Single-cell spatial pharmacobiology for imaging antibody-based therapies in solid tumors

Nature Biotechnology, Published online: 08 June 2026; doi:10.1038/s41587-026-03171-8

We have developed single-cell spatial pharmacobiology (SSP), which combines in situ imaging of a systemically infused fluorescent therapeutic antibody with high-plex spatial proteomics. Applied to head and neck and pancreatic tumors from patients treated in phase 1 trials, SSP revealed marked spatial heterogeneity in antibody delivery and target engagement, which was shaped by conserved stromal barriers.

Effects of SGLT2 inhibition on incident heart failure in carriers of cardiomyopathy-associated genetic variants

Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04439-x

In a whole-exome sequencing analysis, the beneficial effects of the SGLT2 inhibitor dapagliflozin in reducing the risk of future heart failure hospitalization in individuals with type 2 diabetes were markedly greater in individuals who carried a cardiomyopathy-associated genetic variant compared with noncarriers, suggesting a personalized preventative therapy based on genetic information.

Post-adjuvant chemotherapy in ctDNA-positive patients with resected colorectal cancer: a randomized phase 3 trial

Nature Medicine, Published online: 08 June 2026; doi:10.1038/s41591-026-04428-0

In the randomized, double-blind phase 3 ALTAIR trial, patients with resected colorectal cancer who became positive for circulating tumor DNA during post-adjuvant surveillance received trifluridine/tipiracil hydrochloride therapy, which did not significantly prolong disease-free survival compared with placebo.

The Download: how the World Cup ball will fly and OpenAI’s “super app”

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Why this year’s World Cup ball may not fly as far

Much is new about this month’s FIFA World Cup tournament. It hosts more teams than ever before. It’s the first to occur in three different host countries. 

And, like every World Cup for over half a century, it will employ a football with a brand-new design.

Through wind-tunnel experiments, researchers found that long-distance kicks with Adidas’s new Trionda ball might not travel as far as they did in the past. The payoff is a more predictable flight path, something players have not always enjoyed from World Cup balls.

Find out how a few grooves and seams can change the way the game is played.

—Jenna Ahart

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 OpenAI plans to turn ChatGPT into a ‘super app’ before its IPO
The revamp would combine coding tools and AI agents. (Financial Times $)
+ The super app ambitions first emerged last year. (Fast Company)
+ OpenAI is also building a fully automated researcher. (MIT Technology Review)

2 Trump wants the US government to take a stake in AI companies
He will meet AI leaders to discuss the plan. (BBC)
+ Which would create “a partnership with the American public.” (Reuters $)
+ He wants a slice of the AI boom. (Axios)

3 Google has agreed to pay SpaceX $30 billion for AI computing power
The $920 million-a-month contract runs through June 2029. (NYT $)
+ Google will use about 110,000 Nvidia GPUs owned by SpaceX. (CNBC)
+ It comes days after Anthropic struck a SpaceX data center deal. (WSJ $)

4 AI is set to make everyday life more expensive
Its insatiable thirst for resources is likely to push up inflation. (WP $)
+ We did the math on AI’s energy footprint. (MIT Technology Review)

5 Europe is accelerating its withdrawal from US Big Tech
New analysis reveals dozens of moves to alternative providers. (Wired $) + Last week, the EU launched a “made in Europe” drive. (Reuters $)

6 ICE plans to give local police a new facial recognition app
It would allow them to verify a person’s immigration status. (404 Media)
+ Is the Pentagon allowed to surveil Americans with AI? (MIT Technology Review)

7 Silicon Valley’s lure is fading for India’s tech talent
Due to Trump’s immigration policies and AI-driven layoffs. (Rest of World

8 ‘Recursive self-improvement’ has sparked fears of AI escaping control
Nobody is sure about the consequences of RSI. (The Economist $)
+ Here are five ways that AI is learning to improve itself. (MIT Technology Review)

9 Gene-edited embryos are getting closer, but a key safety gap remains
Current techniques still fail to edit every cell. (New Scientist $)
+ “Base-edited baby” is one of our 10 Breakthrough Technologies for 2026. (MIT Technology Review)

10 NASA astronauts will wear high-tech Prada underwear on their moon trips
Ventilation tubes are knitted into the garments. (The Verge)

Quote of the day

“Chat is dead.” 

