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Diagnostic Discrimination of BOKE STARS, a Bimodal Continuous Performance Test, for Attention-Deficit/Hyperactivity Disorder Assessment in Chinese Children: Single-Center Case-Control Study
Background: Attention-deficit/hyperactivity disorder (ADHD) affects 6.3% of Chinese children, but only 10% are diagnosed, as diagnosis is hindered by low awareness and lack of culturally adapted, objective tools. Existing continuous performance tests are unimodal…
Clinical Decision Support for Digital Dietary Counseling Under GLP-1 Receptor Agonist Therapy: Convergent Mixed Methods Usability and Treatment Satisfaction Pilot Study of the Personalized Nutrition Advisor
Background: Dietary counseling is an essential complement to the growing use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to achieve sustainable weight loss. Diverse patient needs, the demand for ongoing support, and limited resources…
Medtech CDMO Aptyx names new CEO
Aptyx has promoted CFO David Price to the role of CEO effective immediately, succeeding former Aptyx CEO Gregg Tobin. Price joined the Tempe, Arizona-based medical device contract development and manufacturing organization as CFO in…
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Manual therapy ameliorates neuromuscular dysfunction in spastic model rat: involvement of the C-Fiber-mediated CaMKII pathway
BackgroundThis study investigated whether manual therapy applied to tendon organs ameliorated neuromuscular dysfunction in rats with spasticity induced by upper motor neuron injury associated with spastic cerebral palsy, and analyzed the potential involvement of the C-fiber-mediated CaMKII signaling pathway.MethodsMale rats…
Sex as a biological variable in amblyopia: implications for developmental plasticity and treatment
Amblyopia is a common childhood visual disorder caused by abnormal visual experience that drives visual cortical plasticity during the sensitive period. The timing and forms of treatment with patching therapy and other therapeutic interventions have been extensively studied; however, sex…
Altered glymphatic function in nasopharyngeal carcinoma following radiotherapy: novel insights from choroid plexus volume and free-water fraction analyses
Background and purposeRadiotherapy (RT) often causes delayed radiation-induced brain injury (RBI) with unclear pathophysiology; emerging evidence links this to glymphatic dysfunction, but radiation effects on cerebrospinal fluid (CSF) dynamics and interstitial fluid-CSF exchange are unstudied. Thus, we used choroid plexus…
Analysis of risk factors for tic disorders in children in Hubei region based on liquid chromatography-tandem mass spectrometry
ObjectiveThis study aims to investigate the correlation between trace element concentrations, 25-hydroxyvitamin D [25(OH)D] levels, and the severity of tic disorders (TD) in children from the Hubei region. Additionally, it seeks to explore the interrelationships among these monitored indicators to…
Excessive Internet use and depressive symptom levels in adolescents with depressive disorders: chain mediation of social anxiety and sleep quality
BackgroundAdolescents with depressive disorders are at elevated risk for adverse mental health outcomes, and excessive Internet use has been increasingly linked to greater symptom severity. Therefore, this study aimed to examine the chain mediating roles of social anxiety and sleep…
Late-life difficult-to-treat depression and dementia subtypes: a naturalistic cohort study using electronic health records
IntroductionLate-life difficult-to-treat depression (LL-DTD) and dementia frequently coexist in later life, but it remains unclear whether clinical and sociodemographic characteristics, as well as medication exposure patterns, differ across dementia subtypes among older adults with both conditions.MethodsWe analysed anonymised electronic health…
Markers of neuroinflammation in the CSF of patients with difficult to treat psychiatric disease
IntroductionThe immune system is recognized as participating in the pathophysiology of psychiatric disease and there is renewed interest in identifying biomarkers of this immune activation. MethodsWe measured serum and cerebral spinal fluid (CSF) autoantibodies with other routine and novel markers…
When the market asks no price: AI chatbot interaction as psychic market disruption
The rapid adoption of AI chatbots for emotional support and quasi-therapeutic interaction raises questions that existing clinical and regulatory frameworks are not equipped to address. This Perspective applies the psychic arbitrage framework—which reconceptualizes defense mechanisms as energy-conversion operations on internal…
Distinct sleep-disordered breathing phenotypes in elderly patients with depressive disorder: links to hypoxemia severity and inflammatory burden
ObjectiveTo identify sleep-disordered breathing phenotypes in older adults with depressive disorder and obstructive sleep apnea-hypopnea syndrome (OSAHS) and to evaluate their associations with systemic inflammation.MethodsElderly patients with depressive disorder and OSAHS were consecutively enrolled from January to December 2025. A Gower…
Federal appeals court blocks mailing of abortion pill mifepristone
Mifepristone, involved in most abortions in the U.S., can now be distributed only in person and at clinics.
Opinion: What do medical students think about their education?
“No one's pulling the pieces together”: a conversation with medical students about preventive care education.
Opinion: STAT readers on MAHA activists, perimenopause, and diversity in medical school
“Unfortunately, the resources don't exist to take every flat-earther to the International Space Station to change their mind,” a STAT reader writes.
Adding weekly GLP-1 to cognitive behavioral therapy further reduces heavy drinking
Clinical trial suggests semaglutide may help patients with alcohol use disorder and obesity.
Musk v. Altman week 1: Elon Musk says he was duped, warns AI could kill us all, and admits that xAI distills OpenAI’s models
In the first week of the landmark trial between Elon Musk and OpenAI, Musk took the stand in a crisp black suit and tie and argued that OpenAI CEO Sam Altman and president Greg Brockman had deceived him into bankrolling…
Applicable Scenarios, Desired Features, and Risks of AI Psychotherapists in Depression Treatment From the Patient’s Perspective: Exploratory Qualitative Study
Background: Depression is a pervasive global mental health issue, yet access to trained professionals remains severely limited. With the rapid advancement of artificial intelligence (AI), digital tools are increasingly seen as a viable way to address this shortage. However, questions…
OTX-202 Smartphone App to Reduce Suicidal Ideation Among High-Risk Transition-Age Youth: Open-Label, Single-Arm, Phase 1 Clinical Trial
Background: The transition from adolescence to adulthood (18 to 25 years) is associated with an increased risk of suicidal ideation and behaviors. Suicide-focused cognitive behavioral therapies (CBTs) have been shown to significantly reduce suicidal ideation and behaviors but are not…
Cyber-Insecurity in the AI Era
Cybersecurity was already under strain before AI entered the stack. Now, as AI expands the attack surface and adds new complexity, the limits of legacy approaches are becoming harder to ignore. This session from MIT Technology Review’s EmTech AI conference…
Operationalizing AI for Scale and Sovereignty
Companies are taking control of their own data to tailor AI for their needs. The challenge lies in balancing ownership with the safe, trusted flow of high‑quality data needed to power reliable insights. This conversation from MIT Technology Review’s EmTech…
The Download: a new Christian phone network, and debugging LLMs
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. A new US phone network for Christians aims to block porn and gender-related content A new…
Computational learning phenotypes are not related to individual differences in resting-state fMRI connectivity
People learn from experience, but with considerable individual differences in the degree and type of behavioral adjustments resulting from a given experience. Error driven learning rules provide an elegant framework for explaining both learning behavior and its neural signatures; however,…