<![CDATA[Faster aging may be linked to schizophrenia, according to new research.]]>

Treating enterprise AI as an operating layer

There’s a fault line running through enterprise AI, and it’s not the one getting the most attention. The public conversation still tracks foundation models and benchmarks—GPT versus Gemini, reasoning scores, and marginal capability gains. But in practice, the more durable advantage is structural: who owns the operating layer where intelligence is applied, governed, and improved. One model treats AI as an on-demand utility; the other embeds it as an operating layer—the combination of operation software, data capture, feedback loops and governance that sits between models and real work—that compounds with use.

Model providers like OpenAI and Anthropic sell intelligence as a service: you have a problem, you call an API, you get an answer. That intelligence is general-purpose, largely stateless, and only loosely connected to the day-to-day operations where decisions are made. It’s highly capable and increasingly interchangeable. The distinction that matters is whether intelligence resets on every prompt or accumulates over time.

Incumbent organizations, by contrast, can treat AI as an operating layer: instrumentation across operations, feedback loops from human decisions, and governance that turns individual tasks into reusable policy. In that setup, every exception, correction, and approval becomes a chance to learn—and intelligence can improve as the platform absorbs more of the organization’s work. The organizations most likely to shape the enterprise AI era are those that can embed intelligence directly into operational platforms and instrument those platforms so work generates usable signals.

The prevailing narrative says nimble startups will out-innovate incumbents by building AI-native from scratch. If AI is primarily a model problem, that story holds. But in many enterprise domains, AI is a systems problem—integrations, permissions, evaluation, and change management—where advantage accrues to whomever already sits inside high-volume, high-stakes operations and converts that position into learning and automation.

The inversion: AI executes, humans adjudicate

Traditional services organizations are built on a simple architecture: humans use software to do expert work. Operators log into systems, navigate operations, make decisions, and process cases. Technology is the medium. Human judgment is the product.

An AI-native platform inverts this. It ingests a problem, applies accumulated domain knowledge, executes autonomously what it can with high confidence, and routes targeted sub-tasks to human experts when the situation demands judgment that the system can’t yet reliably provide.

But inverting human-AI interaction isn’t just a UI redesign—it requires raw material. It’s only possible when the platform is built on a foundation of domain expertise, behavioral data, and operational knowledge accumulated over years.

The three compounding assets incumbents already own

AI-native startups begin with a clean architectural slate and can move quickly. What they can’t easily manufacture is the raw material that makes domain AI defensible at scale:

  • Proprietary operational data
  • A large workforce of domain experts whose day-to-day decisions generate training signals
  • Accumulated tacit knowledge about how complex work actually gets done

Services companies already have all three. But these ingredients aren’t moats on their own. They become an advantage only when a company can systematically convert messy operations into AI-ready signals and institutional knowledge—then feed the results back into operations so the system keeps improving.

Codifying expertise into reusable signals

In most services organizations, expertise is tacit and perishable. The best operators know things they cannot easily articulate: heuristics developed over the years, edge-case intuitions, and pattern recognition that operate below the level of conscious reasoning.

At Ensemble, the strategy for addressing this challenge is knowledge distillation. The systematic conversion of expert judgment and operational decisions into machine-readable training signals.

In health-care revenue cycle management, for example, systems can be seeded with explicit domain knowledge and then deepen their coverage through structured daily interaction with operators. In Ensemble’s implementation, the system identifies gaps, formulates targeted questions, and cross-checks answers across multiple experts to capture both consensus and edge-case nuance. It then synthesizes these inputs into a living knowledge base that reflects the situational reasoning behind expert-level performance.

Turning decisions into a learning flywheel

Once a system is constrained enough to be trusted, the next question is how it gets better without waiting for annual model upgrades. Every time a skilled operator makes a decision, they generate more than a completed task. They generate a potential labeled example—context paired with an expert action (and sometimes an outcome). At scale, across thousands of operators and millions of decisions, that stream can power supervised learning, evaluation, and targeted forms of reinforcement—teaching systems to behave more like experts in real conditions.

