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New national action plan targets gaps at the intersection of mental health and criminal justice.
FOR IMMEDIATE RELEASE OTTAWA, ON – The Mental Health Commission of Canada (the Commission) today released “Finding New Pathways: An action plan for criminal justice and mental health in Canada”. The plan provides an evidence-based…
Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
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Antisense oligonucleotide-mediated knockdown therapy in two infants with severe KCNT1 epileptic encephalopathy
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04314-9Two individuals with KCNT1-related epileptic encephalopathy were treated with a KCNT1-targeting antisense oligonucleotide, leading to significant reductions in seizure frequency and intensity, but also the development of hydrocephalus.
Elraglusib and chemotherapy in metastatic pancreatic ductal adenocarcinoma: a randomized controlled phase 2 trial
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04327-4In this phase 2 trial, combination treatment with elraglusib, a cell-permeable ATP-competitive inhibitor of glycogen synthase kinase-3β, and gemcitabine plus nab-paclitaxel (GnP), in patients with previously untreated metastatic pancreatic ductal adenocarcinoma led to…
Intravitreal photoswitch therapy in advanced retinitis pigmentosa: a phase 1 open-label trial
Nature Medicine, Published online: 14 April 2026; doi:10.1038/s41591-026-04317-6A first-in-human phase 1 trial shows that intravitreal photoswitch therapy can be administered safely in advanced retinitis pigmentosa, with exploratory signals compatible with light responsiveness following treatment.
White matter pathways mediating dorsolateral prefrontal TMS therapy for depression
Nature Neuroscience, Published online: 14 April 2026; doi:10.1038/s41593-026-02248-6Seguin et al. show that the efficacy of transcranial magnetic stimulation for depression depends on how stimulation spreads through the brain’s wiring. Patients with shorter communication pathways between stimulated sites and mood-related regions…
Rapid temporal processing in the olfactory bulb underlies concentration-invariant odor identification and signal decorrelation
Nature Neuroscience, Published online: 14 April 2026; doi:10.1038/s41593-026-02250-yThis study shows that the brain’s smell center uses precise timing and inhibition to read out early odor signals, enabling reliable odor identity across concentrations while rapidly separating (decorrelating) similar smell patterns for…
HSV-1 strain H129 co-opts neuronal synaptic transmission machinery for its transsynaptic spread
Nature Neuroscience, Published online: 14 April 2026; doi:10.1038/s41593-026-02254-8By assembling into ‘virion vesicles’, the H129 strain of herpes simplex virus-1 hijacks synaptic machinery for its anterograde spread, co-opting voltage-gated Ca2+ channels, Syt7 and SNAREs for presynaptic exit, then nectin-1/CME for postsynaptic…
A fluoride shortage for some U.S. water systems
An experimental Medicare program, how family dynamics affect brain recovery, and other health news from Morning Rounds
Coming soon: 10 Things That Matter in AI Right Now
Each year we compile our 10 Breakthrough Technologies list, featuring our educated predictions for which technologies will have the biggest impact on how we live and work. This year, however, we had a dilemma. While our final picks encompass all…
The problem with thinking you’re part Neanderthal
You’ve probably heard some version of this idea before: that many of us have an “inner Neanderthal.” That is to say, around 45,000 years ago, when Homo sapiens first arrived in Europe, they met members of a cousin species—the broad-browed,…
Opinion: My brother can’t access a just-approved breakthrough drug for his rare disease
Rare disease clinical trials, policy discussions, and advocacy initiatives often leave adults behind.
STAT+: Dana-Farber CEO talks untangling from Mass General Brigham and building new cancer hospital
Dana-Farber CEO Benjamin Ebert has no shortage of ideas and vision for the cancer institute as it untangles from Mass General Brigham and builds a new hospital.
A top WHO official confronts Iran war fallout, and weighs bid for an even bigger role
The director of WHO's Eastern Mediterranean region is weighing whether to run to be the next director-general at a time of tumult over Iran and beyond.
For Ben Sasse, Revolution Medicines’ pancreatic cancer trial felt like his best, only option
Former Sen. Ben Sasse gives a glimpse of what it's like to be a participant in an tough but promising new drug for pancreatic cancer.
Kent and Medway mental health appointments launch online
Kent and Medway Mental Health NHS Trust has a launched a portal to give patients 24/7 online access to their mental health appointments.
Symptoms of Anxiety and/or Depression and SDM in Older Patients With CLTI
Conditions: Critical Limb Threatening Ischaemia; Depression Disorder; Anxiety Sponsors: Guy's and St Thomas' NHS Foundation Trust; University Hospitals, Leicester Not yet recruiting
Efficacy and Safety of a Theta Burst Stimulation Protocol of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression
Conditions: Major Depressive Disorder (MDD); Depression - Major Depressive Disorder Interventions: Drug: antidepressant therapy; Device: Active rTMS Theta Burst Stimulation; Device: Sham Stimulation Sponsors: Jung-Sun Lee; Korea Health Industry Development Institute; Seoul National University Hospital; Nowon Eulji Medical Center, Eulji…
Early Brainwave Biomarkers for Personalized Neuromodulation in Treatment-resistant Depression
Conditions: Major Depressive Disorder; Treatment Resistant Depression Interventions: Device: Personalized iTBS; Device: Non-Personalized iTBS; Device: Sham iTBS Sponsors: Stanford University; National Institute of Mental Health (NIMH) Not yet recruiting
Effectiveness of Behavioral Activation Group Therapy for Patients With Depression at the Community in Thanh Hoa
Conditions: Depression - Major Depressive Disorder Interventions: Behavioral: Behaviral activation group therapy Sponsors: Hanoi Medical University Completed
NIH-funded breakthrough shrinks CRISPR for precision delivery in the body
Smaller gene-editing system could expand treatment options for cancer, ALS and other diseases.
Author Correction: Real-time surveillance system for patient deterioration: a pragmatic cluster-randomized controlled trial
Nature Medicine, Published online: 13 April 2026; doi:10.1038/s41591-026-04382-xAuthor Correction: Real-time surveillance system for patient deterioration: a pragmatic cluster-randomized controlled trial