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New national action plan targets gaps at the intersection of mental health and criminal justice.
FOR IMMEDIATE RELEASE OTTAWA, ON – The Mental Health Commission of Canada (the Commission) today released “Finding New Pathways: An action plan for criminal justice and mental health in Canada”. The plan provides an evidence-based…
Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
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Associations of psychological distress, gaming motives and internet gaming disorder in adolescents: a network analysis
Background and objectiveThe rapid popularization of the Internet among Chinese adolescents has resulted in the emergence of a public major concern known as Internet Gaming Disorder (IGD). As demonstrated by previous studies, an association has been demonstrated among emotional distress,…
Author Correction: Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function
Nature Neuroscience, Published online: 24 April 2026; doi:10.1038/s41593-026-02312-1Author Correction: Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function
Addendum: Neural anticipation of virtual infection triggers an immune response
Nature Neuroscience, Published online: 24 April 2026; doi:10.1038/s41593-026-02284-2Addendum: Neural anticipation of virtual infection triggers an immune response
Three reasons why DeepSeek’s new model matters
On Friday, Chinese AI firm DeepSeek released a preview of V4, its long-awaited new flagship model. Notably, the model can process much longer prompts than its last generation, thanks to a new design that helps it handle large amounts of…
STAT+: FDA to speed up review of three psychedelics as mental health treatments
Trump's embrace of psychedelics and cannabis is shaking up the GOP’s relationship with mind-altering substances.
STAT+: A biotech VC on what Eli Lilly saw in a struggling cancer startup for $3.2B
What did Eli Lilly see in a struggling biotech startup that made the pharma giant want to pay billions for it? Bryan Roberts has some answers.
STAT+: Utah medical board calls for immediate suspension of state’s AI doctor experiment
A Utah pilot to renew prescriptions using a bot faced backlash from the state's medical board, which called for an immediate suspension.
Toward an NGF-based therapy for Rett syndrome
Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by mutations in the MECP2 gene. Although recent therapeutic advances, such as the approval of Trofinetide, offer partial relief, no comprehensive curative treatment is currently available. Among the emerging strategies,…
Vagus nerve stimulation as an anti-inflammatory therapy for maternal immune activation-induced alterations in offspring microglia and neurodevelopment
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder caused by a combination of genetic and environmental factors. With the increasing prevalence of ASD diagnosis, it is crucial to understand the mechanisms behind preventable causes, such as prenatal infections, and…
Sex-specific impact of vitamin D and B9 concentrations on neuroticism: a polygenic score-based study
IntroductionNeuroticism is a personality domain with prognostic value for physical and mental health. To properly inform public health policy, it is crucial to uncover the mechanisms underlying high neuroticism. Many internal and external factors that affect brain development and functioning…
Lithuanian children’s trauma characteristics and correlates: comparison of clinical and non-clinical samples
IntroductionPrevious studies have shown that children’s exposure to potentially traumatic events and their trauma−related symptoms may not always be consistently identified. This study aims to examine differences in trauma exposure and related psychological outcomes between clinical and non−clinical Lithuanian children.MethodsThis…
A longitudinal inquiry into the vicious cycle of social media addiction and self-injury: the moderating role of resilience
BackgroundThe reciprocal relationship between social networking addiction (SNA) and non-suicidal self-injury (NSSI) represents a critical, yet poorly understood, feedback loop in adolescent psychopathology. This study aimed to longitudinally test a “vicious cycle” model, examining the bidirectional effects between SNA and…
Impact of extremely low frequency electromagnetic fields exposure on sleep quality and mental health in a Tunisian power plant: a cross-sectional study
IntroductionExtremely low-frequency electromagnetic fields (ELF-EMFs) are ubiquitous in our daily life. They may have an impact not only on physical health but also on mental health.ObjectivesTo assess the impact of occupational exposure to the ELF-EMFs on sleep quality, depression, anxiety…
Mental health in the time of polycrisis: geopolitical determinants and modern psychiatry
Psychiatry is increasingly being practised in environments affected by geopolitical instabilities, including economic fragmentation, democratic backsliding, and widening inequities. The confluence of these phenomena contributes to what has been described as a contemporary polycrisis, encompassing synchronous disruptions that reinforce one…
The value of patient-focused drug development
Nature Medicine, Published online: 24 April 2026; doi:10.1038/s41591-026-04364-zThe value of patient-focused drug development
Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial
Nature Medicine, Published online: 24 April 2026; doi:10.1038/s41591-026-04354-1In a biomarker-driven trial evaluating radiotherapy with erlotinib, everolimus or dasatinib in patients with newly diagnosed diffuse intrinsic pontine glioma, the primary endpoint of overall survival was not met, but features associated with…
Cross-reactive anti-prophage antibodies and bacterial heteroresistance implicated in phage therapeutic failure
Nature Medicine, Published online: 24 April 2026; doi:10.1038/s41591-026-04301-0A 22-year-old patient with cystic fibrosis and chronic, drug-resistant Bordetella bronchialis infection received compassionate-use phage therapy. Serum samples revealed that pre-existing antiphage immunity existed before treatment, indicating that future studies must evaluate antiphage…
From the discovery of GLP-1 to today’s diabetes/obesity therapy and beyond
Glucagon-like peptide-1 was discovered as an insulinotropic peptide from the gut during a search for candidates for the incretin effect. It turned out to also inhibit glucagon secretion and is now considered an important regulator of glucose metabolism. In further…
Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo
Nature Neuroscience, Published online: 24 April 2026; doi:10.1038/s41593-026-02247-7By studying 23 neurodevelopmental disorder genes across model systems and brain cell types, the authors uncovered shared downstream effects that converge on synaptic biology, epigenetic regulation and mitochondrial function.
Health-care AI is here. We don’t know if it actually helps patients.
I don’t need to tell you that AI is everywhere. Or that it is being used, increasingly, in hospitals. Doctors are using AI to help them with notetaking. AI-based tools are trawling through patient records, flagging people who may require certain…