For example, if an organization processes 50,000 cases a week and captures just three high-quality decision points per case, that’s 150,000 labeled examples every week without creating a separate data-collection program.

A more advanced human-in-the-loop design places experts inside the decision process, so systems learn not just what the right answer was, but how ambiguity gets resolved. Practically, humans intervene at branch points—selecting from AI-generated options, correcting assumptions, and redirecting operations. Each intervention becomes a high-value training signal. When the platform detects an edge case or a deviation from the expected process, it can prompt for a brief, structured rationale, capturing decision factors without requiring lengthy free-form reasoning logs.

Building toward expertise amplification

The goal is to permanently embed the accumulated expertise of thousands of domain experts—their knowledge, decisions, and reasoning—into an AI platform that amplifies what every operator can accomplish. Done well, this produces a quality of execution that neither humans nor AI achieve independently: higher consistency, improved throughput, and measurable operational gains. Operators can focus on more consequential work, supported by an AI that has already completed the analytical groundwork across thousands of analogous prior cases.

The broader implication for enterprise leaders is straightforward. Advantages in AI won’t be determined by access to general-purpose models alone. It will come from an organization’s ability to capture, refine, and compound what it knows, its data, decisions, and operational judgment, while building the controls required for high-stakes environments. As AI shifts from experimentation to infrastructure, the most durable edge may belong to the companies that understand the work well enough to instrument it and can turn that understanding into systems that improve with use.

This content was produced by Ensemble. It was not written by MIT Technology Review’s editorial staff.

The Download: cyberscammers’ banking bypasses, and carbon removal troubles

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Cyberscammers are bypassing banks’ security with illicit tools sold on Telegram 

Inside a money-laundering center in Cambodia, an employee opens a banking app on his phone. It asks for a photo linked to the account, so he uploads a picture of a 30-something Asian man. 

The app then requests a video “liveness” check. The scammer holds up a static image of a woman who doesn’t match the account. After 90 seconds, he’s in. 

The exploit relies on illicit hacking services sold on Telegram that break “Know Your Customer” (KYC) facial scans. MIT Technology Review found 22 channels and groups advertising these services. This is what we discovered. 

—Fiona Kelliher 

Is carbon removal in trouble? 

—Casey Crownhart 

Last week, news emerged that Microsoft was pausing carbon removal purchases. It was a bombshell—Microsoft effectively is the carbon removal market, single-handedly purchasing around 80% of all contracted carbon removal. 

The report sparked fear across the industry, raising questions about the future of carbon removal and the role of Big Tech. Read the full story. 

This story is from The Spark, our weekly newsletter exploring the technology that could combat the climate crisis. Sign up to receive it in your inbox every Wednesday. 

The quest to measure our relationship with nature 

—Emma Marris 

Humans have done some destructive things to the ecosystems around us. But conservationists are learning that we can also be a force for good. 

To understand how we work best with nature, a group of scientists, authors, and philosophers have developed new measurements of human-nonhuman relationships. Now, a team in the United Nations is continuing the work. Find out why—and what they hope to achieve. 

This story is from the next issue of our print magazine, which is all about nature. Subscribe now to read it when it lands on Wednesday, April 22.  

The must-reads 

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology. 

1 Ukraine says Russian troops have surrendered to robots  
They claim a fully automated attack captured army positions for the first time in history. (404 Media) 
+ Europe’s vision for future wars is full of drones. (MIT Technology Review) 
 
2 Monkeys with BCIs are navigating virtual worlds using only their thoughts 
The research could help people with paralysis. (New Scientist)  
+ But these implants still face a critical test. (MIT Technology Review) 
 
3 NASA wants to put nuclear reactors on the Moon 
They could power lunar bases and extend spaceflight. (Wired $) 
+ NASA is also building a nuclear-powered spacecraft. (MIT Technology Review) 

4 Plans for online age verification in the US are raising red flags 
Experts warn of compliance issues and potential data breaches. (NBC News) 
+ In the EU, an age verification app is about to launch. (Reuters $) 

