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STAT+: Another big deal, another sign biotech M&A is back

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Good morning! Pharma companies are on a biotech buying spree, an LSD pill just delivered unusually strong late-stage depression data, and the FDA reverses course of Regenxbio’s treatment.

Also: Today, thousands of industry players (and me!) are gathering in San Diego for BIO to talk deals, science, and whatever comes next. Check out the last item for a jaunt down memory lane about the conference.

Continue to STAT+ to read the full story…

The Download: record-breaking subsea tunnels and flexible data centers

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Inside the world’s deepest and longest subsea road tunnel

—Niall Firth

I’m currently around 1,000 feet beneath the North Sea, in a dark, dank cave. It smells weird. And I’m increasingly aware of the pressure from millions of tons of seawater just above my head.

I’m under the iconic fjords of Norway to visit what will soon become the world’s longest and deepest subsea road tunnel—an exceptional engineering feat that will carry drivers deep beneath the North Sea.

I’m here to understand how you make a 16.6-mile highway that sits 1,280 feet below the sea at its deepest point. And also—at a time when it can feel hard to get anything done—to reassure myself that ambitious engineering is still possible. That we can still make things. 

Step inside Norway’s Rogfast tunnel and see how engineers are making it happen.

This story is from the next edition of our magazine, which is all about engineering. Subscribe now to get a copy when it lands on Wednesday!

Want to get a data center online quickly? Give it some flex.

The AI boom is putting unprecedented pressure on the electric grid. But rather than rushing to build new power plants, companies could find part of the solution right under our noses—or, more precisely, in the transmission lines under our feet and above our heads.

If data centers can limit the power they draw during high-demand stretches, they won’t need to wait for big infrastructure upgrades or build their own off-grid generation.

The idea of flexibility isn’t entirely foreign to grid operators. But a new generation of software could make the process faster, smarter, and more precise for the AI era.

Find out how the challenge of powering AI could lead to a smarter, more flexible grid.

—Amos Zeeberg

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 SK Hynix has overtaken Samsung as South Korea’s most valuable company
It’s also now the world’s most valuable memory chipmaker. (Reuters $)
+  And one of the biggest beneficiaries of the global AI boom. (BBC)
+ AI’s need for memory chips is set to skyrocket device prices. (WSJ $)

2 Trump says he no longer views Anthropic as a national security threat
“Well, not now, but a week ago, maybe,” he told The Axios Show. (Axios)
+ He praised the response of Anthropic CEO Dario Amodei. (Reuters $)
+ Anthropic’s IPO outcome could depend on the midterms. (WSJ $)
+ A culture war tactic against Anthropic has backfired. (MIT Technology Review)

3 SpaceX has received the lowest possible ESG rating
Index provider MSCI gave the company a triple C. (Financial Times $)
+ Russia got the same score after invading Ukraine. (Business Times)
+ Elon Musk previously called ESG metrics the “Devil Incarnate.” (CNBC)

4 A Tesla on Autopilot allegedly crashed into a Texas home and killed a woman
The driver said his Tesla Model 3 was in self-driving mode. (NYT $)
+ Tesla’s AI trainers don’t trust its self-driving tech. (Reuters $)

5 Polymarket reportedly paid creators to post fake betting videos
Clips showed them winning big on bets they would have really lost. (WSJ $)
+ Polymarket bets on an Iran deal are fueling insider-trading fears. (Bloomberg $)

6 Physicists have proposed that black holes don’t exist
They may be something much stranger: “gravastars.” (404 Media)
+ This is the first ever photo of a black hole. (MIT Technology Review)

7 A daring space rescue mission is set to launch this week
A spacecraft will try to lift an observatory into a safer orbit. (Space)
+ We’re putting more stuff into space than ever. (MIT Technology Review)

8 Nothing’s next budget phone has been cancelled due to “RAMageddon”
The company said memory prices pushed costs too high. (The Verge $)
+ Buying a used phone makes more sense than ever. (Wired $)

9 A viral doomsday scenario aims to pierce Europe’s AI complacency
It envisions the US and China tearing Europe into pieces. (Guardian)

10 Scientists have invented a way to brew espresso with ultrasonic waves
No hot water required. (Wired $)

Quote of the day

“Even before we start reaping the benefits of AI in our devices, we are already paying the bill.” 

