IntroductionAttention-deficit/hyperactivity disorder (ADHD) in adults often co-occurs with eating disorders (EDs), potentially through shared difficulties in emotional regulation, and executive functions. This study explored the associations between cognitive flexibility as a component of executive functions, core adult ADHD symptom dimensions and emotional eating-related eating behaviorsin adults with ADHD and healthy controls, within the framework of executive functions.MethodsThis case-control study included 76 adults with ADHD and 69 healthy controls. Participants completed the Self-Report Wender-Reimherr Adult Attention Deficit Disorder Scale (SR-WRAADDS), Emotional Eating Questionnaire (EEQ), Hospital Anxiety and Depression Scale, Cognitive Control and Flexibility Questionnaire (CCFQ), and Berg’s Card Sorting Test. Group differences were tested with t-tests, correlations with Spearman’s ρ, and hierarchical regression (Approval No: I11-798-23).ResultsThe ADHD group had significantly higher EEQ scores (t = 5.39, p =0.001). The ADHD group also showed lower CCFQ total score (t (125) = –5.52, p <0.001). EEQ scores were positively correlated with SR-WRAADDS Attention Deficit (ρ =0.331, p =0.003), and CCFQ Cognitive Control over Emotion (ρ = −0.256, p =0.02). Regression analysis identified attention deficit as the only significant predictor of the EEQ total scorein the ADHD group.DiscussionOur findings suggest that impairments in executive functioning—including cognitive flexibility, attentional regulation, and emotion-related control mechanisms—may play a more central role in the relationship between ADHD and emotional eating-related eating behaviors. Longitudinal studies are warrented to further elucidate these mechanisms.
Narcolepsy as an immune-associated hypothalamic encephalopathy: orexin dysfunction and implications for precision sleep medicine
Narcolepsy can no longer be adequately conceptualized by excessive sleepiness and cataplexy. It is increasingly recognized as a multisystem hypothalamic encephalopathy, rooted in the selective loss or dysfunction of orexin neurons, yet extending across motor, psychiatric, metabolic, and autonomic domains. Over the past two decades, convergent genetic, neuropathological, and immunological evidence has positioned narcolepsy type 1 as increasingly consistent with the spectrum of immune-mediated neurological diseases while challenging the validity of current classifications that hinge on cataplexy or multiple sleep latency testing. Borderland phenotypes, variable orexin biology, and post-infectious or secondary forms underscore the limitations of rigid categorical nosologies and support a spectrum-based framework. Advances in immunology, imaging, and systems biology highlight the limitations of purely symptomatic treatment and support the exploration of mechanism-based interventions, including orexin receptor agonism, immune-targeted strategies in early disease, and regenerative or circuit-repair approaches. In this narrative review, based on literature identified through searches of PubMed, Web of Science, and Scopus through December 2025, we synthesize evidence across epidemiology, pathophysiology, diagnosis, and therapy, and propose an integrative clinical algorithm that moves beyond categorical diagnoses toward a phenotype–biomarker–mechanism stratification model. We suggest that narcolepsy should no longer be considered a rare curiosity of sleep medicine but rather a model disorder illuminating the vulnerability of hypothalamic circuits and the complex interplay between sleep, emotion and immunity.
