Relationship between spontaneous EEG oscillations at 7 and 45 days of acute plateau exposure and the plateau acclimatization index

IntroductionThis study tracked 47 high-altitude migrants to investigate the adaptive mechanisms of the brain to hypoxic environments.MethodsEEG and physiological indicators (SpO2, HCT, AAI) were recorded during the acute (7 days) and chronic (45 days) phases of high-altitude exposure. EEG complexity was assessed using multiscale entropy (MSE), and inter-regional brain coupling was also analyzed.ResultsCompared with the chronic phase, EEG complexity in the frontal, parietal, and occipital lobes was higher in the acute phase, whereas inter-regional brain coupling was stronger in the chronic phase. SpO2 decreased during the acute phase and then slowly recovered; HCT continued to rise; AAI showed a decelerating downward trend. Correlation analysis revealed that SpO2 was negatively correlated with fine-scale MSE, and HCT was negatively correlated with medium- to coarse-scale MSE. AAI was correlated only with occipital MSE during the acute phase. During the chronic phase, AAI was negatively correlated with MSE coupling across multiple brain regions but not with MSE itself.DiscussionThese findings suggest that hypoxia may increase fine-scale complexity by enhancing local neural interconnections, whereas elevated HCT reduces long-range interactions between distributed neural populations. The brain exhibits a compensatory pattern of “complexity reduction with enhanced inter-regional coupling” during hypoxic adaptation, which may represent an optimization of neural efficiency under sustained hypoxia.

Transcranial magnetic stimulation and motor overflow: a systematic review in neurological disorders

Motor overflow, a neuromotor phenomenon characterized by involuntary activation of muscles during voluntary movement, reflects impairments in interhemispheric and intracortical inhibition and is commonly observed in conditions such as stroke, cerebral palsy, dystonia, and Parkinson’s disease. Transcranial Magnetic Stimulation (TMS) is a non-invasive neuromodulatory technique with potential to modulate the cortical excitability underlying overflow-related dysfunctions. This systematic review aimed to evaluate the efficacy of TMS in reducing motor overflow across neurological populations. Seven randomized controlled trials (RCTs) were included, encompassing participants with stroke, cerebral palsy, Parkinson’s disease, and focal hand dystonia. Protocols varied in frequency (1–10 Hz), target area (M1, SMA, PSC, PMC), and design (e.g., crossover, combined protocols with constraint-induced therapy or cerebellar stimulation; Motor overflow was directly assessed in only two studies, one involving Parkinson’s disease and one involving dystonia, thereby limiting cross-study comparisons. Therefore, evidence supporting a direct effect of TMS on motor overflow remains preliminary and condition-specific. In dystonia, high-frequency rTMS (10 Hz) targeting the primary somatosensory cortex led to significant reductions in overflow, demonstrated by handwriting kinematics. In Parkinson’s disease, although physiological modulation (reduced IHI) was observed after SMA stimulation, mirror movements remained unchanged. In stroke and cerebral palsy populations, overflow was not directly evaluated, though improvements in motor function, spasticity, and cortical excitability were consistently reported. Risk of bias was low in most included studies, although gaps in allocation reporting and standardization of outcome measures were noted. This review highlights the potential of TMS, particularly high-frequency protocols, to modulate motor overflow in focal dystonia. However, the lack of targeted assessment in other neurological conditions suggests a critical need for future trials with standardized protocols and specific outcome measures focused on overflow to clarify the therapeutic role of TMS in rehabilitation.

Neuroprotective effects of paederoside against mitochondrial dysfunction in rotenone-induced cell models of Parkinson’s disease