—Francisco Jeronimo, an analyst at IDC, tells CNBC that consumers are covering the costs of the ongoing memory shortage.

One More Thing

Bill Kirwa drives for Wasili, an Uber-style ridesharing company

BRIAN OTIENO


How mobile money supercharged Kenya’s sports betting addiction

As the lorry he’d flagged down lurched through Kenya’s western highlands, Bill Kirwa’s Infinix smartphone dinged with a notification. The bet of 3,500 shillings he’d placed with mobile money—then worth approximately $35—had just turned into nearly $8,500.

Kirwa, now 26, put the windfall to good use, purchasing a car that enabled him to drive for Wasili, an Uber-style ride-hailing service. But he continued gambling, and over time, his losses mounted. In just a few years, he’s effectively erased his big win.  

Kirwa’s experience is hardly unique. Across Africa, the rapid spread of smartphones and mobile money has fueled an explosion in online gambling. But nowhere is the craze as acute as it is in Kenya. Find out why.

—Jonathan W. Rosen

We can still have nice things

A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.)

+ A clever Bengal cat has seemingly learned to understand English—and talk back.
+ This list of the 100 greatest bird names lovingly captures the quirks of avian taxonomy.
+ Darth Vader’s weird chestplate transforms into a cassette player in these reworked Star Wars clips.
+ Trace the history and evolution of heavy metal music through the interactive genres and playlists of Map of Metal.

Bridging the gap from mechanism to clinic: a translational perspective on taVNS for gastrointestinal disorders

In recent years, multiple clinical and translational studies have investigated the application and mechanisms of transcutaneous auricular vagus nerve stimulation (taVNS) in gastrointestinal disorders (GIDs), with consideration given to pathophysiology, stimulation parameters, and patient-specific factors. In this review, we systematically synthesize recent evidence from clinical trials and preclinical models published in leading gastroenterology and neurology journals. Our focus is on taVNS-mediated modulation of the brain–gut axis, particularly its role in improving autonomic balance, reducing visceral sensitivity, and attenuating inflammatory responses, with the aim of enhancing therapeutic outcomes in functional and inflammatory GIDs. There is a need to optimize stimulation protocols through mechanistic insights and to promote the use of this non-invasive, well-tolerated neuromodulation approach. These advances are essential for expanding taVNS accessibility in clinical practice, especially for patients with refractory symptoms, comorbid psychological conditions, and in settings where conventional treatments are limited or contraindicated. Personalized taVNS strategies and biomarker-guided dosing represent emerging trends in neuromodulation therapy. However, standardized protocols and predictive models have yet to be established for widespread clinical implementation.

Paradoxical reflex bradycardia in paroxysmal sympathetic hyperactivity following traumatic brain injury: a case report

BackgroundParoxysmal sympathetic hyperactivity (PSH) is a devastating complication of traumatic brain injury (TBI), characterized by the simultaneous onset of various manifestations due to sympathetic overactivity. Paradoxical bradycardia, an uncommon manifestation of PSH, is poorly characterized, and there is limited evidence regarding its clinical features, pathophysiological mechanisms and targeted management.Case presentationA 25-years-old male sustained severe traumatic brain injury in a nighttime motorcycle collision with a parked vehicle and underwent multiple neurosurgical procedures. He developed typical PSH on day 48 post injury, with a Paroxysmal Sympathetic Hyperactivity Assessment Measure (PSH-AM) score of 27. On the 92nd day post-injury, the patient developed persistent resting bradycardia (40–66 beats/min) after cranioplasty, while a reduced maximum heart rate (140–159 beats/min) was noted during PSH episodes. He subsequently experienced an acute PSH episode with severe bradycardia (38–43 beats/min, PSH-AM score of 20). After excluding common predisposing factors, intravenous isoproterenol (initial dose 4 μg/min, titrated to 2 μg/min) was administered in combination with anti-PSH medication regimen, and the patient’s clinical symptoms were relieved. The patient was discharged in a stable condition and had no further episodes of bradycardia at the 3-months follow-up.ConclusionParadoxical bradycardia represents an atypical clinical phenotype of post-TBI PSH, likely mediated by an atypical Cushing reflex secondary to fluctuating intracranial pressure elevations during PSH exacerbations. Clinically, for TBI patients with unexplained bradycardia, potential primary causes should be actively explored, with particular attention to monitoring dynamic changes in intracranial pressure.

