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Development of a User-Informed Decision Aid for Contraceptive Decision-Making Among Adolescents and Young Adults: Qualitative Study
Background: Adolescents and young adults seeking contraceptive care face many considerations related to differences in contraceptive indications and knowledge, which are often overlooked and can lead to contraceptive nonadherence or nonuse as well as…
Deprexis for Veteran Depression: Open-Label Pilot Trial Examining Feasibility, Acceptability, and Preliminary Efficacy
Background: Depression carries the highest burden of mental health–related disability in the United States. Approximately 13% of military veterans report elevated rates of depression. Despite the availability of evidence-based treatments for depression, nearly 50%…
Spinal Cord Injury Stem Cell Transplant Clears Phase I, Improves Motor Scores
In the first-in-human Phase I study, the treatment improved movement and function in several participants, paving the way for larger trials to determine if it can restore neurological abilities. The post Spinal Cord Injury…
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Multimodal Depression Detection Through Conversational Interactions with an Emotion-Aware Social Robot: Pilot Study
Background: Depression affects more than 300 million people worldwide and is a leading contributor to the global disease burden. Traditional diagnostic methods, such as structured clinical interviews, are reliable but impractical for frequent or large-scale screening. Self-report tools like the…
New U.S. recommendation on hepatitis B vaccine will have dire consequences, studies project
Policy that recommends offering hep B vaccine at birth only to babies perceived to be at risk will lead to increased numbers of infected infants, new studies project.
Supreme Court grapples with multibillion-dollar wave of lawsuits over Roundup cancer claims
The Supreme Court seemed divided Monday over whether to block thousands of lawsuits alleging the maker of the weedkiller Roundup failed to warn people it could cause cancer.
STAT+: Erasca touts strong, though preliminary, results in trial of pancreatic and lung cancer therapy
The drugmaker Erasca said results on its experimental pill in a trial of pancreatic cancer and non-small cell lung cancer exceeded its expectations.
STAT+: Dems say RFK Jr. has a pattern of failing to answer their questions
Kennedy broke his pledge to share a controversial contract, highlighting Democrats' frustrations with the health secretary.
Enhancing Sleep and Mental Health: Longitudinal, Observational, Real-World Study From a Digital Mental Health Platform
Background: Poor sleep is closely linked to mental health challenges and workplace burnout. Mental health and workplace stressors can impair sleep, while good sleep quality supports cognitive and emotional resources to cope with daily challenges. Despite positive outcomes of maintaining…
Comparing Perceptions of ChatGPT Use in Health Attitude Contexts Among Users and Nonusers: Cross-Sectional Study
Background: In light of the growing use of artificial intelligence (AI) in health care, individuals’ access to and use of health information are transforming. ChatGPT, an AI chatbot, provides immediate responses to health queries, with the potential to influence health-related…
The Effectiveness and Mechanisms of Action of App-Based Interventions for Improving Mental Health and Workplace Well-Being: Randomized Controlled Trial
Background: Depression is the most common mental health disorder worldwide and frequently leads to workplace absence. As face-to-face treatment can be difficult to access, app-based interventions are a popular solution, although their effectiveness in working populations and their mechanisms of…
Trump administration warns against using federal dollars on fentanyl test strips
The Trump administration underlines a “clear shift away from harm reduction and practices” that it says facilitates illegal drug use.
Emotional Training via Telerehabilitation After Surgical Treatment for Facial Palsy: Prospective, Assessor-Blinded, 2-Arm Pilot Cohort Study
Background: Peripheral facial nerve palsy is a debilitating condition that may necessitate surgical intervention. Although motor rehabilitation is considered essential, the most effective approach has not yet been determined. Objective: This study aimed to evaluate the feasibility and effectiveness of…
The missing step between hype and profit
This story originally appeared in The Algorithm, our weekly newsletter on AI. To get stories like this in your inbox first, sign up here. In February, I picked up a flyer at an anti-AI march in London. I can’t say for…
Rebuilding the data stack for AI
Artificial intelligence may be dominating boardroom agendas, but many enterprises are discovering that the biggest obstacle to meaningful adoption is the state of their data. While consumer-facing AI tools have dazzled users with speed and ease, enterprise leaders are discovering…
The Download: DeepSeek’s latest AI breakthrough, and the race to build world models
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Three reasons why DeepSeek’s new model matters On Friday, Chinese AI firm DeepSeek released a preview…
Sociodemographic factors, anxiety and attitudes toward generative artificial intelligence among nurses
BackgroundAlthough generative artificial intelligence offers substantial potential benefits in healthcare, negative attitudes and elevated anxiety among nurses may hinder its effective integration into clinical practice. Evidence regarding the psychological impact of generative artificial intelligence on nurses remains limited.ObjectiveThis study examined…
Improving metagenome binning by integrating intrinsic features and taxonomy
Nature Biotechnology, Published online: 27 April 2026; doi:10.1038/s41587-026-03098-0TaxVAMB combines sequence features with taxonomic information for improved metagenome binning.
Ten lessons from a decade of scientific translation at the Crick
Nature Medicine, Published online: 27 April 2026; doi:10.1038/s41591-026-04355-0Ten lessons from a decade of scientific translation at the Crick
The arrival of digital twins and in silico trials in drug development
Nature Medicine, Published online: 27 April 2026; doi:10.1038/s41591-026-04344-3The regulatory landscape for drug evaluation is shifting. For digital twins and in silico trials to become reliable evidence for drug approvals, these digital tools will require input from regulators and the public…
The TARGET guideline for reporting observational studies of interventions
Nature Medicine, Published online: 27 April 2026; doi:10.1038/s41591-026-04358-xThe TARGET guideline for reporting observational studies of interventions
The All of Us Research Program’s wearables dataset
Nature Medicine, Published online: 27 April 2026; doi:10.1038/s41591-026-04352-3The authors present the All of Us Research Program dataset, containing Fitbit data from 59,000 participants spanning 14 years, 39 million steps and 31 million sleep observations.