Tag: Anxiety

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Case Report: Multimodal clinical and neurophysiological effects of cranial electrotherapy stimulation in a patient with chronic stress and sleep disturbance

IntroductionCranial Electrotherapy Stimulation (CES) is a non-invasive brain stimulation (NIBS) technique used for anxiety and sleep disorders; however, case-level evidence linking clinical improvement with objective neurophysiological change remains limited. This case presents a multimodal examination of the therapeutic and neurophysiological effects of CES in a patient with sleep disturbances and chronic stress.MethodsA 51-year-old woman with chronic stress, anxiety, and persistent sleep disturbance following thyroid and parathyroid surgery, refractory to pharmacological treatment, underwent a 16-week CES intervention. Outcomes were assessed at baseline and follow-up using EQ-5D-5L, DASS-21, GAD-7, PSQI, and resting-state Electroencephalography (EEG).ResultsAnxiety, stress, and depressive symptoms improved to within normal ranges, alongside significant improvements in mental health-related quality of life. EEG demonstrated increased posterior alpha activity and improved frontal symmetry. Sleep quality showed modest improvement.ConclusionThis case suggests that CES may be a safe adjunctive intervention associated with symptomatic improvement and changes in neurophysiological patterns in stress-related conditions, supporting further controlled investigation.
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Reduced serum cortisol, IGF-1, GLP-1, and T3 levels in medication-free children and adolescents with obsessive–compulsive disorder: a case–control study

IntroductionObsessive–compulsive disorder (OCD) frequently emerges during childhood and adolescence and has been associated with alterations in multiple neurobiological systems. Neuroendocrine pathways involved in stress regulation, neurodevelopment, metabolic signaling, and thyroid function interact closely to influence brain circuits implicated in OCD. However, studies simultaneously examining several neuroendocrine parameters in pediatric OCD remain limited.MethodsThis case–control study included 52 medication-free children and adolescents with OCD and 42 healthy controls aged 8–17 years. Psychiatric diagnoses were established using the Schedule for Affective Disorders and Schizophrenia for School-Age Children—Present and Lifetime Version (K-SADS-PL) according to DSM-5 criteria. Obsessive–compulsive symptom severity was assessed using the Children’s Yale–Brown Obsessive Compulsive Scale (CY-BOCS). Anxiety and depressive symptoms were evaluated using the Screen for Child Anxiety Related Emotional Disorders (SCARED) and the Children’s Depression Inventory (CDI), respectively. Serum levels of adrenocorticotropic hormone (ACTH), cortisol, growth hormone (GH), Insulin-like growth factor-1 (IGF-1), Glucagon-like peptide-1 (GLP-1), relaxin-3 (RLN-3), triiodothyronine (T3), and thyroid-stimulating hormone (TSH) were measured using ELISA. Group differences were examined using covariance-based models controlling for age, sex, BMI percentile, anxiety (SCARED), and depressive symptoms (CDI).ResultsInitial analyses showed that children and adolescents with OCD had significantly lower serum levels of cortisol, IGF-1, GLP-1, and T3 compared with healthy controls. These differences remained significant after controlling for age, sex, BMI percentile, and the SCARED and CDI total score, with adjusted analyses showing lower levels of cortisol (p = 0.003), IGF-1 (p = 0.013), GLP-1 (p = 0.017), and T3 (p = 0.015) in the OCD group. Correlation analyses did not reveal significant associations between biochemical parameters and OCD symptom severity after correction for multiple comparisons.DiscussionThese findings suggest that pediatric OCD may be associated with alterations in several neuroendocrine pathways rather than isolated changes within a single hormonal system. Further longitudinal studies are needed to better clarify the biological basis and clinical significance of these findings.
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NeuroFinance Human Stress Trial During Financial and Informational Volatility

Conditions: Psychological Stress; Anxiety; Emotional Stress; Autonomic Nervous System Dysfunction; Sleep Disturbance; Insomnia; Behavioral Health; Cognitive Fatigue; Occupational Stress; Financial Stress; Burnout Syndrome; Heart Rate Variability; Neurobehavioral Manifestations

Interventions: Device: Wearable Physiologic Monitoring Platform

Sponsors: Truway Health, Inc.

