Study links specific cell populations to patient risk in melanoma and liver cancer.
Adapting Behavioral Interventions for Dementia to Address NCDs and Mental Health
Conditions: Mental Health; Non Communicable Diseases; Dementia
Interventions: Behavioral: BECOME-D Intervention
Sponsors: Possible; University of California, San Francisco; National Institute of Mental Health (NIMH); Ministry of Health and Population, Nepal
Completed
Interventions: Behavioral: BECOME-D Intervention
Sponsors: Possible; University of California, San Francisco; National Institute of Mental Health (NIMH); Ministry of Health and Population, Nepal
Completed
MDMA Assisted Therapy for BN
Conditions: Bulimia Nervosa
Interventions: Drug: MDMA-AT; Drug: MDMA-AT-BN; Behavioral: Standard Treatment (ST)
Sponsors: Icahn School of Medicine at Mount Sinai
Not yet recruiting
Interventions: Drug: MDMA-AT; Drug: MDMA-AT-BN; Behavioral: Standard Treatment (ST)
Sponsors: Icahn School of Medicine at Mount Sinai
Not yet recruiting
Pilot Randomized Trial of BA-GSH in VA PC-MHI
Conditions: Depression
Interventions: Behavioral: Behavioral Activation-Guided Self-Help
Sponsors: VA Office of Research and Development
Not yet recruiting
Interventions: Behavioral: Behavioral Activation-Guided Self-Help
Sponsors: VA Office of Research and Development
Not yet recruiting
Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression : A Multicenter Randomized Controlled Trial
Conditions: Major Depressive Disorder (MDD); Probiotic Intervention
Interventions: Combination Product: Sertraline combined with Lactobacillus crispatus; Combination Product: Sertraline combined with placebo
Sponsors: First Affiliated Hospital of Chongqing Medical University
Not yet recruiting
Interventions: Combination Product: Sertraline combined with Lactobacillus crispatus; Combination Product: Sertraline combined with placebo
Sponsors: First Affiliated Hospital of Chongqing Medical University
Not yet recruiting
Transcranial Photobiomodulation (tPBM) for Somatic Symptoms in Treatment-Resistant Depression
Conditions: Treatment-resistant Depression (TRD); Major Depression Disorder
Interventions: Device: transcranial photobiomodulation
Sponsors: Taipei Veterans General Hospital, Taiwan
Recruiting
Interventions: Device: transcranial photobiomodulation
Sponsors: Taipei Veterans General Hospital, Taiwan
Recruiting
Photobiomodulation on Core Symptoms of Autism
Conditions: Autism
Interventions: Device: Photobiomodulation
Sponsors: Suez University
Not yet recruiting
Interventions: Device: Photobiomodulation
Sponsors: Suez University
Not yet recruiting
Internet addiction among nursing students: application of latent profile analysis and network analysis
BackgroundInternet addiction is widely reported and heterogeneous among nursing students. However, variable-centered approaches may not fully capture profile differences and core symptom patterns, potentially limiting precise interventions. Therefore, identifying distinct profiles and key symptoms is important for informing effective prevention.ObjectiveThis study aims to identify distinct internet addiction profiles among nursing students, explore the characteristics and core symptoms of these profiles, and investigate the factors associated with their variation.MethodsA cross-sectional survey was conducted among undergraduate nursing students from September to November 2025. Latent profile analysis (LPA) and network analysis were performed to characterize the patterns of problematic internet use across identified profiles.ResultLatent Profile Analysis revealed four distinct problematic internet use profiles: No-Problematic Internet Use Profile (17.895%), Low-Problematic Internet Use Profile (41.957%), Moderate-Problematic Internet Use Profile (26.676%), and High-Problematic Internet Use Profile (13.472%). Multinomial logistic regression identified gender, monthly household income, and physical activity as significant factors associated with profile membership. Network analysis highlighted central symptoms specific to each profile: Health-related problems (RP-IH) and compulsive internet use and withdrawal symptoms (Sym-C & Sym-W) exhibited the highest centrality within the Moderate- and High-Problematic Internet Use Profiles.ConclusionInternet addiction among undergraduate nursing students is a heterogeneous phenomenon that can be categorized into four distinct profiles. Our findings clarify key associated factors and identify central symptoms specific to each profile, potentially providing an empirical basis for nursing educators to develop targeted psychological interventions.
Shinya Yamanaka
Dr. Shinya Yamanaka is recognized for the generation of induced pluripotent stem cells (iPSCs) from fibroblasts by a combination of multiple transcription factors, and he won the Nobel Prize in Physiology or Medicine in 2012 jointly with Sir John B. Gurdon for this discovery. Twenty years after the discovery, the Cell Reports Medicine editorial team discusses with Dr. Yamanaka the scientific, technical, and translational milestones that have shaped the field of regenerative medicine. We also discuss the role of iPSCs in disease modeling and drug discovery, the interplay with genome editing, and ongoing issues that still prevent the widespread clinical application of iPSC-derived therapies.
The healthy human global project – Hong Kong: A community-based cross-sectional study of a healthy Asian population
A deeply phenotyped healthy Hong Kong cohort reveals age- and sex-dependent immune, clinical, and lifestyle variation, highlighting population-specific differences and the need to extend systems immunology frameworks beyond European ancestry.