The introduction of blood-based biomarkers (BBMs) for Alzheimer’s disease (AD) represents one of the most transformative advances in neurodegenerative disease research over the past decade.1,2 For the first time, biological evidence of AD pathology can be obtained through a minimally invasive, scalable blood test, opening new opportunities for early diagnosis, patient triage, and implementation of disease-modifying therapies.3 Among the available biomarkers, phosphorylated tau (p-tau) species, particularly plasma p-tau217, have consistently shown excellent diagnostic performance across the AD continuum, recently culminating in regulatory approval of plasma p-tau217-based assays in both the USA and Europe.
[Comment] Inosine accumulation in hydrosalpinx fluid: a metabolic barrier to early embryonic development
Hydrosalpinx affects 10–30% of women with tubal factor infertility and is known to impair in vitro fertilization (IVF) outcomes by reducing implantation rates and increasing pregnancy loss. Although surgical interventions such as neosalpingostomy or salpingotomy can reduce the risk of pregnancy loss by approximately half compared with no treatment,1 the detrimental effects of hydrosalpinx on fertility have long been recognized. The embryotoxicity of hydrosalpinx fluid has been documented for decades in mouse models.
[Articles] P2Y12–P-selectin-mediated platelet activation in a murine model of dengue-associated thrombocytopenia
These findings indicate that DENV-induced thrombocytopenia arises from the combined effects of impaired megakaryopoiesis and platelet hyperactivation, highlighting platelet activation pathways as potential therapeutic targets for dengue-associated thromboinflammatory complications.
[Comment] Precision oncology in adjuvant aspirin therapy for colorectal cancer: emerging genetic markers and persistent uncertainties
Randomised clinical trials (RCTs) have recently been conducted in patients with resected early-stage colorectal cancer (CRC) to evaluate the effects of aspirin versus placebo on disease-free survival (DFS) and overall survival (OS), particularly among those with tumours harbouring mutations in phosphatidylinositol 3-kinase (PI3K) pathway genes (most notably in the PIK3CA gene) or PTGS-2 (COX-2; cyclooxygenase-2) overexpression (Table 1).1–3
[Articles] HCV-specific CD4+ T-cells are susceptible to HIV-1 and contribute to viral persistence during antiretroviral therapy
We provide evidence that HCV-specific CD4+ T-cells are targets of integrative HIV-1 infection and carry proviruses that persist during ART despite HCV resolution.
<![CDATA[Why teens use drugs and alcohol: avoidant attachment and emotional isolation fuel addiction; attachment-based therapy rebuilds bonds and cuts relapse.]]>
<![CDATA[New rapid-acting and long-acting injectables help bridge hospital-to-community care, cutting post-discharge nonadherence and relapse risk.]]>
<![CDATA[New rapid-acting and long-acting injectables help bridge hospital-to-community care, cutting post-discharge nonadherence and relapse risk.]]>
<![CDATA[Clinical AI in psychiatry falters when designers miss ward realities; better ethnographic UX research reduces alert fatigue, cognitive load, and boosts meaningful adoption.]]>
<![CDATA[Clinical AI in psychiatry falters when designers miss ward realities; better ethnographic UX research reduces alert fatigue, cognitive load, and boosts meaningful adoption.]]>