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Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
Circio and GenAssist Collaborate on Gene Therapy for Muscle Disease and In Vivo Cell Therapy
An official at Circio says that by integrating Circio's and GenAssist's complementary technologies, the parties aim to focus on the development of a joint next generation of AAV gene therapy candidates. The post Circio…
Detection of Self-Harm in Electronic Mental Health Records Using Privacy-Preserving Local Language Models: Methodological Study
Background: Self-harm is the strongest risk factor for suicide and an important outcome for mental health care. Although prevalent in clinical populations, it is often imprecisely captured in routinely collected clinical data, where it…
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STAT+: Allogene Therapeutics’ CAR-T treatment eliminates residual cancer cells in B-cell lymphoma patients
The new data bolster Allogene’s efforts to develop a new, easily administered cell therapy that could delay or prevent cancer recurrence.
STAT+: Spyre Therapeutics IBD drug shows promise in early trial
The inflammatory bowel disease therapy succeeded in its first major testing, setting up a competition with several large drugmakers.
You have no choice in reading this article—maybe
Uri Maoz loved doing his human research, back when he was getting his PhD. He was studying a very specific topic in computational neuroscience: how the brain instructs our arms to move and how our gray matter in turn perceives…
Job titles of the future: Wildlife first responder
Grizzly bears have made such a comeback across eastern Montana that in 2017, the state hired its first-ever prairie-based grizzly manager: wildlife biologist Wesley Sarmento. For some seven years, Sarmento worked to keep both the bears, which are still listed…
Opinion: STAT+: Landmines await Vinay Prasad’s successor at the FDA
Who would want to be the head of the FDA's Center for Biologics Evaluation and Research?
STAT+: Hospitals roll out chatbots, looking to reclaim their role in patients’ health conversations
A handful of hospitals are launching their own chatbots, a risky bet aimed at better serving current patients and gaining new ones.
Trial of Center-Based Early Start Denver Model vs. Pivotal Response Treatment in Children With Autism
Conditions: Autism Spectrum Disorder (ASD); Autism Interventions: Behavioral: Early Start Denver Model (ESDM); Behavioral: Pivotal Response Treatment (PRT); Behavioral: Developmental Reciprocity Treatment (DRT) Sponsors: Stanford University; John and Marcia Goldman Foundation Not yet recruiting
Trial Phase: Syndemic Adapted Medly Uganda
Conditions: Mental Health Interventions: Device: Syndemic-Adapted Medly Uganda (SAMU) Sponsors: Yale University; National Institute of Mental Health (NIMH) Not yet recruiting
Evaluation of an Online ACT and Compassion-based Intervention for Disorders of Gut-Brain Interaction
Conditions: DGBI; Depression/Anxiety Interventions: Behavioral: Acceptance and Commitment Therapy with explicit self-compassion training; Other: Education Sponsors: Örebro University, Sweden; Sahlgrenska University Hospital; Göteborg University; Uppsala University Not yet recruiting
Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS) for Treatment of Post-Traumatic Stress Disorder (PTSD)
Conditions: Posttraumatic Stress Disorder (PTSD) Interventions: Device: Transcranial Magnetic Stimulation; Device: Transcranial Magnetic Stimulation Sham Sponsors: Massachusetts General Hospital; United States Air Force Research Laboratory Not yet recruiting
Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD)
Conditions: PTSD; Post Traumatic Stress Disorder PTSD; PTSD - Post Traumatic Stress Disorder; Post Traumatic Stress Disorder; Post Traumatic Stress Disorders; Post-traumatic Stress Disorder (PTSD); Post-Traumatic Stress Disorder, PTSD Interventions: Device: non-invasive vagus nerve stimulation Sponsors: Acacia Clinics; ElectroCore INC;…
AI-Guided Relaxation for Hemodialysis Anxiety
Conditions: Renal Insufficiency, Chronic; Anxiety; Relaxation Therapy; Maintenance Hemodialysis; Stress, Psychological Interventions: Device: AI-Guided Relaxation Platform; Other: Standard Hemodialysis Nursing Care Sponsors: Alexandria University Not yet recruiting
Opinion: Sports betting is creating a twofold public health crisis for some young men
“Even if not everybody is losing a ton of money right now, you're creating this culture of large numbers of gamblers,” Isaac Rose-Berman says on the First Opinion Podcast.
Opinion: What STAT readers think about nutrition education in med school
“Is ‘lack of education’ really what we think the problem is in prevention care?” a STAT reader asks.
Epigenetics at Birth Links Microbiome to Neurodevelopment, Potentially ASD and ADHD
Researchers have found that the human gut microbiome and epigenetics are intertwined, and that both contribute to early life neurodevelopment, and potentially to the development of ASD and ADHD. The post Epigenetics at Birth Links Microbiome to Neurodevelopment, Potentially ASD…
GAO report shows gap between scale of illegal vapes and enforcement
The Justice Department's actions on illegal vapes pales next to the scale of the problem, anti-smoking advocates say.
STAT+: Replimune skin cancer drug that became FDA flashpoint is rejected again
A cancer drug candidate that, rightly or wrongly, became a flashpoint at FDA, fails on a second try at approval.
What’s in a name? Moderna’s “vaccine” vs. “therapy” dilemma
Is it the Department of Defense or the Department of War? The Gulf of Mexico or the Gulf of America? A vaccine—or an “individualized neoantigen treatment”? That’s the Trump-era vocabulary paradox facing Moderna, the covid-19 shot maker whose plans for…
The Download: an exclusive Jeff VanderMeer story and AI models too scary to release
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Constellations —Constellations is a short story by Jeff VanderMeer, the author of the critically acclaimed, bestselling…
How blindness shapes personality: a neuro-ecological account
IntroductionThe established link between personality and psychological well-being underscores the need to understand how major life changes, such as vision loss, reshape an individual’s disposition. While previous research has produced inconsistent findings, the roles of concurrent environmental factors and underlying…