Tag: News Approved

Posted on

In Memoriam: Judith L. Rapoport, MD

Dr. Judith L. Rapoport has left an indelible mark on the field of obsessive compulsive disorder (OCD) — not only through her extraordinary scientific contributions, but through the compassion, curiosity, and humanity she brought to her work. For countless individuals and families, her legacy is not just measured in research breakthroughs, but in hope restored and lives changed.

At a time when OCD was widely misunderstood, often hidden, and rarely discussed, Dr. Rapoport helped bring it into the light. Through her pioneering work at the National Institute of Mental Health, she gave shape and voice to a condition that many struggled to name. She was among the first to recognize that OCD could affect children, and that these young people deserved understanding, accurate diagnosis, and effective care. This insight alone transformed the trajectory of the field and opened doors for earlier intervention and support for families who had long felt alone.

judith-rapoport-silver-spring-md-obituary

What set Dr. Rapoport apart was not only her intellect, but her deep commitment to the people behind the science. She approached each question with both rigor and empathy, helping to establish treatments that have since become the gold standard, including exposure and response prevention (ERP) and medication. Her work helped shift the narrative—away from blame or misunderstanding, and toward recognition of OCD as a real, treatable medical condition.

Beyond the lab and clinic, Dr. Rapoport had a rare gift for storytelling. Her book, The Boy Who Couldn’t Stop Washing, brought readers into the lived experience of OCD with clarity and care. For many, it was the first time they saw their own struggles reflected with such honesty and dignity. It helped families feel seen, understood, and less alone — an impact that continues to ripple outward today. The Boy Who Couldn’t Stop Washing impacted professionals as well, providing an eye-opening introduction and gateway to the world of working with OCD.

For these accomplishments and more, Dr. Rappaport received the IOCDF’s 2018 Career Achievement Award. Her influence extends through the many clinicians and researchers she has mentored, each carrying forward her dedication to both excellence and empathy. Through them, her work continues to grow, shaping the future of OCD research and care in ways that are both profound and deeply human.

To honor Dr. Judith Rapoport is to honor a career defined not only by discovery, but by kindness and purpose. She helped the world better understand OCD — but more importantly, she helped people living with OCD feel understood. And in doing so, she changed lives in ways that will endure for generations.

The post In Memoriam: Judith L. Rapoport, MD appeared first on International OCD Foundation.

Posted on

The Mental Health Commission of Canada is pleased to welcome Shauna Cronin

The Mental Health Commission of Canada is pleased to welcome Shauna Cronin (she/her) as our new Vice President, Programs, effective April 27, 2026.

Shauna brings nearly two decades of national leadership in mental health system transformation, program design, and policy innovation. Her experience spans complex, multi‑partner initiatives across governments, communities, and lived and living experience networks, with notable contributions through organizations such as CAMH, Frayme, Stepped Care Solutions 2.0, and the Global Leadership Exchange.

A widely respected and internationally recognized leader, Shauna is known for turning bold vision into measurable impact. Her work has consistently advanced equity, strengthened service integration, and elevated Canada’s leadership in mental health, while meaningfully valuing First Nations, Inuit, and Métis voices as part of an ongoing reconciliation journey.

Shauna holds advanced degrees in political science, strategic communications, and international affairs, is currently pursuing a Master’s in Nonprofit and Philanthropic Leadership, and holds a Health Leadership designation from the Rotman School of Management. She brings a rare combination of deep policy insight, collaborative systems leadership, and a genuine commitment to people and outcomes.

We look forward to the perspective, care, and leadership Shauna will bring as she joins our exceptional Programs team and helps advance mental health and well-being across Canada.

The post The Mental Health Commission of Canada is pleased to welcome Shauna Cronin appeared first on Mental Health Commission of Canada.

Posted on

Speech in noise prediction by use of cortical auditory evoked potentials in normal hearing and sensorineural hearing loss: a systematic review

