Radically different
T cells don’t simply switch on—they reshape themselves. When these immune sentinels recognize a target, they rapidly reorganize their internal scaffolding to build an immunological synapse, a nanoscale interface that determines how strongly they respond. But that architectural overhaul needs brakes. Without them, T cells risk becoming hypersensitive, reacting to weak cues, and drifting toward autoimmunity. Now, new work reveals that one of those brakes—PTPN22 (proline-serine-threonine phosphatase–interacting protein 1)—acts not only on signaling molecules but also on the cytoskeletal machinery that sculpts the synapse itself.
In a study published in Science Signaling, lead author Megan Joseph, PhD, of University College London and colleagues uncover how PTPN22 interacts with the cytoskeletal adaptor protein PSTPIP1 to restrain actin remodeling at the T‑cell synapse. Their paper, “PTPN22 regulates T-cell synapse formation through PSTPIP1-dependent actin remodeling,” shows that this phosphatase plays a previously unappreciated role at the plasma membrane, shaping how T cells respond to antigens of varying affinity. As the authors wrote, “These findings uncover a PTPN22–PSTPIP1 signaling axis that is critical for regulating cytoskeletal remodeling and receptor organization, providing insights into T-cell hyperactivation that may be relevant to autoimmune disease.”
PTPN22 is already well known as a negative regulator of early T‑cell activation. Variants in the gene, including the autoimmune‑associated R620W allele, have been linked to diseases ranging from lupus to rheumatoid arthritis. Using super‑resolution DNA‑PAINT imaging, Joseph et al. visualized how T cells reorganize their actin networks as they engage activating ligands. In wild‑type Jurkat cells, PTPN22 helped maintain orderly actin dynamics. In its absence, however, PSTPIP1 accumulated at T cell receptors (TCRs), disrupting Arp2/3‑dependent actin polymerization and generating dense central F‑actin foci, as well as enhanced Ca2+ signaling, especially under low-affinity stimulation of the TCR, according to the paper.
This hyper‑remodeling had functional consequences. PTPN22‑deficient cells became unusually sensitive to low‑affinity antigens, responding more vigorously than their wild‑type counterparts. “Autoimmunity is inherently linked to immune tolerance mechanisms normally associated with low-affinity TCR responses to self, which, when breeched lead to inappropriate immune reactions. To better understand how PTPN22 contributes to these processes, we used WT and PTPN22 KO TCR−/− Jurkat cells engineered to express a transgenic TCR with high affinity for the pTax peptide and low affinity for the pHuD peptide,” the authors wrote.
Joseph and colleagues suggest that understanding this axis could inform both autoimmune research and efforts to modulate T‑cell activation in cancer immunotherapy. By mapping how PTPN22 and PSTPIP1 coordinate actin remodeling, the study provides a mechanistic foothold for exploring how synapse architecture shapes immune outcomes.
The post T-Cell Synapse Formation Is Restrained by PTPN22–PSTPIP1 Signaling appeared first on GEN – Genetic Engineering and Biotechnology News.
You know that 1980s Dolly Parton hit “9 to 5”? I wonder if RFK Jr. has heard it? He often works in his office from 10 a.m. to 4 p.m., according to the New York Times. Send news tips and ways to make a livin’ to John.Wilkerson@statnews.com or John_Wilkerson.07 on Signal.
The federal government paid for a report on alcohol consumption. But it refused to publish the results, which show that even people who drink less than one alcoholic beverage a day are increasing their chances of developing a serious illness, Isabella Cueto reports.
The scientists who conducted the study believe the findings were suppressed because they are unfavorable to powerful special interests.
Researchers at the University of Maryland School of Medicine’s Center for Vaccine Development and Global Health (CVD) reported encouraging interim results from an early clinical trial that tested a new dual vaccine against Lassa fever and rabies. The study found the vaccine to be safe and induced immune responses against both the Lassa fever and rabies viruses (RB). There are currently no vaccines against Lassa fever on the market.
“This vaccine is designed to protect against two viruses of global health importance,” said study principal investigator Justin Ortiz, MD, MS, professor of medicine at UMSOM and vaccine researcher at CVD. “By combining targets into a single product, it could reduce the need for separate vaccination efforts and streamline delivery in settings where access is limited.”
Ortiz is first and corresponding author of the researchers’ published paper in Nature Medicine, titled “Adjuvanted inactivated rabies virus-vectored Lassa virus vaccine in healthy adults: a phase 1 trial,” in which they said, “If efficacy is confirmed, this combination vaccine could help protect populations from two priority pathogens and have a meaningful public health impact in regions where both diseases remain major threats.”
