Three things to watch amid Anthropic’s latest feud with the government

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For those of you enjoying your summer unaware of Anthropic’s latest feud with the US government, here’s a recap: In April the company said it had built an AI model called Mythos that was so good at working with code it could pose a global cybersecurity threat. Anthropic gave access to a small group of cybersecurity experts so they could see what they were up against. Then it released a modified version called Fable which it said was safer to the public on Tuesday, June 9. That Friday, the federal government told the company it was a threat to national security and placed export controls on the new release. Anthropic revoked access to both models hours later.

People worried about catastrophic effects of AI—broadly labeled “doomers”—have said for years that the technology poses a threat to humanity and published proposals for how the government should intervene in its development. The doomers just got their government intervention—not over a bioweapon or rogue AI, but in response to an AI model that’s basically just really good at coding. And the result so far looks less like a safety plan than like a superficial reaction.

There’s plenty to dissect about what happened in those few days that led to such drastic action from the government, and it’s notable that Amazon CEO Andy Jassy was the one who told government officials that Fable would be dangerous (Amazon is both invested in Anthropic and building its own competing AI models). It’s also possible this will be a short-lived ban from the government that doesn’t survive legal scrutiny (it’s not clear that Anthropic’s offering access to Fable really counts as “exporting” it, for example). 

But there are ripple effects happening already. 

For one, this is making a whole lot of people not want to rely on American AI companies. TheFrench politician Bruno Retailleau described it as a “wake-up call” that should motivate Europe to build more AI. But any vision of turning Paris into Silicon Valley—touted by many other European leaders following the shutdown of Anthropic’s models—is complicated by one big thing: China. 

Open-source models from China are very capable and incredibly cheap, and they can be downloaded to run on anyone’s servers with no rules or guardrails. (This makes them attractive to companies that don’t want access turned off on the basis of a decision from the White House—but equally attractive to cybercriminals, the type that Anthropic hoped to fend off by building safety guardrails into its models.) 

It’s possible that companies, including those in the US and Europe, will decide that working with Chinese models is just easier, as the skyrocketing of shares in the Chinese startup Zhipu suggests. Playing this forward, is it possible the government’s next drastic decision will be to say that US companies using models from China pose a threat to national security? I wouldn’t write it off. 

Second, it’s possible that shutting off access to Anthropic’s models will leave the country morevulnerable to cybersecurity attacks, not less. Leading cybersecurity experts have said as much in an open letter to the government, writing that access to Anthropic’s models was helping researchers prepare defenses, and that the company’s models are no more dangerous than other leading models that are widely available. Such is the risk of applying the concept of nonproliferation to software—trying to control and restrict dangerous AI models in the manner of the uranium used for nuclear weapons. 

The third thing worth watching is how US lawmakers will react. Remember that following Anthropic’s last feud with the government over how the Pentagon could or could not use its models, a slate of new bills was introduced that would define the limits of military AI.

Right now, the biggest players shaping how AI gets used are the companies and the White House. There’s been much talk about more federal AI regulation, and polling suggests most Americans want it. Lawmakers are still figuring out whether to form rules on how kids use chatbots and are far from a clear answer on the extent to which the government should vet the safety of AI models. But with every drastic action from the White House, the pressure for regulations rises.

To state the obvious, predictions are hard when the administration’s attitudes toward AI  change with the wind. When President Trump took office, he threw out the restrictive rulebook for how to make AI safe and promised to get out of the way of tech companies. The White House has now called the most valuable AI startup a risk to national security once in the spring, and again in summer. What will fall bring?

STAT+: FDA to launch pilot program to speed up early-stage clinical trials

WASHINGTON — Federal health officials announced a pilot program Monday to speed up early-stage clinical trials, which they say will reduce development timelines by six to 12 months, in hopes of encouraging U.S.-based trials and combating Chinese dominance in the field.

The pilot comes as the Food and Drug Administration, through the president’s 2027 fiscal budget, asks Congress to establish a permanent, faster process for the existing Investigational New Drug pathway. That proposal was championed by former FDA Commissioner Marty Makary before he resigned last month, though officials said on a Monday morning call that this program had been in the works since the start of the administration.

