News Feed
Constructing the history of a contested region
Science, Volume 394, Issue 6823, Page 492-492, October 2026.
Spawning Season: An Experiment in Queer Parenthood
Science, Volume 394, Issue 6823, Page 492-492, October 2026.
News
3090 results
Opinion: The cloudy truth about ‘blue zones’
“There's been interest in longevity, promoting it, for millennia. But this 25-year campaign really brought it to the forefront,” Eric Topol says of blue zones.
Opinion: Marty Makary misunderstood something fundamental about the FDA
“The norm-shattering masks a more fundamental misunderstanding of how administrative power can bring about lasting change,” writes Joshua Sharfstein.
NIH-supported project expands access to care for children with amblyopia
Open-access tool guides eye doctors without specific pediatric eye care training in amblyopia diagnosis and management.
Preclinical and Emerging Clinical Evidence Supporting the Translational Potential of GLP-1 Receptor Agonists for Treating Psychostimulant and Nicotine Use Disorders
Psychostimulant use disorder (PSUD) and nicotine use disorder (NUD) affect tens of millions of people worldwide, yet no clinically-approved medications exist for PSUD and existing NUD treatments have limited long-term efficacy. Recent preclinical evidence suggests that glucagon-like peptide-1 receptor (GLP-1R)…
Psychiatric risk implications from behavioral and neural effects of adolescent exposure to environmental insecticides: a systematic review of rodent studies
Adolescence is a sensitive neurodevelopmental period marked by remodeling of brain circuits that support cognitive development and emotion and behavior regulation. These maturation processes heighten psychiatric vulnerability to environmental exposures, including to toxicants such as insecticides. Epidemiological studies show widespread…
Continuous Theta-Burst Stimulation Improves Long-Term Outcomes in Alcohol Use Disorder by Modulating a Craving-Related Dynamic Network
Alcohol use disorder (AUD) is a chronic, relapsing disorder characterized by craving. While continuous theta-burst stimulation (cTBS) shows promise for AUD, its long-term effects on drinking reduction and underlying mechanisms remain unclear. We evaluated the 12-month efficacy of right dorsolateral…
Musk v. Altman week 3: Musk and Altman traded blows over each other’s credibility. Now the jury will pick a side.
In the final week of the Musk v. Altman trial, lawyers traded blows over Elon Musk’s and OpenAI CEO Sam Altman’s credibility. Altman was grilled on his alleged history of lying and self-dealing involving companies that do business with OpenAI.…
Factors Influencing the Initiation and Continued Engagement of Digital Mental Health Tools Among Adults: Theory of Planned Behavior–Informed Systematic Review
Background: Digital mental health tools (DMHTs) offer scalable support, but engagement varies. Understanding the shapes of initiation and ongoing use is essential for effective design and implementation. Objective: This study aims to synthesize determinants of adults’ initiation and engagement with…
STAT+: FDA drug center head Tracy Beth Høeg leaves as agency faces leadership vacuum
The acting director of the FDA’s drug center, Tracy Beth Høeg, is leaving the agency. The news come days after Commissioner Marty Makary handed in his resignation.
Reducing Intrusive Trauma Memories Using a Brief Mental Imagery Competing Task Intervention: Case Series of Trauma-Exposed Women in Iceland
Background: There is a need for scalable and simple interventions for trauma-exposed people. In this case series, we built on our previous case study and case series findings and further explored the use and potential effectiveness of a brief novel…
Large Language Models and Their Applications in Mental Health: Scoping Review
Background: Large language models (LLMs) are poised to transform mental health care, offering advanced capabilities in diagnosis, prognosis, and decision support. Since their inception, numerous mental health-focused LLMs have emerged in the scientific literature, reflecting the growing interest in leveraging…
STAT+: Takeda will pay $13.6 million to settle allegations it paid kickbacks to doctors
Takeda Pharmaceuticals agreed to pay $13.6 million to settle allegations that it paid kickbacks to doctors to prescribe an antidepressant.
