The Download: Claude’s inner workings, and the future of world models

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

What Anthropic’s latest AI discovery does—and doesn’t—show

—James O’Donnell

When Anthropic announced last week that it had found a new window into its models’ “internal thoughts” as they reason through answers, there was one colleague I had to talk to: senior editor Will Douglas Heaven.

Aside from having a PhD in computer science, Will has spent a lot of time digging into what we can say about how AI models work. I spoke with him about what we should take from Anthropic’s new (and typically quirky) research. Here’s what he had to say.

This article is from The Algorithm, our weekly AI newsletter. Sign up to receive it in your inbox every Monday.

How will AI understand the real world?

Today’s AI systems can generate text, images, and code with impressive skill, but they still struggle with the complexities of the physical world. To bridge this gap, many researchers believe you need something called a world model.

At a LinkedIn Live event today, MIT Technology Review will investigate how this technology could transform robotics and help unlock a new generation of intelligent machines. Join Will Douglas Heaven, our senior editor for AI, and Sam Sinha, founding AI researcher and head of world models at 1X Technologies, for the discussion. 

Register here to attend the free session at 9:30 PDT, 12:30 PM EDT, and 5:30 PM BST. 

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 New York has become the first state to enact a data center moratorium
Its governor banned large data-center construction for up to a year. (WSJ $)
+ A bill passed by state lawmakers could go even further. (Verge)
+ Everyone hates data centers. (MIT Technology Review)

2 Smartphone shipments have hit a 13-year low due to the memory crunch
They fell 11% in the second quarter of 2026. (Reuters $)
+ The memory chip ‌shortage has increased prices. (Gizmodo)
+ And threatens the promise of Moore’s Law. (MIT Technology Review)

3 Sugar molecules have been found in interstellar space for the first time
It hints that life on Earth may have been seeded from space. (Nature) 
+ And boosts the odds of living organisms existing elsewhere. (New Scientist $)
+ Researchers used radio telescopes and data to spot the molecules. (NYT $)

4 Nvidia has halved its Asia buyer list to stop AI chips reaching China
It introduced a “white list” of companies that passed tougher checks. (FT $)
+ It moved amid tighter chip controls from the ‌Trump ⁠administration. (Reuters $)

5 Russian state hackers are targeting routers to spy and steal, the US warns
The government has warned users to secure their devices. (Ars Technica)
+ Now is a good time for doing crime. (MIT Technology Review)

6 Trump moved his crypto gains into stocks while urging people to buy more
His crypto projects earned him a fortune—but steep losses for retail buyers. (Reuters $)
+ He’s called for Congress to pass a new crypto bill to honor Lindsey Graham. (CNBC)

7 A new cell therapy has saved four children with terminal brain cancer
They were treated with an experimental immunotherapy. (New Scientist $)
+ Access for older children will also be limited. (Bloomberg $)

8 The LAPD has halted use of Flock surveillance cameras due to privacy issues
Flock’s automated license plate readers have caused concerns. (LA Times $)
+ It’s also been criticized for sharing data with state and federal officials. (Engadget) 

9 The US has approved launching a space mirror that reflects sunlight onto Earth
As part of a controversial plan to power solar panels round the clock. (Wired $)
+ But geoengineering faces many practical challenges. (MIT Technology Review)

10 Anthropic says Claude’s values vary depending on your language
It’s most cautious in English and most deferential in Arabic. (Gizmodo) 

Quote of the day

“The age when humans are the highest life form on earth will end. For better ​or for worse, it will happen and it can’t be stopped.” 

—SoftBank CEO Masayoshi Son predicts that AI will overtake human intelligence by 2040 in a speech at his company’s annual corporate conference in Tokyo, Reuters reports.

One More Thing

Inside the strange limbo facing millions of IVF embryos

Millions of embryos created through IVF sit frozen in time, stored in cryopreservation tanks around the world. Many are left in a peculiar limbo, with no clear path forward.

UK residents can discard them, make them available to other prospective parents, or donate them for research. People in the US can also opt for “adoption,” “placing” their embryos with families they get to choose. In Germany, people aren’t typically allowed to freeze embryos at all. And in Italy, unused embryos must remain frozen, ostensibly forever. 

While these embryos remain in suspended animation, patients, clinicians, embryologists, and legislators must grapple with the essential question of what to do with them. What do these embryos mean to us? Who should be responsible for them? 

Dive into the ethical and legal challenges surrounding frozen IVF embryos.

—Jessica Hamzelou

We can still have nice things

A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.)

