VOCALE LBD: Online Peer Support for Caregivers of People With Lewy Body Dementia

Conditions: Lewy Bodies Disease; Depression Disorder; Caregiver Burden; Caregivers

Interventions: Behavioral: VOCALE LBD: Virtual Online Communities for Aging Life Experiences: Lewy Body Dementia; Other: Standard of Care Educational Materials

Sponsors: University of Washington; National Institute of Mental Health (NIMH); The Lewy Body Dementia Association (LBDA); National Institute on Aging (NIA); National Institutes of Health (NIH)

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Intellectual-cultural orientation of family environment and adolescent depressive symptoms: the mediating role of game addiction

IntroductionExisting data indicate that an increasing number of adolescents are becoming addicted to online games, while the prevalence of depressive symptoms within this demographic is also on the rise. Depression is a primary comorbidity associated with game addiction, but the influencing factors and mechanisms remain unclear. This study aims to explore the mediating role of game addiction in the relationship between the intellectual-cultural orientation of family environment and adolescent depressive symptoms.MethodsA cross-sectional study was conducted on 1,105 pairs of mothers and adolescents in a high school in Henan Province, China, through online investigation from November 17, 2021 to December 11, 2021. The intellectual-cultural orientation, game addiction and adolescent depressive symptoms were measured by the subscale of Intellectual-cultural orientation in Family Environment Scale, Game Addiction Scale for Adolescents and Children’s Depression Inventory respectively. The SPSS PROCESS macro 3.3 software was used to analyze the mediating effect.ResultsThe findings revealed that Intellectual-cultural orientation was negatively correlated with both adolescent game addiction and depressive symptoms. Game addiction served as a significant mediator between Intellectual-cultural orientation and depressive symptoms in adolescents. Furthermore, gender and annual household income significantly associated with the strength of the mediating effect of game addiction on the relationship between Intellectual-cultural orientation and adolescent depressive symptoms. Specifically, boys and adolescents from low-incomefamilies were more likely to suffer from game addiction.DiscussionThese findings suggest that future family based interventions aimed at preventing adolescent depression should specifically target the reduction of game time, particularly among boys and adolescents from low-income families.

A neural signature to predict attention shifting delays in children and adults

Nature Neuroscience, Published online: 08 June 2026; doi:10.1038/s41593-026-02295-z

Moment-to-moment lapses in attention shifting impair behavior and learning. These lapses are common in individuals with neurodevelopmental disorders involving attention deficits. We identify a neural signature that predicts delayed performance on a set-shifting task and show that real-time closed-loop neuromodulation can prevent lapses and improve performance.

Health workers at the epicenter of Congo’s Ebola outbreak labor with little pay or rest

MONGBWALU, Congo — Dr. Richard Lokudu, the medical director of Mongbwalu General Referral Hospital, has received barely any compensation for his work on the front line of one of Congo’s deadliest Ebola virus outbreaks.

Lokudu and several of his colleagues work all day at the hospital treating an influx of patients. Notifications of suspected cases come even late at night.

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