Leeds has been selected as the UK site for a European research pilot to improve diabetes treatment in young people using digital tools.
The Download: a useful quantum machine and a record-breaking subsea tunnel
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.
PsiQuantum has a plan to make a massive quantum computer out of light
The machine that could change the world will be housed in a room that looks like a data center crossed with an ice cream factory.
Inside, some 100 stainless-steel cabinets each hold hundreds of chips. On those chips, thousands of light particles will fly through a maze of optical switches and beam splitters. Each photon must be accounted for, because precisely measuring where it ends up will help answer questions that current computers might take millions of years to solve.
This computer, as described, does not exist. It’s the brainchild of a company called PsiQuantum, founded in 2016 by four physicists from UK universities. In a crowded field of deep-pocketed competitors with similarly fantastical visions, the company aims to be the first to build a useful quantum machine.
Read the full story on the company’s quest.
—James O’Donnell
MIT Technology Review Narrated: inside the world’s deepest and longest subsea road tunnel
—Niall Firth
I’m currently around 1,000 feet beneath the North Sea, in a dark, dank cave. It smells weird. And I’m increasingly aware of the pressure from millions of tons of seawater just above my head.
I’m under the iconic fjords of Norway to visit what will soon become the world’s longest and deepest subsea road tunnel—an exceptional engineering feat that will carry drivers deep beneath the North Sea.
I’m here to understand how you make a 16.6-mile highway that sits 1,280 feet below the sea at its deepest point. And also—at a time when it can feel hard to get anything done—to reassure myself that ambitious engineering is still possible. That we can still make things.
This is our latest story to be turned into an MIT Technology Review Narrated podcast, which we publish each week on Spotify and Apple Podcasts. Just navigate to MIT Technology Review Narrated on either platform, and follow us to get all our new content as it’s released.
The must-reads
I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.
1 Meta allegedly used AI to target workers with health issues for layoffs
Their lawsuit says Meta relied on AI to create a termination list. (Guardian)
+ And pinpointed staff who took maternity or disability leave. (Reuters $)
+ One was allegedly informed the day before her water broke. (Ars Technica)
+ The layoffs aimed to offset Meta’s AI spending. (Gizmodo)
+ AI agents are not your “coworkers.” (MIT Technology Review)
2 OpenAI’s first consumer device will be a mobile smart speaker
The screenless device will serve as an “AI companion.” (Bloomberg $)
+ It’ll let you talk with ChatGPT. (Verge)
+ And use a camera and sensor to understand your environment. (Reuters $)
+ It’s set to launch next year. (Engadget)
3 The US military sent explosive drone boats into combat for the first time
They attacked an Iranian midget submarine and naval port. (Ars Technica)
+ Underwater drones may shape a war in Taiwan. (MIT Technology Review)
4 DeepMind’s CEO has called for a US-led body to test frontier AI models
Demis Hassabis wants the watchdog to vet national security threats. (FT $)
+ If dangers mount, it would coordinate an industry-wide slowdown. (Axios)
5 Data centers are set to add billions in power costs in 13 states
A power auction is slated to produce $6.3 billion in new charges. (NYT $)
+ Australia plans to govern the use of water and power for AI. (WSJ $)
6 xAI’s unpermitted power pollution hits Black communities hardest
Elon Musk’s xAI has been installing gas turbines without permits. (Reuters $)
+ We need to focus on Big Tech’s energy footprint. (MIT Technology Review)
7 Stripe and Advent have offered to buy PayPal for more than $53 billion
The payments giant and private equity firm have made a joint bid. (Reuters $)
+ Apple and Google Pay have eroded PayPal’s market share. (Bloomberg $)
8 DeepSeek plans to file for IPO as soon as this year
The Chinese AI pioneer is likely to list in Shanghai. (WSJ $)
+ Here’s why DeepSeek’s latest model matters. (MIT Technology Review)
9 A hard, lightweight “bio-metal” has been discovered in sea worm jaws
It could have applications in engineering. (New Scientist $)
10 A new $3,000 fitness suit electrocutes you to boost your gains
Celebrities love it—but not everyone’s a fan. (404 Media)
Quote of the day
“By economic and engineering measures, generative AI might be the worst technology ever deployed.”
—Alex Reisner, a staff writer at The Atlantic, explains why GenAI’s scaling problem is an engineering disaster.
One More Thing
FRANZISKA BARCZYK
Hackers made death threats against this security researcher. Big mistake.
In April 2024, an anonymous hacker began posting death threats on Telegram and Discord channels aimed at a cybersecurity researcher named Allison Nixon. It wasn’t long before others piled on. Someone shared AI-generated nudes of her.
They targeted Nixon because she had become a formidable threat. As chief research officer at the cyber investigations firm Unit 221B, named after Sherlock Holmes’s apartment, she had built a career tracking cybercriminals and helping get them arrested.
For years, Nixon had lurked quietly in online chat channels or used pseudonyms to engage with perpetrators and bring them to justice. Now, she resolved to unmask the people behind the death threats—and take them down for crimes they admitted to committing.
Find out why they learned to regret their choice of target.
