Is AI actually improving healthcare?
Nature Medicine, Published online: 21 April 2026; doi:10.1038/s41591-026-04329-2
Is AI actually improving healthcare?
The Q-MONSTAR consortium: advancing fault-tolerant quantum computing for precision oncology
Nature Medicine, Published online: 21 April 2026; doi:10.1038/s41591-026-04346-1
The Q-MONSTAR consortium: advancing fault-tolerant quantum computing for precision oncology
Exposure to negative physical and social factors accelerates brain aging
Nature Medicine, Published online: 21 April 2026; doi:10.1038/s41591-026-04348-z
In a study that included 18,701 people from 34 countries, 73 aggregated physical and social exposomes exhibited nonlinear, synergistic effects that accelerated brain aging. In some cases, these effects were comparable to or stronger than those of mild cognitive impairment and dementia. Environmental inequities might shape brain aging and demand multisectoral and structural policy responses.
Show us the evidence for the value of medical AI
Nature Medicine, Published online: 21 April 2026; doi:10.1038/s41591-026-04389-4
Claims that medical AI is improving care must be backed by appropriate evidence.
Modifying exposure to plastic-associated chemicals in daily living
Nature Medicine, Published online: 21 April 2026; doi:10.1038/s41591-026-04349-y
A study shows that extensively limiting plastic use in food systems, diet and daily life can reduce exposure to plastic-associated chemicals such as phthalates and bisphenols, indicating that large-scale regulatory actions are needed for true public health impact.
Biophysical modeling of excitation/inhibition balance and conversion to psychosis in the clinical high risk syndrome
Reduced mismatch negativity (MMN) and P300 event-related potential (ERP) components are widely replicated in schizophrenia and are also observed in individuals at clinical high risk for psychosis (CHR-P) who subsequently convert to psychosis. It is unknown whether they reflect changes in excitatory and/or inhibitory synaptic function, both implicated in schizophrenia and considered potential drug targets.
Genomic approaches for understanding the evolution of the human brain
Nature Neuroscience, Published online: 21 April 2026; doi:10.1038/s41593-026-02277-1
This Review describes how an approach that starts from genetic changes under selection during human evolution and integrates comparative and functional studies can reveal adaptive phenotypes across different evolutionary timescales.
Constituent-constrained word prediction during language comprehension
Nature Neuroscience, Published online: 21 April 2026; doi:10.1038/s41593-026-02272-6
Zou et al. reveal a key difference between human brains and large language models (LLMs). While LLMs are optimized to predict the next word, the human brain modulates prediction efficiency by strategically grouping words into phrases.
AACR 2026: A Video Update from San Diego
The American Association for Cancer Research (AACR) meeting is off and running in San Diego. Julianna LeMieux, PhD, Deputy Editor in Chief at GEN, and Damian Doherty, Editor in Chief at Inside Precision Medicine, are on the ground—in the talks, expo hall, and press room, covering as much of the news as they can. Here, they take a moment to chat about the first few days at the meeting.
The post AACR 2026: A Video Update from San Diego appeared first on GEN – Genetic Engineering and Biotechnology News.

