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Macmillan and ORCHA launch app library for cancer patients
Macmillan and ORCHA have launched a digital health app library to help cancer patients assess apps to support them throughout their care.
Development and Usability Evaluation of an E-Learning Tool for Blended Learning in Pediatric Endocrinology: Formative Pilot Study
Background: Residents in pediatric endocrinology subspecialty units encounter diverse educational scenarios spanning theory, skills, and attitudes; yet, brief residencies frequently limit their exposure to certain clinical cases. Research in medical education demonstrates that e-learning…
A 2-Tiered Rescue Protocol to Mitigate Difficulty-Based Failures of ChatGPT (GPT-5) and Gemini on the German M2 Medical Examination: Evaluation Study
Background: Large language models (LLMs) have demonstrated expert-level performance on medical licensing examinations, but most benchmarks focus on final accuracy. Critical gaps remain in understanding model efficiency (latency), the efficacy of tiered “rescue” protocols…
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Transcutaneous auricular vagus nerve stimulation for paroxysmal sympathetic hyperactivity syndrome after intracerebral hemorrhage: a hypothesis-generating case report
ObjectiveTo observe the clinical effect of transcutaneous auricular vagus nerve stimulation (taVNS) in drug-refractory paroxysmal sympathetic hyperactivity (PSH).MethodsThis case report describes the clinical course of a 63-year-old male with PSH following intracerebral hemorrhage. PSH episodes were characterized by tachypnea, tachycardia,…
Functional methods for evaluating the efficacy of retinal optogenetic therapy for vision restoration
Optogenetic therapy is a promising strategy for vision restoration. Functional assays have an important role in assessing the modulation of neural activity in response to light stimulation. Each functional assay needs to be carefully considered and evaluated for the preclinical…
Speech recognition performance with dual-microphone audio processors in mandarin-speaking cochlear implant users
BackgroundCochlear implant (CI) audio processor upgrades have demonstrated speech recognition benefits in non-tonal language populations, but high-level evidence for native Mandarin-speaking CI users (a tonal language with unique signal processing requirements) remains critically limited. This study aimed to assess the…
Cortical activity during cognitive and walking tasks in individuals with chronic nonspecific low back pain: a functional near-infrared spectroscopy study
IntroductionPrevious research demonstrates that individuals with chronic nonspecific low back pain (CNSLBP) exhibit changes of gait patterns. However, the neural mechanisms responsible for these adverse events remain unelucidated. In this study, we used functional near-infrared spectroscopy (fNIRS) to investigate cortical…
Intracerebroventricular diphtheria toxin causes off-target toxicity in CD11b-DTR and wild-type mice, revealing limitations of DTR-based depletion studies
Diphtheria toxin receptor (DTR)–based depletion models are widely used to study microglial and macrophage function, yet the extent to which diphtheria toxin (DT) produces off-target effects remains incompletely defined. Here, we examined tolerability, behavioural outcomes, and cellular responses following intracerebroventricular…
Psychiatric comorbidities and sexual health risks in HIV-serodiscordant heterosexual couples involving women with borderline personality disorder: a mixed-method study and theoretical modeling
BackgroundHIV-serodiscordant heterosexual couples consist of one partner who is HIV-positive and the other who is HIV-negative. Our previous studies found that the HIV-negative female partner in no-prevention couples (NPC) may be affected by borderline personality disorder (BPD) and might have…
Psychological function in the context of protracted stress during war: a multi-sample, multivariate longitudinal study
Continuous traumatic stress has wide-ranging implications for important life outcomes across multiple domains. We present the design protocol from the first waves of one of the most comprehensive studies of the impact of one pervasive continuous traumatic stress context—war—on individuals.…
Cyclothymic and anxious affective temperament in perinatal depression: findings from an exploratory cross-sectional study
IntroductionThe perinatal period represents a vulnerable period in which women may experience high psychic distress due to psychological, biological and social changes. The prevalence of perinatal depression (PND) is estimated around 15%-20% during pregnancy and 16%-18% after childbirth. Although several…
Auditory processing and communication in autism: exploring verbal abilities and vocal affective cues
This study examined the role of auditory processing in autism spectrum disorder, focusing on its association with verbal and non-verbal vocal communication skills in children and adolescents. A total of 97 English-speaking autistic participants (ages 7.9–17.4 years, mean = 12.3)…
Association between the geriatric nutritional risk index and postoperative delirium: a meta-analysis
BackgroundMalnutrition has been suggested as an important contributor to postoperative delirium (POD). The geriatric nutritional risk index (GNRI), a simple indicator based on serum albumin and body weight, has been increasingly evaluated in surgical patients. This meta-analysis aimed to clarify…
High-fidelity intravital imaging of biological dynamics with latent-space-enhanced digital adaptive optics
Nature Biotechnology, Published online: 23 April 2026; doi:10.1038/s41587-026-03107-2Intravital imaging is improved by applying deep learning to wave-optics modeling.
Genome editing of phylogenetically distinct bacteria using cross-species retron-mediated recombineering
Nature Biotechnology, Published online: 23 April 2026; doi:10.1038/s41587-026-03076-6Retron-based systems for genome editing are functional across bacterial species.
How to meaningfully evaluate AI in clinical medicine
Nature Medicine, Published online: 23 April 2026; doi:10.1038/s41591-026-04350-5How to meaningfully evaluate AI in clinical medicine
Africa’s moment for health security
Nature Medicine, Published online: 23 April 2026; doi:10.1038/s41591-026-04330-9Advancing pandemic readiness to secure Africa’s health sovereignty.
Intestinal metaplasia is the only precursor to esophageal adenocarcinoma
Nature Medicine, Published online: 23 April 2026; doi:10.1038/s41591-026-04332-7We integrated large-scale epidemiological and genomic data from patients with esophageal adenocarcinoma to compare cancers with and without Barrett’s esophagus (BE). We found shared risk factors, molecular features, evolutionary trajectories and BE lineage…
BOLD fMRI reflects both vascular and metabolic signals
Nature Neuroscience, Published online: 23 April 2026; doi:10.1038/s41593-026-02288-yA recent study by Epp et al. uses advanced, quantitative functional MRI measures to demonstrate that the ‘canonical’ interpretation of blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI) — that increases and decreases in brain activation…
Early dopamine disruption in the entorhinal cortex of a knock-in model of Alzheimer’s disease
Nature Neuroscience, Published online: 23 April 2026; doi:10.1038/s41593-026-02260-wThe authors reveal entorhinal cortex dopaminergic and behavioral dysfunction in Alzheimer’s model mice, suggesting the possibility that entorhinal dopamine loss may contribute to aspects of Alzheimer’s disease.
Trump reclassifies state-licensed medical marijuana as a less-dangerous drug in a historic shift
President Trump is reclassifying state-licensed medical marijuana as a less-dangerous drug, a major policy shift long sought by advocates.
STAT+: Pharmalittle: We’re reading about cheap telehealth visits, pharma withholding meds in Europe, and more
Drugmakers have begun using coupons to discount the cost of telehealth visits with clinicians who can prescribe their drugs
The Download: introducing the Nature issue
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Introducing: the Nature issue When we talk about “nature,” we usually mean something untouched by humans.…