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Opinion: Beware the unintended consequences of testosterone screening for military servicemembers
“I fear that the widespread rollout of testosterone screening may lead to some surprising and unintended consequences,” writes a urologist who studies testosterone.
Organ Aging Linked to Breakdown in Immune Cell Interaction and Senescent Neutrophil Clearance
A study in mice and in human cells found that blocking a single receptor on tissue-resident macrophages promoted clearance of accumulating senescent neutrophils, preserved the youthfulness of multiple organs in mice, and substantially slowed…
Opinion: STAT readers on the value of primary care, obesity as a disease, and more
“The real opportunity is to move beyond policies and narratives that pit specialties against one another,” presidents of the AAFP, ACP, and AAP write.
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Cyberscammers are bypassing banks’ security with illicit tools sold on Telegram
From inside a money-laundering center in Cambodia, an employee opens a popular Vietnamese banking app on his phone. The app asks him to upload a photo associated with the account, so he clicks on a picture of a 30-something Asian…
Call for expert – Research & report on deinstitutionalisation and psychosocial disabilities in Europe
Seeking an expert to support the development of a study on deinstitutionalisation (DI) and psychosocial disabilities in Europe, exploring how mental health systems and disability-inclusive policies can be better aligned at the EU level. The post Call for expert –…
STAT+: New Bain biotech startup, building on BMS drugs, gets a name and a CEO
Beeline Medicine is focused on development of five inflammatory and immune disorder drugs, starting with a potential daily pill for lupus.
No one’s sure if synthetic mirror life will kill us all
For four days in February 2019, some 30 synthetic biologists and ethicists hunkered down at a conference center in Northern Virginia to brainstorm high-risk, cutting-edge, irresistibly exciting ideas that the National Science Foundation should fund. By the end of the…
STAT+: Flawed study on the antidepressant Paxil came with a cautionary note — if you knew how to find it
When scientific journals publish expressions of concerns, they have an obligation to do so prominently, Ed Silverman writes.
Opinion: Hosting the ‘intellectual wrestling match’ between MAHA, public health
“These sides aren't talking to each other. And there's a lot riding on it”: the podcast trying to bridge MAHA and public health.
STAT+: AI could check millions of CT scans for heart risk. Who will pay for it?
New AI tools could screen existing CT scans to asses risk for heart disease. But, who'll pay for it, and will it improve health outcomes?
Building trust in the AI era with privacy-led UX
The practice of privacy-led user experience (UX) is a design philosophy that treats transparency around data collection and usage as an integral part of the customer relationship. An undertapped opportunity in digital marketing, privacy-led UX treats user consent not as…
Five Digits Test – Validation of a Neuropsychological Test of Inhibition for Patients With Neuropsychiatric Conditions
Conditions: Autism; ADHD Interventions: Diagnostic Test: Five Digits Test Sponsors: Umeå University; Region Västerbotten Recruiting
Analysis of Influencing Factors for the Development of PTSD in Emergency Department Trauma Patients
Conditions: Trauma Patients; PTSD Sponsors: The First Affiliated Hospital of Air Force Medicial University Not yet recruiting
Effectiveness of Behavioral Activation Group Therapy for Patients With Depression at the Community in Thanh Hoa
Conditions: Depression - Major Depressive Disorder Interventions: Behavioral: Behaviral activation group therapy Sponsors: Hanoi Medical University Completed
Symptoms of Anxiety and/or Depression and SDM in Older Patients With CLTI
Conditions: Critical Limb Threatening Ischaemia; Depression Disorder; Anxiety Sponsors: Guy's and St Thomas' NHS Foundation Trust; University Hospitals, Leicester Not yet recruiting
Efficacy and Safety of a Theta Burst Stimulation Protocol of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression
Conditions: Major Depressive Disorder (MDD); Depression - Major Depressive Disorder Interventions: Drug: antidepressant therapy; Device: Active rTMS Theta Burst Stimulation; Device: Sham Stimulation Sponsors: Jung-Sun Lee; Korea Health Industry Development Institute; Seoul National University Hospital; Nowon Eulji Medical Center, Eulji…
Early Brainwave Biomarkers for Personalized Neuromodulation in Treatment-resistant Depression
Conditions: Major Depressive Disorder; Treatment Resistant Depression Interventions: Device: Personalized iTBS; Device: Non-Personalized iTBS; Device: Sham iTBS Sponsors: Stanford University; National Institute of Mental Health (NIMH) Not yet recruiting
User Experience and Early Clinical Outcomes of a Mental Wellness Chatbot for Depression and Anxiety: Pilot Evaluation Mixed Methods Study
Background: Artificial intelligence–powered conversational agents (ie, chatbots) are increasingly popular outlets for users seeking psychological support, yet little is known about how users experience early-stage prototypes or which therapeutic processes contribute to clinical improvement. A transparent evaluation of emerging chatbot…
Development of Virtual Mental Health Stepped Care Service for a Heart Failure Remote Management Program: Qualitative Descriptive Study
Background: Depression is highly prevalent yet undertreated among people living with heart failure, indicating barriers to mental health services. Although various digital mental health interventions have been developed to detect, treat, and manage depression in this population, these interventions have…
Redefining the future of software engineering
Software engineering has experienced two seismic shifts this century. First was the rise of the open source movement, which gradually made code accessible to developers and engineers everywhere. Second, the adoption of development operations (DevOps) and agile methodologies took software…
STAT+: Congress returns to a packed health care agenda
The key health care issues we're watching as Congress returns from recess.
Mitochondrial dysfunction, neuroinflammation, and associated mechanisms in sepsis-associated encephalopathy: from pathogenesis to emerging therapeutics
Sepsis-associated encephalopathy (SAE) is a devastating neurological complication of sepsis, leading to diffuse brain dysfunction, long-term cognitive deficits, and increased mortality. Its pathogenesis is complex, with mitochondrial dysfunction and neuroinflammation emerging as central, interconnected drivers. This review systematically elucidates the…