Radically different
At Paragon 28, now part of Zimmer Biomet, engineers asked if there was a better implant shape to support foot and ankle anatomy. It took three novel instruments and a novel implant to make it a reality. When Paragon 28 Director of Engineering Ken Roggow and his team approached the drawing board to design a…
The post How ZB’s Paragon 28 created a novel curved foot nail system appeared first on Medical Design and Outsourcing.
A new startup has found that the Chinese biotech industry is good for more than obesity drugs and cancer therapies.
The company, Tortugas Neuroscience, launched Tuesday with plans to develop two schizophrenia and tinnitus drugs licensed from Chinese drugmaker Jiangsu Hansoh Pharmaceutical Group. The startup will also test two other medicines for focal epilepsy and encephalopathies that were originally created by Japanese pharmaceutical company Eisai Co. Ltd.
Tortugas has $106 million from Cure Ventures, The Column Group, and AN Ventures to begin testing the drugs in mid-stage trials in the U.S.
BioAge Labs said Tuesday that its investigational pill for cardiovascular risk prevention significantly reduced inflammation in an early study, as more drug companies target inflammation as a way to treat a range of chronic conditions.
In a Phase 1 study of people with obesity and elevated inflammation levels, patients taking a 60-milligram dose of the drug, called BGE-102, experienced an 86% reduction in a measure of inflammation called high-sensitivity C-reactive protein (hs-CRP) after three weeks. That’s a similar level of reduction seen in patients who took a higher 120-mg dose in the study, which the company previously reported.
Additionally, 87% of patients taking the 60-mg dose achieved hs-CRP levels of less than 2 mg/liter, the threshold thought to be associated with a lower risk of cardiovascular complications.
In the past, even with an icebreaker and during peak melt season, getting to the North Pole wasn’t a sure bet. It took favorable winds to crack the frozen ocean surface, and ships had to fight through ice that had grown many meters thick over several winters. In the summer of 2025, though, Jochen Knies from the Arctic University of Norway, Tromsø, and his team met little resistance on their way to 90 degrees North with the research vessel Kronprins Haakon. The geologist “didn’t hear the usual grinding of ice” against the hull that he remembered from 1996, when he first reached the pole by ship. Instead, thin floes and large stretches of open water made for an easy, quiet passage. To him, it was “a reminder of how quickly the Arctic is changing.”
Since the late 1970s, when satellite observations of the polar seas began, summer ice cover of the Arctic Ocean has declined by more than 40%. In less than half a century, a frozen area the size of the Mediterranean Sea has turned into blue open water with the rapid warming of the high northern latitudes. If this trend continues, there could soon be summers at the North Pole with no sea ice whatsoever. The last time this happened may have been some 120,000 years ago. But no one knows for certain.
That’s why Knies and his colleagues, a team of researchers from Norway and Germany, set out from Svalbard to the central Arctic last August. The aim of their five-week mission was to determine whether this region had been ice-free in recent Earth history—and if so, when. As part of a €12.5 million project financed by the European Union, they also came to answer some questions about the future of the Arctic and beyond: How does the loss of sea ice affect the marine ecosystem? What are the consequences for ocean circulation and global climate?
In search of clues, the expedition collected sediment cores up to 22 meters in length at different locations across the Arctic seafloor. Marine sediments are valuable climate archives that give scientists a window into bygone eras. Like diligent record keepers, they can log past water temperatures, sea-ice coverage, and the strength of ocean currents. These data are encrypted in the chemical and physical properties of the plankton remains and weathered rock deposited on the seabed.
While sediment cores several meters long had been recovered on earlier expeditions in the central Arctic, there is no scientific consensus on how old the deposits actually are or whether sea ice ever completely disappeared in summer.
To decode the Arctic’s climate archive, Knies brought a team of experts from various disciplines onboard the Kronprins Haakon to dig deeper and obtain fresh samples they could subject to the latest analytical techniques.
Some of this work was done while the researchers were still at sea. Now, at their home laboratories, they are finalizing their analysis of the seafloor samples. One important task is dating the sediments, which may be up to 2 million years old. The team uses a combination of methods to do this, including measuring magnetization, the decay of radioactive elements, and the exposure of mineral grains to sunlight before sinking to the depths. Once they can place them on a timeline, the materials in the cores will help researchers paint a picture of what the Arctic Ocean looked like in times that were warmer than today. For example, the presence or absence of the molecule IP25, which is produced exclusively by ice algae, could tell them how far the sea ice receded at a given time.
At the end of the study, the team hopes to have data that could improve climate projections for a future ice-free “blue Arctic,” helping us understand how it could affect marine life and carbon storage, Atlantic Ocean circulation, or extreme weather events in Europe and North America.
Tim Kalvelage is a freelance science reporter based in Bremen, Germany, who focuses on climate, ocean, and polar research. He has been to the North Pole twice.
In outpatient medicine, decisions move quickly.
A prescription is sent to a pharmacy. A referral goes out to a specialist. A test is ordered. From the patient’s perspective, the process feels immediate. Care begins moving forward as soon as the visit ends.
Circa 1970, the renowned Russian neuropsychologist Alexander Luria together with Karl Pribram from Stanford University and other neuroscientists of that era introduced the term “executive functions” into the scientific lexicon to denote complex behaviors such as attention and awareness. They identified the frontal lobe — the front of the brain — as the “executive of the brain” responsible for these behaviors based on their experiments with primates and patients with specific brain injuries.
Over time, the concept evolved to include mental processes needed to focus, concentrate, and pay attention when challenged by multiple simultaneous sources of information to weigh options and make informed decisions as opposed to impulsive ones.