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Opinion: Beware the unintended consequences of testosterone screening for military servicemembers
“I fear that the widespread rollout of testosterone screening may lead to some surprising and unintended consequences,” writes a urologist who studies testosterone.
Organ Aging Linked to Breakdown in Immune Cell Interaction and Senescent Neutrophil Clearance
A study in mice and in human cells found that blocking a single receptor on tissue-resident macrophages promoted clearance of accumulating senescent neutrophils, preserved the youthfulness of multiple organs in mice, and substantially slowed…
Opinion: STAT readers on the value of primary care, obesity as a disease, and more
“The real opportunity is to move beyond policies and narratives that pit specialties against one another,” presidents of the AAFP, ACP, and AAP write.
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The quest to measure our relationship with nature
As a movement, environmentalism has been pretty misanthropic. Understandably so—we humans have done some destructive things to the ecosystems around us. In the 21st century, though, mainstream conservation is learning that humans can be a force for good. Foresters are…
The noise we make is hurting animals. Can we learn to shut up?
When the covid-19 pandemic started, Jennifer Phillips thought about the songs of the sparrows. They were easier to hear, because the world had suddenly become quieter. Car traffic plummeted as people sheltered at home and shifted to remote work. Air…
Opinion: STAT+: The medical AI revolution requires rethinking health care’s architecture
"Instead of organizing health data around institutions, we might organize it around individuals," write Meta's Freddy Abnousi and Stanford's Celina Yong.
Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECT
Conditions: Major Depressive Disorder; Bipolar Disorder; Schizophrenia Interventions: Device: Device: Arterial Tourniquet; Device: Device: Venous Tourniquet Sponsors: Medipol University Not yet recruiting
AI-Assisted 4-Week Psychodynamic Therapy and Cognitive Behavioral Therapy Via Smartphone for Social Anxiety: A Randomized Pilot Study (STePS-Ai)
Conditions: Social Anxiety Disorder (SAD) Interventions: Behavioral: Ai chatbot Sponsors: Stockholm University Active, not recruiting
An inducible base editing platform for cancer functional genomics in vivo
Nature Biotechnology, Published online: 15 April 2026; doi:10.1038/s41587-026-03079-3We developed a functional genomics platform using a small-molecule-controllable base editor that enables gene editing with reduced cellular toxicity and minimal transcriptional perturbation. The resulting high efficiency of the method potentiates in vivo…
Baseline Mismatch Negativity Amplitude Predicts Direction and Magnitude of Ketamine Effect in Healthy Volunteers — A “Disordinal” Effect
Mismatch negativity (MMN) is a component of the auditory event-related potential (ERP) that is elicited during a passive oddball paradigm where task-irrelevant infrequent deviants are presented in a stream of more frequent standard stimuli. MMN is believed to index a…
Can psychiatric genetics advance without incorporating a lifecourse perspective?
Psychiatric disorders unfold over the lifecourse, yet genomic studies of these conditions overwhelmingly rely on phenotypes collected at a single time point, often in adulthood. Genome-wide association studies (GWAS) of psychiatric conditions may therefore miss genetic variants with time-varied relevance…
[Comment] Youth mental health in central Asia: research needs
Little research has been published on mental health difficulties in young people (aged 10–24 years) living in central Asia,1 a region comprising Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. As researchers and representatives from academic, non-governmental, governmental, and UN organisations working…
[Comment] Magnetic seizure therapy: balancing efficacy and cognition
Few treatments in psychiatry match the antidepressant efficacy of convulsive therapy. Yet despite this therapeutic potency, persistent stigma and concerns about cognitive adverse effects—particularly autobiographical memory disturbance associated with electroconvulsive therapy, ECT—continue to limit its wider adoption.1 This tension is…
[Comment] Assessing adolescents’ use of artificial intelligence in psychiatric practice
In a recent clinical encounter with one of the authors (AP), a young boy with autism insisted that his mother hated him—because ChatGPT said so. After asking whether a parent who sets limits must dislike their child, he interpreted the…
Determinants of Digital Health Literacy Among Patients With Serious Mental Illness: Cross-Sectional Survey
Background: Individuals with serious mental illness increasingly use digital devices and the internet to access health information and services but often face challenges when navigating digital tools, which may limit the benefits they receive from online health resources and digital…
STAT+: CMS proposes rolling back breakthrough device payment flexibilities
CMS is proposing to repeal a pathway that allows breakthrough devices to get supplementary payments.
Motoneurons Inhibitory Synapses Homeostatically Respond to Neuronal Activity and Modulate Amyotrophic Lateral Sclerosis Pathogenesis
Alterations in excitation/inhibition (E/I) balance and changes in motor neurons (MN) activity may contribute to MN vulnerability in ALS. The balance of pathogenic versus adaptive changes occurring in inhibitory synapses and affecting E/I balance remain unclear. Confocal microscopy of MN…
Development of a Contextualized, Research-Based Flemish Assessment Framework for Digital Care, Assistance, and Support: Delphi Study
Background: The rapid evolution of digital technologies has transformed health, mental health, and social care, offering new modalities of digital care, assistance, and support through web-based platforms, mobile apps, extended reality, wearables, and artificial intelligence systems. Despite this proliferation, there…
STAT+: Novartis CEO joins Anthropic’s board
Revolution Medicines $2B fundraise, Structure's new hire hints at acquisition efforts, and more Readout biotech news
STAT+: FDA panel will meet to discuss allowing broader access to certain peptides
The FDA will convene an outside panel of advisers to discuss whether to allow compounding pharmacies to manufacture certain peptides
STAT+: A $15 AI test, Project Glasswing, and how Doctronic pilot blindsided Utah medical board
In this edition of STAT's AI Prognosis: A $15 AI test, what Project Glasswing means for health care, and an update on Doctronic's AI pilot in Utah.
STAT+: Pharmalittle: We’re reading about FDA seeking more data on a Lilly obesity pill, a pharma 340B win, and more
The FDA asked Eli Lilly for more data on liver injury linked to its newly approved obesity pill, Foundayo