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Flu Virus Interaction with Host Cell Machinery Mapped Inside Infected Cells
Researchers developed a customized experimental workflow combining cross-linking mass spectrometry with AlphaFold-based structural modeling and functional assays to directly map protein-protein interactions in influenza-infected human cells. The post Flu Virus Interaction with Host Cell…
A 3-Tier AI Model for COVID-19 Triage Using Pharyngeal Images: Algorithm Development and Validation
Background: SARS-CoV-2 remains a common cause of acute respiratory illness; however, symptom-based triage poorly discriminates it from other febrile conditions. A recently developed artificial intelligence (AI)–powered pharyngeal camera acquires pharyngeal images and clinical data…
PM Burnham appoints Yvette Cooper as health secretary
New prime minister Andy Burnham has appointed Yvette Cooper as Secretary of State for Health and Social Care.
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Digging for clues about the North Pole’s past
In the past, even with an icebreaker and during peak melt season, getting to the North Pole wasn’t a sure bet. It took favorable winds to crack the frozen ocean surface, and ships had to fight through ice that had…
Opinion: The U.S. health care system is built around looking backward
A reconstruction layer has fallen on medicine. It asks: Was the original decision justified?
Opinion: What happens when a chief executive loses executive functions?
When a CEO develops acquired executive dysfunction yet remains in their role, the challenges are significant.
Cibisatamab and FAP-4-1BBL in microsatellite-stable colorectal cancer: a phase 1b trial
Nature Medicine, Published online: 20 April 2026; doi:10.1038/s41591-026-04380-zAs presented at the 2026 AACR Annual Meeting: in a phase 1b trial, patients with microsatellite-stable colorectal cancer received a FAP-4-1BB ligand together with the CEA-directed T cell engager cibisatamab; the treatment was…
Ciltacabtagene autoleucel in high-risk smoldering multiple myeloma: the CAR-PRISM phase 2 trial
Nature Medicine, Published online: 20 April 2026; doi:10.1038/s41591-026-04365-yAs presented at the 2026 AACR Annual Meeting, in a phase 2 trial, treatment of patients with high-risk smoldering multiple myeloma with BCMA-targeting CAR T cell therapy ciltacabtagene autoleucel was safe and led…
Microbiome signature of Parkinson’s disease in healthy and genetically at-risk individuals
Nature Medicine, Published online: 20 April 2026; doi:10.1038/s41591-026-04318-5Microbiome analysis suggests that gut microbial changes in Parkinson’s disease evolve progressively from healthy individuals to genetically at-risk individuals to clinically affected patients, with the degree of dysbiosis correlating with disease progression.
STAT+: At AACR, a provocative use of CAR-T, Merck’s new thing and cancer’s geography problem
At AACR, a bold use of CAR-T raises hopes and provocative questions about its use in smoldering multiple myeloma.
STAT+: Former banker brought on to revitalize Pfizer’s strategy departs his post
Andrew Baum, a former Citi analyst, has left his role as Pfizer's executive vice president and chief strategy and innovation officer.
Access to Technology-Mediated Community Mental Health Care Among Low-Socioeconomic Status Consumers With Serious Mental Illness: Qualitative Study
Background: Access to mental health care is critical for the effective management of serious mental illness (SMI), but consumers with low socioeconomic status (SES) have lower rates of service usage and worse retention in care. Digital technologies are often lauded…
Opportunities for Digital Health to Support Early Psychosis Care in Ghana: Qualitative Study Among Patients, Caregivers, and Clinicians
Background: Youth experiencing early psychosis in West Africa often face delays in accessing evidence-based treatment. Digital mental health interventions may offer an acceptable and scalable approach to improve access to early psychosis care in West Africa; however, few data exist…
Popular Online Content as a Treatment-as-Usual Control in Digital Mental Health Intervention Trials: Secondary Analysis of Two Online Randomized Controlled Trials With Repeated Measures
Background: Treatment-as-usual (TAU) conditions are intended to reflect the support typically received in routine treatment settings. For digital mental health interventions (DMHIs) delivered online, TAU conditions should reflect the usual patterns of online help-seeking. The lack of ecologically valid TAU…
STAT+: In early trial, CAR-T results raise hope of preventing multiple myeloma in high-risk patients
A CAR-T trial shows promise in preventing smoldering multiple myeloma from becoming the real thing.
STAT+: Trump order to advance psychedelic treatments generates excitement — and worries
President Trump’s executive order on was largely applauded by advocates. But some also quietly worried the White House’s role risks politicizing their field and undermining its credibility.
Opinion: The contradiction at the heart of Republicans’ embrace of psychedelics
“The research is clear about one thing: Recovery is not primarily a pharmacological event,” write Dimitri Mugianis and Ross Ellenhorn.
The Download: murderous ‘mirror’ bacteria, and Chinese workers fighting AI doubles
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. No one’s sure if synthetic mirror life will kill us all In February 2019, a group…
Short-term intrinsic connectivity changes induced by cognitive exertion in healthy participants
IntroductionChanges in brain intrinsic connectivity on the timescale of minutes, as provoked by a cognitive task, have not been well documented.MethodsA total of two 7.5-min 7 Tesla functional MRI (fMRI) scans (Run 1 and Run 2), separated by 90 s, were…
Altered static and dynamic regional homogeneity in basal ganglia–thalamocortical circuits and their association with neuropsychiatric manifestations in Wilson’s disease
PurposeWilson’s disease (WD) is an autosomal recessive disorder caused by ATP7B mutations, resulting in impaired copper metabolism and progressive neuropsychiatric manifestations. This study investigated spatiotemporal alterations in regional brain activity using static and dynamic resting-state fMRI with regional homogeneity (ReHo),…