News Feed
Most Accurate Non-Invasive Tests for Liver Disease Identified in Landmark Studies
Two major studies have identified the most accurate non-invasive tests for diagnosing and assessing the severity of metabolic dysfunction-associated steatotic liver disease (MASLD), potentially reducing the need for liver biopsies. The post Most Accurate…
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
News
3070 results
STAT+: Biotech raises $42 million to run Huntington’s disease trial
Latus Bio raised $42 million as it prepares to seek FDA approval to start a clinical trial for its gene therapy for Huntington's disease.
Immigration changes are driving foreign researchers to leave the U.S. — or not come to begin with
Labs are seeing fewer applications from international students and researchers, and some doctoral students are considering leaving early.
Opinion: Are blue zones real? Answering that question is harder than ever
"Blue zones" as a concept have strayed far and wide from their humble roots, write Shelley Wood and Eric Topol.
Opinion: STAT+: China’s strict new supply chain regulations could create massive problems for Western biopharma companies
China is now a peer competitor in drug innovation — and it intends to stay that way on its own terms, writes Dennis Kwok.
Manual therapy ameliorates neuromuscular dysfunction in spastic model rat: involvement of the C-Fiber-mediated CaMKII pathway
BackgroundThis study investigated whether manual therapy applied to tendon organs ameliorated neuromuscular dysfunction in rats with spasticity induced by upper motor neuron injury associated with spastic cerebral palsy, and analyzed the potential involvement of the C-fiber-mediated CaMKII signaling pathway.MethodsMale rats…
Sex as a biological variable in amblyopia: implications for developmental plasticity and treatment
Amblyopia is a common childhood visual disorder caused by abnormal visual experience that drives visual cortical plasticity during the sensitive period. The timing and forms of treatment with patching therapy and other therapeutic interventions have been extensively studied; however, sex…
Altered glymphatic function in nasopharyngeal carcinoma following radiotherapy: novel insights from choroid plexus volume and free-water fraction analyses
Background and purposeRadiotherapy (RT) often causes delayed radiation-induced brain injury (RBI) with unclear pathophysiology; emerging evidence links this to glymphatic dysfunction, but radiation effects on cerebrospinal fluid (CSF) dynamics and interstitial fluid-CSF exchange are unstudied. Thus, we used choroid plexus…
Analysis of risk factors for tic disorders in children in Hubei region based on liquid chromatography-tandem mass spectrometry
ObjectiveThis study aims to investigate the correlation between trace element concentrations, 25-hydroxyvitamin D [25(OH)D] levels, and the severity of tic disorders (TD) in children from the Hubei region. Additionally, it seeks to explore the interrelationships among these monitored indicators to…
Excessive Internet use and depressive symptom levels in adolescents with depressive disorders: chain mediation of social anxiety and sleep quality
BackgroundAdolescents with depressive disorders are at elevated risk for adverse mental health outcomes, and excessive Internet use has been increasingly linked to greater symptom severity. Therefore, this study aimed to examine the chain mediating roles of social anxiety and sleep…
Late-life difficult-to-treat depression and dementia subtypes: a naturalistic cohort study using electronic health records
IntroductionLate-life difficult-to-treat depression (LL-DTD) and dementia frequently coexist in later life, but it remains unclear whether clinical and sociodemographic characteristics, as well as medication exposure patterns, differ across dementia subtypes among older adults with both conditions.MethodsWe analysed anonymised electronic health…
Markers of neuroinflammation in the CSF of patients with difficult to treat psychiatric disease
IntroductionThe immune system is recognized as participating in the pathophysiology of psychiatric disease and there is renewed interest in identifying biomarkers of this immune activation. MethodsWe measured serum and cerebral spinal fluid (CSF) autoantibodies with other routine and novel markers…
When the market asks no price: AI chatbot interaction as psychic market disruption
The rapid adoption of AI chatbots for emotional support and quasi-therapeutic interaction raises questions that existing clinical and regulatory frameworks are not equipped to address. This Perspective applies the psychic arbitrage framework—which reconceptualizes defense mechanisms as energy-conversion operations on internal…
Distinct sleep-disordered breathing phenotypes in elderly patients with depressive disorder: links to hypoxemia severity and inflammatory burden
ObjectiveTo identify sleep-disordered breathing phenotypes in older adults with depressive disorder and obstructive sleep apnea-hypopnea syndrome (OSAHS) and to evaluate their associations with systemic inflammation.MethodsElderly patients with depressive disorder and OSAHS were consecutively enrolled from January to December 2025. A Gower…
Federal appeals court blocks mailing of abortion pill mifepristone
Mifepristone, involved in most abortions in the U.S., can now be distributed only in person and at clinics.
