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3090 results

Drug Target for Fragile X Syndrome Identified Through Preclinical Study

Researchers identified the synaptic protein EPAC2 as a potential therapeutic target for fragile X syndrome, and showed that blocking EPAC2 in an FXS mouse model restored abnormal patterns of brain activity and improved several FXS-associated behavioral symptoms. The post Drug…

Tags: Academic research, Anxiety, Autism, Biotech, Mental health

Read more

AI Model Predicts Alzheimer’s Progression from a Single MRI Scan

A new AI framework developed by UCSF researchers can predict Alzheimer’s disease progression and future cognitive decline from a single MRI scan without requiring PET imaging, fluid biomarkers, or baseline cognitive testing. The post AI Model Predicts Alzheimer’s Progression from…

Tags: Academic research, Biomarker, Mental health, Sexual drive and regulation, United States

Read more

What to expect from Google this week

This story originally appeared in The Algorithm, our weekly newsletter on AI. To get stories like this in your inbox first, sign up here. When Google opens its doors tomorrow for its annual developer conference, I/O, it will do so as…

Tags: Academic research, Charity / nonprofit, Cognitive focus and executive control, United States

Read more

Inside Anduril and Meta’s quest to make smart glasses for warfare

The defense-tech company Anduril has shared new details about the augmented-reality headset for the military it’s prototyping with Meta, including a vision for ordering drone strikes via eye-tracking and voice commands. Quay Barnett, who leads the efforts as a vice…

Tags: Cognitive focus and executive control, Medical device

Read more

Genetic and clinical investigation of insulin-degrading enzyme in Parkinson’s disease within the Chinese Han population

IntroductionGrowing evidence suggests a mechanistic link between type 2 diabetes mellitus and Parkinson’s disease (PD), with insulin-degrading enzyme (IDE) implicated in both insulin and amyloid-β metabolism, as well as α-synuclein degradation. However, the role of IDE in PD pathogenesis remains…

Tags: Academic research, Appetite and ingestive regulation, Sexual drive and regulation

Read more

From autophagy–lysosomal deficits to neurodegeneration in Niemann-Pick type C1 disease: implications for age-related neurodegenerative disorders

Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder caused by loss-of-function mutations in the NPC1 gene. NPC1 deficit primarily disrupts lipid homeostasis and subsequently drives cellular degeneration through mechanisms involving impaired autophagy and mitophagy, mitochondrial dysfunction, and,…

Tags: Sexual drive and regulation

Read more

Effects of motor imagery brain-computer interface task on quantitative EEG features in patients with prolonged disorders of consciousness

ObjectiveTo analyze quantitative electroencephalographic (EEG) characteristics during Motor Imagery Brain-Computer Interface (MI-BCI) task in patients with prolonged disorders of consciousness (pDoC).MethodsForty-three patients with pDoC due to various brain injuries were enrolled. Based on modified Coma Recovery Scale-Revised (CRS-R) assessments, the…

Tags: Sleep and arousal regulation

Read more

Amelioration of tic disorder by Jujuboside A via gut microbiota remodeling and intestinal 5-HT signaling

BackgroundTic disorder (TD) is a common chronic neuropsychiatric condition manifesting during childhood and adolescence. Jujuboside A (JuA) may alleviate TD symptoms; however, the mechanisms underlying its therapeutic effects remain unclear.MethodsWe established a rat model of TD and used histological techniques…

Tags: Genomics, Motor and impulse regulation, Tic & Tourette

Read more

Neurocognitive function among individuals with problematic social media use

BackgroundWith the development of technology and the internet, social networks gained momentum quickly and play a central role in daily activities. Despite this, there is a public health concern over excessive or problematic social media use. There is also a…

Tags: Academic research, Anxiety, Cognitive focus and executive control, Depression, Mood and emotional regulation, Substance abuse, Substance use

Read more

Microstructural abnormalities in the ATR and VOF underlie tone awareness deficits in Chinese children with developmental dyslexia: a DTI study

ObjectiveTone awareness is crucial for reading in Chinese children, significantly affecting those with developmental dyslexia (DD). This paper identifies microstructural abnormalities in the inferior fronto-occipital fasciculus (IFOF), uncinate fasciculus (UF), anterior thalamic radiation (ATR), and vertical occipital fasciculus (VOF) in…

Tags: Academic research

Read more

Heatwave-related variations in psychiatric consultations and admissions: a time-series analysis

BackgroundHeatwaves are becoming increasingly frequent and intense across Europe, posing significant risks to physical and mental health. Emerging evidence suggests that prolonged exposure to high temperatures may exacerbate psychiatric symptoms and increase the demand for acute mental health services.ObjectivesThis study…

Tags: Academic research, Healthcare provider, Mental health

Read more

Psychological inflexibility and resilience in anxiety: insights from machine-learning and robust mediation-based models

IntroductionPsychological inflexibility (PI) has been associated with anxiety symptoms, while resilience serves as a protective factor; however, their roles and interrelationship remain poorly understood. We investigated the role of PI on anxiety-related symptoms while assessing the mediating role of resilience…

Tags: Anxiety, Depression, Mental health, Mood and emotional regulation

Read more

The trajectories of Demoralization Syndrome and its related factors among elderly patients with end-stage kidney disease: a longitudinal study

ObjectiveElderly ESKD patients frequently experience a range of psychosocial difficulties, with Demoralization Syndrome (DS) being especially prevalent. This study sought to delineate distinct longitudinal trajectories of DS and to examine factors associated with trajectory membership.MethodsA prospective longitudinal cohort of 363…

