Lumateperone for Late-Life Depression

Conditions: Treatment Resistant Depression (TRD); Late Life Depression (LLD); Depression / Major Depressive Disorder

Interventions: Drug: Lumateperone; Drug: Placebo

Sponsors: Eric Lenze; Intra-Cellular Therapies, Inc.

Not yet recruiting

NeuroFinance Human Stress Trial During Financial and Informational Volatility

Conditions: Psychological Stress; Anxiety; Emotional Stress; Autonomic Nervous System Dysfunction; Sleep Disturbance; Insomnia; Behavioral Health; Cognitive Fatigue; Occupational Stress; Financial Stress; Burnout Syndrome; Heart Rate Variability; Neurobehavioral Manifestations

Interventions: Device: Wearable Physiologic Monitoring Platform

Sponsors: Truway Health, Inc.

Not yet recruiting

Effectiveness of a culturally adapted psychoeducational intervention for family caregivers of children with hematologic malignancy: a randomized controlled trial

ObjectiveThis study aimed to develop and evaluate a culturally adapted psychoeducational intervention to address the severe psychological distress and caregiving burden commonly experienced by caregivers of newly diagnosed pediatric hematologic malignancy patients during the early stages of illness.MethodsAmong 116 randomized caregivers, 90 completed all three assessments and were included in the complete-case analysis. The intervention group received a 4-week psychoeducation program delivered by medical social workers, whereas the control group received routine care. Outcomes were assessed at baseline, post-intervention, and 48-day follow-up.ResultsCompared with controls, caregivers in the intervention group showed greater reductions in depressive and post-traumatic stress symptoms after the intervention, and these reductions were maintained at follow-up. Caregiver burden showed a delayed reduction, with between-group differences becoming apparent at follow-up. Anxiety levels decreased over time in both groups, but the group × time interaction was not statistically significant.ConclusionThe culturally adapted psychoeducational intervention was associated with reductions in depressive and post-traumatic stress symptoms and a delayed reduction in caregiver burden, but did not show an additional effect on anxiety beyond routine care. These findings provide preliminary support for structured, culturally responsive psychoeducational support in pediatric hematology settings.