Opinion: What do medical students think about their education?
“No one's pulling the pieces together”: a conversation with medical students about preventive care education.
Opinion: STAT readers on MAHA activists, perimenopause, and diversity in medical school
“Unfortunately, the resources don't exist to take every flat-earther to the International Space Station to change their mind,” a STAT reader writes.
Adding weekly GLP-1 to cognitive behavioral therapy further reduces heavy drinking
Clinical trial suggests semaglutide may help patients with alcohol use disorder and obesity.
Musk v. Altman week 1: Elon Musk says he was duped, warns AI could kill us all, and admits that xAI distills OpenAI’s models
In the first week of the landmark trial between Elon Musk and OpenAI, Musk took the stand in a crisp black suit and tie and argued that OpenAI CEO Sam Altman and president Greg Brockman had deceived him into bankrolling…
Applicable Scenarios, Desired Features, and Risks of AI Psychotherapists in Depression Treatment From the Patient’s Perspective: Exploratory Qualitative Study
Background: Depression is a pervasive global mental health issue, yet access to trained professionals remains severely limited. With the rapid advancement of artificial intelligence (AI), digital tools are increasingly seen as a viable way to address this shortage. However, questions…
OTX-202 Smartphone App to Reduce Suicidal Ideation Among High-Risk Transition-Age Youth: Open-Label, Single-Arm, Phase 1 Clinical Trial
Background: The transition from adolescence to adulthood (18 to 25 years) is associated with an increased risk of suicidal ideation and behaviors. Suicide-focused cognitive behavioral therapies (CBTs) have been shown to significantly reduce suicidal ideation and behaviors but are not…
News Feed
Most Accurate Non-Invasive Tests for Liver Disease Identified in Landmark Studies
Two major studies have identified the most accurate non-invasive tests for diagnosing and assessing the severity of metabolic dysfunction-associated steatotic liver disease (MASLD), potentially reducing the need for liver biopsies. The post Most Accurate…
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
News
3070 results
STAT+: Biotech raises $42 million to run Huntington’s disease trial
Latus Bio raised $42 million as it prepares to seek FDA approval to start a clinical trial for its gene therapy for Huntington's disease.
Immigration changes are driving foreign researchers to leave the U.S. — or not come to begin with
Labs are seeing fewer applications from international students and researchers, and some doctoral students are considering leaving early.
Opinion: Are blue zones real? Answering that question is harder than ever
"Blue zones" as a concept have strayed far and wide from their humble roots, write Shelley Wood and Eric Topol.
Opinion: STAT+: China’s strict new supply chain regulations could create massive problems for Western biopharma companies
China is now a peer competitor in drug innovation — and it intends to stay that way on its own terms, writes Dennis Kwok.