The World Health Organization has identified Lassa virus (LASV) as a public health threat in western Africa and made Lassa fever a priority disease for research. “Transmission occurs primarily through contact with food or household items contaminated by urine or feces from Mastomys rodents, although person-to-person spread can occur via exposure to bodily fluids or contaminated surfaces,” the investigators noted in their paper. Like Ebola, Lassa virus can trigger severe illness and periodic outbreaks in African nations.
Lassa virus infections occur in 300,000 people every year resulting in 5,000 deaths, according to figures cited by the authors, but these numbers are likely an underestimate due to limited surveillance. The disease is particularly dangerous in pregnancy with over 80% of late-term infections resulting in deaths to the mother or fetus. Additionally, regions where Lassa fever is common, such parts of Western and Sub-Saharan Africa, also have a high burden of rabies, with thousands of deaths annually, a disease that is almost always fatal once symptoms develop. The newly reported first-in-human trial was designed to evaluate the safety and immunogenicity of an adjuvanted inactivated rabies virus expressing the Lassa virus glycoprotein complex (GPC) on the surface of the virus. “Scientists at Thomas Jefferson University developed an inactivated rabies-vectored combination vaccine derived from an attenuated rabies strain, LASSARAB, expressing both the rabies glycoprotein and the LASV (Josiah strain) GPC,” the authors explained. “The RABV platform provides a well-established foundation for a dual-target vaccine.”
For the randomized, controlled trial 54 healthy adult volunteers from the Baltimore area were randomly assigned to receive different doses of LASSARAB, with an adjuvant or a licensed rabies vaccine control. Participants received two vaccine doses 28 days apart. Immune responses were studied through 61 days post-vaccination for an interim analysis. The results indicate that LASSARAB was safe with no serious adverse events (AEs) reported after vaccination. Additionally, the candidate vaccine induced rapid and robust antibody responses against both Lassa and rabies viruses when compared with the control, which only induced an immune response against rabies virus.
The study is ongoing, and vaccine safety and immune responses will be further studied through 394 days post-vaccination. “The final study report will be prepared after study completion and will include serious AEs and AEs of special interest through day 394, protocol-defined exploratory LASV and RABV antibody responses assessed at days 121 and 394, and any additional post hoc analyses, as applicable,” the team stated.
If the results indicate continued elevated immune responses from vaccination, researchers will proceed with more advanced clinical trials. Importantly, this investigational vaccine can be freeze-dried for storage, enabling distribution to areas of the world where it may be difficult to maintain cold chains. Importantly, this investigational vaccine can be freeze-dried for storage, enabling distribution to areas of the world where it may be difficult to maintain cold chains.
“These data support the feasibility of a bivalent rabies-vectored vaccine integrated into routine immunization for regions where cold-chain capacity is limited,” the team added.
“This study highlights CVD’s commitment to tackling diseases of global significance,” commented Stefan Kappe, PhD, director of the Center for Vaccine Development and Global Health and the Myron M. Levine Endowed Professor of Pediatrics. “LASSARAB not only targets diseases of concern but utilizes a platform that could make distribution attainable in the areas of the world that are most affected by these diseases.”
Added UMSOM dean Mark T. Gladwin, MD, “Climate change is causing Lassa fever to extend its reach far beyond its Nigerian and West African origins, putting an estimated 700 million people at risk worldwide. By 2070, the number of countries across Africa that will develop ecological conditions suitable for Lassa virus spread could drastically increase, so a vaccine to prevent this deadly infection is desperately needed.”
Last year, before results were available, the trial was highlighted by Nature Medicine in its 2025 feature, “Eleven clinical trials that will shape medicine in 2026,” which identified studies to watch based on their potential to address major unmet health needs.
The post First-in-Human Trial Reports Promising Dual Lassa–Rabies Vaccine Data appeared first on GEN – Genetic Engineering and Biotechnology News.
Incyte has agreed to acquire Vega Therapeutics for up to $2 billion, the companies said, in a deal designed to bolster the buyer’s hematology pipeline with antibody assets led by VGA039, a Phase III candidate for von Willebrand disease (VWD).
