPABISurf, SPM12, and GRETNA. Expected Results: We anticipate that individuals with schizophrenia will show reduced interoceptive accuracy, altered subjective interoceptive awareness, and abnormal intrinsic neural activity and connectivity within interoception-related circuits, including the anterior insula, anterior cingulate cortex, amygdala, and thalamus. Structural abnormalities within thalamo-cortical pathways are also expected. Interoceptive deficits are hypothesized to correlate with symptom severity and cognitive performance.ConclusionsThis study will provide an integrated characterization of interoceptive dysfunction and its neural correlates in schizophrenia. Findings may advance understanding of bodily self-disturbance and emotional dysregulation and support the development of future interoception-focused therapeutic approaches.Clinical trial registrationhttps://www.chictr.org.cn/, identifier ChiCTR2500110551.