IntroductionParkinson’s disease (PD) is the second most prevalent neurodegenerative disorder and is one of the leading causes of neurological disability. Although there are currently no cures or treatments for this disease, many patients with PD may therapeutically benefit from preventing or mitigating mitochondrial dysfunction. This study aimed to investigate the protective effects of paederoside against rotenone-induced neuronal damage in Neuro-2A (N2A) cell models of PD.MethodsFirst, the cytotoxic effects of rotenone on N2A cells were assessed using the cell counting kit-8 assay to establish a cell model of PD. Second, the effects of paederoside on mitochondrial complex I activity, mitochondrial swelling, and caspase-3 activity in the rotenone-induced cellular model were investigated. Finally, the impact of paederoside on tyrosine hydroxylase-positive cells in a rotenone-induced co-culture of N2A cells and BV-2 cells (N2A/BV-2) was studied.ResultsN2A cells were significantly damaged by rotenone in a time- and concentration-dependent manner; a 48 h rotenone treatment at 20 nM was used to create a cell model of PD. Pretreatment with 1 μM paederoside notably increased mitochondrial complex I activity in N2A cells with rotenone-induced impairment, leading to 42.85% increase. Additionally, pretreatment with 0.1, 1, and 10 μM paederoside considerably alleviated rotenone-induced mitochondrial swelling as indicated by the optical density (OD) (10 min)/OD(0 min) ratio, which increased by 1.21-, 1.33-, and 1.37-fold, respectively. Notably, pretreatment with 10 μM paederoside significantly inhibited caspase-3 activation triggered by rotenone in this cellular setting, resulting in a 39.93% decrease in enzyme activity. Moreover, pretreatment with 10 μM of paederoside markedly enhanced the number of TH-positive cells in a co-culture system consisting of N2A/BV-2 cells induced by rotenone, with increases of 82.79%.ConclusionPretreatment with paederoside may protect against mitochondrial dysfunction in cell models of PD induced by rotenone.

Virtual reality based attentional bias modification training for patients with obsessive-compulsive disorder: a feasibility study

BackgroundAttentional bias modification (ABM) training is employed to modulate attentional bias and alleviate clinical symptoms in obsessive-compulsive disorder (OCD) patients. This study aimed to develop a novel, ecologically valid ABM paradigm based on virtual reality (VR). The intent was to enhance the efficacy of traditional computerized ABM and to preliminarily examine its feasibility in patients with contamination-based obsessive-compulsive disorder (OCD).Method15 patients with OCD who were currently receiving pharmacotherapy were recruited and allocated to either an ABM group, which received VR-ABM training twice weekly for four weeks (eight sessions in total), or a TAU group, which continued their routine outpatient treatment, including pharmacotherapy, psychotherapy, and physical therapy.Result5 patients in ABM group and 5 patients in TAU group completed the 4-week follow-up. VR-ABM paradigm effectively elicited target symptoms, with virtual scenarios inducing moderate levels of obsessive-compulsive symptoms and anxiety. Notably, all participants in the VR-ABM group reported the program to be appropriately challenging, effectively eliciting obsessive-compulsive symptoms and improving subjective concentration.ConclusionThese preliminary findings support the feasibility of the novel VR-ABM training in OCD and warrant further investigation in larger, controlled trials to rigorously evaluate its therapeutic efficacy.

Systematic review of animal studies on the use of herbal medicine for attention-deficit/hyperactivity disorder

BackgroundAttention-deficit/hyperactivity disorder (ADHD), a common neurodevelopmental condition, often requires treatment with stimulants such as methylphenidate and nonstimulants such as atomoxetine. Despite their effectiveness, medication-related side effects, adherence and symptom control issues have increased the interest in alternative therapies, especially herbal medicine. However, existing preclinical studies vary in quality and relevance. This systematic review evaluates animal studies investigating herbal medicines for ADHD; identifies limitations in experimental models, behavioral assessments, safety evaluation, and methodological rigor; and proposes a framework to guide future research.MethodsFollowing PRISMA 2020 guidelines, PubMed and Web of Science were systematically searched for eligible studies published between 1995 and March 2025 that used animal models to interventions for the treatment of ADHD-like symptoms.ResultsAnalysis of 25 studies revealed a strong reliance on a limited range of animal models, particularly the spontaneously hypertensive rat (48%), with 88% of studies using male animals exclusively. Behavioral assessments predominantly focused on hyperactivity (72%), whereas evaluations of inattention and impulsivity were comparatively limited. Herbal interventions were associated with improvements in ADHD-like behaviors and modulation of catecholaminergic neurotransmission, including increased dopamine and norepinephrine levels in the prefrontal cortex. Additional mechanisms included activation of neurotrophic signaling pathways (brain-derived neurotrophic factor/TrkB) and suppression of proinflammatory mediators such as TNF-α and IL-1β. However, 80% of the studies did not report safety outcomes, and no study clearly described randomization or blinding procedures, limiting the translational relevance of the findings. Despite these limitations, several formulations, including the Long Mu Qing Xin mixture, An Shen Ding Zhi Ling demonstrated promising multitarget effects.ConclusionAlthough herbal medicines demonstrate promising multipathway effects for ADHD, progress remains constrained by the limited diversity of animal models and narrow scope of behavioral assessments. Future research should prioritize the use of diverse models, more comprehensive assessments, and the implementation of rigorous methodological standards.

