Tag: Bipolar

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<![CDATA[Experts discuss rapid cycling and bipolar II, and weigh lithium as an often overlooked treatment option. ]]>
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Erratum

Erratum to: “The Link Between Weight Gain and Hippocampal Atrophy in Bipolar Disorder: A Longitudinal Investigation in 934 Participants,” by Fraiha-Pegado et al. (Biol Psychiatry 2026); https://doi.org/10.1016/j.biopsych.2026.01.020.

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Evaluating the Impact of Ketogenic Therapy on Symptom Severity and Metabolic Side Effect Profile Among Individuals Living With Bipolar Disorder in A Rural Southern Catchment Area

Conditions: Bipolar Disorder

Interventions: Dietary Supplement: Ketogenic foodstuffs; Other: Standard of Care Oral antipsychotics; Other: Standard of care long acting injectable medication for bipolar disorder

Sponsors: University of Alabama at Birmingham; Baszucki Family Foundation; Baptist Health System Montgomery

Not yet recruiting
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<![CDATA[New cohort and global data link teen high-potency cannabis use to higher psychosis, bipolar, and suicide risks. Here’s what psychiatrists and mental health clinicians should know in the era of legalization.]]>
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Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder

Large-scale T1-weighted MRI studies have established grey-matter abnormalities in bipolar disorder (BD), with our group contributing to consensus findings. However, structural connectivity, particularly within emotion- and reward-related circuits, remains poorly understood. Diffusion-weighted MRI (dMRI) enables investigation of white-matter pathways, yet prior work is constrained by small samples, methodological heterogeneity, and unclear medication effects. We conducted the largest dMRI network analysis in BD, relating symptom burden and polypharmacy to tractography-derived connectivity and graph-theoretic metrics.

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Case Report: Prism for PTSD in severe traumatic brain injury with psychiatric comorbidities: two cases

BackgroundTraumatic brain injury (TBI) with post-traumatic stress disorder (PTSD) is treatment-resistant, with conventional psychotherapy showing limited efficacy due to neurocognitive impairments.Case SummaryWe report two patients with severe TBI and psychiatric comorbidities treated with Prism neurofeedback.Case 144-year-old female, 35 years post-childhood TBI, with agoraphobia and hyperacusis, achieved 42% PTSD reduction and substantial functional gains (social reintegration, independent driving) sustained through 4-month follow-up.Case 240-year-old male, 3.5 years post-adult TBI with bipolar II disorder and severe PTSD (PCL-5 = 62), achieved 90% PTSD reduction with complete remission sustained at 1-month follow-up, enabling return to work and family system transformation. Both patients developed personalized regulatory strategies and maintained gains without relapse.ConclusionsPrism neurofeedback demonstrates clinically meaningful outcomes in severe TBI-PTSD where traditional psychotherapy shows limited efficacy. The intervention’s circumvention of cognitive processing demands may explain the favorable outcomes. Controlled trials are warranted.