Petrova et al. develop a high-throughput human iPSC-derived sensory neuron platform for drug discovery in chemotherapy-induced peripheral neuropathy. They uncover that inhibition of three members of the STE20 kinase family (MAP4K4/MINK1/TNIK) is neuroprotective against paclitaxel-induced axon damage, with validation in primary human and mouse models.
Radically different