Job demands and resources in relation to burnout and educational coexistence among Chilean education workers

This study aimed to examine the fit of a structural equation model relating selected job demands and job resources to burnout and perceptions of educational coexistence among Chilean education personnel. A total of 710 workers from this sector (administrators, teachers, and teaching assistants) participated. Structural equation modeling (SEM) was conducted using robust maximum likelihood estimation and absolute and incremental fit indices. The proposed model showed acceptable fit (χ² = 3181, df = 1307, p <.001; CFI Robust = 0.911; TLI Robust = 0.907; GFI = 0.956; RMSEA Robust = 0.049). Workload and work-family conflict were positively associated with burnout (R² = 0.612; p <.001), whereas role clarity and social support were positively associated with perceptions of educational coexistence (R² = 0.396; p <.001). Overall, the findings are consistent with the Job Demands-Resources framework and suggest that, in this sample, job demands are more strongly linked to burnout, whereas job resources are more strongly linked to perceptions of educational coexistence. The study is discussed in relation to the Chilean educational context and the implementation of the National Policy on Educational Coexistence.

Geoengineering still faces major practical challenges

Solar geoengineering is often portrayed as a sort of emergency brake. Something along the lines of Pull in case of climate emergency to scatter light-reflecting particles to bounce sunlight out of the atmosphere and cool the planet.

But it might be less like a simple brake and more like a complicated, entirely unsolved puzzle.

Some researchers are starting to look into how nations or companies would go about trying to cool the planet—and there’s a lot to figure out. My colleague James Temple dug into these engineering challenges in his latest feature story. My biggest takeaway? This all might be a lot harder than I thought.

I’ll admit, I’ve always thought of geoengineering as a relatively low-tech solution. That’s partly because over the years we’ve seen some companies do their own low-cost guerrilla “experiments,” tossing balloons up into the atmosphere and claiming to have made some small dent in climate change.

But to actually actively cool the planet in a significant way, and to make sure we understand exactly what effect we’re having, there’s a lot that researchers still need to learn. 

First, there’s the problem of getting up into the atmosphere. Generally, the target for solar geoengineering efforts is the stratosphere, since the air there is drier and more stable, so particles deposited there would stay aloft and move around the planet, lowering temperatures over a wider area and for a longer time.

You can release the particles in balloons, but balloons may not go where you want them to. And at a large scale, you’d be leaving a lot of litter all over the planet. That leaves aircraft, but conventional planes aren’t suited to fly around in the stratosphere. (Commercial aircraft generally fly at around 12 kilometers above the Earth’s surface, while geoengineering would require reaching roughly 20 kilometers.) The air is thinner higher up, so aircraft with massive wings would probably fare better than more conventional designs.

One design, from a startup called Iris Aero, shows just how much rethinking of our current flight technologies might be needed—the plane is almost unsettling in its proportions. Its wings are so long, on a stubby little body. It reminds me of a water strider, those bugs that have super-long legs to scurry around on a pond’s surface.

And that’s just the beginning. There’s also the question of what, exactly, would be best to scatter up in the stratosphere. The idea behind geoengineering comes from volcanoes—after an eruption, sulfuric acid ends up floating around in the atmosphere, and it can temporarily cool the planet. But that chemical is sticky and would be heavy to carry, so scattering some sort of precursor to sulfuric acid would probably be better. Researchers, including some at the University of Chicago, one of the leading institutions in this field, are working to figure out the best formula. 

I’m struck by how complicated this turns out to be, and I’m also left with a big question: As research turns from modeling and simulations to the practical aspects of this incredibly controversial technology, what does it mean to be doing this work?

There are major concerns about what effects might come from large-scale attempts to cool the planet. The effects could be positive for some parts of the globe and negative for others. Established weather patterns, like the monsoon season in South Asia, could shift. There are major questions about what the governance for the use of geoengineering should look like, and who gets to decide whether to go ahead. 