5 An AI chip boom just pushed Taiwan’s stock market past the UK’s 
It’s risen past $4 trillion to become the world’s seventh largest. (FT $) 
+ Future AI chips could be built on glass. (MIT Technology Review) 

6 The public backlash against data centers is intensifying in the US 
Protests and litigation are blocking projects. (CNBC) 
+ One potential solution? Putting them in space. (MIT Technology Review) 

7 Five-minute EV charging is becoming a reality 
China’s BYD has started rolling it out. (Gizmodo)  
+ “Extended-range electric vehicles” are about to hit US streets. (Atlantic $) 

8 Stealth signals are bypassing Iran’s internet blackout  
Files hidden in satellite TV broadcasts keep information flowing. (IEEE) 
 
9 Shoe brand Allbirds made a shock pivot to AI, sending stock up 700%  
No bubble to see here, folks. (CNBC)  
+ What even is the AI bubble? (MIT Technology Review) 

10 The largest ever map of the universe is complete  
It captures 47 million galaxies and quasars. (Space.com) 

Quote of the day 

“I like the internet as much as anybody, but we’ve got to go on an internet diet. We don’t need to pay for corporations to do their internet stuff.” 

 —Sylvia Whitt, a 78-year-old retiree based in Virginia, tells the Washington Post why they’re protesting against data centers.  

One More Thing 

a collage of hands and suggestive body shapes

ISRAEL VARGAS

AI and the future of sex 

Some Republican lawmakers want to criminalize porn and arrest its creators. But what if porn is wholly created by an algorithm? In that case, whether it’s obscene, ethical, or safe becomes a secondary issue. The primary concern will be what it means for porn to be “real”—and what the answer demands from all of us. 

Technological advances could even remove the “messy humanity” from sex itself. The rise of AI-generated porn may be a symptom of a new synthetic sexuality, not the cause. Read the full story. 

—Leo Herrera 

We can still have nice things 

A place for comfort, fun and distraction to brighten up your day. (Got any ideas? Drop me a line.) 

+ An animator turned his son’s drawings into epic anime characters. 
+ Hundreds of baby green sea turtles made a spectacular first journey to the ocean. 
+ You can now track rocket launches from take-off to orbit in real time. 
+ These musical mistakes prove that even the classics aren’t perfect. 

Role of TRPC1 in the pathogenesis of depression induced by traumatic brain injury

BackgroundTraumatic brain injury (TBI) is one of the leading causes of mortality and disability, with many patients developing long-term sequelae. Depression is among the most common psychiatric complications following TBI, yet its underlying mechanisms remain unclear. Transient receptor potential canonical 1 (TRPC1) has been implicated in neurological disorders, but its role in post-TBI depression is not well understood.MethodsA controlled cortical impact (CCI) model was used to induce moderate TBI in mice. At 4 weeks post-injury, depressive-like behaviors were assessed using the tail suspension test (TST), forced swim test (FST), and sucrose preference test (SPT). Subsequently, reactive astrocytes and microglia were quantified, along with the expression of inflammatory cytokines, in the ipsilateral hippocampus. Synaptic function was also evaluated.ResultsBehavioral tests revealed that TBI mice exhibited significant depressive- and anxiety-like behaviors at 4 weeks post-injury. Concurrently, TRPC1 expression was downregulated in the ipsilateral hippocampus, accompanied by reduced levels of synaptic-associated proteins, elevated pro-inflammatory cytokines, and increased reactive astrocytes and microglia. Further experiments demonstrated that TRPC1 overexpression attenuated neuroinflammation, restored synaptic function, and ameliorated depressive-like behaviors in TBI mice.ConclusionThis study suggests that TBI may trigger depression by downregulating TRPC1, thereby promoting neuroinflammation and synaptic dysfunction. Conversely, TRPC1 overexpression mitigates these effects, highlighting its potential as a therapeutic target for post-TBI depression.

