Scaling creativity in the age of AI

Storytelling is core to humanity’s DNA, stemming from our impulse to express ideals, warnings, hopes, and experiences. Technology has always been woven through the medium and the distribution: from early humans’ innovation of natural pigments and charcoals for cave paintings to literal representation by the camera.

The landscape of storytelling continues to shift under our feet. Social and streaming platforms have multiplied, audiences have fragmented, and our demand for fresh, unique media is insatiable. A recent McKinsey podcast cites that we are watching upwards of 12 hours of video content daily, often on multiple devices and multiple platforms.

All this content is expensive to produce: With a baseline budget of $150M, a Hollywood feature runs $1M per minute of finished film; prestige streaming content is in the hundreds of thousands per minute. And since consumers want to engage with authentic, original material, every company is now effectively a media company. That means we all face the same pressure: more content, with the same time and budget constraints.

There is no longer a question whether to use AI for content; the math doesn’t work any other way. What leaders need to focus on now is how to adapt responsibly, protect brand integrity, uplift team creativity, and build customer trust.

A few things worth holding onto as this era accelerates:

  • AI amplifies what’s already there, both good and bad. Weak strategy stays weak.
  • Responsible adoption means knowing what’s in your tools and models. Provenance and transparency are the foundation, not the finish line.
  • Scale without taste is just noise. Investing in your team’s judgment is what makes more content matter.
  • Fundamentals of great storytelling have not changed. Regardless of format or channel, what makes audiences lean in are still characters, arc, ingenuity, and surprise.

The permanent sprint

Creative teams are trapped on the endless hamster wheel of production, and it’s not slowing down. According to Adobe research, content demand will grow 5x over the next two years. Social content shelf life is now measured in hours, not weeks. Keeping fresh work in the pipeline is a permanent sprint, requiring teams to rethink how creative production functions.

The first move is freeing creative teams by having AI absorb the repetitive work so they have space for the strategic creative decisions that require human ingenuity. In a recent study from Adobe, 94% of creatives report that AI helps them produce content faster, saving an average of 17 hours per week. That recovered time is not a productivity metric; it is renewed creative capacity.

As a use case, Nestlé offers a useful blueprint. Its teams operate across 180 countries with a portfolio of iconic brands including Nescafé, KitKat, and Purina. Using Adobe Firefly Custom Models embedded in existing content workflows allows teams to generate assets in a brand-informed style without disrupting creative flow. At Nestlé, workflow cycle times dropped 50%. “With Firefly Custom Models, we can react at the speed of culture. It’s the closest thing we’ve had to magic.” says Wael Jabi, global strategic comms lead for KitKat.

As we move into the agentic era, the possibilities expand further. Adobe’s Creative Agent thinks in systems, not tasks, orchestrating across workflows, apps, and processes to close the gap between idea and execution, and get teams out of the production cycles that consume their productivity.

Build for your brand, not every brand

A company’s brand is how the world recognizes and connects with them. And it’s more than a collection of assets—it is dynamic, subjective, and expressed in thousands of micro-decisions made every day by the people who know it best. As production scales, keeping everything tuned to the brand gets more challenging. Off-the-shelf AI cannot replicate the level of nuance creative teams bring to content, and there’s a real cost to getting it wrong; diluting a brand in market with almost-right output is not an acceptable option. Customer trust is fragile.

Starting with a bespoke AI model built with Adobe Firefly Foundry addresses this directly. Firefly Foundry starts with a commercially safe base model and trains further on a company’s IP, making it possible to produce content that genuinely reflects the team’s vision.

And to ensure that Firefly Foundry models truly represent the creatives at the helm, Adobe has partnered with film studios like Wonder Studios, Promise.ai, and B5 Studios, and the “big three” talent agencies CAA, UTA, and WME to deeply understand what it means (and what it takes) to build an IP-immersive model that keeps creatives at the center as these film studios and talent agencies scale their visions. These brand ecosystems can accelerate nearly every phase of the production process, from ideation and storyboarding to production and promotion, all while preserving artistry and authorship. And to power the next generation of creativity and content, Adobe has recently announced a strategic partnership with NVIDIA, delivering best-in-class creative control along with enterprise-grade, commercially safe content at scale.

Generic AI gives teams a starting point. But a model trained on a brand’s own IP gets them to the finish line, while still leaving room for the creative calls that matter most.

