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Expression of Concern for: Nicotine breaks down preformed Alzheimer’s β-amyloid fibrils in vitro
Expression of Concern for: “Nicotine breaks down preformed Alzheimer’s β-amyloid fibrils in vitro,” by Ono et al. (Biol Psychiatry 2002; 52:880–886); https://doi.org/10.1016/S0006-3223(02)01417-8.
Opinion: The podcast bringing together MAHA and public health for hard conversations
“These sides aren't talking to each other. And there's a lot riding on it”: The hosts of “Why Should I Trust You?” on bringing together MAHA and public health.
Optimism for Trump’s CDC pick is tempered by questions about RFK Jr.’s role
As one CDC employee, who asked not to be named, put it on Friday, among staff “the general vibe is guarded but hopeful.”
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The Download: bad news for inner Neanderthals, and AI warfare’s human illusion
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. The problem with thinking you’re part Neanderthal There’s a theory that many of us have an…
EEG-based stroke severity classification using higher-order topological features and graph convolutional networks
IntroductionElectroencephalography (EEG)-based stroke analysis has mainly relied on conventional signal and network descriptors, while higher-order brain network structures remain insufficiently characterized.MethodsWe used persistent homology to extract cycle-based topological features from EEG functional networks, capturing higher-order organization with reduced sensitivity to…
Cerebral blood flow and functional connectivity immediate changes following intradermal acupuncture in major depressive disorder
BackgroundAcupuncture has been increasingly applied as an adjunctive treatment for major depressive disorder (MDD), yet its central neurobiological mechanisms remain insufficiently understood. Cerebral blood flow (CBF) and functional connectivity strength (FCS) provide complementary perspectives on regional metabolic activity and large-scale…
Effect of low-intensity focused ultrasound on hippocampus of alcohol addicted mice: a preliminary study
Alcohol addiction is a chronic relapsing brain disorder characterized by significant neurobiological changes, particularly within the hippocampus, which mediates emotional regulation and reward-seeking behavior. Previous studies have shown that alcohol-induced neuronal injury contributes to withdrawal-associated anxiety and persistent alcohol preference.…
Transcutaneous auricular vagus nerve stimulation to alleviate metformin-associated gastrointestinal adverse events and optimize glycaemic control: a randomized, sham-controlled pilot trial protocol
BackgroundGastrointestinal adverse events (GI AEs) are the main dose-limiting side effects of metformin in type 2 diabetes mellitus (T2DM), reducing adherence and compromising long-term glycaemic control. Current strategies (dose adjustment or combination therapy) seldom address both tolerability and sustained metabolic…
The patterns of relapse and abstinence: using machine learning to identify a multidimensional signature of long-term outcome after inpatient alcohol withdrawal treatment
AimsA machine learning approach to identify a multidimensional signature associated with relapse and long-term outcome in alcohol dependence treatment.DesignIn this observational naturalistic study, inpatients with alcohol dependence received qualified detoxification plus CBT (Cognitive Behavioral Therapy) and were followed up 6-months…
Psychometric validation of the revised Chinese version of the Dimensional Anhedonia Rating Scale in psychiatric outpatients
ObjectiveTo refine the Chinese version of the Dimensional Anhedonia Rating Scale (DARS) and evaluate the psychometric properties of the Revised Chinese DARS (RC-DARS) in a large sample of first-visit psychiatric outpatients.MethodsThe study was conducted in two sequential phases at a…
Interoceptive dysfunction and its neural correlates in schizophrenia: protocol for a cross-sectional multimodal MRI study
BackgroundInteroception—the perception and integration of internal bodily signals—is fundamental to emotion regulation, bodily self-awareness, and predictive coding. Emerging evidence suggests that interoceptive disturbances may contribute to core psychopathological features of schizophrenia. Our research group recently conducted a systematic review and…
Electroconvulsive therapy in an adolescent with dissociative identity disorder and depression: a case report
BackgroundDissociative identity disorder (DID) is a psychiatric condition characterized by the existence of at least two distinct identities. This disorder often serves as a defense mechanism, a response to severe childhood trauma, aimed at protecting the individual from overwhelming emotions…
Anxiety among Chinese primary school teachers under the “double reduction” policy: prevalence and associated factors
ObjectivesThe implementation of the “Double Reduction” Policy in China has raised concerns about increased anxiety levels among primary school teachers. However, the prevalence of anxiety symptoms and the factors associated with them remain unclear. This study aims to investigate the…
Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments
Nature Biotechnology, Published online: 17 April 2026; doi:10.1038/s41587-026-03075-7Modular integration of bacterial strains expands the application range of whole-cell bioelectric sensors.
A roadmap to competitive preclinical packages
Nature Medicine, Published online: 17 April 2026; doi:10.1038/s41591-026-04345-2Should researchers avoid translational research in animals in favor of human or AI models? We argue that this debate should focus not on comparing species but instead on how experimental systems can be…
New gene-editing approaches for β-hemoglobinopathies
Nature Medicine, Published online: 17 April 2026; doi:10.1038/d41591-026-00021-7Three phase 1/2 trials show that direct editing of HBG1 and HBG2 promoters is a promising disease‑agnostic strategy for treating β‑hemoglobinopathies such as sickle-cell disease and β-thalassemia.
How robots learn: A brief, contemporary history
Roboticists used to dream big but build small. They’d hope to match or exceed the extraordinary complexity of the human body, and then they’d spend their career refining robotic arms for auto plants. Aim for C-3P0; end up with the…
The case for fixing everything
The handsome new book Maintenance: Of Everything, Part One, by the tech industry legend Stewart Brand, promises to be the first in a series offering “a comprehensive overview of the civilizational importance of maintenance.” One of Brand’s several biographers described…
STAT+: Cell therapy primed liver transplant patients to avoid organ rejection, small study shows
A few transplant patients in a small study were able to stop using immunosuppressive drugs, thanks to pre-transplant cell therapy.
Opinion: Don’t believe headlines saying that vaccine skepticism is widespread
Despite some headlines, a new poll does not show that most Americans no longer trust vaccines.
Opinion: Health care is not ready for the new era of AI-enabled cyberattacks
“When health care infrastructure is attacked and held for ransom by hackers, patients become real casualties,” writes Andrea Downing.