Nature Biotechnology, Published online: 14 April 2026; doi:10.1038/s41587-026-03095-3
FAMSA2 accurately aligns millions of protein sequences at high speed.
Editorial Expression of Concern: Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04390-x
Editorial Expression of Concern: Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions
The gut microbiome as a fingerprint of antibiotic use history
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04360-3
Antibiotic use over the past 8 years was associated with alterations in the gut microbiome composition in 14,979 individuals. These analyses integrated data from the Swedish National Prescribed Drug Register and stool metagenomic profiles. Alterations were found even after a single antibiotic course and varied markedly across different antibiotic classes.
Antisense oligonucleotide-mediated knockdown therapy in two infants with severe KCNT1 epileptic encephalopathy
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04314-9
Two individuals with KCNT1-related epileptic encephalopathy were treated with a KCNT1-targeting antisense oligonucleotide, leading to significant reductions in seizure frequency and intensity, but also the development of hydrocephalus.
Elraglusib and chemotherapy in metastatic pancreatic ductal adenocarcinoma: a randomized controlled phase 2 trial
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04327-4
In this phase 2 trial, combination treatment with elraglusib, a cell-permeable ATP-competitive inhibitor of glycogen synthase kinase-3β, and gemcitabine plus nab-paclitaxel (GnP), in patients with previously untreated metastatic pancreatic ductal adenocarcinoma led to prolonged overall survival compared with GnP only.
Intravitreal photoswitch therapy in advanced retinitis pigmentosa: a phase 1 open-label trial
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04317-6
A first-in-human phase 1 trial shows that intravitreal photoswitch therapy can be administered safely in advanced retinitis pigmentosa, with exploratory signals compatible with light responsiveness following treatment.
White matter pathways mediating dorsolateral prefrontal TMS therapy for depression
Nature Neuroscience, Published online: 14 April 2026; doi:10.1038/s41593-026-02248-6
Seguin et al. show that the efficacy of transcranial magnetic stimulation for depression depends on how stimulation spreads through the brain’s wiring. Patients with shorter communication pathways between stimulated sites and mood-related regions had better clinical outcomes.
Rapid temporal processing in the olfactory bulb underlies concentration-invariant odor identification and signal decorrelation
Nature Neuroscience, Published online: 14 April 2026; doi:10.1038/s41593-026-02250-y
This study shows that the brain’s smell center uses precise timing and inhibition to read out early odor signals, enabling reliable odor identity across concentrations while rapidly separating (decorrelating) similar smell patterns for better discrimination.
HSV-1 strain H129 co-opts neuronal synaptic transmission machinery for its transsynaptic spread
Nature Neuroscience, Published online: 14 April 2026; doi:10.1038/s41593-026-02254-8
By assembling into ‘virion vesicles’, the H129 strain of herpes simplex virus-1 hijacks synaptic machinery for its anterograde spread, co-opting voltage-gated Ca2+ channels, Syt7 and SNAREs for presynaptic exit, then nectin-1/CME for postsynaptic entry.
A fluoride shortage for some U.S. water systems
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