When agents become the audience

AI is not only reshaping how we create; it is reshaping how customers find and engage with brands entirely. According to Adobe Digital Insights, AI-powered shopping has surged 4,700%. Agentic web traffic is up 7,851% year over year. Yet, most businesses still have significant gaps in AI-led brand visibility. If content is invisible to AI agents, then a brand is invisible to customers.

Major League Baseball is ahead of this curve. Using Adobe LLM Optimizer, the league monitors how its content surfaces across AI interfaces and makes real-time adjustments to maintain visibility. As fans search for tickets, stats, or game-day experiences, the league ensures its brand shows up wherever that search is happening. And with Adobe’s recent acquisition of Semrush, brand visibility goes even further.

The agentic web created an entirely new content surface that did not exist two years ago, and this exponential proliferation of content illustrates precisely why scaled, on-brand content production has become a strategic imperative. A well-built agentic foundation offers full visibility into (and control over) every piece of content, from production to performance.

How to prepare for AI integration

Here are a few steps to get started:

Audit before automation. Content supply chains usually include duplicated processes, unclear ownership, and assets living in many different places. Before AI can accelerate anything, develop a clear map of how content moves through the organization today: who creates it, who approves it, where it lives, and where it breaks down. AI applied to a broken process just breaks it faster.

Walk through workflows. Resist the urge to overhaul everything at once. Start with production tasks that are high-volume, low-stakes, and well-defined: asset resizing, localization, and background generation. Use those wins to build internal confidence before expanding into more complex creative territory.

Build responsible governance from the start. Governance added as an afterthought becomes a bottleneck. Building it in from the beginning creates a competitive advantage that lets teams move fast with confidence. And this means clear policies on model training, content provenance, human review thresholds, and communicating AI use to customers. The brands that earn lasting trust will treat transparency as a feature, not a footnote.

This content was produced by Adobe. It was not written by MIT Technology Review’s editorial staff.

Guarding biotech from China and big bets in longevity

On this week’s episode of “The Readout LOUD,” the hosts discuss STAT’s Breakthrough Summit West, where powerful leaders from health care and science rubbed shoulders. They share some of the juicy conversations and insights, including BridgeBio CEO Neil Kumar’s comments that the company is publishing  “not the right structures” in their research publications.

Listeners also will hear Allison’s interview with Joe Betts-LaCroix, CEO of the Sam Altman-backed longevity company Retro Biosciences. Retro is preparing for its first clinical data readout and examining just how much impact AI can have in drug development.

Read the rest…

<![CDATA[Unpack gaming, gambling, social media, and exercise addiction, spotlighting comorbid anxiety, withdrawal signs, and harm-reduction treatment.]]>

Functional brain alterations associated with acupuncture for chronic pain: a scoping review of fMRI studies

BackgroundChronic pain (CP) is a public health challenge recognized as involving large-scale functional brain dysregulation. Acupuncture is widely used as a non-pharmacological intervention for CP, yet its central mechanisms remain incompletely understood. fMRI provides an approach for investigating acupuncture-related brain alterations in CP.MethodsEight databases were searched from inception to March 27, 2025 for fMRI studies investigating acupuncture’s central effects in CP. Eligible studies included randomized controlled trials and observational studies involving migraine, knee osteoarthritis, fibromyalgia, sciatica, chronic shoulder pain, chronic neck pain, cervical spondylosis, chronic low back pain, and lumbar disk herniation. Data on characteristics, acupuncture protocols, neuroimaging findings, and outcomes were extracted and narratively synthesized. Reporting quality of acupuncture interventions was assessed using STRICTA, risk of bias of randomized controlled trials using RoB 2, and methodological quality of observational studies using the Newcastle–Ottawa Scale.ResultsA total of 64 studies were included. CP was characterized by widespread functional brain abnormalities, mainly involving the default mode network, sensorimotor network, and pain- and emotion-related regions such as the anterior cingulate cortex, precuneus, insula, and thalamus. Across longitudinal and controlled analyses, acupuncture-related brain changes were most consistently reflected in altered functional connectivity, local neural synchrony, and regional spontaneous activity. Functional connectivity findings suggested a potentially ACC-centered circuit pattern, whereas regional homogeneity findings revealed bidirectional modulation across multiple brain regions. Comparative evidence further indicated that VA, SA, and EEA may engage partially overlapping but distinct neural processes. Reporting of core acupuncture protocol components was generally adequate, whereas methodological quality remained heterogeneous.ConclusionCurrent fMRI evidence suggests that CP involves large-scale network-level functional imbalance and that acupuncture may be associated with modulation of key abnormal nodes and circuits related to pain perception, sensory processing, and emotional regulation. The available evidence supports a cautious interpretation that acupuncture-related brain effects may predominantly reflect a state-dependent recalibration of dysregulated brain networks. Future studies should prioritize large-sample, multicenter, longitudinal, and multimodal designs, together with rigorous control settings and more rigorous, externally validated machine learning-based prediction studies, to better distinguish differential central effects across intervention conditions and advance mechanism-informed personalized acupuncture in CP management.