Not yet recruiting
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Effectiveness of a culturally adapted psychoeducational intervention for family caregivers of children with hematologic malignancy: a randomized controlled trial

ObjectiveThis study aimed to develop and evaluate a culturally adapted psychoeducational intervention to address the severe psychological distress and caregiving burden commonly experienced by caregivers of newly diagnosed pediatric hematologic malignancy patients during the early stages of illness.MethodsAmong 116 randomized caregivers, 90 completed all three assessments and were included in the complete-case analysis. The intervention group received a 4-week psychoeducation program delivered by medical social workers, whereas the control group received routine care. Outcomes were assessed at baseline, post-intervention, and 48-day follow-up.ResultsCompared with controls, caregivers in the intervention group showed greater reductions in depressive and post-traumatic stress symptoms after the intervention, and these reductions were maintained at follow-up. Caregiver burden showed a delayed reduction, with between-group differences becoming apparent at follow-up. Anxiety levels decreased over time in both groups, but the group × time interaction was not statistically significant.ConclusionThe culturally adapted psychoeducational intervention was associated with reductions in depressive and post-traumatic stress symptoms and a delayed reduction in caregiver burden, but did not show an additional effect on anxiety beyond routine care. These findings provide preliminary support for structured, culturally responsive psychoeducational support in pediatric hematology settings.
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Determinants of mental health distress among health workers in Abu Dhabi, United Arab Emirates

Healthcare workers (HCWs) remain at elevated risk of psychological distress, yet post-pandemic evidence from the United Arab Emirates is scarce. This cross-sectional electronic survey assessed depression, anxiety, and stress among physicians and nurses providing direct clinical care across Abu Dhabi Health Services Company in March 2024. Mental health outcomes were measured using the DASS-21, and multivariable logistic regression identified associated factors. Among 383 HCWs (mean age 40.8 years; 70% female; 65% nurses), the prevalence of depression, anxiety, and stress was 49%, 45%, and 46%, respectively. Middle Eastern HCWs had significantly higher odds of depression (Adjusted Odds Ratio (aOR)=1.94; 95% CI: 1.13–3.35), anxiety (aOR=1.80; 95% CI: 1.03–3.21), and stress (aOR=2.42; 95% CI: 1.37–4.33) compared with Asian HCWs. Workplace conflict strongly predicted distress as conflicts with colleagues increased the odds of depression (aOR=3.36; 95% CI: 1.92–6.05), anxiety (aOR=1.99; 95% CI: 1.14–3.53), and stress (aOR=3.78; 95% CI: 2.10–7.00). Chronic fatigue was associated with depression (aOR=4.21; 95% CI: 1.61–13.2), anxiety (aOR=3.89; 95% CI: 1.39–13.8), and stress (aOR=3.34; 95% CI: 1.32–9.63). Protective factors included age ≥40 years for stress (aOR=0.61; 95% CI: 0.39–0.96) and postgraduate education for anxiety (aOR=0.55; 95% CI: 0.31–0.94) with nurses had lower stress than physicians (aOR=0.47; 95% CI: 0.23–0.94). Post-pandemic mental-health symptoms remain substantial among Abu Dhabi HCWs, particularly younger providers and those exposed to workplace conflict or chronic fatigue. Sustained mental-health programs, routine screening, and targeted support for high-risk groups are urgently required to protect clinician well-being and healthcare system resilience.
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Platform shift in mental health support among undergraduates: from campus counselors to GenAI-based consultation​

China is advancing the implementation of the “AI+” initiative and exploring the promotion of AI technology in scenarios such as health management and assisted diagnosis. Against this backdrop, universities are accelerating the adoption of GenAI virtual counseling tools to address the growing psychological issues among undergraduates, including depression, anxiety, and academic stress. However, research on why students are shifting from traditional in-person psychological consultations to GenAI consultations remains limited. Therefore, this study focuses on the student population, collecting data through online questionnaires and employing the PLS-SEM method to systematically analyze the key factors and underlying mechanisms influencing students’ willingness to transition from campus psychologists to GenAI virtual doctors. The findings reveal that privacy concerns, social anxiety, and stigma surrounding mental illness significantly enhance students’ inclination toward AI consultations. The comfort level of interacting with AI and the accessibility of AI services play mediating roles. Additionally, perceived AI information quality significantly moderates the pathways through which privacy concerns, social anxiety, and stigma influence the willingness to switch. This study provides a theoretical foundation and practical reference for universities to develop intelligent psychological support systems that align with students’ actual needs.