Exosome-based therapy for epilepsy: a systematic review and meta-analysis of preclinical studies
ObjectiveThis study aims to quantitatively assess the efficacy of exosome therapy for epilepsy through a systematic review and meta-analysis of preclinical animal experiments. We seek to clarify its overall effects on seizure reduction, cognitive function preservation, and neuroinflammation suppression.MethodsA systematic…
Molecular mechanisms of autophagy-lysosomal pathway dysfunction in neurodegenerative diseases and therapeutic strategies for lysosomal repair: a review
The autophagy-lysosomal pathway (ALP) is a critical intracellular protein degradation system responsible for maintaining proteostasis and metabolic balance within cells. Dysfunction of this pathway has been increasingly recognized as a key pathological basis underlying various neurodegenerative diseases (NDs). This review…
RNA editing in Parkinson’s disease: emerging mechanisms, translational potential, and current challenges
Parkinson’s disease (PD) is a major neurodegenerative disorder characterized by progressive loss of dopaminergic neurons and accumulation of α-synuclein. Current treatments primarily focus on symptom alleviation, highlighting the necessity for identifying novel molecular therapeutic targets. RNA editing, as a post-transcriptional…
Autonomic dysreflexia: the concealed killer behind recurrent cerebral hemorrhage in spinal cord injury—a case report with management insights
Autonomic dysreflexia (AD) is a potentially life-threatening complication of high-level spinal cord injury (SCI), marked by paroxysmal hypertension. Although cerebrovascular events can be triggered by severe hypertension, the direct association between AD and intracerebral hemorrhage (ICH) necessitates increased clinical awareness.…
A hierarchical machine learning model for predicting self-harm and suicidal behaviour in hospitalised patients with schizophrenia using clinical history and nursing observations
ObjectiveThis study aimed to develop and evaluate a two-layered machine learning framework that combines admission clinical information with longitudinal nursing observations to identify schizophrenia inpatients at high risk of self-harm or suicidal acts.MethodsWe retrospectively reviewed the records of 477 patients…
Context-dependent interaction between oxytocin gene polymorphisms and alcohol dependence in modulating negative emotions during acute alcohol withdrawal in adult males
ObjectiveThe importance of multiple gene-environment interaction (G × E) has been highlighted in understanding the etiology of negative emotions. This study examines the impact of oxytocin (OXT) polymorphisms (rs2740210, rs6133010, and rs2740209) in combination with alcohol dependence on anxiety and…
News Feed
Constructing the history of a contested region
Science, Volume 394, Issue 6823, Page 492-492, October 2026.
Spawning Season: An Experiment in Queer Parenthood
Science, Volume 394, Issue 6823, Page 492-492, October 2026.
News
3090 results
Opinion: The cloudy truth about ‘blue zones’
“There's been interest in longevity, promoting it, for millennia. But this 25-year campaign really brought it to the forefront,” Eric Topol says of blue zones.
Opinion: Marty Makary misunderstood something fundamental about the FDA
“The norm-shattering masks a more fundamental misunderstanding of how administrative power can bring about lasting change,” writes Joshua Sharfstein.
NIH-supported project expands access to care for children with amblyopia
Open-access tool guides eye doctors without specific pediatric eye care training in amblyopia diagnosis and management.
Preclinical and Emerging Clinical Evidence Supporting the Translational Potential of GLP-1 Receptor Agonists for Treating Psychostimulant and Nicotine Use Disorders
Psychostimulant use disorder (PSUD) and nicotine use disorder (NUD) affect tens of millions of people worldwide, yet no clinically-approved medications exist for PSUD and existing NUD treatments have limited long-term efficacy. Recent preclinical evidence suggests that glucagon-like peptide-1 receptor (GLP-1R)…
Psychiatric risk implications from behavioral and neural effects of adolescent exposure to environmental insecticides: a systematic review of rodent studies
Adolescence is a sensitive neurodevelopmental period marked by remodeling of brain circuits that support cognitive development and emotion and behavior regulation. These maturation processes heighten psychiatric vulnerability to environmental exposures, including to toxicants such as insecticides. Epidemiological studies show widespread…
Continuous Theta-Burst Stimulation Improves Long-Term Outcomes in Alcohol Use Disorder by Modulating a Craving-Related Dynamic Network
Alcohol use disorder (AUD) is a chronic, relapsing disorder characterized by craving. While continuous theta-burst stimulation (cTBS) shows promise for AUD, its long-term effects on drinking reduction and underlying mechanisms remain unclear. We evaluated the 12-month efficacy of right dorsolateral…
Musk v. Altman week 3: Musk and Altman traded blows over each other’s credibility. Now the jury will pick a side.