In a Fox News op-ed, health secretary Robert F. Kennedy Jr. wrote that the U.S. is “losing ground” against China in clinical research and touted the actions as a way to reverse that trend.

Continue to STAT+ to read the full story…

Confirmed Ebola cases in Congo outbreak top 1,000 with 254 deaths, authorities say

BUNIA, Congo — Confirmed cases in the Ebola outbreak in eastern Congo have reached 1,003, including 254 deaths, officials said, as tracing those who had been in contact with patients remains a major challenge.

A total of 100 people have recovered in the outbreak concentrated in the Ituri province since it was declared on May 15, Congo’s Ministry of Health said Sunday. At least 365 patients are in hospitals or in isolation, it said.

Read the rest…

<![CDATA[Pediatric experts link insomnia and mental health, favor CBT over sedatives, and warn against cannabis for sleep.]]>

Brain-Infiltrating T Cells Linked to Social Deficits in Autism Mouse Model

The prevalence of autism spectrum disorder (ASD) is roughly one in 36 people, with a male-to-female ratio of 4:1. The disorder is known to be influenced by multiple factors, both genetic (gene mutations and copy number variations) and environmental, such as infections during pregnancy. However, the role of immunity in genetic ASD remains unclear.

One area of interest lies in lymphocytes—cells that are known to shape neurodevelopment and behavior. But their roles in neurodevelopmental disorders are not well defined.

Now, new research shows that a subset of T cells—γδ T cells—can infiltrate the brain and contribute to changes in social behavior in a genetic mouse model that mimics behavioral features of ASD. Depleting these cells from the brain increased sociability, suggesting that targeting abnormal immune function during neurodevelopment may offer interventions for ASD.

This work is published in Science Immunology in the paper, “CXCL16-mediated recruitment of γδ T cells to the brain reduces sociability in mice.”

Infections during pregnancy can induce the release of interleukin-17A (IL-17A) from T helper 17 cells and γδ T cells. Prior research has linked this type of maternal immune activation to neurodevelopmental disorders, but there is a lack of evidence connecting IL-17A and social behaviors in genetic mouse models.

To investigate this further, a team of researchers from the Division of Allergy and Immunology in the Medical Institute of Bioregulation at Kyushu University, in Fukuoka, Japan, studied 15q11-13 duplication (15q dup) mice—a mouse model that mimics a chromosome duplication found in some humans with ASD. These mice also demonstrate reduced social interactions, behavioral inflexibility, and increased anxiety-like behaviors.

The team analyzed immune cell populations in the brains of the 15q dup mice. Their findings suggest an increase in γδ T cells in the developing brains when compared with wild-type mice.

Using single-cell RNA sequencing (scRNA-seq), the team uncovered that this was most likely due to microglia in the brain expressing the chemokine CXCL16, which promotes immune cell migration. CXCL16 was highly expressed in the brains of 15q dup mice and contributed to increased infiltration of γδ T cells.

In addition, experiments revealed that deleting IL-17A–producing γδ T cells or blocking them with antibodies after birth increased sociability and reduced anxiety-like behaviors in the 15q dup mice.

Taken together, the authors note that these findings suggest that “immune dysregulation contributes to social behavior deficits in 15q dup mice, consistent with observations in maternal immune activation models, and may represent a potential target for interventions for ASD-associated differences in social behavior.”

The post Brain-Infiltrating T Cells Linked to Social Deficits in Autism Mouse Model appeared first on GEN – Genetic Engineering and Biotechnology News.

<![CDATA[Phase 3 results show single-dose DT120 lysergide ODT delivers rapid, lasting relief in major depressive disorder with mild, transient adverse effects.]]>

STAT+: Another big deal, another sign biotech M&A is back

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Good morning! Pharma companies are on a biotech buying spree, an LSD pill just delivered unusually strong late-stage depression data, and the FDA reverses course of Regenxbio’s treatment.

Also: Today, thousands of industry players (and me!) are gathering in San Diego for BIO to talk deals, science, and whatever comes next. Check out the last item for a jaunt down memory lane about the conference.