Enhancing adult neurogenesis attenuates hippocampal-related behavioral deficits in an Alzheimer’s mouse model

Alzheimer’s disease (AD) is the most prevalent form of dementia, characterized by progressive memory loss, cognitive decline, and emotional dysregulation. Adult hippocampal neurogenesis (AHN) critically contributes to cognition and mood but undergoes precipitous decline during AD progression. Here, we investigated whether enhancing AHN through genetic expansion of endogenous neural stem cells (NSC) ameliorates AD-related phenotypes. Using lentiviral overexpression of the cell cycle regulators Cdk4 and CyclinD1 in the dentate gyrus of 3xTg-AD mice, we show that enhancing AHN is accompanied by partial improvements in selected behavioral measures associated with hippocampal function, including in the open-field test and Morris water maze. These findings indicate that the AD-compromised neurogenic niche remains responsive to NSC-targeted stimulation and support the use of AHN as a potential additional avenue for multi-modal therapeutic strategies for AD.

Physical factor therapies for insomnia: a narrative review of mechanisms, clinical evidence, and phenotype-guided applications

Although pharmacological treatments for insomnia remain widely prescribed, their long-term use is constrained by risks of tolerance, dependence, and residual daytime effects. This has prompted growing interest in non-pharmacological interventions that target insomnia’s underlying mechanisms. This narrative review examines five physical factor therapies for insomnia: auditory stimulation, phototherapy, thermotherapy, electrical stimulation, and magnetic stimulation. They are classified according to their primary sites of action into peripheral sensory modulation, central neuromodulation, or systemic autonomic regulation. In each context, research findings about circadian entrainment, thermoregulatory promotion of falling asleep, attenuation of cortical hyperarousal, and restoration of autonomic balance are discussed. Clinical evidence from randomized controlled trials and meta-analyses is critically appraised, with emphasis on therapeutic efficacy, safety, and limitations. Overall, physical factor therapies may constitute promising adjunctive options for selected insomnia phenotypes, but current evidence remains heterogeneous and preliminary for several modalities. Recent advances in portable and home-based technologies support their feasibility, although long-term effectiveness, adherence, and cost-effectiveness remain to be established. Future research should prioritize larger sham-controlled trials, objective sleep and circadian outcomes, standardized protocols, biomarker-guided stratification, and closed-loop intervention systems.

Psychological distress and caregiver burden among informal caregivers of patients with earthquake-related and stroke-related dependency: a comparative study

ObjectiveThis study aimed to compare the psychological burden of informal caregivers of patients with earthquake-related dependency and those caring for patients with stroke-related dependency following the 6 February 2023 Türkiye–Syria earthquakes.MethodsA total of 90 informal caregivers of dependent patients were included in this comparative study: 60 caregivers of stroke patients and 30 caregivers of patients with earthquake-related dependency. Participants were assessed using the Beck Depression Inventory, Beck Anxiety Inventory, Beck Hopelessness Scale, Caregiver Burden Scale, and the PTSD Checklist for DSM-5 (PCL-5).ResultsCaregiver burden was significantly higher among male caregivers (p=0.026). Caregivers of patients with earthquake-related dependency more frequently reported receiving external support than caregivers of stroke patients (p=0.004). Overall, caregiving was perceived as a moderate burden in both groups. The distributions of depressive symptoms, anxiety symptoms, and hopelessness levels did not differ significantly between the groups (p=0.172, p=0.172, and p=0.834, respectively). Among caregivers of stroke patients, PTSD symptoms and caregiver burden showed moderate positive correlations with depression, anxiety, and hopelessness (all p<0.05). In caregivers of patients with earthquake-related dependency, caregiver burden was associated only with hopelessness (p=0.045).ConclusionInformal caregivers of patients with earthquake-related and stroke-related dependency experienced comparable levels of psychological distress, despite differences in caregiving context and disaster-related adversity. The higher frequency of external support among caregivers of patients with earthquake-related dependency may be associated with this pattern, suggesting that family and social support may be relevant to caregiver psychological outcomes in post-disaster settings.