News Feed
Most Accurate Non-Invasive Tests for Liver Disease Identified in Landmark Studies
Two major studies have identified the most accurate non-invasive tests for diagnosing and assessing the severity of metabolic dysfunction-associated steatotic liver disease (MASLD), potentially reducing the need for liver biopsies. The post Most Accurate…
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
News
3070 results
Astrocytic cholesterol jams brain clearance in AD
Nature Neuroscience, Published online: 05 May 2026; doi:10.1038/s41593-026-02310-3Zhang and colleagues identify astrocytic calcium–cholesterol–AQP4 signaling that drives glymphatic dysfunction in early Alzheimer’s disease (AD). Attenuating this signaling restored glymphatic flow, reduced amyloid burden and improved cognition in young 5xFAD mice only…
Molecular mechanism of calcium permeability and magnesium block in NMDA receptors
Nature Neuroscience, Published online: 05 May 2026; doi:10.1038/s41593-026-02283-3Using cryo-electron microscopy and electrophysiology, this study explains the structural basis for Ca2+ permeation and Mg2+ block in NMDA receptors and identifies a surrounding lipid network that may tune Mg2+-dependent voltage sensitivity.
What you need to know about hantavirus (don’t panic)
The latest on the abortion pill, paternal deaths, and more health news from Morning Rounds
STAT+: Cytokinetics drug Myqorzo meets twin efficacy goals in study of genetic heart disease
A Cytokinetics heart disease drug — already approved in one indication — succeeded in another Phase 3 trial, a potential boost for sales.
A blueprint for using AI to strengthen democracy
Every few centuries, changes in how information moves reshape how societies govern themselves. The printing press spread vernacular literacy, helping give rise to the Reformation and, eventually, representative government. The telegraph made it possible to administer vast nations like the…
Opinion: The ‘brain drain’ narrative about health professionals misses half of the story
52 health professionals returned home to 43 countries. Here are the unexpected challenges and opportunities they faced.
Opinion: The cruise ship hantavirus outbreak is a warning sign to the U.S.
Leaving the WHO means the U.S. lacks access to necessary information about infectious disease.
STAT+: Top lawmaker takes aim at doctor lobby, linking AMA’s billing codes to fraud fight
A top Republican is asking if the AMA's codes are helping to fuel health care fraud.
Neural Correlates of Suicidal Behavior in Youth
Conditions: Suicidal Ideation; Suicide Attempt; Suicidal Behavior; Depression / Major Depressive Disorder; Hopelessness; Neurobiological Interventions: Behavioral: CAMS Sponsors: The Cleveland Clinic; MQ Mental Health Research Not yet recruiting
The PREVENT Resilience Study
Conditions: Psychological Trauma Interventions: Device: Transcranial Magnetic Stimulation (TMS); Other: TMS Sham Sponsors: Emory University; National Institute of Mental Health (NIMH) Not yet recruiting
TUBSIS 2.0 – Tobacco Use Behavioral Support and Intervention System
Conditions: Tobacco Use Disorder; Nicotine Dependence; Vaping; Smoking Tobacco Interventions: Behavioral: TUBSIS 2.0 Sponsors: University of Zurich; State Secretariat for Education Research and Innovation, Switzerland Recruiting
The Effectiveness of 4-STEP-Training Program for Social Media Addiction (4-STEP-TPS) and Psychological Problems Among Adolescence
Conditions: 4-STEP-Training Program for Social Media Addiction Interventions: Behavioral: 4-STEP-Training Program for Social Media Addiction (4-STEP-TPS) Sponsors: Government College University Faisalabad Not yet recruiting
PrevED MR. Improving Emotion Dysregulation Through Mixed Reality Based Dialectical Behavioral Therapy in Adolescents and Young Adults at Risk of Developing Eating Disorders.
Conditions: Eating Disorders; Emotion Dysregulation Interventions: Behavioral: PrevED MR Intervention Sponsors: Universitat Internacional de Catalunya; Ministerio de Ciencia e Innovación, Spain Not yet recruiting
Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence
Conditions: Generalized Anxiety; Fear of Failure; Rumination Interventions: Behavioral: Imagery Rescripting Intervention Sponsors: University of Social Sciences and Humanities, Warsaw Recruiting
Two-week Intensive Outpatient Trauma Treatment.