Vega, a wholly owned subsidiary of privately held Star Therapeutics, focuses on developing treatments for bleeding disorders. Vega’s lead candidate VGA039 could, if approved, be the first subcutaneous prophylactic therapy with a more convenient once-monthly, self-administered dosing regimen for patients with VWD, compared with current therapies requiring more frequent (2-3x/week) intravenous infusions.
VGA039 is a monoclonal antibody designed to modulate Protein S with the aim of improving hemostasis, potentially improving the body’s ability to control bleeding in numerous bleeding disorders. VGA039 is under study in the Phase III VIVID-6 trial (NCT07115004), a global single arm crossover study designed to investigate the safety and efficacy of subcutaneous administration of VGA039 as prophylaxis for bleeding in patients with every type of VWD, including those with a high disease burden.
VIVID-6’s estimated completion date is October 2028, with data expected to be read out in early 2029.
“VGA039 fits directly into our strategy of building a top-tier growth company for the future,” Incyte CEO Bill Meury said in a statement. “It is a first-in-class, Phase III asset with compelling early data, a manageable development path and the potential to become an important new growth driver in one of our core therapeutic areas, hematology. The transaction has all of the attributes we look for in business development opportunities.”
In a presentation to analysts Monday morning, Incyte quantified that potential market opportunity as “$1B+ global net sales opportunity.”—an estimate with which three analysts concur:
“VGA039 has the potential to address a clear unmet need for a practical, targeted therapy for von Willebrand disease, and even with conservative assumptions around pricing and market penetration, VGA039 has a clear path to a more than $1 billion market opportunity,” Matt Phipps, PhD, partner and group head of biotechnology equity research with William Blair, wrote Monday in a research note.
“Overall, we believe the deal for VGA039 fits well into Incyte’s current hematology franchise and capabilities and offers a relatively de-risked Phase III asset with blockbuster commercial potential in the 2030s,” Phipps added.
Jessica Fye, a managing director and senior equity research analyst with J.P. Morgan, was also bullish on VGA039’s commercial potential: “We think mgmt [management] framing VGA039 as a potential $1bn+ global sales opportunity is credible and think it should be able to leverage some of INCY’s existing presence with hematology centers.”
Faisal Khurshid, equity analyst with Jefferies, agreed that VGA039 “could have blockbuster potential” assuming it is priced at about $500,000/year compared with the $0.5 to $1 million range of current prophylactic therapies, and assuming ~2,000 patients at hemophilia treatment centers receive frequent IV prophylaxis out of 7,000-10,000 patients who have severe or recurrent bleeds.
“We feel that VGA039 largely fits INCY’s strategic goals and is well-positioned to succeed in Ph[ase III],” Khurshid wrote in a research note.
Despite the positive comments from analysts, Incyte shares dipped 1.7% Monday, from $102.38 to $100.64, though the stock rebounded Tuesday in early trading, rising nearly 3% to $103.31 as of 10:25 a.m. ET.
VGA039 has received the FDA’s Fast Track, Orphan Drug, Breakthrough Therapy, and Rare Pediatric Disease (RPD) designations. The RPD designation made Star Therapeutics eligible to receive a Rare Pediatric Disease Priority Review Voucher (PRV) upon approval of a Biologics License Application for VGA039—eligibility that would transfer to Incyte if its acquisition of Vega occurs as planned. The voucher may be redeemed to obtain priority review for a subsequent marketing application or transferred or sold to another sponsor.
The Breakthrough Therapy designation was supported by interim data from the Phase I/II multidose study (NCT05776069) of VGA039 in adult and adolescent patients with VWD, showing substantial bleed reductions across all types of VWD and all types of bleeds. The data was presented at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition in December 2025.
Vega’s pipeline includes two other programs, both preclinical—a complement therapy program, and an undisclosed program.
Acquiring Vega and its pipeline is among moves Incyte has undertaken in recent months under Meury to recoup the billions of dollars in sales that it stands to lose once its aging blockbuster Jakafi® (ruxolitinib) loses patent exclusivity in 2028—one of the Top 20 Drugs Heading for the Patent Cliff through 2029, according to a recent GEN A-List.
Jakafi, marketed outside the U.S, as Jakavi®, generated $3.093 billion in net product revenues last year, up 11% from $2.792 billion in 2024. Jakafi finished the first quarter with $757.755 million in net product revenues, up 7% from $709,412 in Q1 2025.
Incyte has agreed to pay Star $1.25 billion upfront for Vega, plus up to $750 million in payments tied to achieving sales milestones.
