Digital Phenotyping via Passive Network Traffic Monitoring: Prospective Observational Study in University Students

Background: Digital behaviors such as sleep, social interactions, and productivity reflect how individuals structure their daily lives. Among university students, online activity patterns mirror academic schedules, social rhythms, and lifestyle habits, with disruptions linked to sleep, stress, and well-being. Existing approaches—including wearables, apps, and surveys—depend on self-report or active participation, limiting long-term adherence. Passive sensing of network traffic offers a scalable alternative for the unobtrusive capture of smartphone usage patterns that preserves privacy. Objective: This study evaluated the degree to which encrypted smartphone network traffic, collected via a standard virtual private network (VPN), can capture patterns of digital behavior. We assessed feasibility (sustained data capture) and acceptability (usability, burden, and privacy perceptions) and examined how traffic-derived features reveal aspects of digital behavior—including timing, intensity, and regularity—relevant to health and daily functioning. Methods: We conducted a 2-week prospective observational study at New York University. Participants installed the WireGuard VPN client on personal smartphones, enabling passive capture of encrypted network traffic. Feasibility was assessed using a mixed methods approach combining quantitative measures of user retention and data coverage with qualitative analysis of semistructured exit interviews. Acceptability was evaluated using the System Usability Scale, NASA Task Load Index, and qualitative interview analysis. Exploratory analyses visualized traffic-derived features in relation to digital activity patterns. Results: Thirty-eight students consented, of whom 29 (76.3%) contributed valid network traffic data and formed the analytic cohort. Within this cohort, 93% of participants (27/29; Wilson 95% CI 78%‐98%) contributed at least 5 days of monitoring, corresponding to 71% retention relative to all consented participants (27/38; Wilson 95% CI 55%‐83%). The mean data coverage within the analytic cohort (n=24) was 74.1% (SD 19.3%; median 77.1%, IQR 63.6%-90.0%; bootstrap 95% CI 66.3%‐81.4%). These participants contributed an average of 311.6 (∼13 d, SD 3.5) hours of monitored traffic, ranging from 121 to 496 hours. Acceptability outcomes were evaluated among participants completing the exit survey and interview. Usability ratings were high (System Usability Scale score: mean 78, SD 14.96), and perceived workload was low (NASA Task Load Index scores were minimal). Participants described the system as easy to install, unobtrusive, and generally trustworthy, although some reported temporarily disabling the VPN during activities they considered private. No inferential statistical tests were conducted; analyses were descriptive. Exploratory analyses indicated that traffic-derived features reflected daily digital activity rhythms and revealed distinctive lifestyle patterns, including gaming and irregular late-night food delivery use. Conclusions: VPN-based monitoring of encrypted smartphone traffic was feasible and acceptable, enabling sustained passive data collection with minimal burden. This approach shows promise as a scalable, device-agnostic method for digital phenotyping that captures fine-grained behavioral rhythms while preserving privacy. With broader validation, this technique could expand the toolkit for studying health and well-being in everyday life.
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STAT+: Zap in a cap: How one neurotech startup is using a hat to treat depression

Wake up. Brush your teeth. Wash your face. 

And put on your lifesaving baseball hat.

That’s right. If you have treatment-resistant depression, this could be the regular morning routine in your future. The hat would activate a blueberry-sized device implanted in your skull that sends a pulse of electricity into your brain.

This is Jacob Robinson’s vision — and it got closer to reality on Friday after the Food and Drug Administration approved a request from Robinson’s startup, Motif Neurotech, to start an initial feasibility trial to test the efficacy of their device in treating depression that hasn’t responded to other treatments. Scientists have been zapping brains to alleviate depression for decades through a method called transcranial magnetic stimulation, or TMS. Motif wants to do the same thing, but with a twist.