Tags: Academic research, Healthcare provider

Read more

News Feed

News

Disease
Functional Domain
Type
Source
Reset filters

3090 results

Drug Target for Fragile X Syndrome Identified Through Preclinical Study

Researchers identified the synaptic protein EPAC2 as a potential therapeutic target for fragile X syndrome, and showed that blocking EPAC2 in an FXS mouse model restored abnormal patterns of brain activity and improved several FXS-associated behavioral symptoms. The post Drug…

Tags: Academic research, Anxiety, Autism, Biotech, Mental health

Read more

AI Model Predicts Alzheimer’s Progression from a Single MRI Scan

A new AI framework developed by UCSF researchers can predict Alzheimer’s disease progression and future cognitive decline from a single MRI scan without requiring PET imaging, fluid biomarkers, or baseline cognitive testing. The post AI Model Predicts Alzheimer’s Progression from…

Tags: Academic research, Biomarker, Mental health, Sexual drive and regulation, United States

Read more

What to expect from Google this week

This story originally appeared in The Algorithm, our weekly newsletter on AI. To get stories like this in your inbox first, sign up here. When Google opens its doors tomorrow for its annual developer conference, I/O, it will do so as…

Tags: Academic research, Charity / nonprofit, Cognitive focus and executive control, United States

Read more

Inside Anduril and Meta’s quest to make smart glasses for warfare

The defense-tech company Anduril has shared new details about the augmented-reality headset for the military it’s prototyping with Meta, including a vision for ordering drone strikes via eye-tracking and voice commands. Quay Barnett, who leads the efforts as a vice…

Tags: Cognitive focus and executive control, Medical device

Read more

Genetic and clinical investigation of insulin-degrading enzyme in Parkinson’s disease within the Chinese Han population

IntroductionGrowing evidence suggests a mechanistic link between type 2 diabetes mellitus and Parkinson’s disease (PD), with insulin-degrading enzyme (IDE) implicated in both insulin and amyloid-β metabolism, as well as α-synuclein degradation. However, the role of IDE in PD pathogenesis remains…

Tags: Academic research, Appetite and ingestive regulation, Sexual drive and regulation

Read more

From autophagy–lysosomal deficits to neurodegeneration in Niemann-Pick type C1 disease: implications for age-related neurodegenerative disorders

Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder caused by loss-of-function mutations in the NPC1 gene. NPC1 deficit primarily disrupts lipid homeostasis and subsequently drives cellular degeneration through mechanisms involving impaired autophagy and mitophagy, mitochondrial dysfunction, and,…

Tags: Sexual drive and regulation

Read more

Effects of motor imagery brain-computer interface task on quantitative EEG features in patients with prolonged disorders of consciousness

ObjectiveTo analyze quantitative electroencephalographic (EEG) characteristics during Motor Imagery Brain-Computer Interface (MI-BCI) task in patients with prolonged disorders of consciousness (pDoC).MethodsForty-three patients with pDoC due to various brain injuries were enrolled. Based on modified Coma Recovery Scale-Revised (CRS-R) assessments, the…

Tags: Sleep and arousal regulation

Read more

Amelioration of tic disorder by Jujuboside A via gut microbiota remodeling and intestinal 5-HT signaling

BackgroundTic disorder (TD) is a common chronic neuropsychiatric condition manifesting during childhood and adolescence. Jujuboside A (JuA) may alleviate TD symptoms; however, the mechanisms underlying its therapeutic effects remain unclear.MethodsWe established a rat model of TD and used histological techniques…

Tags: Genomics, Motor and impulse regulation, Tic & Tourette

Read more

Neurocognitive function among individuals with problematic social media use

BackgroundWith the development of technology and the internet, social networks gained momentum quickly and play a central role in daily activities. Despite this, there is a public health concern over excessive or problematic social media use. There is also a…

Tags: Academic research, Anxiety, Cognitive focus and executive control, Depression, Mood and emotional regulation, Substance abuse, Substance use

Read more

Microstructural abnormalities in the ATR and VOF underlie tone awareness deficits in Chinese children with developmental dyslexia: a DTI study

ObjectiveTone awareness is crucial for reading in Chinese children, significantly affecting those with developmental dyslexia (DD). This paper identifies microstructural abnormalities in the inferior fronto-occipital fasciculus (IFOF), uncinate fasciculus (UF), anterior thalamic radiation (ATR), and vertical occipital fasciculus (VOF) in…

Tags: Academic research

Read more

Heatwave-related variations in psychiatric consultations and admissions: a time-series analysis

BackgroundHeatwaves are becoming increasingly frequent and intense across Europe, posing significant risks to physical and mental health. Emerging evidence suggests that prolonged exposure to high temperatures may exacerbate psychiatric symptoms and increase the demand for acute mental health services.ObjectivesThis study…

Tags: Academic research, Healthcare provider, Mental health

Read more

Psychological inflexibility and resilience in anxiety: insights from machine-learning and robust mediation-based models

IntroductionPsychological inflexibility (PI) has been associated with anxiety symptoms, while resilience serves as a protective factor; however, their roles and interrelationship remain poorly understood. We investigated the role of PI on anxiety-related symptoms while assessing the mediating role of resilience…

Tags: Anxiety, Depression, Mental health, Mood and emotional regulation

Read more

The trajectories of Demoralization Syndrome and its related factors among elderly patients with end-stage kidney disease: a longitudinal study

ObjectiveElderly ESKD patients frequently experience a range of psychosocial difficulties, with Demoralization Syndrome (DS) being especially prevalent. This study sought to delineate distinct longitudinal trajectories of DS and to examine factors associated with trajectory membership.MethodsA prospective longitudinal cohort of 363…

Tags: Academic research, Healthcare provider

Read more