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<![CDATA[Why settle for “less bad”? Clinicians urge aggressive depression care aimed at true remission, balancing side effects and patient priorities.]]>
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<![CDATA[Explore today’s narcolepsy care: wake-promoting meds, oxybates for cataplexy, and pitolisant’s histamine boost—plus sleep habits that matter.]]>
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<![CDATA[Experts share how roluperidone provides a new opportunity in the schizophrenia treatment landscape.]]>
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The Download: water threats in Iran and AI’s impact on what entrepreneurs make

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Desalination plants in the Middle East are increasingly vulnerable 

As the conflict in Iran has escalated, a crucial resource is under fire: the desalinization technology that supplies water in the region. 
 
President Donald Trump has threatened to destroy “possibly all desalinization plants” in Iran if the Strait of Hormuz is not reopened. The impact on farming, industry, and—crucially—drinking in the Middle East could be severe. Find out why. 

—Casey Crownhart 

This story is part of MIT Technology Review Explains, our series untangling the complex, messy world of technology to help you understand what’s coming next. You can read more from the series here. 

AI is changing how small online sellers decide what to make 

For small entrepreneurs, deciding what to sell and where to make it has traditionally been a slow, labor-intensive process. Now that work is increasingly being done by AI.   

Tools like Alibaba’s Accio compress weeks of product research and supplier hunting into a single chat. Business owners and e-commerce experts say they’re making sourcing more accessible—and slashing the time from product idea to launch.  

Read the full story on how AI is leveling the path to global manufacturing. 

—Caiwei Chen 

The gig workers who are training humanoid robots at home 

When Zeus, a medical student in Nigeria, returns to his apartment from a long day at the hospital, he straps his iPhone to his forehead and records himself doing chores.  
 
Zeus is a data recorder for Micro1, which sells the data he collects to robotics firms. As these companies race to build humanoids, videos from workers like Zeus have become the hottest new way to train them.   
 
Micro1 has hired thousands of them in more than 50 countries, including India, Nigeria, and Argentina. The jobs pay well locally, but raise thorny questions around privacy and informed consent. The work can be challenging—and weird. Read the full story.  

—Michelle Kim 

This is our latest story to be turned into an MIT Technology Review Narrated podcast, which we’re publishing each week on Spotify and Apple Podcasts. Just navigate to MIT Technology Review Narrated on either platform, and follow us to get all our new content as it’s released. 

The must-reads 

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology. 

1 Anthropic’s new model found security problems in every OS and browser 
Claude Mythos has been heralded as a cybersecurity “reckoning.” (The Verge)  
+ Anthrophic is limiting the rollout over hacking fears. (CNBC) 
+ It’s also launching a project that lets Mythos flag vulnerabilities. (Gizmodo) 
+ Apple, Google, and Microsoft have joined the initiative. (ZDNET) 

2 Iranian hackers are targeting American critical infrastructure 
Their focus is on energy and water infrastructure. (Wired) 
+ They’re targeting industrial control devices. (TechCrunch)  

3 Google’s AI Overviews deliver millions of incorrect answers per hour 
Despite a 90% accuracy rate. (NYT $) 
+ AI means the end of internet search as we’ve known it. (MIT Technology Review) 

4 Elon Musk is trying to oust OpenAI CEO Sam Altman in a lawsuit 
As remedies for Altman allegedly defrauding him. (CNBC) 
+ Musk wants any damages given to OpenAI’s nonprofit arm. (WSJ $) 

5 ICE has admitted it’s using powerful spyware 
The tools that can intercept encrypted messages. (NPR) 
+ Immigration agencies are also weaponizing AI videos. (MIT Technology Review) 

6 Greece has joined the countries banning kids from social media 
Under-15s will be blocked from 2027. (Reuters) 
+ Australia introduced the world’s first social media ban for children. (Guardian) 
+ Indonesia recently rolled out the first one in Southeast Asia. (DW)  
+ Experts say they’re a lazy fix. (CNBC) 

7 Intel will help Elon Musk build his Terafab in Texas 
They aim to manufacture chips for AI projects. (Engadget) 
+ Musk says it will be the largest-ever semiconductor factory. (Engadget) 
+ Future AI chips could be built on glass. (MIT Technology Review)  

8 TikTok is building a second billion-euro data center in Finland 
It’s moving data storage for European users. (Reuters) 
+ Finland has become a magnet for data centers. (Bloomberg $) 
+ But nobody wants one in their backyard. (MIT Technology Review) 

9 Plans for Canada’s first “virtual gated community” have sparked a row 
The AI-powered surveillance system has divided neighbors. (Guardian) 
+ Is the Pentagon allowed to surveil Americans with AI? (MIT Technology Review) 

10 The high-tech engineering of the “space toilet” has been revealed 
Artemis II is the first mission to carry one around the world. (Vox) 

Quote of the day 

“This case has always been about Elon generating more power and more money for what he wants. His lawsuit remains nothing more than a harassment campaign that’s driven by ego, jealousy and a desire to slow down a competitor.” 

—OpenAI criticizes Musk’s legal action in an X post. 

One More Thing 

USWDS

Inside the US government’s brilliantly boring websites 

You may not notice it, but your experience on every US government website is carefully crafted. 

Each site aligns an official web design and a custom typeface. They aim to make government websites not only good-looking but accessible and functional for all. 