Continue to STAT+ to read the full story…

The Download: record-breaking subsea tunnels and flexible data centers

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Inside the world’s deepest and longest subsea road tunnel

—Niall Firth

I’m currently around 1,000 feet beneath the North Sea, in a dark, dank cave. It smells weird. And I’m increasingly aware of the pressure from millions of tons of seawater just above my head.

I’m under the iconic fjords of Norway to visit what will soon become the world’s longest and deepest subsea road tunnel—an exceptional engineering feat that will carry drivers deep beneath the North Sea.

I’m here to understand how you make a 16.6-mile highway that sits 1,280 feet below the sea at its deepest point. And also—at a time when it can feel hard to get anything done—to reassure myself that ambitious engineering is still possible. That we can still make things. 

Step inside Norway’s Rogfast tunnel and see how engineers are making it happen.

This story is from the next edition of our magazine, which is all about engineering. Subscribe now to get a copy when it lands on Wednesday!

Want to get a data center online quickly? Give it some flex.

The AI boom is putting unprecedented pressure on the electric grid. But rather than rushing to build new power plants, companies could find part of the solution right under our noses—or, more precisely, in the transmission lines under our feet and above our heads.

If data centers can limit the power they draw during high-demand stretches, they won’t need to wait for big infrastructure upgrades or build their own off-grid generation.

The idea of flexibility isn’t entirely foreign to grid operators. But a new generation of software could make the process faster, smarter, and more precise for the AI era.

Find out how the challenge of powering AI could lead to a smarter, more flexible grid.

—Amos Zeeberg

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 SK Hynix has overtaken Samsung as South Korea’s most valuable company
It’s also now the world’s most valuable memory chipmaker. (Reuters $)
+  And one of the biggest beneficiaries of the global AI boom. (BBC)
+ AI’s need for memory chips is set to skyrocket device prices. (WSJ $)

2 Trump says he no longer views Anthropic as a national security threat
“Well, not now, but a week ago, maybe,” he told The Axios Show. (Axios)
+ He praised the response of Anthropic CEO Dario Amodei. (Reuters $)
+ Anthropic’s IPO outcome could depend on the midterms. (WSJ $)
+ A culture war tactic against Anthropic has backfired. (MIT Technology Review)

3 SpaceX has received the lowest possible ESG rating
Index provider MSCI gave the company a triple C. (Financial Times $)
+ Russia got the same score after invading Ukraine. (Business Times)
+ Elon Musk previously called ESG metrics the “Devil Incarnate.” (CNBC)

4 A Tesla on Autopilot allegedly crashed into a Texas home and killed a woman
The driver said his Tesla Model 3 was in self-driving mode. (NYT $)
+ Tesla’s AI trainers don’t trust its self-driving tech. (Reuters $)

5 Polymarket reportedly paid creators to post fake betting videos
Clips showed them winning big on bets they would have really lost. (WSJ $)
+ Polymarket bets on an Iran deal are fueling insider-trading fears. (Bloomberg $)

6 Physicists have proposed that black holes don’t exist
They may be something much stranger: “gravastars.” (404 Media)
+ This is the first ever photo of a black hole. (MIT Technology Review)

7 A daring space rescue mission is set to launch this week
A spacecraft will try to lift an observatory into a safer orbit. (Space)
+ We’re putting more stuff into space than ever. (MIT Technology Review)

8 Nothing’s next budget phone has been cancelled due to “RAMageddon”
The company said memory prices pushed costs too high. (The Verge $)
+ Buying a used phone makes more sense than ever. (Wired $)

9 A viral doomsday scenario aims to pierce Europe’s AI complacency
It envisions the US and China tearing Europe into pieces. (Guardian)

10 Scientists have invented a way to brew espresso with ultrasonic waves
No hot water required. (Wired $)

Quote of the day

“Even before we start reaping the benefits of AI in our devices, we are already paying the bill.” 

—Francisco Jeronimo, an analyst at IDC, tells CNBC that consumers are covering the costs of the ongoing memory shortage.

