Radically different
Good morning. Remember when the streets were covered in snow? The passage of time is so wild. Below we’ve got some news to start another week.
The American Diabetes Association’s annual conference in New Orleans wraps up today, after three days of data readouts, presentations, and, unexpectedly, a police interaction? Here are some highlights:
Nature Biotechnology, Published online: 08 June 2026; doi:10.1038/s41587-026-03171-8
We have developed single-cell spatial pharmacobiology (SSP), which combines in situ imaging of a systemically infused fluorescent therapeutic antibody with high-plex spatial proteomics. Applied to head and neck and pancreatic tumors from patients treated in phase 1 trials, SSP revealed marked spatial heterogeneity in antibody delivery and target engagement, which was shaped by conserved stromal barriers.
Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04439-x
In a whole-exome sequencing analysis, the beneficial effects of the SGLT2 inhibitor dapagliflozin in reducing the risk of future heart failure hospitalization in individuals with type 2 diabetes were markedly greater in individuals who carried a cardiomyopathy-associated genetic variant compared with noncarriers, suggesting a personalized preventative therapy based on genetic information.
Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04428-0
In the randomized, double-blind phase 3 ALTAIR trial, patients with resected colorectal cancer who became positive for circulating tumor DNA during post-adjuvant surveillance received trifluridine/tipiracil hydrochloride therapy, which did not significantly prolong disease-free survival compared with placebo.
Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04469-5
A nationwide retrospective analysis of 4.5 million Korean adults found that electronic cigarette use after smoking cessation was associated with higher lung cancer incidence and mortality compared with complete smoking cessation.