MIT Technology Review dug into the system’s history and features. Find out what we discovered. 

—Jon Keegan 

We can still have nice things 

A place for comfort, fun and distraction to brighten up your day. (Got any ideas? Drop me a line.) 

+ Rejoice in the splendor of the “Earthset” image captured by Artemis II. 
+ Meet the fearless cat chasing off bears. 
+ This document vividly explains what makes the octopus so unique. 
+ Revealed: the rhythmic secret that makes emo music so angsty. 

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Continuous attractor dynamics in spatial navigation: from population geometry to flexible computation

A central computational problem in spatial navigation is how spatial representations remain stable under noise and uncertainty, and update reliable estimations of continuous variables such as head-direction and position, which respectively rely on the head-direction system and the grid-cells system in the entorhinal cortex. The two systems demonstrate strong population-level dynamics, suggesting a potential framework to explain the critical problem of spatial representations. Currently, the framework involves continuous attractor networks and the neural field theories as an unified perspective, from which the population activity can be described as evolving of continuous variables on a low-dimensional attractor manifold, together with the selective instantiation of these dynamics across symmetry-related or context-dependent subspaces. From this viewpoint, a key question is how different sources of information, such as self-motion, sensory cues and environmental structure, interact with attractor dynamics to regulate the evolution and stability of population states. Specifically, external inputs can stabilize attractor states by anchoring them to landmarks; intrinsic network connectivity, symmetry, and multi-timescale dynamics determine whether an attractor is stable and whether it supports continuous motion; environmental boundaries and geometric constraints can systematically shape the local geometry of spatial activity patterns; direction- or context-dependent signals may selectively recruit neuronal subpopulations with specific tuning preferences; and cross-level organization of attractor dynamics, enabling a unified representational and control framework from individual decision-making to collective behavioral organization. Through the joint action of these mechanistic dimensions, continuous attractor representations are able to support the core computations required for navigation. More broadly, this perspective provides a theoretical foundation for understanding how continuous spatial representations are computed, read out, and flexibly manipulated to support planning and behavioral control.
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Prefrontal and hippocampal microstructural gray matter following cognitive training under moderate hypoxia in mood disorders: a randomized controlled trial

BackgroundCognitive impairment persists during partial or full remission in 50–70% of individuals with mood disorders and impacts daily functioning and clinical prognosis. Preclinical evidence suggests that extended exposure to moderate hypoxia, combined with motor-cognitive learning, may elevate neuroplasticity and improve cognition. In these individuals with remitted mood disorders, we found that cognitive training under repeated moderate normobaric hypoxia improved executive function, and here investigate neurobiological mechanisms.MethodsParticipants with major depressive disorder (MDD) or bipolar disorder (BD) in partial or full remission were randomized to 3 weeks of 3.5-h daily normobaric hypoxia (12% O2) combined with cognitive training five to 6 days per week or treatment-as-usual (TAU). Participants were assessed with cognitive tests and diffusion-weighted MRI at baseline and 1 month after treatment completion (week 8) as part of the ALTIBRAIN trial (ClinicalTrials.gov: NCT06121206). Prefrontal and hippocampal gray matter microstructure were modelled with Neurite Orientation Dispersion and Density Imaging (NODDI).ResultsFifty-seven participants (mean age 39 years, SD: 13, 70% female) with baseline MRI data were included. No significant effects of hypoxia-cognition training vs. TAU on neurite density index (NDI) or orientation dispersion index (ODI) were observed in either the prefrontal cortex or hippocampus (all p-FDR ≥ 0.832). No significant associations were observed between microstructural changes and changes in cognitive function in either region (all p-FDR ≥ 0.721). At baseline, microstructure in both regions was not associated with executive function or global cognition (all p > 0.40).ConclusionThe absence of detectable microstructural changes, despite selective improvements in executive function, indicates that NODDI-derived metrics did not capture structural correlates of the cognitive response to hypoxia-cognition training. Whether this reflects functional neural mechanisms, measurement insensitivity, or the timing of the single follow-up assessment remains to be determined. Future studies should incorporate multiple imaging time points to capture the dynamic trajectories of putative microstructural brain changes.
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Personalized audiovisual gamma stimulation enhances neural connectivity and entrainment beyond fixed 40 Hz protocols

BackgroundConventional 40 Hz gamma stimulation is applied across individuals, potentially overlooking inter-individual neural variability.ObjectiveThis study evaluated conversation gamma frequency (CGF)–a personalized gamma frequency derived from task engagement–against the fixed 40 Hz and individual gamma frequency (IGF) derived from auditory responses.MethodsIn Experiment 1, gamma center frequencies were measured under resting, reading, and conversation conditions. In Experiment 2, EEG was used to compare neural entrainment effects across CGF, 40 Hz, and IGF conditions.ResultsConversation gamma frequency stimulation induced stronger neural activation and functional connectivity in the frontal, temporal, and parietal cortices compared to 40 Hz or IGF. Theta-gamma coupling analysis revealed significantly increased phase synchronization under CGF compared to 40 Hz with enhanced connectivity. However, entrainment declined as the frequency difference between CGF, and 40 Hz increased, emphasizing the limitation of fixed-frequency stimulation.ConclusionThese findings provide EEG-based mechanistic evidence that individualized gamma stimulation may represent a hypothesis-generating strategy for future neurorehabilitation research in aging and neurodegenerative conditions.