—A senior OpenAI employee tells the Financial Times why the company is shifting focus from chatbots to AI agents.

One More Thing

BETH HOECKEL


How AI is helping historians better understand our past

The digitization of historical records is making it possible to study the past in new ways. Historians are now using machine learning—particularly deep neural networks—to analyze everything from centuries-old astronomy textbooks to ancient Greek inscriptions.

The technology is helping researchers uncover new patterns in the historical record. But it also introduces risks, including the possibility that machine learning will slip bias or outright falsifications into our understanding of the past.

Read the full story on how AI is transforming the study of history.

—Moira Donovan

We can still have nice things

A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.)

+ Take a tour of extinct everyday objects to travel back to pre-smartphone life.
+ This a cappella cover of “I Want To Know What Love Is” nails the power-ballad drama.
+ Korea’s ingenious “one-a-day” banana packs are designed so each one ripens sequentially.
+ Casino dialogue has been synced over Looney Tunes footage in this unexpectedly perfect mashup.

STAT+: Combination of pancreatic cancer drugs from Tango, Revolution leads to high response rate

Revolution Medicines’ experimental pancreatic cancer drug has been the star of the oncology field in recent weeks, with new data showing the medicine produced unprecedented outcomes for patients. 

Its next act — this time as a co-lead — was revealed Monday.

Tango Therapeutics said that in an early-stage clinical trial, a combination of its drug vopimetostat along with Revolution’s daraxonrasib led to a durable responses in the large majority of pancreatic cancer patients who received both medicines. 

Continue to STAT+ to read the full story…

Why this year’s World Cup ball may not fly as far

Much is new about this month’s upcoming FIFA World Cup tournament, which will be held in the US, Canada, and Mexico. It hosts more teams than ever before. It’s the first to occur in three different host countries. And, like predecessor cups for over half a century, it will employ a soccer ball with a brand-new design.

One group of researchers that has been testing the physics of World Cup balls for the past 20 years recently studied this new entry, called the Trionda. Made by Adidas, the Trionda features four red, green, and blue panels textured with deep grooves and maple leaf, green eagle, and star emblems to represent the three host countries. Through wind-tunnel experiments, the research team found that this ball improves over previous versions in some ways, but long-distance kicks might not go as far as they did in the past. 

“The simple picture is that Trionda may very slightly punish extreme distance, but it should reward clean technique and predictable flight,” says team member John Eric Goff, who researches sports physics and is an incoming professor of engineering practice at Purdue University.  “Goalkeepers, defenders hitting long passes, and long-range shooters are where I would look first for visible differences.” 

Researchers used a wind tunnel to study the Trionda ball at the University of Tsukuba.
TAKESHI ASAI, SUNGCHAN HONG, AND RICHONG LIU

Adidas has been designing new balls for each World Cup since the 1970s. Some of the design changes in the first few decades were aesthetic: The 1986 ball featured graphics inspired by Aztec temples for the Mexico tournament, and 1994’s had space graphics in honor of the moon landing’s 25th anniversary. There were some structural differences too, such as upgraded foam cores and improved water resistance. But by and large, the balls used the same design of 32 pentagonal panels stitched together. 

That changed in the 2006 World Cup in Germany, when Adidas introduced the +Teamgeist ball. It featured just 14 curved panels, which were thermally bonded together rather than stitched. The design helped keep moisture out so the ball wouldn’t grow heavier throughout the game, Goff says. It was around this time that he started studying soccer balls. In the years since then, he and his colleagues have followed the transformations as Adidas has released balls with different surface textures and even fewer panels—design changes significant enough to affect game play. 

In-flight motion

Goff discovered early on that by analyzing a ball’s trajectory data, he could derive its drag coefficient—a number that determines the air resistance it experiences midflight at a given speed. Shortly after, he began working with a team in Japan to analyze how the World Cup ball’s in-flight behavior changes with each new design. 

The experiments, carried out at the University of Tsukuba in Japan, have been purposely consistent over the years because “maintaining continuity is important for comparing new data with historical data sets,” says Takeshi Asai, a professor there who works on the experiments. They entail attaching the ball to a metal rod connected to an instrument called a force balance, which measures aerodynamic forces such as drag and lift as the ball is exposed to the same wind speeds it would experience in a real soccer game—seven to 35 meters per second. 