In the final week of the Musk v. Altman trial, lawyers traded blows over Elon Musk’s and OpenAI CEO Sam Altman’s credibility. Altman was grilled on his alleged history of lying and self-dealing involving companies that do business with OpenAI.…
Factors Influencing the Initiation and Continued Engagement of Digital Mental Health Tools Among Adults: Theory of Planned Behavior–Informed Systematic Review
Background: Digital mental health tools (DMHTs) offer scalable support, but engagement varies. Understanding the shapes of initiation and ongoing use is essential for effective design and implementation. Objective: This study aims to synthesize determinants of adults’ initiation and engagement with…
STAT+: FDA drug center head Tracy Beth Høeg leaves as agency faces leadership vacuum
The acting director of the FDA’s drug center, Tracy Beth Høeg, is leaving the agency. The news come days after Commissioner Marty Makary handed in his resignation.
Reducing Intrusive Trauma Memories Using a Brief Mental Imagery Competing Task Intervention: Case Series of Trauma-Exposed Women in Iceland
Background: There is a need for scalable and simple interventions for trauma-exposed people. In this case series, we built on our previous case study and case series findings and further explored the use and potential effectiveness of a brief novel…
Large Language Models and Their Applications in Mental Health: Scoping Review
Background: Large language models (LLMs) are poised to transform mental health care, offering advanced capabilities in diagnosis, prognosis, and decision support. Since their inception, numerous mental health-focused LLMs have emerged in the scientific literature, reflecting the growing interest in leveraging…
STAT+: Takeda will pay $13.6 million to settle allegations it paid kickbacks to doctors
Takeda Pharmaceuticals agreed to pay $13.6 million to settle allegations that it paid kickbacks to doctors to prescribe an antidepressant.
Exosome-based therapy for epilepsy: a systematic review and meta-analysis of preclinical studies
ObjectiveThis study aims to quantitatively assess the efficacy of exosome therapy for epilepsy through a systematic review and meta-analysis of preclinical animal experiments. We seek to clarify its overall effects on seizure reduction, cognitive function preservation, and neuroinflammation suppression.MethodsA systematic…
Molecular mechanisms of autophagy-lysosomal pathway dysfunction in neurodegenerative diseases and therapeutic strategies for lysosomal repair: a review
The autophagy-lysosomal pathway (ALP) is a critical intracellular protein degradation system responsible for maintaining proteostasis and metabolic balance within cells. Dysfunction of this pathway has been increasingly recognized as a key pathological basis underlying various neurodegenerative diseases (NDs). This review…
RNA editing in Parkinson’s disease: emerging mechanisms, translational potential, and current challenges
Parkinson’s disease (PD) is a major neurodegenerative disorder characterized by progressive loss of dopaminergic neurons and accumulation of α-synuclein. Current treatments primarily focus on symptom alleviation, highlighting the necessity for identifying novel molecular therapeutic targets. RNA editing, as a post-transcriptional…
Autonomic dysreflexia: the concealed killer behind recurrent cerebral hemorrhage in spinal cord injury—a case report with management insights
Autonomic dysreflexia (AD) is a potentially life-threatening complication of high-level spinal cord injury (SCI), marked by paroxysmal hypertension. Although cerebrovascular events can be triggered by severe hypertension, the direct association between AD and intracerebral hemorrhage (ICH) necessitates increased clinical awareness.…
A hierarchical machine learning model for predicting self-harm and suicidal behaviour in hospitalised patients with schizophrenia using clinical history and nursing observations
ObjectiveThis study aimed to develop and evaluate a two-layered machine learning framework that combines admission clinical information with longitudinal nursing observations to identify schizophrenia inpatients at high risk of self-harm or suicidal acts.MethodsWe retrospectively reviewed the records of 477 patients…
Context-dependent interaction between oxytocin gene polymorphisms and alcohol dependence in modulating negative emotions during acute alcohol withdrawal in adult males
ObjectiveThe importance of multiple gene-environment interaction (G × E) has been highlighted in understanding the etiology of negative emotions. This study examines the impact of oxytocin (OXT) polymorphisms (rs2740210, rs6133010, and rs2740209) in combination with alcohol dependence on anxiety and…