+ This website turns live LA Metro data into music.
+ British grammar is enlivening the American World Cup.
+ Comedy icon Mel Brooks recently turned 100. Here’s a look back at his legendary career.
+ Take a trip through modern music with this cinematic set from Thomas Bangalter, one-half of French house music duo Daft Punk.

<![CDATA[Discover how coordinated schizophrenia care teams—clinicians, social supports, and peers—improve communication, housing, work, and quality of life.]]>

Cellares and Sonoma Biotherapeutics Agree to Automate Engineered Treg Cell Therapy Manufacturing

Officials at Cellares and Sonoma Biotherapeutics say their companies will automate the manufacturing of SBT-77-7101, an engineered regulatory T cell (Treg) therapy for autoimmune and inflammatory diseases. The product is in Phase I clinical development for poly-refractory rheumatoid arthritis (RA) in patients who have exhausted all available treatment options.

Cellares plans to translate SonomaBio’s SBT-77-7101 manufacturing process onto its Cell Shuttle and automate in-process and release testing through the Cell Q™ quality control system. The company operates its first commercial-scale Smart Factory in Bridgewater, NJ, with additional facilities under construction in Europe and Japan.

“Tregs are uniquely sensitive to the manufacturing process. Cellares brings the Cell Shuttle platform, and global infrastructure to help us deliver on our clinical ambitions at scale for the hardest-to-treat RA patients.” said Stephen Dilly, PhD, president, CEO, and board chair of Sonoma Biotherapeutics.

“Every new cell therapy modality we bring to the Cell Shuttle and Cell Q expands what is possible for the field and for patients in need,” added Fabian Gerlinghaus, co-founder and CEO of Cellares. “Tregs are among the most technically demanding cell types to manufacture reliably. We are honored to partner with SonomaBio and demonstrate that our platform can directly translate to Tregs.

“SonomaBio has developed one of the most advanced Treg programs in the clinic, and we look forward to contributing to their clinical success as they bring this groundbreaking therapy to patients.”

 

 

The post Cellares and Sonoma Biotherapeutics Agree to Automate Engineered Treg Cell Therapy Manufacturing appeared first on GEN – Genetic Engineering and Biotechnology News.

<![CDATA[Clinicians track relapse risk in schizophrenia by spotting functional decline, paranoia, missed care, and triggers, using family check-ins, brief scales, and labs.]]>
<![CDATA[Where can vagus nerve stimulation fit into treating depression?]]>

FDA authorized Zyn nicotine pouches without knowing what they were made of, says former agency scientist

Four years into the U.S. Food and Drug Administration’s review of Zyn nicotine pouches, and not long before the agency approved them for sale, an FDA toxicologist ran some informal tests in her kitchen that led her to question whether the agency truly understood the addictive product it was about to green-light.

Christy Leppanen worked for the FDA’s Center for Tobacco Products, where she led a project examining the potential for microplastics exposure. A scientist who had worked on an environmental assessment of Zyn had repeatedly told her that the nicotine pouches melt in the mouth. But during a public health conference in late 2024, Leppanen said, she talked to an academic who reinforced her understanding that they don’t. 

Read the rest…

Opinion: It looks like your doctor and talks like your doctor. But it’s not your doctor

Imagine a patient who arrives at her doctor’s clinic furious. She shows her doctor a video of him — white coat, plausible exam room, familiar cadence — endorsing an over-the-counter hormone supplement for menopausal symptoms, dismissing standard therapies as “pharma scams,” and offering a discount code.

But the physician never recorded that message. Someone built a deepfake from online recordings, including interviews, webinars, and patient-facing videos, and used the synthetic likeness to sell an unregulated product. This scenario is no longer hypothetical. Investigations have documented AI-generated videos impersonating specific clinicians whom they name to promote supplements and other dubious treatments on major platforms. 

Read the rest…

STAT+: 10 charts that explain America’s hidden alcohol epidemic

“The Deadliest Drug,” a multipart series by STAT, spotlights an epidemic hidden in plain sight: excessive alcohol use. Alcohol kills more Americans each year than all illicit drugs combined, and yet health officials, industry leaders, and the public rarely focus on it. STAT reporters Isabella Cueto and Lev Facher examined the epidemic’s human cost and the complex causes — from personal to political — of the most harmful substance use crisis in the U.S. STAT data editor J. Emory Parker amplified many of the findings in data-rich charts. 

These charts capture the toll, emerging risks, shifting usage, and economic stakes of America’s relationship to alcohol. 

Drinking-related adverse events, including emergency room visits, have soared in recent decades. American emergency rooms recorded roughly 5.4 million visits due to alcohol in 2022, and in many states, alcohol-related hospitalizations dwarf those stemming from other substances, like opioids. 

Continue to STAT+ to read the full story…