Experts who champion research in geoengineering often draw a line between a desire to support learning more about the technology and a call to deploy it. Many would argue that we should understand it better, so we can make informed decisions.

But to me, there’s a clear difference between atmospheric modeling and detailed engineering work on an aircraft. If there’s public research that essentially amounts to a set of practical instructions, I can’t help but feel like it could enable any number of individual actors or nations to take geoengineering into their own hands. It also might normalize the idea of using the technology. 

Some experts shared concerns along these lines with James, arguing that the shift to practical engineering work requires more oversight. Some called research in this area dangerous.

One alternative perspective I found interesting came from Shuchi Talati, executive director of the nonprofit Alliance for Just Deliberation on Solar Geoengineering.

Rather than further practical research making a slippery slope slipperier, it could have the opposite effect, she told James. “The actual practice of R&D will be a sticky slope, because there will be more real-world problems that come up that we haven’t even thought of yet,” she says. Engineering research could challenge the “idealized notions” of how easy the technology would actually be, she adds.

It’s hard to argue against better understanding potential tools to address climate change. But if we draw a map towards a potential future, it might become difficult to control who follows it. 

This article is from The Spark, MIT Technology Review’s weekly climate newsletter. To receive it in your inbox every Wednesday, sign up here. 

Opinion: Congress should embrace strategic health diplomacy

Whether our nation’s foreign policy is grounded in America First or American exceptionalism, improving global health should be a top policy priority of the United States. The recent hantavirus outbreak and evolving Ebola crisis serve as a reminder to Congress that the well-being of Americans is tied to the well-being of people around the globe.

Two of us, as former U.S. senators, were fortunate to play leading roles in the launch of PEPFAR, the President’s Emergency Plan for AIDS Relief, in 2003. Our research at the Bipartisan Policy Center demonstrated that beyond saving 26 million lives and preventing millions of HIV infections, PEPFAR contributed to a positive opinion of the U.S., better socioeconomic indices, and reduced political instability in target countries compared with non-PEPFAR countries. We termed this effect “strategic health diplomacy” — the idea that by addressing global health, America advances its own national strategic interests.

Read the rest…

Alcohol and cannabis use severity in relation to compulsive sexual behavior and problematic pornography use in a non-clinical sample: a cross-sectional study

IntroductionCompulsive Sexual Behavior Disorder (CSBD) and problematic pornography use (PPU) frequently co-occur with substance use disorders, yet their associations with specific substances in non-clinical populations remain poorly understood. The present study examined associations between alcohol and cannabis use severity and CSBD and PPU symptoms in a non-clinical adult sample.MethodsEligible adults were invited to complete an anonymous online survey between May and October 2025. Alcohol and cannabis use severity scores were assessed using AUDIT and CUDIT-R questionnaires, respectively. Participants compulsive sexual behavior disorders (CSBD) and problematic pornography use (PPU) scores were assessed using CSBI-13 and BPS questionnaires. Associations between substance use severity and compulsive sexual behaviors were assessed using linear adjusted regression.ResultsA total of 158 adults (61.4% women) aged 18–60 years were analysed with a mean alcohol and cannabis use severity scores of 16.29 (± 4.53) and 15.49 (± 5.08), respectively among current users, and a mean compulsive sexual behavior disorders of 21.14 (± 7.74), with a mean PPU score of 6.99 (± 2.55). In unadjusted regression models, increases in alcohol and cannabis use severity were associated with increases in CSBD and PPU scores. However, no significant increase of both outcomes was observed for alcohol use severity (CSBD: B = 0.18, 95% CI [-0.13; 0.49], p = .251; PPU: B = 0.04, 95% CI [-0.05; 0.13], p = .381) and cannabis use severity (CSBD: B = 0.09, 95% CI [-0.13; 0.31], p = .409; PPU: B = 0.03, 95% CI [-0.03; 0.09], p = .325) after controlling for age and gender.ConclusionOur study showed a positive but non-significant association between alcohol and cannabis use severity with both CSBD and PPU after controlling for age and gender, suggesting the underlying associations may be explained by sociodemographic differences in the study population. However, longitudinal studies and advanced analysis approaches including those that handle zero inflated data or latent dependant variable are needed to validate these findings.