—Kim Zetter
We can still have nice things
A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.)
+ A musician has discovered the true masters of metal breakdowns: birds.
+ Photographer Fontanesi’s surreal photo splits transform everyday images into spectacular hybrid scenes.
+ Over 30 actors, filmmakers, and friends recount how Steven Spielberg infiltrated Hollywood in this terrific article.
+ Who would win the World Cup if less important things than soccer decided it, like life expectancy and happiness? A new game tests your knowledge.
What to know about the parasitic diarrhea outbreak
Get your daily dose of health and medicine every weekday with STAT’s free newsletter Morning Rounds. Sign up here.
Good morning. I dedicate the first item in today’s newsletter to a friend who is suffering from what she suspects to be cyclosporiasis. Feel free to forward this email to your friends who need information but are scared to wade through online discussions on the outbreak.
STAT+: Medicare Advantage insurers face new bipartisan scrutiny over AI and care denials
Sens. Richard Blumenthal (D-Conn.) and Josh Hawley (R-Mo.) are calling on the nation’s largest Medicare Advantage insurers to provide internal records and detailed information on their use of artificial intelligence to block rehabilitative care.
The lawmakers’ request — a moment of bipartisan scrutiny on a controversial federal health care program — comes just one month after a government investigation unearthed a continuing pattern of denials within Medicare Advantage.
In letters provided to STAT, Blumenthal and Hawley told executives at UnitedHealth Group, Humana, and CVS Health that recent findings by the Office of the Inspector General for the Health and Human Services Department undercut their companies’ claims to have reduced barriers to crucial medical services.
Opinion: Why we still don’t know what foods are the source of the cyclospora outbreak
As of Tuesday, a parasite called cyclospora has sickened nearly 7,000 people in 34 states so far this summer. On Monday, Michigan health officials announced their first potential source: lettuce and salad greens. Their advice was sound: Buy whole heads, discard the outer leaves, wash what’s left. But it landed after vinegar rinses and peeling rituals had circulated online for weeks.
Michigan’s announcement was careful: Lettuce keeps surfacing in interviews, other foods cannot be ruled out, and no grower or supplier has been named. That is what a “potential source” is — a hypothesis strong enough to keep pulling on. Weeks into one of the largest cyclosporiasis surges on record, we still cannot answer the question people need answered: Which food is making us sick? The Centers for Disease Control and Prevention cannot yet say whether this is one outbreak with a common source or several unconnected clusters.
STAT+: Swing Therapeutics acquired by medical VR platform XR Health
Swing Therapeutics, developer of a Food and Drug Administration-cleared digital treatment for fibromyalgia, has been acquired by medical virtual reality company XR Health.
Swing is XR Health’s sixth acquisition in the last two years and finds the VR developer taking a new business direction as it aims to be a go-to source of digital treatments for disease. The terms of the deal were not disclosed because, as XR Health CEO Eran Orr explained, “it won’t be the last” acquisition for the company.
XR Health, Orr claimed, has dozens of different apps on its platform currently and delivered a million user sessions in 2025. Offerings include a range of meditation and cognitive behavioral therapy-based VR experiences targeted at mental health issues, pain, hot flashes, and more. XR Health’s large packages of VR treatments are registered with the FDA but not cleared.
Flood of comments on White House grantmaking overhaul is largely negative, analysis shows
An analysis of a torrent of public comments submitted on a White House proposal to change the way federal contracts and grants are doled out shows a widespread rebuke of the potential change by scientists and others.
The analysis, done by researchers at the University of North Carolina at Chapel Hill in partnership with STAT, used a large language model to classify whether a comment was supportive or in opposition and to identify themes mentioned in comments. It found that about 95% were in opposition and just 1% supported the proposed changes to the “Uniform Guidance.” A total of 496,769 public comments were submitted before the deadline of Monday at midnight, and an analysis of the 52,322 comments that have been posted in full show an overwhelming rebuke of the proposal.
Northamptonshire links digital care plans to NHS Record Locator
Digital care plans for patients in Northamptonshire have been linked to the NHS National Record Locator for faster treatment recommendations.
AstraZeneca Licenses Global Rights to Dizal Lung Cancer Drug for Up-to-$1.5B
AstraZeneca has acquired exclusive global rights to develop and commercialize Dizal Pharmaceutical’s marketed lung cancer drug Zegfrovy® (sunvozertinib), through an agreement that could generate up to $1.5 billion for the spinout of the pharma giant’s onetime Chinese R&D operation.
Wuxi City, China-based Dizal has inked an exclusive license agreement with AstraZeneca to expand the development of Zegfrovy into new indications beyond the one for which it has approvals in the United States and China—namely the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutations, whose disease has progressed on or after platinum-based chemotherapy.
Dizal has been pursuing approvals from the FDA and China’s Center for Drug Evaluation (CDE) for a new indication for Zegfrovy, as a first-line treatment for NSCLC with exon 20 insertion EGFR mutations. In May, Dizal presented at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting and simultaneously published in The New England Journal of Medicine (NEJM), positive results in the indication from its Phase III WU-KONG28 trial (NCT05668988).