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FDA warns device manufacturers of nitrosamine impurities that could cause cancer

The FDA Center for Devices and Radiological Health (CDRH) is warning manufacturers of drug-device combination products of the potential for nitrosamine impurities, which are classified as probable carcinogens associated with forms of cancer. The FDA did not name specific devices or kinds of devices that could be at risk in the letter it sent to…

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Stryker pay drops for top executives and the median employee

Stryker has disclosed lower compensation for its top executives and median employee in a recent filing with the U.S. Securities and Exchange Commission. Median employee pay dropped for the second consecutive year, while executive compensation decreased due to lower cash performance bonuses and option awards. Stryker was the world’s fifth-largest medical device company in our…

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Speech recognition performance with dual-microphone audio processors in mandarin-speaking cochlear implant users

BackgroundCochlear implant (CI) audio processor upgrades have demonstrated speech recognition benefits in non-tonal language populations, but high-level evidence for native Mandarin-speaking CI users (a tonal language with unique signal processing requirements) remains critically limited. This study aimed to assess the speech perception performance of the SONNET 2 and RONDO 3 dual-microphone audio processors in native Mandarin-speaking CI users.MethodsThis prospective single-subject repeated-measures study enrolled 51 native Mandarin-speaking CI users. Speech recognition performance was tested across five processor configurations: the legacy baseline processor, SONNET 2 (S2) in omnidirectional (S2.OMNI) and adaptive intelligence (S2.Adaptive) modes, and RONDO 3 (R3) in omnidirectional (R3.OMNI) and adaptive intelligence (R3.Adaptive) modes. Outcome measures included monosyllabic words, disyllabic words, and sentence recognition in quiet, and sentence recognition in co-located speech-shaped noise (S0N0 paradigm). The pre-specified primary endpoint was sentence recognition in noise for S2.OMNI vs. the legacy processor; confirmatory linear mixed-effects models (LMMs) and subgroup analyses were exclusively performed for the primary endpoint, with pairwise comparisons for all secondary exploratory endpoints.ResultsIn quiet, all four upgraded configurations yielded significantly higher monosyllabic word recognition scores vs. the legacy baseline (all p < 0.05, FDR-adjusted); all configurations except R3. Adaptive showed significant improvements in disyllabic word recognition (all p < 0.05, FDR-adjusted). In the S0N0 noise condition, S2.OMNI and R3.OMNI significantly enhanced sentence recognition vs. the legacy processor (p < 0.001 and p = 0.011, respectively, FDR-adjusted), while no significant benefit was detected for either adaptive mode after FDR correction. LMM analysis confirmed that upgrading to the S2.OMNI configuration was an independent positive predictor of noise sentence recognition (F = 9.885, p = 0.003), with consistent significant benefits across pediatric/adult and unilateral/bilateral users in pre-specified subgroup analyses.ConclusionThis study provides confirmatory evidence that upgrading to the S2.OMNI configuration significantly improves sentence recognition in noise in native Mandarin-speaking CI users, with consistent benefits across key clinical subgroups. Exploratory analyses show that the S2 and R3 processors also deliver significant improvements in word recognition in quiet, These results fill a critical evidence gap for tonal language CI populations and may help guide clinical device selection.

STAT+: Federal test of AI prior authorization is delaying care for seniors, report says

Washington state hospitals say their Medicare patients are waiting two to four times longer in some cases for procedures that are now subject to prior authorization under a new Medicare program. 

The report from Sen. Maria Cantwell (D-Wash.) is among the first to document alleged patient harm stemming from the Centers for Medicare and Medicaid Services’ new Wasteful and Inappropriate Service Reduction, or WISeR, Model. Cantwell is one of several Democratic members of Congress who have been urging CMS to scrap the program, which launched Jan. 1. 

Cantwell aired her concerns about WISeR to Health and Human Services Secretary Robert F. Kennedy Jr. at a Senate Committee on Finance hearing Wednesday. She said CMS is using artificial intelligence as a “denial device” and that patients are waiting weeks to get sign off for services that previously didn’t require approval. 

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An Artificial Intelligence System for Multimodal, Multi-class Diagnosis of Pancreatic Cystic Lesions Based on Endoscopic Ultrasonography

Conditions: Endoscopic Ultrasound (EUS); Pancreatic Cystic Lesion (PCL)

Interventions: Device: iEUS-PCL(intelligent endoscopic ultrasound system- pancreatic cystic lesion)

Sponsors: Qilu Hospital of Shandong University; Liaocheng People’s Hospital; Taian City Central Hospital; Qilu Hospital of Shandong University (Qingdao); Binzhou People’s Hospital; Shandong Provincial Hospital; The Affiliated Hospital of Qingdao University; Qianfoshan Hospital; Shengli Oilfield Hospital; Binzhou Medical University

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