Spatial evolution in temporal dynamics of hemodynamic response function in human superior colliculi with ultra-high-resolution MRI at 9.4T

The superior colliculus (SC) plays a crucial role in multisensory integration, visual information processing, saccadic target selection, visual selective attention, and decision making. In particular, the SC has a key role in oculomotor coordination, following a rostro-caudal organization. The rostral SC, which corresponds to foveal representation, is linked to fixation, microsaccades, smooth pursuit, and vergence adjustments. In contrast, the caudal SC, representing more peripheral visual field, is associated with the large gaze shifts (saccades). However, evidence regarding whether this functional gradient is preserved in the human SC remains limited. In this study, we employed a sequence-following visual-motor task to specifically engage SC activity. We measured blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) responses to brief neural activity, known as hemodynamic response function (HRF). We showed a spatial gradient of the BOLD positive HRFs (pHRF) along the rostro-caudal axis of the SC. The pHRF was primarily located in the rostral SC, and it gradually weakened toward the caudal SC, where negative HRF (nHRF) was often observed. The systematic rostro-caudal evolution of HRFs were consistent both within and across subjects, consistent with results from previous electrophysiological studies. Our work showed the feasibility of using ultra-high-field fMRI to non-invasively examine neurovascular dynamics in a small and deeply located subcortical structures of the human brain.

Diffusion tensor imaging-functional MRI fusion reveals disrupted white matter structure–function coupling in HIV-associated asymptomatic neurocognitive impairment

ObjectiveConventionally, blood oxygen level-dependent (BOLD) signals derived from resting-state functional magnetic resonance imaging (rs-fMRI) are attributed to gray matter, but recent evidence confirms stable low-frequency oscillations within white matter. While structure–function coupling is pivotal in neuropsychiatry, it remains underexplored in HIV-associated neurocognitive disorders (HAND). Focusing on Asymptomatic Neurocognitive Impairment (ANI), the earliest stage of HAND, this study establishes a white matter skeleton-based fusion framework integrating diffusion tensor imaging (DTI) and rs-fMRI to investigate underlying mechanisms.MethodsWe enrolled 47 patients with ANI and 48 matched healthy controls. Fractional anisotropy (FA) images from DTI and BOLD signals derived from rs-fMRI were projected onto a unified white matter skeleton to achieve structure–function spatial alignment. FA, skeleton-based white matter amplitude of low-frequency fluctuations (SWALFF), and its dynamic variability (dSWALFF) were calculated. Group differences in white matter structure and function were assessed, with structure–function coupling examined in regions showing overlapping FA-SWALFF and FA-dSWALFF alterations. Additionally, a novel White Matter Dys-coupling Index (WDI) was proposed to quantify the deviation between structural integrity and functional activity and evaluate its clinical relevance.ResultsCompared to controls, ANI patients exhibited widespread FA reductions and increased mean diffusivity (MD) and radial diffusivity (RD), indicating diffuse demyelination. Functionally, a spatial dissociation emerged: SWALFF was reduced in posterior occipital pathways (left vertical occipital fasciculus, forceps major), whereas SWALFF and dSWALFF were elevated in prefrontal pathways (forceps minor). Overlapping regions revealed complex coupling patterns, ranging from concordant decline to compensatory upregulation and decoupling. The interaction between FA and dSWALFF further highlighted instability in dynamic regulation. The WDI was significantly correlated with infection duration, immune status, and cognitive domain scores.ConclusionThis study identifies a characteristic “coupling imbalance” in the white matter of ANI patients, defined by the coexistence of structural degeneration and functional reorganization. We propose the WDI as a quantitative metric for this deviation. Its significant associations with clinical and cognitive metrics suggest its potential as a neuroimaging biomarker for the early identification and mechanistic understanding of HAND.

MambaSSM: efficient segmentation of brain structures in anisotropic 3D EM images via state-space models

Accurate segmentation of brain structures from anisotropic 3D electron microscopy (EM) images remains challenging due to the trade-off between global context modeling and computational efficiency. While state-space models (SSMs) like Mamba have shown promise in capturing long-range dependencies, their direct application to anisotropic EM data has been limited. We introduce MambaSSM, a novel network that adapts SSMs to anisotropic 3D EM images via a tailored scanning strategy. Our method features two core modules: an SSM-based anisotropic adaptation module for early-stage feature learning and an SSM-based isotropic adaptation module for later-stage refinement. These modules are interleaved with convolutional layers to enable multi-scale feature extraction. Evaluated on two public datasets (SNEMI3D and MitoEM-R), MambaSSM achieves superior segmentation accuracy with significantly lower memory usage compared to CNN, Transformer, and Mamba based baselines.

