Science, Volume 392, Issue 6803, June 2026.
Long-term isolation and archaic introgression shape functional genetic variation in Near Oceania
Science, Volume 392, Issue 6803, June 2026.
Summer reading 2026
Science, Volume 392, Issue 6803, Page 1118-1124, June 2026.
The air pollution benefits of low-severity fire
Science, Volume 392, Issue 6803, June 2026.
Assessing the net climate benefits of improved grazing intensity in global rangelands
Science, Volume 392, Issue 6803, Page 1161-1166, June 2026.
Microglia at a key inflection point in Alzheimer’s disease
Nature Medicine, Published online: 11 June 2026; doi:10.1038/s41591-026-04409-3
We analyzed brains from octogenarians and cognitively resilient centenarians to understand why some individuals with substantial Alzheimer’s disease pathology develop dementia whereas others remain cognitively intact. Spatial transcriptomics revealed gene expression changes in discrete tissue domains surrounding amyloid plaques and tau pathology that distinguish early, clinically silent, disease from later stages associated with cognitive decline.
Major Depressive Disorder from a Brain-Body Perspective: Reproducible Central Cardiac Interoception Deficits and Peripheral Autonomic Dysfunctions Dissociate
Brain-heart interaction (BHI) offers a systems-level framework for understanding major depressive disorder (MDD), yet reproducible cross-system markers remain unclear. We aimed to identify reproducible BHI impairments in MDD and clarify their physiological and clinical correlates.
Focused ultrasound ablation for psychiatric disorders
Modern circuit-based neurosurgical interventions address a critical unmet need for patients with treatment-resistant psychiatric illness. Magnetic resonance–guided high-intensity focused ultrasound (HIFU) enables incisionless, millimeter-precision thermoablation via staged sonications with real-time monitoring, reshaping the risk–benefit profile of traditional neurosurgical interventions for psychiatric disorders.Here, we review the clinical evidence for HIFU ablation and contrast it with alternative platforms, including radiofrequency ablation, radiosurgery, laser interstitial thermal therapy, and deep brain stimulation.
Advancing Clinical Translational Research for Profound Autism
Autism Spectrum Disorder (ASD) has emerged as a key battleground in the federal assault on science. US government leaders have systematically ignored expert advice, reanimated baseless claims about the causal role of vaccines, forwarded thinly supported hypotheses blaming ASD on parental behavior, and promoted unsubstantiated treatments. This barrage comes at a time when the prospects for dramatic near-term advances in clinical translation, particularly for the severe end of the ASD spectrum, have never been greater.
Focused Ultrasound Neuromodulation for Substance Use Disorder
Given the prevalence of substance use disorder (SUD), elevated overdose death rates, and limited approved pharmacotherapies for SUD, new treatment approaches are necessary. Neuromodulation is a potential adjunctive treatment for SUD to reduce substance use and risk factors associated with drug use recurrence, such as craving. One form of neuromodulation, focused ultrasound (FUS), has significant potential given that it is non-invasive and capable of targeting subcortical structures implicated in the brain’s reward circuity with great precision.