The team tests the ball in different orientations, “but you can only do a few because the Trionda ball is $170,” Goff says, and each new test effectively destroys it. The experiments show the team how the drag coefficient changes with speed, and Goff then writes code to simulate the ball’s overall trajectory as it flies through the air.  

The team’s analysis has shown how recent World Cup balls evolved since the eight-panel Jabulani ball for the 2010 event. The Jabulani faced much criticism from players—particularly goalkeepers, who said it had a deceptive trajectory that “dipped wickedly,” as one player told the Guardian

Adidas JABULANI, official ball of the FIFA World Cup 2010

ALAMY
Adidas Brazuca Match ball for the 2014 World Cup

ADOBE STOCK
Trionda official 2026 FIFA match ball

TAKESHI ASAI, SUNGCHAN HONG, RICHONG LIU

The 2010 Jabulani ball (left) had eight panels and a smooth texture that translated into unpredictable performance. Later balls, like the 2014 Brazuca (center) and this year’s Trionda (right) have fewer panels but more roughness.

The ball had one key flaw: It was too smooth. Even though its drag coefficient was relatively low at high speeds, once the ball slowed to a certain point the coefficient would ratchet up, causing it to lose speed quite fast and behave as the 2010 players complained. This sudden transition—called the drag crisis—occurs at higher speeds for smoother balls, but with added texture like seams and grooves, the transition can be avoided until a ball reaches lower speeds. This allows the ball to travel farther and generally behave in a more predictable way during typical play. 

“It’s the same reason why golf balls have dimples and baseballs have those nice 108 double stitches. If those rough features of those balls were not there, you would not get anywhere near the kind of distance when those balls are thrown or hit that you see now,” Goff says. “There has to be some kind of a roughness on the ball to move this transition to a smaller speed.”

New grooves

Subsequent designs have been able to push the drag crisis to lower speeds, according to the analysis by Goff and his colleagues. The Brazuca ball used in 2014, for instance, has only six panels, but their total seam length is much longer, adding to the surface’s roughness. And this year’s Trionda ball contains just four panels, but each panel also has three deep grooves for more texture. 

There’s a trade-off to this roughness, though. While Goff and his colleagues found that the Trionda ball experiences the drag crisis at the slowest speed since 2010, its drag coefficient is also higher than that of the other balls at high speeds. That means that even though the most dramatic change doesn’t happen until the ball is moving quite slowly, the ball will still slow down faster than its recent predecessors during the faster portion of its flight. So the trajectories of long kicks may be a few meters shorter, Goff says. Adidas did not respond to a request for comment.

Fortunately, players in the upcoming World Cup should already be familiar with these added nuances, as they’ve had access to the new ball for at least a few months. The ball, Goff notes, is quite similar to Nike’s Flight ball in design, so players who’ve spent more time with that ball may have an added advantage. 

Meanwhile, Goff continues sending the group’s papers to his colleagues FIFA and Adidas in hope of providing some new insights, and he’s been sent balls by Adidas in the past. Adidas does perform its own unpublished tests of each new ball. The New York Times reported last year that the Trionda’s 3.5-year testing process included robotics designed to kick the ball at specific speeds as well as testing in seven of the 16 host locations. 

But as Goff sees it, soccer is “the world’s most popular sport, [this is] its most important tournament, and the most important piece of equipment in that tournament is this ball right here,” indicating the the Trionda ball that he had on camera with him during our Zoom call. “I think they’re interested in what some external testing looks like.”

When it’s time to save a limb, novel clinic meets unhoused people where they are 

BOSTON — Carlton Haynes hugged his left knee, pulling it toward his shoulder as hard as he could. He was desperate to blunt the pain shooting from an open, oozing wound on his right shin. Anahita Dua, a vascular surgeon leading an unusual clinic created by Massachusetts General Hospital that Saturday, told him he was going to the ER and then the OR, where she would remove damaged skin and treat the wound. 

Without this stopgap measure, she warned him, he’d almost certainly need amputation. OK, he said, but first he wanted a smoke. 

Read the rest…