Conditions: Posttraumatic Stress Disorder (PTSD) Interventions: Other: Prolonged exposure and EMDR Sponsors: Oslo University Hospital Recruiting
KALM-B: Ketamine-assisted Psychotherapy (KAP) to Lessen Morbidity After Burn Injury
Conditions: PTSD and Trauma-related Symptoms Interventions: Behavioral: Preparatory Session; Drug: Ketamine-assisted Psychotherapy Session #1; Drug: Ketamine-assisted Psychotherapy Session #2; Behavioral: Integration Session Sponsors: Irma Fleming; University of Utah Not yet recruiting
Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and Symptoms of Depression
Conditions: Depression; Anxiety Interventions: Drug: Psilocybin Sponsors: University of Washington Not yet recruiting
Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
Conditions: Treatment Resistant Depression (TRD) Interventions: Behavioral: Psychedelic Integration Coaching Sponsors: Massachusetts General Hospital; Fireside Project Recruiting
Group PACBT for Depression
Conditions: Depression - Major Depressive Disorder; Psilocybin; Cognitive Behavioral Therapy Interventions: Drug: Psilocybin (drug); Behavioral: Group Cognitive Behavioral Therapy Sponsors: University of California, Los Angeles Not yet recruiting
Study to Evaluate Efficacy and Safety of Roluperidone in Adult Subjects With Negative Symptoms and Stable Positive Symptoms of Schizophrenia and to Evaluate the Relapse Rate of Roluperidone and Antipsychotic Medications
Conditions: Negative Symptoms of Schizophrenia Interventions: Drug: Roluperidone; Drug: risperidone; Drug: aripiprazole; Drug: olanzapine; Drug: Placebo Sponsors: Minerva Neurosciences Recruiting
News Feed
Most Accurate Non-Invasive Tests for Liver Disease Identified in Landmark Studies
Two major studies have identified the most accurate non-invasive tests for diagnosing and assessing the severity of metabolic dysfunction-associated steatotic liver disease (MASLD), potentially reducing the need for liver biopsies. The post Most Accurate…
Brain Quality Control Selectively Eliminates Neurons with Abnormal Variants in Development
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism. The post…
News
3070 results
Astrocytic cholesterol jams brain clearance in AD
Nature Neuroscience, Published online: 05 May 2026; doi:10.1038/s41593-026-02310-3Zhang and colleagues identify astrocytic calcium–cholesterol–AQP4 signaling that drives glymphatic dysfunction in early Alzheimer’s disease (AD). Attenuating this signaling restored glymphatic flow, reduced amyloid burden and improved cognition in young 5xFAD mice only…
Molecular mechanism of calcium permeability and magnesium block in NMDA receptors
Nature Neuroscience, Published online: 05 May 2026; doi:10.1038/s41593-026-02283-3Using cryo-electron microscopy and electrophysiology, this study explains the structural basis for Ca2+ permeation and Mg2+ block in NMDA receptors and identifies a surrounding lipid network that may tune Mg2+-dependent voltage sensitivity.
What you need to know about hantavirus (don’t panic)
The latest on the abortion pill, paternal deaths, and more health news from Morning Rounds
STAT+: Cytokinetics drug Myqorzo meets twin efficacy goals in study of genetic heart disease
A Cytokinetics heart disease drug — already approved in one indication — succeeded in another Phase 3 trial, a potential boost for sales.
A blueprint for using AI to strengthen democracy
Every few centuries, changes in how information moves reshape how societies govern themselves. The printing press spread vernacular literacy, helping give rise to the Reformation and, eventually, representative government. The telegraph made it possible to administer vast nations like the…
Opinion: The ‘brain drain’ narrative about health professionals misses half of the story
52 health professionals returned home to 43 countries. Here are the unexpected challenges and opportunities they faced.