Research progress on social participation of young and middle-aged stroke survivors: a narrative review

Stroke is characterized by high morbidity, disability, and mortality, and has become the third leading cause of death worldwide. In China, stroke accounts for 39.9% of all cerebrovascular diseases, with young and middle-aged survivors (aged 40–60 years) comprising 33% of global stroke survivors in this age group and over 51.51% of all stroke cases in China. Despite significant improvements in treatment, 70–80% of survivors still lose the ability to live independently, and social participation declines to varying degrees. Social participation plays an important role in rehabilitation outcome indicators, which can reflect the overall recovery of survivors and is closely related to quality of life. Guided by the International Classification of Functioning, Disability and Health (ICF) framework, this review aims to examine the current status, assessment tools, and influencing factors of social participation among young and middle-aged stroke survivors, with the goal of informing future research and guiding clinical practice.

The relationship between impulsivity and non-suicidal self-injury in adolescents: the chain-mediated effects of parenting style and distress tolerance

ObjectiveThe purpose of this study is to explore the related risk factors and protective factors of adolescent non suicidal self injury (NSSI).MethodsUtilizing the experience sampling method, we recruited 311 adolescents engaging in NSSI, all without other mental disorders, from five public high schools in a specific city. Questionnaire surveys were administered, employing the Chinese version of the Short-Form Egna Minnen av Barndoms Uppfostran (s-EMBU-C), Distress Tolerance Scale-Revised (DTS-CR), Adolescent Self-harm Behavior Questionnaire, Barratt Impulsiveness Scale version 11 (BIS-11).Results1) The findings indicate that NSSI in adolescents is positively correlated with impulsivity and negative parenting styles (P < 0.01), while it is negatively correlated with distress tolerance and positive parenting styles (P<0.01). Impulsivity is negatively correlated with distress tolerance and positive parenting styles (P < 0.01) and positively correlated with negative parenting styles (P < 0.01). Furthermore, distress tolerance is negatively correlated with negative parenting styles (P < 0.01) and positively correlated with positive parenting styles (P < 0.01). 2) This study reveals that both negative and positive parenting styles serve as complete mediators in the relationship between impulsivity and NSSI behavior in adolescents, with distress tolerance as a significant factor.ConclusionImpulsivity significantly influences NSSI behavior in adolescents through the mediation of parenting styles (both negative and positive) and distress tolerance.

A qualitative study on the participation experience in a mental health recovery program based on WHO QualityRights in South Korea

IntroductionThe World Health Organization’s QualityRights initiative offers a practical framework for developing rights-based, person-centered, and recovery-oriented mental health systems. In Korea, the face-to-face WHO QualityRights specialized training module, Recovery practices for mental health and well-being, was culturally and clinically adapted for local use, incorporating Open Dialogue principles. This adaptation led to the development of the group-based “QualityRights Recovery Program.” This study examines the experiences and perspectives of individuals with lived experience of mental health challenges, their family caregivers, and mental health practitioners who participated in this program to inform the local implementation of recovery-oriented mental health practices.MethodsEighteen participants were recruited from two mental health facilities in Suwon, Republic of Korea. Researchers conducted semi-structured interviews and used thematic analysis to examine participants’ experiences with the 13-week QualityRights Recovery Program, which was adapted for the Korean clinical context.ResultsFour major themes emerged: (1) participation and engagement in recovery, (2) changes in communication and decision-making, (3) mutual understanding and shifts in perception, and (4) redefining recovery concepts and therapeutic aims.ConclusionParticipants’ perspectives on the QualityRights Recovery Program indicate its potential to restore the autonomy and well-being of individuals with lived experience, while also positively influencing the perspectives of their caregivers and practitioners. These findings provide guidance for expanding rights-based, recovery-oriented mental health interventions in Korea.