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10x Clinical Expansion Advances with CLIA Lab Plans, Cleveland Clinic Partnership
Traditionally focused on research tools for academic, government, and industry customers, 10x has moved this year to launch clinical collaborations with top-tier institutions—the most recent of which was announced last month with Cleveland Clinic.…
Blood Cancer Therapies Informed by Spatial Remodeling of Bone Marrow
An AI-based approach assesses disease severity in patients with myelodysplastic neoplasms (MDS), a form of blood cancer where one-third of patients progress to a more aggressive state called acute myeloid leukemia. The post Blood…
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Addendum: Neural anticipation of virtual infection triggers an immune response
Nature Neuroscience, Published online: 24 April 2026; doi:10.1038/s41593-026-02284-2Addendum: Neural anticipation of virtual infection triggers an immune response
Three reasons why DeepSeek’s new model matters
On Friday, Chinese AI firm DeepSeek released a preview of V4, its long-awaited new flagship model. Notably, the model can process much longer prompts than its last generation, thanks to a new design that helps it handle large amounts of…
STAT+: FDA to speed up review of three psychedelics as mental health treatments
Trump's embrace of psychedelics and cannabis is shaking up the GOP’s relationship with mind-altering substances.
STAT+: A biotech VC on what Eli Lilly saw in a struggling cancer startup for $3.2B
What did Eli Lilly see in a struggling biotech startup that made the pharma giant want to pay billions for it? Bryan Roberts has some answers.
STAT+: Utah medical board calls for immediate suspension of state’s AI doctor experiment
A Utah pilot to renew prescriptions using a bot faced backlash from the state's medical board, which called for an immediate suspension.
Odor-specific olfactory stimulation is associated with selective transcriptional changes and partial improvement of stress-evoked bladder overactivity in mice
Chronic psychological stress is known to induce functional and molecular alterations in central circuits regulating micturition. Here, we investigated whether odor-specific olfactory stimulation modulates stress-associated bladder dysfunction and related brain transcriptional responses. Female C57BL/6J mice were subjected to repeated water…
Vagus nerve stimulation as an anti-inflammatory therapy for maternal immune activation-induced alterations in offspring microglia and neurodevelopment
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder caused by a combination of genetic and environmental factors. With the increasing prevalence of ASD diagnosis, it is crucial to understand the mechanisms behind preventable causes, such as prenatal infections, and…
Toward an NGF-based therapy for Rett syndrome
Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by mutations in the MECP2 gene. Although recent therapeutic advances, such as the approval of Trofinetide, offer partial relief, no comprehensive curative treatment is currently available. Among the emerging strategies,…
Impact of extremely low frequency electromagnetic fields exposure on sleep quality and mental health in a Tunisian power plant: a cross-sectional study
IntroductionExtremely low-frequency electromagnetic fields (ELF-EMFs) are ubiquitous in our daily life. They may have an impact not only on physical health but also on mental health.ObjectivesTo assess the impact of occupational exposure to the ELF-EMFs on sleep quality, depression, anxiety…
Associations of psychological distress, gaming motives and internet gaming disorder in adolescents: a network analysis
Background and objectiveThe rapid popularization of the Internet among Chinese adolescents has resulted in the emergence of a public major concern known as Internet Gaming Disorder (IGD). As demonstrated by previous studies, an association has been demonstrated among emotional distress,…
Sex-specific impact of vitamin D and B9 concentrations on neuroticism: a polygenic score-based study
IntroductionNeuroticism is a personality domain with prognostic value for physical and mental health. To properly inform public health policy, it is crucial to uncover the mechanisms underlying high neuroticism. Many internal and external factors that affect brain development and functioning…
Mental health in the time of polycrisis: geopolitical determinants and modern psychiatry
Psychiatry is increasingly being practised in environments affected by geopolitical instabilities, including economic fragmentation, democratic backsliding, and widening inequities. The confluence of these phenomena contributes to what has been described as a contemporary polycrisis, encompassing synchronous disruptions that reinforce one…
Adult attachment and intimate relationship satisfaction among university students: the chain mediating roles of appreciation and sense of giving
BackgroundSatisfying intimate relationships are fundamental to young adults’ psychological well-being. Although adult attachment theory provides a robust framework for understanding relationship quality, the mechanisms linking higher attachment anxiety and avoidance to lower relationship satisfaction remain underexplored. This study tested a…
The value of patient-focused drug development
Nature Medicine, Published online: 24 April 2026; doi:10.1038/s41591-026-04364-zThe value of patient-focused drug development
Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial
Nature Medicine, Published online: 24 April 2026; doi:10.1038/s41591-026-04354-1In a biomarker-driven trial evaluating radiotherapy with erlotinib, everolimus or dasatinib in patients with newly diagnosed diffuse intrinsic pontine glioma, the primary endpoint of overall survival was not met, but features associated with…
Cross-reactive anti-prophage antibodies and bacterial heteroresistance implicated in phage therapeutic failure
Nature Medicine, Published online: 24 April 2026; doi:10.1038/s41591-026-04301-0A 22-year-old patient with cystic fibrosis and chronic, drug-resistant Bordetella bronchialis infection received compassionate-use phage therapy. Serum samples revealed that pre-existing antiphage immunity existed before treatment, indicating that future studies must evaluate antiphage…
From the discovery of GLP-1 to today’s diabetes/obesity therapy and beyond
Glucagon-like peptide-1 was discovered as an insulinotropic peptide from the gut during a search for candidates for the incretin effect. It turned out to also inhibit glucagon secretion and is now considered an important regulator of glucose metabolism. In further…
Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo
Nature Neuroscience, Published online: 24 April 2026; doi:10.1038/s41593-026-02247-7By studying 23 neurodevelopmental disorder genes across model systems and brain cell types, the authors uncovered shared downstream effects that converge on synaptic biology, epigenetic regulation and mitochondrial function.
The Download: supercharged scams and studying AI healthcare
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. We’re in a new era of AI-driven scams When ChatGPT was released in late 2022, it…
Health-care AI is here. We don’t know if it actually helps patients.
I don’t need to tell you that AI is everywhere. Or that it is being used, increasingly, in hospitals. Doctors are using AI to help them with notetaking. AI-based tools are trawling through patient records, flagging people who may require certain…