Manual therapy ameliorates neuromuscular dysfunction in spastic model rat: involvement of the C-Fiber-mediated CaMKII pathway
BackgroundThis study investigated whether manual therapy applied to tendon organs ameliorated neuromuscular dysfunction in rats with spasticity induced by upper motor neuron injury associated with spastic cerebral palsy, and analyzed the potential involvement of the C-fiber-mediated CaMKII signaling pathway.MethodsMale rats…
Sex as a biological variable in amblyopia: implications for developmental plasticity and treatment
Amblyopia is a common childhood visual disorder caused by abnormal visual experience that drives visual cortical plasticity during the sensitive period. The timing and forms of treatment with patching therapy and other therapeutic interventions have been extensively studied; however, sex…
Altered glymphatic function in nasopharyngeal carcinoma following radiotherapy: novel insights from choroid plexus volume and free-water fraction analyses
Background and purposeRadiotherapy (RT) often causes delayed radiation-induced brain injury (RBI) with unclear pathophysiology; emerging evidence links this to glymphatic dysfunction, but radiation effects on cerebrospinal fluid (CSF) dynamics and interstitial fluid-CSF exchange are unstudied. Thus, we used choroid plexus…
Analysis of risk factors for tic disorders in children in Hubei region based on liquid chromatography-tandem mass spectrometry
ObjectiveThis study aims to investigate the correlation between trace element concentrations, 25-hydroxyvitamin D [25(OH)D] levels, and the severity of tic disorders (TD) in children from the Hubei region. Additionally, it seeks to explore the interrelationships among these monitored indicators to…
Excessive Internet use and depressive symptom levels in adolescents with depressive disorders: chain mediation of social anxiety and sleep quality
BackgroundAdolescents with depressive disorders are at elevated risk for adverse mental health outcomes, and excessive Internet use has been increasingly linked to greater symptom severity. Therefore, this study aimed to examine the chain mediating roles of social anxiety and sleep…
Late-life difficult-to-treat depression and dementia subtypes: a naturalistic cohort study using electronic health records
IntroductionLate-life difficult-to-treat depression (LL-DTD) and dementia frequently coexist in later life, but it remains unclear whether clinical and sociodemographic characteristics, as well as medication exposure patterns, differ across dementia subtypes among older adults with both conditions.MethodsWe analysed anonymised electronic health…
Markers of neuroinflammation in the CSF of patients with difficult to treat psychiatric disease
IntroductionThe immune system is recognized as participating in the pathophysiology of psychiatric disease and there is renewed interest in identifying biomarkers of this immune activation. MethodsWe measured serum and cerebral spinal fluid (CSF) autoantibodies with other routine and novel markers…
When the market asks no price: AI chatbot interaction as psychic market disruption
The rapid adoption of AI chatbots for emotional support and quasi-therapeutic interaction raises questions that existing clinical and regulatory frameworks are not equipped to address. This Perspective applies the psychic arbitrage framework—which reconceptualizes defense mechanisms as energy-conversion operations on internal…
Distinct sleep-disordered breathing phenotypes in elderly patients with depressive disorder: links to hypoxemia severity and inflammatory burden
ObjectiveTo identify sleep-disordered breathing phenotypes in older adults with depressive disorder and obstructive sleep apnea-hypopnea syndrome (OSAHS) and to evaluate their associations with systemic inflammation.MethodsElderly patients with depressive disorder and OSAHS were consecutively enrolled from January to December 2025. A Gower…
Federal appeals court blocks mailing of abortion pill mifepristone
Mifepristone, involved in most abortions in the U.S., can now be distributed only in person and at clinics.
Opinion: What do medical students think about their education?
“No one's pulling the pieces together”: a conversation with medical students about preventive care education.
Opinion: STAT readers on MAHA activists, perimenopause, and diversity in medical school
“Unfortunately, the resources don't exist to take every flat-earther to the International Space Station to change their mind,” a STAT reader writes.
Adding weekly GLP-1 to cognitive behavioral therapy further reduces heavy drinking
Clinical trial suggests semaglutide may help patients with alcohol use disorder and obesity.
Musk v. Altman week 1: Elon Musk says he was duped, warns AI could kill us all, and admits that xAI distills OpenAI’s models
In the first week of the landmark trial between Elon Musk and OpenAI, Musk took the stand in a crisp black suit and tie and argued that OpenAI CEO Sam Altman and president Greg Brockman had deceived him into bankrolling…
Applicable Scenarios, Desired Features, and Risks of AI Psychotherapists in Depression Treatment From the Patient’s Perspective: Exploratory Qualitative Study
Background: Depression is a pervasive global mental health issue, yet access to trained professionals remains severely limited. With the rapid advancement of artificial intelligence (AI), digital tools are increasingly seen as a viable way to address this shortage. However, questions…
OTX-202 Smartphone App to Reduce Suicidal Ideation Among High-Risk Transition-Age Youth: Open-Label, Single-Arm, Phase 1 Clinical Trial
Background: The transition from adolescence to adulthood (18 to 25 years) is associated with an increased risk of suicidal ideation and behaviors. Suicide-focused cognitive behavioral therapies (CBTs) have been shown to significantly reduce suicidal ideation and behaviors but are not…