The boards of Incyte and Star have approved the acquisition deal, through which Incyte will acquire all of Vega’s outstanding shares through a stock purchase agreement. The deal is subject to expiration of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act and other customary closing conditions.
Incyte expects to incur an R&D charge of approximately $1.25 billion, to be included in third quarter and full year 2026 GAAP and non-GAAP results, as a result of the acquisition.
However, the benefits of an acquisition by Incyte outweigh its costs, Vega and parent Star Therapeutics reason.
“This milestone reflects our team’s deep commitment to innovation and underscores our strategy to develop first-in-class and best-in-class therapies for serious conditions with high unmet need,” stated Adam Rosenthal, PhD, Star’s founder and CEO.
The post Incyte to Acquire Vega Therapeutics for Up-to-$2B, Growing Hematology Pipeline with Phase III VWD Candidate appeared first on GEN – Genetic Engineering and Biotechnology News.
It didn’t have to be this way.
The condemnations keep coming four days after security officers escorted five diabetes experts out of the American Diabetes Association meeting in New Orleans for handing out copies of an editorial criticizing federal cuts to biomedical research. Expelling the doctors and scientists has shocked people in the field, and the ADA’s communications explaining it have only made matters worse, leaders in diabetes research and practice told STAT.
Background: Chronic insomnia is a highly prevalent sleep disorder that adversely affects quality of life and mental health. Cognitive behavioral therapy for insomnia (CBT-I) is internationally recommended as the first-line treatment, and digital CBT-I (dCBT-I) has been developed to improve accessibility and scalability. While existing dCBT-I systems effectively support structured behavioral training through standardized protocols, they provide relatively limited support for users’ cognitive exploration and meaning-making processes, particularly in helping users reflect on and internalize the rationale behind CBT-I practices in daily life. These limitations may contribute to challenges in sustained engagement and long-term adherence. Objective: This study aimed to examine the usability and feasibility of SleepPathfinder, a conversational CBT-I support chatbot that integrates Socratic questioning and a self-decision mechanism to support users’ understanding of and engagement with CBT-I practices. Methods: SleepPathfinder was designed around a 4-stage conversational flow: education on CBT-I techniques, Socratic cognitive exploration, self-decision, and advice provision. We conducted (1) a single-session pilot usability study (n=45) to assess system stability and user experience and (2) a 5-day condition-based comparative experiment (n=30) consisting of daily sessions, comparing an exploratory dialogue condition with a directive, protocol-guided dialogue condition. Quantitative measures assessed usability, cognitive appraisals related to sleep problems, autonomy-related experiences, and behavioral readiness, while qualitative feedback and conversational log analyses were used to examine interaction patterns and engagement characteristics. Results: In the comparative experiment, the exploratory dialogue condition showed a tendency toward reduced perceived threat and severity appraisal of sleep problems compared with the directive condition, accompanied by moderate effect sizes in cognitive perception measures. Autonomy-related experiences, including perceived choice and engagement, demonstrated suggestive upward trends in the exploratory condition. Behavioral intention changes were comparable across conditions, while overall readiness for change increased across participants. Conversational log analyses indicated that greater depth and volume of user self-narrative were associated with larger shifts in cognitive appraisals, whereas the frequency of chatbot questions alone was not. The pilot usability study indicated generally positive evaluations of system usability and content credibility, while identifying areas for improvement in emotional responsiveness and conversational naturalness. Conclusions: These findings suggest that a Socratic questioning–based and self-decision–based conversational structure is usable and feasible as a supportive interaction layer within dCBT-I systems. Rather than altering the directive behavioral structure of CBT-I, such an approach may complement existing protocols by facilitating cognitive exploration and supporting user-perceived autonomy. This study provides design-oriented evidence to inform the refinement of dialogue-supported digital CBT-I systems aimed at enhancing user engagement with CBT-I practices.
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Research from the University of Toronto shows long-term exposure to moderate air pollution increases a person’s risk of fatty build up in the blood vessels of the heart, which can lead to serious cardiovascular events like heart attack.
As reported in the journal Radiology, the study also showed that women were particularly badly affected and had an 81% increased risk for obstructive coronary artery disease if exposed to long-term air pollution.
“Even at exposure levels below current Canadian air quality standards, long-term air pollution was independently associated with more advanced coronary artery disease—suggesting current regulations may not be fully protective and that air pollution belongs alongside blood pressure, cholesterol and smoking as a modifiable cardiovascular risk factor,” said lead author Kate Hanneman, MD, associate professor at the University of Toronto, in a press statement.