A compressed sensing neuromorphic processor for sparse signal classification

This paper presents a neuromorphic processing system integrating a compressed sensing spiking neural network (CSSNN) designed for sparse signal classification. The proposed CSSNN combines data coding, data compression, and SNN classification, enabling end-to-end optimization of network performance and model compression. Evaluated on the MNIST, N-MNIST, and DVS Gesture datasets, under uniform compression ratios (CRs) of 0.1, 0.05, 0.025, and 0.01, the proposed CSSNN consistently reduces the total number of network operations (OPs) by at least 80% compared with compressed learning methods using fixed Gaussian random matrix (GRM) sampling matrices, while maintaining minimal accuracy loss. A specialized CSSNN processor is designed based on a spike-driven processing flow. Validated on field-programmable gate arrays (FPGAs) and evaluated in the 40 nm CMOS process for application-specific integrated circuit (ASIC) design, this CSSNN processor achieves 96.12% classification accuracy with 8-bit fixed-point quantization on the MNIST dataset. The energy consumption of the ASIC is estimated to be 2.089 mW under a 1.1-V supply voltage and 100 MHz frequency.

Structural connectome analysis using a graph-based deep model for prediction of non-imaging variables

We address the prediction of non-imaging variables based on structural brain connectivity derived from diffusion magnetic resonance images, using graph-based machine learning. We predict age and the mini-mental state examination (MMSE) score as examples of a demographic and a clinical variable. We propose a machine-learning model inspired by graph convolutional networks (GCNs), which takes a brain connectivity graph as input and processes the data separately through a parallel GCN mechanism with multiple branches. The novelty of our work lies in the model architecture, especially the Connectivity Attention Block, which learns an embedding representation of brain graphs while providing graph-level attention. We show experiments on publicly available datasets of PREVENT-AD and OASIS3. We validate our model by comparing it to existing methods and via ablations. This quantifies the degree to which the connectome varies depending on the task, which is important for improving our understanding of health and disease across the population. The proposed model generally demonstrates higher performance especially for age prediction compared to the existing machine-learning algorithms we tested, including classical methods and (graph and non-graph) deep learning.

Association between frailty and postoperative delirium after transcatheter aortic valve replacement: a meta-analysis

BackgroundPostoperative delirium (POD) is a common complication following transcatheter aortic valve replacement (TAVR) and is associated with adverse outcomes in older patients. Frailty, a multidimensional geriatric syndrome, has been increasingly recognized as a potential risk factor for POD. However, existing evidence remains inconsistent. This meta-analysis aimed to evaluate the association between frailty and POD after TAVR.MethodsA systematic search of PubMed, Embase, and Web of Science was conducted from inception to January 22, 2026. Cohort studies evaluating the association between preprocedural frailty and POD after TAVR were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a random-effects model accounting for the influence of potential heterogeneity.ResultsTen cohort studies involving 7,702 patients were included. Frailty was present in 2,062 (26.8%) patients, and 786 (10.2%) developed POD. Pooled analysis showed that frailty was significantly associated with an increased risk of POD after TAVR (OR: 2.17, 95% CI: 1.60–2.95; I2 = 55%). The association was stronger in studies with sample size ≥ 500 compared with < 500 (OR: 2.74 vs. 1.38; p for subgroup difference < 0.001). The effect estimates were consistent across subgroups stratified by study design, age, sex, frailty assessment methods, follow-up duration, analytic models, and study quality (all p for subgroup difference > 0.05). Notably, studies using CAM-ICU to diagnose POD showed a stronger association than those using DSM criteria or other methods (OR: 3.60 vs. 1.56 and 2.53; p = 0.006). Meta-regression identified sample size as a significant source of heterogeneity (p = 0.02).ConclusionsFrailty is associated with an increased risk of POD after TAVR. These findings highlight the importance of frailty assessment for perioperative risk stratification and support targeted strategies to prevent delirium in high-risk patients undergoing TAVR.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD420261352173.

