Nature Medicine, Published online: 21 April 2026; doi:10.1038/s41591-026-04346-1
The Q-MONSTAR consortium: advancing fault-tolerant quantum computing for precision oncology
Exposure to negative physical and social factors accelerates brain aging
Nature Medicine, Published online: 21 April 2026; doi:10.1038/s41591-026-04348-z
In a study that included 18,701 people from 34 countries, 73 aggregated physical and social exposomes exhibited nonlinear, synergistic effects that accelerated brain aging. In some cases, these effects were comparable to or stronger than those of mild cognitive impairment and dementia. Environmental inequities might shape brain aging and demand multisectoral and structural policy responses.
Show us the evidence for the value of medical AI
Nature Medicine, Published online: 21 April 2026; doi:10.1038/s41591-026-04389-4
Claims that medical AI is improving care must be backed by appropriate evidence.
Modifying exposure to plastic-associated chemicals in daily living
Nature Medicine, Published online: 21 April 2026; doi:10.1038/s41591-026-04349-y
A study shows that extensively limiting plastic use in food systems, diet and daily life can reduce exposure to plastic-associated chemicals such as phthalates and bisphenols, indicating that large-scale regulatory actions are needed for true public health impact.
Biophysical modeling of excitation/inhibition balance and conversion to psychosis in the clinical high risk syndrome
Reduced mismatch negativity (MMN) and P300 event-related potential (ERP) components are widely replicated in schizophrenia and are also observed in individuals at clinical high risk for psychosis (CHR-P) who subsequently convert to psychosis. It is unknown whether they reflect changes in excitatory and/or inhibitory synaptic function, both implicated in schizophrenia and considered potential drug targets.
Genomic approaches for understanding the evolution of the human brain
Nature Neuroscience, Published online: 21 April 2026; doi:10.1038/s41593-026-02277-1
This Review describes how an approach that starts from genetic changes under selection during human evolution and integrates comparative and functional studies can reveal adaptive phenotypes across different evolutionary timescales.
Constituent-constrained word prediction during language comprehension
Nature Neuroscience, Published online: 21 April 2026; doi:10.1038/s41593-026-02272-6
Zou et al. reveal a key difference between human brains and large language models (LLMs). While LLMs are optimized to predict the next word, the human brain modulates prediction efficiency by strategically grouping words into phrases.
AACR 2026: A Video Update from San Diego
The American Association for Cancer Research (AACR) meeting is off and running in San Diego. Julianna LeMieux, PhD, Deputy Editor in Chief at GEN, and Damian Doherty, Editor in Chief at Inside Precision Medicine, are on the ground—in the talks, expo hall, and press room, covering as much of the news as they can. Here, they take a moment to chat about the first few days at the meeting.
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Regulatory tips from a breakthrough noninvasive device startup
Compremium’s noninvasive Quantis CVP (central venous pressure) measurement device joined the FDA’s Total Product Life Cycle Advisory Program (TAP) after earning Breakthrough Device designation in January 2026. The FDA designed TAP to “help spur more rapid development of high-quality, safe, effective, and innovative medical devices that are critical to public health” and expedite patient access…
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Henry Schein discloses exec pay for longtime CEO Stan Bergman’s final year
Henry Schein reported pay increases for three of its five executives in 2025, while median employee pay increased from the year before. The Melville, New York-based medical product supplier is the 11th-largest medical device company in the world, according to Medical Design & Outsourcing’s 2025 Medtech Big 100 ranking by revenue. Since then, Henry Schein increased…
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