In the study, Zegfrovy showed a median progression-free survival (PFS) of 10.3 months compared with 7.5 months PFS for platinum-doublet chemotherapy in untreated NSCLC patients with EGFR exon 20 insertion mutations (exon20ins).
“The efficacy of sunvozertinib was superior to that of chemotherapy as first-line treatment for advanced NSCLC with EGFR exon 20 insertions,” the researchers concluded in their study, “First-Line Sunvozertinib in NSCLC with EGFR Exon 20 Insertion Mutations,” which was published May 29 in NEJM.
Dizal also showed Zegfrovy delivering a BICR-assessed best objective response rate (BoR) of 68.1% vs. 35.4% with chemotherapy, and a median duration of response (DoR) of 11.2 months vs. 7.1 months for chemo.
Based on those results, Dizal has filed supplemental New Drug Applications (NDAs) for Zegfrovy in the first line to the FDA and China’s Center for Drug Evaluation (CDE). Both regulators have granted their Breakthrough Therapy designations to Zegfrovy in that setting.
“AstraZeneca is a leader in treating EGFR-mutated lung cancer, and we are eager to add Zegfrovy to our world-class portfolio of innovative medicines for patients whose tumors carry exon 20 insertion mutations,” Dave Fredrickson, executive vice president of AstraZeneca’s Oncology Hematology Business Unit, said in a statement. “With this agreement, we will bring a differentiated, oral targeted treatment to these patients with limited options across the globe.”
20% jump
Dizal shareholders reacted to the agreement with AstraZeneca warmly enough to send shares traded on the Shanghai Stock Exchange jumping 20%, from RMB 46.94 ($6.93) to RMB 56.33 ($8.31). But the news did not appear to wow AstraZeneca investors, as shares of the pharma giant traded on the London Stock Exchange dipped 1.95% today, from 12,610 pence to 12,364 pence. Shares traded on the New York Stock Exchange also fell 1.95% as of 2:17 pm ET, from $169.47 to $166.16.
Dizal was established in 2017 as a joint venture between AstraZeneca and China’s State Development & Investment Corp. (SDIC), with AstraZeneca spinning out the R&D operations of its China Commercial Innovation Center to Dizal as well as three preclinical candidates, one each in cardiometabolic disease, respiratory disease, and oncology, the drug that was eventually developed into Zegfrovy. Xiaolin Zhang, PhD, who headed the innovation center, was appointed Dizal’s CEO, a position he still holds.
AstraZeneca has agreed to pay Dizal $600 million upfront; up to $900 million tied to achieving development, regulatory, and sales-related milestones; plus tiered double-digit royalties on global sales of Zegfrovy. The milestone payments consist of up to $400 million in clinical development-related payments and up to $500 million in sales-related payments, Dizal disclosed in a regulatory filing to the Shanghai Stock Exchange.
In March, Dizal reported that Zegfrovy generated about RMB 576 million (about $85.057 million) in revenue last year, up 85% from 2024. Zegfrovy accounted for nearly three-fourths (72%) of Dizal’s total 2025 sales of RMB 801 million ($118.282 million).
Zegfrovy is a once-daily oral irreversible epidermal growth factor receptor (EGFR) inhibitor approved by the FDA in July 2025 based on evidence from the Phase I/II WU-KONG1B trial (NCT03974022) in patients with locally advanced or metastatic NSCLC with EGFR exon 20 insertion mutations whose disease has progressed on platinum-based chemotherapy and received Zegfrovy 200 mg once daily with food.
WU-KONG1B enrolled 202 patients with locally advanced or metastatic NSCLC with EGFR exon 20 insertion mutations who had received previous platinum-based chemotherapy. The trial was conducted at 89 sites in the United States, Argentina, Australia, Canada, China, Chile, France, Italy, Malaysia, South Korea, Spain, and Taiwan.
AstraZeneca’s licensing deal with Dizal is expected to close in the second half of this year, subject to customary closing conditions and regulatory clearances. AstraZeneca said the transaction does not impact its 2026 financial guidance to investors, which it reaffirmed on April 29 as calling for a mid-to-high single-digit percentage increase in total revenue, and a low double-digit increase in “core” earnings per share from primary ongoing business activities.
“As a leading global company with a strong lung cancer franchise, AstraZeneca will help ensure patients around the world can benefit from this innovation discovered by Dizal scientists in China,” stated Zhang.
The post AstraZeneca Licenses Global Rights to Dizal Lung Cancer Drug for Up-to-$1.5B appeared first on GEN – Genetic Engineering and Biotechnology News.
Oxytocin in the amygdala links social and reward signals to cataplexy in mice
Nature Neuroscience, Published online: 14 July 2026; doi:10.1038/s41593-026-02349-2
Loss of orexin neurons in narcolepsy leads to sleepiness and cataplexy episodes, which are most common in social contexts. In a mouse model, an oxytocin-sensitive circuit in the central amygdala is both necessary and sufficient for cataplexy induced by socialization and reward, which links positive emotional signals to motor suppression and highlights a potential therapeutic target.