IntroductionSpeech perception in noise (SPiN) is a critical challenge for individuals with sensorineural hearing loss (SNHL), and current behavioral assessments can be unreliable in populations with language barriers or cognitive impairment. Cortical auditory evoked potentials (CAEPs) can serve as a supplementary measurement as they often show strong correlations with SPiN outcomes across diverse hearing profiles.MethodsFollowing PRISMA and SWiM guidelines, this systematic review includes studies from PubMed, Web of Science, and Scopus databases that examined the relationship between non-task related CAEPs and SPiN outcomes in adults with normal hearing, SNHL, or cochlear implants.ResultsSixteen studies were included, encompassing 238 participants with SNHL and 204 participants with normal hearing. Across studies, N1 latency, P2 latency, and N1-P2 amplitude of the onset CAEP and acoustic change complex (ACC) are most consistently correlated with SPiN performance, particularly in sentence-based tests. The mismatch negativity (MMN) showed limited predictive value, as findings varied by age and hearing status. A meta-analysis was not conducted due to methodological heterogeneity.ConclusionOnset CAEP and ACC N1 and P2 latencies together with N1-P2 amplitudes particularly demonstrate potential as electrophysiological indicators of SPiN performance. Their clinical utility is promising for populations where behavioral testing can be unreliable, such as CI users or individuals with cognitive or language barriers. However, standardization of protocols and further longitudinal research are needed to validate their application in clinical settings.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD42023404158, identifier PROSPERO (CRD42023404158).
Posted on

MTCL2 Is Essential for the Bipolar-to-Multipolar Transition in the Dendrite Extension of Cerebellar Granule Neurons

The dynamic regulation of neuronal polarity is essential for the formation of neural networks during brain development. Primary cultures of rodent neurons recapitulate several aspects of this polarity regulation, providing valuable insights into the molecular mechanisms underlying axon specification, dendrite formation, and neuronal migration. However, the process by which the preexisting bipolarity of migrating neurons is disrupted to form multipolar dendrites remains to be elucidated. In this study, we demonstrate that MTCL2, a microtubule-crosslinking protein associated with the Golgi apparatus, plays a crucial role in this type of polarity transformation exhibited by cerebellar granule neurons (CGNs) in mice of either sex. MTCL2 is highly expressed in CGNs and gradually accumulates in dendrites as the cells develop polarity. MTCL2 knockdown inhibited the bipolar-to-multipolar transition of dendrite extension observed in their differentiation in vitro as well as in vivo. During this transformation, the Golgi apparatus shifts from the base of the preexisting bipolar neurites to the lateral or apical side of the nucleus in the cell body. There, it forms a close association with the microtubule cage that wraps around the nucleus. The resulting upward extension of the Golgi apparatus is tightly coupled with the randomization of its position in the x–y plane. Knockdown and rescue experiments demonstrated MTCL2 promotes these changes in the Golgi position in a microtubule- and Golgi-binding activity-dependent manner. These results suggest that MTCL2 promotes the development of multipolar short dendrites by sequestering the Golgi apparatus from the base of the preexisting neurite into the microtubule cage.

Posted on
<![CDATA[A new US Department of War backed phase 2a study will test BXCL501’s efficacy in easing acute stress reactions and preventing PTSD.]]>
Posted on

Prefrontal and hippocampal microstructural gray matter following cognitive training under moderate hypoxia in mood disorders: a randomized controlled trial

BackgroundCognitive impairment persists during partial or full remission in 50–70% of individuals with mood disorders and impacts daily functioning and clinical prognosis. Preclinical evidence suggests that extended exposure to moderate hypoxia, combined with motor-cognitive learning, may elevate neuroplasticity and improve cognition. In these individuals with remitted mood disorders, we found that cognitive training under repeated moderate normobaric hypoxia improved executive function, and here investigate neurobiological mechanisms.MethodsParticipants with major depressive disorder (MDD) or bipolar disorder (BD) in partial or full remission were randomized to 3 weeks of 3.5-h daily normobaric hypoxia (12% O2) combined with cognitive training five to 6 days per week or treatment-as-usual (TAU). Participants were assessed with cognitive tests and diffusion-weighted MRI at baseline and 1 month after treatment completion (week 8) as part of the ALTIBRAIN trial (ClinicalTrials.gov: NCT06121206). Prefrontal and hippocampal gray matter microstructure were modelled with Neurite Orientation Dispersion and Density Imaging (NODDI).ResultsFifty-seven participants (mean age 39 years, SD: 13, 70% female) with baseline MRI data were included. No significant effects of hypoxia-cognition training vs. TAU on neurite density index (NDI) or orientation dispersion index (ODI) were observed in either the prefrontal cortex or hippocampus (all p-FDR ≥ 0.832). No significant associations were observed between microstructural changes and changes in cognitive function in either region (all p-FDR ≥ 0.721). At baseline, microstructure in both regions was not associated with executive function or global cognition (all p > 0.40).ConclusionThe absence of detectable microstructural changes, despite selective improvements in executive function, indicates that NODDI-derived metrics did not capture structural correlates of the cognitive response to hypoxia-cognition training. Whether this reflects functional neural mechanisms, measurement insensitivity, or the timing of the single follow-up assessment remains to be determined. Future studies should incorporate multiple imaging time points to capture the dynamic trajectories of putative microstructural brain changes.