Science, Volume 392, Issue 6799, Page 718-723, May 2026.
Raf-like protein kinase heterocomplexes directly regulate the plant plasma membrane H+-ATPase
Science, Volume 392, Issue 6799, Page 755-760, May 2026.
Accelerated Himalayan river meandering and dynamics due to climate change
Science, Volume 392, Issue 6799, May 2026.
A powerhouse species in peril
Science, Volume 392, Issue 6799, Page 693-693, May 2026.
PSA screening for prostate cancer reduces disease-specific deaths, new review shows
Prostate-specific antigen (PSA) blood testing is likely to reduce the risk of death from prostate cancer, found a new review published on Thursday by an influential international science research organization — a shift in medical evidence that could encourage wider use.
The Cochrane review’s first author, Juan Franco from Heinrich Heine University Düsseldorf in Germany, said at a press conference that they have “moderate certainty” that the screening test, which identifies high levels of PSA as a potential marker of prostate cancer, leads to a reduction in disease-specific deaths. The benefits are marginal: the review analyzed results from six trials involving 800,000 participants conducted in Europe and North America, and found about two fewer prostate cancer deaths for every 1,000 men screened.
[Editorial] Maternal depression: improving estimates and care
The first Wednesday of May marks World Maternal Mental Health Day, now celebrating a decade of advocacy to prioritise maternal mental health. Maternal depression is a prevalent illness that increases the risk of maternal morbidity and mortality, and contributes to adverse outcomes for offspring and family. Despite its substantial burden, maternal depression remains underdetected and undertreated.
[Comment] From policy to practice: implementing China’s measures to strengthen student mental health
In October 2025, China’s Ministry of Education issued ten national measures to strengthen mental health work in primary and secondary schools.1 These measures target major school-linked stressors such as academic pressure, physical activity, sleep, and internet use, and they call for whole-staff responsibility and cross-department collaboration. The policy signals a shift from episodic crisis response towards a public mental health agenda spanning prevention, early identification, supportive school environments, and referral pathways.
[Comment] Applying a quality lens to strengthening WHO European region child and youth mental health services
Child and youth mental health is a growing area of concern across the WHO European region. However, evidence on how to strengthen the quality of child and youth mental health care is lacking,1 and governance mechanisms, such as quality standards, treatment guidelines, and protocols for child and youth mental health, exist in only a few countries across this region.
[Comment] How much is enough in ADHD pharmacotherapy?
The evidence base for ADHD pharmacotherapy has answered one question more confidently than any other: whether medications are effective, on average, in reducing core ADHD symptoms. We know that several stimulant and non-stimulant treatments, including methylphenidate, amphetamines, atomoxetine, and guanfacine, improve symptoms at the patient-group level.1 What has remained harder to identify is where titration should stop: the point at which further dose escalation is unlikely to yield meaningful additional benefit and might instead worsen tolerability.
[Comment] Perinatal psychiatry: thinking in threes—before, during, and after pregnancy
Perinatal psychiatry is a recent specialty. Only a few countries offer specific training and specialised care, even though it is considered a major public health issue worldwide.1 Perinatal psychiatry remains ill-defined and has often been reduced to women’s mental health during pregnancy and postpartum. However, the World Psychiatric Association recognises that perinatal mental health is both a maternal (if not parental) and an infant mental health issue.2 Peripartum depression is considered the most common health risk for parents and their offspring.