Associations between serum tumor necrosis factor-alpha, hippocampal-prefrontal-ventricular volumes, and clinical profiles in schizophrenia: a biomarker and neuroimaging study in North Sumatera, Indonesia

IntroductionSchizophrenia is a neurodevelopmental disorder with systemic inflammation that is thought to play a role in its pathophysiology. The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) has been reported to be dysregulated in individuals with schizophrenia, but its relationship with brain volume changes remains inconsistent. This study aimed to analyze differences in TNF-α levels and brain volume (hippocampus, prefrontal cortex, and lateral ventricles) and their correlations in schizophrenia patients compared to healthy controls.MethodsThis analytical cross-sectional investigation was conducted on 50 schizophrenia patients and 50 healthy Batak controls at the Prof. M. Ildrem Provincial Mental Hospital, Medan. Serum TNF-α levels were measured by ELISA, while brain structure volume was measured by 1.5 T MRI and analyzed using AnalyzePro software.ResultsTNF-α levels in the schizophrenia group were significantly lower (3.35 pg/dl) than in the control group (16.90 pg/dl). No significant differences in hippocampal and prefrontal cortex volume were found between the groups. However, lateral ventricle volume was significantly larger in schizophrenia. Correlation analysis showed a weak negative relationship between TNF-α and prefrontal cortex volume only in the schizophrenia group.DiscussionThe finding of low TNF-α in schizophrenia supports the complexity of immune dysfunction in schizophrenia, which may be influenced by medication or disease phase. Consistent ventricular enlargement reinforces previous neuroanatomical findings. The association of TNF-α with the prefrontal cortex only within the schizophrenia cohort indicates a specific interaction between inflammation and brain morphology in this patient population.ConclusionsThe findings support TNF-α dysregulation in schizophrenia, albeit at lower levels. Lateral ventricular enlargement was consistently found, while changes in hippocampal and prefrontal cortex volume may be more subtle in this population. The negative correlation between TNF-α and the prefrontal cortex in schizophrenia suggests a potential role for inflammation in the pathology of this brain region.

Baseline working memory was associated with improvement in psychological quality of life in patients with persistent depressive symptoms: a prospective observational study

BackgroundCognitive dysfunction is prevalent in patients with depressive symptoms and contributes to impaired quality of life (QOL) and functional outcomes. However, the prognostic significance of specific cognitive domains for long-term outcomes remains unclear in patients with persistent depressive symptoms.MethodsIn this prospective observational study, 119 patients completed the detailed examination program in routine clinical care. Of these, 84 patients with persistent depressive symptoms provided consent for study participation and met the eligibility criteria for inclusion in the present study, including completion of the baseline assessment with the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV). The diagnostically heterogeneous cohort included patients with major depressive disorder/dysthymia as well as bipolar and related disorders. The World Health Organization Quality of Life Instrument, Short Version (WHO-QOL-26) and the World Health Organization Disability Assessment Schedule 2.0 were assessed at baseline, three, and six months; 60 participants provided 3-month follow-up data and 50 provided 6-month follow-up data. Primary hierarchical regression analyses were exploratory and conducted using complete-case data.ResultsAt baseline, participants exhibited relatively higher verbal ability and lower processing speed compared to normative data. While no significant group-level improvement in QOL was observed over six months and functioning did not improve overall, the WHODAS 2.0 standardized total score was temporarily higher at 3 months than at baseline. In exploratory analyses of complete cases, higher baseline working memory was significantly associated with greater improvement in the psychological domain of the WHO-QOL-26 at six months (β = 0.40; ΔR² = 0.14; p < 0.01). No other cognitive domains showed such associations.ConclusionsWorking memory was associated with subsequent improvement in psychological well-being and may represent a candidate prognostic marker in patients with persistent depressive symptoms. Given the exploratory nature and modest sample size, these findings require replication in larger, diverse populations.