The study included 11,128 people who underwent cardiac computed tomography (CT) scans who also had available data for air pollution exposure for around 10 years. The average age was 60 years and 52% were men.
In the cohort, median 10‑year exposures were 7.5 μg/m³ for PM2.5, a common measure of particulate air pollution and 13.4 ppb for nitrogen dioxide. These levels are relatively low compared with many historical and low‑/middle‑income settings but still above the latest World Health Organization guideline of 5 μg/m³ for PM2.5 and 5.3 ppb for nitrogen dioxide.
For each addition increment of PM2.5 (1 μg/m³) people in the study had had about 11% more calcium in their coronary arteries and 13% higher odds of having more atherosclerotic plaque. For each increment of nitrogen dioxide (1 ppb) small but measurable increases in calcium (aprx 1%) and plaque (about 4%) were seen in the coronary arteries of those exposed.
After taking into account age, risk factors, medicines, and other differences, each increment higher long‑term air pollution was linked to more severe, artery‑narrowing heart disease in women, but not in men. Each increment increase in PM2.5 was associated with an 80% higher chance of women having a dangerously narrowed coronary artery and each increase in nitrogen dioxide a 6% increased chance.
There was a similar trend in men, but it was not statistically significant after correcting for possible confounding factors.
“These findings add to the growing body of evidence identifying air pollution as a modifiable risk factor for atherosclerosis,” conclude the authors.
“Considering the epidemiologic data linking air pollution to cardiovascular events, these results reinforce the urgency of global public health initiatives aimed at improving air quality to reduce cardiovascular risk.”
The post Exposure to Moderate Air Pollution Raises Cardiovascular Disease Risk appeared first on Inside Precision Medicine.
A highly anticipated Phase III clinical trial has delivered mixed results in testing whether a blood-based test for minimal residual disease (MRD) could guide early treatment for colorectal cancer recurrence (CRC).
Published in Nature Medicine, the randomized double-blind ALTAIR trial tested whether trifluridine/tipiracil (FTD/TPI) could improve outcomes in patients with resected stage I–IV CRC who tested positive for Natera’s Signatera circulating tumor DNA (ctDNA) test after completing standard therapy but had no radiographic evidence of disease. However, the Phase III study—a collaboration between Natera and several Japanese research institutions and hospitals—failed to meet its primary endpoint for investigator-assessed disease-free survival (DFS).
The findings represent the first completed randomized Phase III “treat-on-molecular-recurrence” (TOMR) trial in CRC and underscore both the promise and limitations of ctDNA-guided intervention strategies, highlighting both the promise and limitations of precision oncology.
In the ALTAIR trail, researchers from the National Cancer Center Hospital East in Kashiwa, Kansai Medical University in Osaka, and NHO Osaka National Hospital evaluated a small subset of patients from a larger clinical trial called the CIRCULATE-Japan GALAXY study. Between June 2020 and June 2023, the GALAXY study enrolled 5,514 patients with resectable stage 0–IV CRC across 152 centers in Japan and Taiwan. The GALAXY cohort and other datasets have consistently shown that postoperative ctDNA positivity is associated with markedly increased recurrence risk. ALTAIR addressed the next critical question: whether intervening at the point of molecular relapse alters clinical outcomes.
Among the 1,104 patients who tested positive for ctDNA following surgery in the GALAXY study, 243 were included in the ALTAIR trial, where they were randomly assigned to either six months of FTD/TPI or a placebo. With a median DFS of 9.3 months in the FTD/TPI arm compared to 5.5 months with a placebo, there was a 21% decrease in the risk of recurrence (HR 0.79; 95% CI 0.60–1.05). The difference did not, however, reach statistical significance (P=0.107).
Although the primary endpoint was formally negative, several exploratory analyses suggested biologic activity. Six-month DFS was 70.5% with FTD/TPI versus 45.5% with placebo, indicating an early separation of the survival curves. The benefit, however, decreased over time, with recurrence curves converging by around 24 months—a trend that aligns more with delayed recurrence than with the lasting elimination of residual disease.
The strongest signal emerged in patients with resected oligometastatic stage IV disease. In this subgroup, FTD/TPI reduced the risk of recurrence or death by 47% (HR 0.53; P=0.012). Investigators noted that stage IV patients also had the highest baseline ctDNA burden, suggesting that molecular tumor load may influence responsiveness to MRD-directed therapy.