One More Thing

Bill Kirwa drives for Wasili, an Uber-style ridesharing company

BRIAN OTIENO


How mobile money supercharged Kenya’s sports betting addiction

As the lorry he’d flagged down lurched through Kenya’s western highlands, Bill Kirwa’s Infinix smartphone dinged with a notification. The bet of 3,500 shillings he’d placed with mobile money—then worth approximately $35—had just turned into nearly $8,500.

Kirwa, now 26, put the windfall to good use, purchasing a car that enabled him to drive for Wasili, an Uber-style ride-hailing service. But he continued gambling, and over time, his losses mounted. In just a few years, he’s effectively erased his big win.  

Kirwa’s experience is hardly unique. Across Africa, the rapid spread of smartphones and mobile money has fueled an explosion in online gambling. But nowhere is the craze as acute as it is in Kenya. Find out why.

—Jonathan W. Rosen

We can still have nice things

A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.)

+ A clever Bengal cat has seemingly learned to understand English—and talk back.
+ This list of the 100 greatest bird names lovingly captures the quirks of avian taxonomy.
+ Darth Vader’s weird chestplate transforms into a cassette player in these reworked Star Wars clips.
+ Trace the history and evolution of heavy metal music through the interactive genres and playlists of Map of Metal.

Bridging the gap from mechanism to clinic: a translational perspective on taVNS for gastrointestinal disorders

In recent years, multiple clinical and translational studies have investigated the application and mechanisms of transcutaneous auricular vagus nerve stimulation (taVNS) in gastrointestinal disorders (GIDs), with consideration given to pathophysiology, stimulation parameters, and patient-specific factors. In this review, we systematically synthesize recent evidence from clinical trials and preclinical models published in leading gastroenterology and neurology journals. Our focus is on taVNS-mediated modulation of the brain–gut axis, particularly its role in improving autonomic balance, reducing visceral sensitivity, and attenuating inflammatory responses, with the aim of enhancing therapeutic outcomes in functional and inflammatory GIDs. There is a need to optimize stimulation protocols through mechanistic insights and to promote the use of this non-invasive, well-tolerated neuromodulation approach. These advances are essential for expanding taVNS accessibility in clinical practice, especially for patients with refractory symptoms, comorbid psychological conditions, and in settings where conventional treatments are limited or contraindicated. Personalized taVNS strategies and biomarker-guided dosing represent emerging trends in neuromodulation therapy. However, standardized protocols and predictive models have yet to be established for widespread clinical implementation.

Paradoxical reflex bradycardia in paroxysmal sympathetic hyperactivity following traumatic brain injury: a case report

BackgroundParoxysmal sympathetic hyperactivity (PSH) is a devastating complication of traumatic brain injury (TBI), characterized by the simultaneous onset of various manifestations due to sympathetic overactivity. Paradoxical bradycardia, an uncommon manifestation of PSH, is poorly characterized, and there is limited evidence regarding its clinical features, pathophysiological mechanisms and targeted management.Case presentationA 25-years-old male sustained severe traumatic brain injury in a nighttime motorcycle collision with a parked vehicle and underwent multiple neurosurgical procedures. He developed typical PSH on day 48 post injury, with a Paroxysmal Sympathetic Hyperactivity Assessment Measure (PSH-AM) score of 27. On the 92nd day post-injury, the patient developed persistent resting bradycardia (40–66 beats/min) after cranioplasty, while a reduced maximum heart rate (140–159 beats/min) was noted during PSH episodes. He subsequently experienced an acute PSH episode with severe bradycardia (38–43 beats/min, PSH-AM score of 20). After excluding common predisposing factors, intravenous isoproterenol (initial dose 4 μg/min, titrated to 2 μg/min) was administered in combination with anti-PSH medication regimen, and the patient’s clinical symptoms were relieved. The patient was discharged in a stable condition and had no further episodes of bradycardia at the 3-months follow-up.ConclusionParadoxical bradycardia represents an atypical clinical phenotype of post-TBI PSH, likely mediated by an atypical Cushing reflex secondary to fluctuating intracranial pressure elevations during PSH exacerbations. Clinically, for TBI patients with unexplained bradycardia, potential primary causes should be actively explored, with particular attention to monitoring dynamic changes in intracranial pressure.