ROTEM Interpretation AI vs Experts
Conditions: Coagulopathy; Thromboelastography; Agreement
Interventions: Other: Large Language Model (LLM) artificial intelligence assesment
Sponsors: Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Not yet recruiting
Interventions: Other: Large Language Model (LLM) artificial intelligence assesment
Sponsors: Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Not yet recruiting
Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers
Conditions: Skin and Connective Tissue Diseases; Neglected Tropical Diseases; Leprosy; Buruli Ulcer; Cutaneous Leishmaniasis; Scabies; Mycetoma; Lymphatic Filariasis; Onchocerciasis; Tungiasis; Post Kala-Azar Dermal Leishmaniasis; Yaws; Podoconiosis
Interventions: Device: A mobile app with AI functionality for diagnosing skin-related NTDs
Sponsors: Kenya Medical Research Institute; Universidad Politecnica de Madrid; FACHHOCHSCHULE ZENTRALSCHWEIZ – HOCHSCHULE LUZERN; SHERWOOD HEALTHCARE SENEGAL SARL; King’s College London; TEACUP CONSULTING SL; MTU AUSTRALO ALPHA LAB; OMODI, AGASNA, ODIEMBO ADVOCATES LLP; OEUVRES HOSPITALIERES FRANCAISES DE L’ORDRE DE MALTE; ARMAUER HANSEN RESEARCH INSTITUTE; Leprosy and Tuberculosis Relief Initiative Nigeria; UNIVERSITE CATHOLIQUE DE BUKAVU
Not yet recruiting
Interventions: Device: A mobile app with AI functionality for diagnosing skin-related NTDs
Sponsors: Kenya Medical Research Institute; Universidad Politecnica de Madrid; FACHHOCHSCHULE ZENTRALSCHWEIZ – HOCHSCHULE LUZERN; SHERWOOD HEALTHCARE SENEGAL SARL; King’s College London; TEACUP CONSULTING SL; MTU AUSTRALO ALPHA LAB; OMODI, AGASNA, ODIEMBO ADVOCATES LLP; OEUVRES HOSPITALIERES FRANCAISES DE L’ORDRE DE MALTE; ARMAUER HANSEN RESEARCH INSTITUTE; Leprosy and Tuberculosis Relief Initiative Nigeria; UNIVERSITE CATHOLIQUE DE BUKAVU
Not yet recruiting
Construction of a Benchmark for Breast Ultrasound AI Interpretation and Performance Evaluation of Multimodal AI Models
Conditions: Breast Neoplasms; Breast Diseases; Ultrasonography
Interventions: Diagnostic Test: Multimodal AI Model Diagnostic Evaluation
Sponsors: Peking Union Medical College Hospital; Chinese Academy of Medical Sciences
Recruiting
Interventions: Diagnostic Test: Multimodal AI Model Diagnostic Evaluation
Sponsors: Peking Union Medical College Hospital; Chinese Academy of Medical Sciences
Recruiting
Prospective Evaluation of Cardiac Point-of-Care Ultrasound (POCUS) Performed by PEM Fellows and Artificial Intelligence Interpretation Compared With a Complete Echocardiography in Children With Preexisting Cardiac Disease
Conditions: Cardiac Anomalies
Interventions: Diagnostic Test: AI Pocus_Cardiac
Sponsors: Nicklaus Children’s Hospital f/k/a Miami Children’s Hospital
Not yet recruiting
Interventions: Diagnostic Test: AI Pocus_Cardiac
Sponsors: Nicklaus Children’s Hospital f/k/a Miami Children’s Hospital
Not yet recruiting
CABG-AI-Supported Discharge Education
Conditions: Coronary Artery Disease; Postoperative Care; Patient Discharge; Recovery of Function; Anxiety; Pain; Stress, Physiological; Surgical Nursing; Nursing; Discharge Education
Interventions: Behavioral: AI-Supported Individualized Discharge Education; Behavioral: Standard Discharge Education
Sponsors: Hasan Kalyoncu University
Not yet recruiting
Interventions: Behavioral: AI-Supported Individualized Discharge Education; Behavioral: Standard Discharge Education
Sponsors: Hasan Kalyoncu University
Not yet recruiting
Evidence of monkeypox virus clade IIb lineage A.2.2 in the Republic of the Congo and co-circulation of clade Ia, Ib and clade IIb
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04256-2
Whole-genome phylogenetic analyses have identified a case of monkeypox virus clade IIb lineage in the Republic of the Congo and co-circulation of three clade lineages, emphasizing the importance of improved surveillance given the risk of possible recombination events in the future.
Efficacy of Spectrally Optimized Light on Cognitive Impairment in Major Depressive Disorder and Its Neuroimaging Mechanisms
Conditions: Major Depressive Disorder (MDD); Neuroimaging; Bright Light Treatment; Cognitive Impairment
Interventions: Device: bright light; Device: dim red light(placebo)
Sponsors: Peking University Sixth Hospital
Not yet recruiting
Interventions: Device: bright light; Device: dim red light(placebo)
Sponsors: Peking University Sixth Hospital
Not yet recruiting
The exposome of brain aging across 34 countries
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04302-z
Exposome analyses across 34 countries showed that social exposures were associated with faster functional brain aging and physical exposures with faster structural brain aging.