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2711 results

Risk for Autism Across Generations

Autism spectrum disorder (ASD) has a complex inheritance pattern and is more common in males. Etiological models suggest that majority of ASD risk is transmitted through common and rare de-novo genetic variation. It has been hypothesized that rare variation could…

Tags: Autism

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Astrocytic cholesterol jams brain clearance in AD

Nature Neuroscience, Published online: 05 May 2026; doi:10.1038/s41593-026-02310-3Zhang and colleagues identify astrocytic calcium–cholesterol–AQP4 signaling that drives glymphatic dysfunction in early Alzheimer’s disease (AD). Attenuating this signaling restored glymphatic flow, reduced amyloid burden and improved cognition in young 5xFAD mice only…

Tags: None

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Molecular mechanism of calcium permeability and magnesium block in NMDA receptors

Nature Neuroscience, Published online: 05 May 2026; doi:10.1038/s41593-026-02283-3Using cryo-electron microscopy and electrophysiology, this study explains the structural basis for Ca2+ permeation and Mg2+ block in NMDA receptors and identifies a surrounding lipid network that may tune Mg2+-dependent voltage sensitivity.

Tags: Academic research, Reality testing and perceptual stability

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A blueprint for using AI to strengthen democracy

Every few centuries, changes in how information moves reshape how societies govern themselves. The printing press spread vernacular literacy, helping give rise to the Reformation and, eventually, representative government. The telegraph made it possible to administer vast nations like the…

Tags: Academic research, Government / public service, Social and attachment drive

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Neural Correlates of Suicidal Behavior in Youth

Conditions: Suicidal Ideation; Suicide Attempt; Suicidal Behavior; Depression / Major Depressive Disorder; Hopelessness; Neurobiological Interventions: Behavioral: CAMS Sponsors: The Cleveland Clinic; MQ Mental Health Research Not yet recruiting

Tags: Academic research, Depression, Healthcare provider, Mental health, Mood and emotional regulation

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The PREVENT Resilience Study

Conditions: Psychological Trauma Interventions: Device: Transcranial Magnetic Stimulation (TMS); Other: TMS Sham Sponsors: Emory University; National Institute of Mental Health (NIMH) Not yet recruiting

Tags: Academic research, Medical device, Mental health

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Group PACBT for Depression

Conditions: Depression - Major Depressive Disorder; Psilocybin; Cognitive Behavioral Therapy Interventions: Drug: Psilocybin (drug); Behavioral: Group Cognitive Behavioral Therapy Sponsors: University of California, Los Angeles Not yet recruiting

Tags: Alternative therapies, CBT, Depression, Mood and emotional regulation, United States

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