In routine clinical practice, PGx testing is preferentially used in youth and adults with clinically complex histories and is associated with shifts in antidepressant prescribing patterns. Exploratory findings suggest hypothesis-generating signals of reduced psychiatric ED utilisation among patients with higher psychiatric complexity, which requires further confirmation. Observed racial disparities highlight the need for earlier and more equitable implementation. Prospective studies incorporating symptom-level and safety outcomes are needed to determine whether PGx-guided prescribing translates into meaningful clinical benefit.
An Exploratory Study on the Prediction of Recurrence Risk of Bipolar Disorder Using Sentiment Analysis Technology Based on Multi-modal Feature Fusion
Conditions: Bipolar Disorder (BD); Healthy Control
Interventions: Other: This is an observational study with no intervention.
Sponsors: Shanghai Mental Health Center
Recruiting
Interventions: Other: This is an observational study with no intervention.
Sponsors: Shanghai Mental Health Center
Recruiting
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
Conditions: Depressive Disorder, Major
Interventions: Drug: Seltorexant; Drug: Placebo
Sponsors: Janssen Research & Development, LLC
Not yet recruiting
Interventions: Drug: Seltorexant; Drug: Placebo
Sponsors: Janssen Research & Development, LLC
Not yet recruiting
Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillectomy
Conditions: Opioid-Induced Respiratory Depression; Postoperative Complications (Cardiopulmonary); Respiratory Complications Due to Anesthesia
Interventions: Device: Infrared Pupillometry
Sponsors: NeurOptics Inc; National Institute on Drug Abuse (NIDA); University of Pittsburgh Medical Center; University of California, San Francisco
Not yet recruiting
Interventions: Device: Infrared Pupillometry
Sponsors: NeurOptics Inc; National Institute on Drug Abuse (NIDA); University of Pittsburgh Medical Center; University of California, San Francisco
Not yet recruiting
tDCS: Sleep to Mood in Depression (S2M-D)
Conditions: Major Depressive Disorder; MDD; Depression; Major Depressive Episode
Interventions: Device: transcranial direct current stimulation (tDCS)
Sponsors: NYU Langone Health; Zabara Foundation
Not yet recruiting
Interventions: Device: transcranial direct current stimulation (tDCS)
Sponsors: NYU Langone Health; Zabara Foundation
Not yet recruiting
Oral small-molecule GLP-1 drugs penetrate deep into the brain to suppress cravings
NIH-funded research identifies new mechanism of action for next-generation weight-loss drugs
NIH-funded study suggests that testosterone suppresses brain tumor growth in males
Findings may warrant exploration of the hormones as glioblastoma treatment
Noise, air pollution exposure and attention-deficit/hyperactivity disorder: a meta-analysis
ObjectiveThis meta-analysis evaluated the associations between noise exposure, air pollutants, and attention-deficit/hyperactivity disorder (ADHD) in children, aiming to inform future prevention strategies.MethodsStudies were systematically retrieved from CNKI, Wanfang, PubMed, Web of Science, Embase, and the Cochrane Library, covering publications from inception to November 2025. Heterogeneity was assessed using Cochran’s Q test and the I² statistic. Subgroup analyses, meta-regression, and sensitivity analyses were performed to evaluate the robustness of the findings.ResultsNoise exposure was associated with a small increase in ADHD risk (odds ratio [OR] = 1.03, 95% confidence interval [CI]: 1.01–1.05), with stronger associations for childhood exposure, whereas prenatal exposure showed no significant effect. Given the modest effect size, this finding should be interpreted cautiously. Particulate matter (PM2.5 and PM10) was significantly associated with ADHD in continuous-exposure models—PM2.5 (OR = 1.32, 95% CI: 1.16–1.50) and PM10 (OR = 1.47, 95% CI: 1.15–1.87). In dichotomous models, PM2.5 was not significant, while PM10 remained positively associated (OR = 1.58, 95% CI: 1.11–2.26). Elevated nitrogen dioxide (NO2) exposure was also associated with a modest increase in ADHD risk (OR = 1.11, 95% CI: 1.02–1.20), whereas nitrogen oxides (NOx), ozone (O3), and sulfur dioxide (SO2) did not show significant associations.ConclusionsNoise and several air pollutants (PM2.5, PM10, and NO2) were significantly associated with increased ADHD risk, particularly during childhood exposure. Other pollutants, including O3 and SO2, did not demonstrate significant effects. These findings suggest that environmental noise and several air pollutants may be associated with ADHD; however, some observed associations, particularly for noise and NO2, were modest in magnitude and should be interpreted cautiously. These results reflect observational associations rather than evidence of a strong or causal effect, while the evidence for some pollutants remains limited or inconclusive. Further research is needed to clarify pollutant-specific associations and the role of exposure timing.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD42024593274, identifier CRD42024593274; https://www.crd.york.ac.uk/PROSPERO/view/CRD42025632899, identifier CRD42025632899.
Retraction: Impaired potentiation of theta oscillations during a visual cortical plasticity paradigm in individuals with schizophrenia
STAT+: Oregon hospitals won’t outsource to national physician chain after all
After a tidal wave of blowback that culminated in a lawsuit, a nonprofit health system has reversed course in its plan to replace its Oregon emergency physicians with a national chain.
PeaceHealth’s announcement Wednesday didn’t disclose what prompted its change of heart, but those familiar with the situation say it’s because the health system’s plan was poised for defeat in a legal challenge. When PeaceHealth said in February it was cutting ties with Eugene Emergency Physicians, the local group that had staffed its Oregon hospitals for 35 years, the news drew tremendous pushback from doctors, nurses, lawmakers, mayors, and emergency medicine groups.
Then, on March 20, the Eugene emergency physicians sued, arguing that PeaceHealth’s plan to use the Atlanta-based staffing chain ApolloMD violated a new Oregon law prohibiting managed service organizations from directly owning medical practices or interfering with clinical decisions. The case has had four hearings, in which the judge was “quite clear” that the scheme violated the law, Senate Bill 951, said Hayden Rooke-Ley, an attorney who represented the doctors and a senior fellow for health care with the American Economic Liberties Project.