A post hoc blinded central radiology review also shifted the primary analysis into nominal statistical significance. After adjudication of discordant imaging events, median DFS was 9.2 months with FTD/TPI versus 5.5 months with placebo (HR 0.75; P=0.0406). However, because the analysis was exploratory and non-prespecified, investigators emphasized that it does not alter the trial’s formally negative outcome.
The ctDNA dynamics themselves proved highly prognostic. Patients achieving sustained ctDNA clearance had dramatically superior outcomes compared with those with transient or persistent positivity. In patients with sustained clearance, median DFS was not reached, while it was 11.8 months for those with transient clearance and only 4.4 months for patients with persistently detectable ctDNA.
Notably, spontaneous or transient ctDNA clearance occurred in a subset of placebo-treated patients, highlighting an emerging challenge in MRD-directed oncology: distinguishing biologically meaningful ctDNA positivity from low-level fluctuation or transient shedding.
The study also raises important questions regarding treatment intensity in asymptomatic patients with molecular relapse alone. Toxicity with FTD/TPI was substantial. Grade ≥3 adverse events occurred in 73% of treated patients versus 3.3% with placebo, driven primarily by hematologic toxicity. Severe neutropenia occurred in 56.6% of patients receiving FTD/TPI, and more than one-third required dose reductions. Despite these toxicities, no treatment-related deaths or new safety signals were observed.
The ALTAIR data arrive amid broader uncertainty regarding ctDNA-guided treatment escalation in CRC. The recent DYNAMIC-III trial similarly failed to demonstrate improved recurrence-free survival with ctDNA-guided intensification in stage III disease. Together, the studies suggest that while ctDNA robustly identifies high-risk patients, translating that prognostic information into effective therapeutic intervention remains challenging.
Still, the investigators argue that ALTAIR establishes the feasibility of large-scale MRD-directed trials and provides a framework for future studies using more active regimens, including immunotherapy combinations or anti-angiogenic strategies.
For now, the trial reinforces a central emerging reality in precision oncology: detecting molecular recurrence is increasingly possible. Preventing clinical relapse after detection remains the more difficult task.
The post First Phase III for Resected CRC ctDNA-Guided Therapy Shows Mixed Results appeared first on Inside Precision Medicine.
A new study published in Nature titled, “Distributed control circuits across a brain-and-cord connectome”, describes a complete wiring diagram of all the connections between neurons in the central nervous system of an adult fruit fly for translational applications.
The work was completed by an international team led by multiple labs at Harvard Medical School (HMS) and Princeton University. The team has made the entire connectome accessible online to propel research into complex behaviors and other fundamentals of the nervous system.
The fruit fly, Drosophila melanogaster, offers an effective model as they are easy to breed and maintain in the lab. Despite having a relatively simple nervous system made up of around 160,000 neurons, they exhibit complex behaviors such as navigation, social interaction, learning, and responding to sensory cues.
To build the connectome, the team used electron microscopy to produce millions of images of neurons and neural connections. AI tools aligned the images into a cohesive 3D map.
“It is really important to have a central nervous system connectome that is as complete as possible so we can link up the brain and body and start thinking about behavior holistically,” said Wei-Chung Allen Lee, PhD, associate professor of neurobiology at HMS and co-corresponding author on the study.
The connectome shows how each neuron connects in the brain and nerve cord at the synapse level. While the map doesn’t span the fly’s entire body, the team used identifiable neurons and literature review to connect the central nervous system to neurons in appendages and sensory organs.
The authors have already used the connectome to explore motor control. While a longstanding idea in neuroscience is for a centralized controller in the brain to make decisions about actions, the authors discovered that motor control in the fruit fly mostly occurs at a local level. For example, movement of a fly’s leg is primarily controlled by the neural circuits for that leg. The local circuits for one leg then communicates with other appendages to carry out complex coordinated movements, such as walking.
“The brain and nerve cord connectomes are each useful on their own, but until you can bridge the two, it’s hard to understand how information moves between the brain and the body,” said co-first author Helen Yang, PhD, a research fellow in neurobiology at HMS.
Looking ahead, the researchers plan to add more information to the connectome, including data describing neuropeptides, molecules that support neuron communication. Insights from the connectome may reveal fundamental principles about how nervous systems operate across species, including in humans.
The post Complete Connectome of Fruit Fly Central Nervous System Now Open-Source appeared first on GEN – Genetic Engineering and Biotechnology News.