Opinion: The cruise ship hantavirus outbreak is a warning sign to the U.S.
Leaving the WHO means the U.S. lacks access to necessary information about infectious disease.
STAT+: Top lawmaker takes aim at doctor lobby, linking AMA’s billing codes to fraud fight
A top Republican is asking if the AMA's codes are helping to fuel health care fraud.
Neural Correlates of Suicidal Behavior in Youth
Conditions: Suicidal Ideation; Suicide Attempt; Suicidal Behavior; Depression / Major Depressive Disorder; Hopelessness; Neurobiological Interventions: Behavioral: CAMS Sponsors: The Cleveland Clinic; MQ Mental Health Research Not yet recruiting
The PREVENT Resilience Study
Conditions: Psychological Trauma Interventions: Device: Transcranial Magnetic Stimulation (TMS); Other: TMS Sham Sponsors: Emory University; National Institute of Mental Health (NIMH) Not yet recruiting
TUBSIS 2.0 – Tobacco Use Behavioral Support and Intervention System
Conditions: Tobacco Use Disorder; Nicotine Dependence; Vaping; Smoking Tobacco Interventions: Behavioral: TUBSIS 2.0 Sponsors: University of Zurich; State Secretariat for Education Research and Innovation, Switzerland Recruiting
The Effectiveness of 4-STEP-Training Program for Social Media Addiction (4-STEP-TPS) and Psychological Problems Among Adolescence
Conditions: 4-STEP-Training Program for Social Media Addiction Interventions: Behavioral: 4-STEP-Training Program for Social Media Addiction (4-STEP-TPS) Sponsors: Government College University Faisalabad Not yet recruiting
PrevED MR. Improving Emotion Dysregulation Through Mixed Reality Based Dialectical Behavioral Therapy in Adolescents and Young Adults at Risk of Developing Eating Disorders.
Conditions: Eating Disorders; Emotion Dysregulation Interventions: Behavioral: PrevED MR Intervention Sponsors: Universitat Internacional de Catalunya; Ministerio de Ciencia e Innovación, Spain Not yet recruiting
Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence
Conditions: Generalized Anxiety; Fear of Failure; Rumination Interventions: Behavioral: Imagery Rescripting Intervention Sponsors: University of Social Sciences and Humanities, Warsaw Recruiting
Two-week Intensive Outpatient Trauma Treatment.
Conditions: Posttraumatic Stress Disorder (PTSD) Interventions: Other: Prolonged exposure and EMDR Sponsors: Oslo University Hospital Recruiting
KALM-B: Ketamine-assisted Psychotherapy (KAP) to Lessen Morbidity After Burn Injury
Conditions: PTSD and Trauma-related Symptoms Interventions: Behavioral: Preparatory Session; Drug: Ketamine-assisted Psychotherapy Session #1; Drug: Ketamine-assisted Psychotherapy Session #2; Behavioral: Integration Session Sponsors: Irma Fleming; University of Utah Not yet recruiting
Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and Symptoms of Depression
Conditions: Depression; Anxiety Interventions: Drug: Psilocybin Sponsors: University of Washington Not yet recruiting
Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
Conditions: Treatment Resistant Depression (TRD) Interventions: Behavioral: Psychedelic Integration Coaching Sponsors: Massachusetts General Hospital; Fireside Project Recruiting
Group PACBT for Depression
Conditions: Depression - Major Depressive Disorder; Psilocybin; Cognitive Behavioral Therapy Interventions: Drug: Psilocybin (drug); Behavioral: Group Cognitive Behavioral Therapy Sponsors: University of California, Los Angeles Not yet recruiting
Study to Evaluate Efficacy and Safety of Roluperidone in Adult Subjects With Negative Symptoms and Stable Positive Symptoms of Schizophrenia and to Evaluate the Relapse Rate of Roluperidone and Antipsychotic Medications
Conditions: Negative Symptoms of Schizophrenia Interventions: Drug: Roluperidone; Drug: risperidone; Drug: aripiprazole; Drug: olanzapine; Drug: Placebo Sponsors: Minerva Neurosciences Recruiting