News Feed
Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
Circio and GenAssist Collaborate on Gene Therapy for Muscle Disease and In Vivo Cell Therapy
An official at Circio says that by integrating Circio's and GenAssist's complementary technologies, the parties aim to focus on the development of a joint next generation of AAV gene therapy candidates. The post Circio…
Detection of Self-Harm in Electronic Mental Health Records Using Privacy-Preserving Local Language Models: Methodological Study
Background: Self-harm is the strongest risk factor for suicide and an important outcome for mental health care. Although prevalent in clinical populations, it is often imprecisely captured in routinely collected clinical data, where it…
News
1476 results
Zingerone alleviates acute seizures by reducing intrinsic hippocampal neuronal excitability in a rat model of temporal lobe epilepsy
BackgroundEpilepsy is a complex neurological disorder characterized by recurrent seizures. Neuroinflammation and excessive neuronal excitation are key pathogenic factors, but current therapies fail to target these mechanisms effectively, highlighting the need for novel therapeutic agents. Zingerone, a bioactive compound derived…
Exploratory assessment of cerebrospinal fluid-related microdynamics after mild traumatic brain injury using intravoxel incoherent motion magnetic resonance imaging
AimThis study aimed to characterize regional alterations in cerebrospinal fluid (CSF) microdynamics following mild traumatic brain injury (TBI) using intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) and compare f-value–based CSF motion between patients with TBI and healthy controls.MethodsIn this…
A novel phase-difference transcranial alternating current stimulation system enables precise dual-site neuromodulation
Precise modulation of large-scale brain networks requires neuromodulation technologies capable of delivering frequency-locked stimulation with accurate and stable inter-regional phase control. However, conventional transcranial alternating current stimulation (tACS) systems generally lack robust dual-channel phase regulation and are rarely validated under…
A survey on data augmentation for EEG-based emotion recognition and cognitive workload decoding
Electroencephalography (EEG) is extensively employed in emotion recognition and cognitive workload decoding. However, signal characteristics and inter-subject variability pose significant challenges for deep learning models, particularly due to data scarcity and limited generalization. Although data augmentation (DA) is a critical…
Effect of transcranial magnetic stimulation on prognosis in patients with postherpetic neuralgia and comorbid depression undergoing interventional neuromodulation therapy: protocol for a randomized double-blind placebo-controlled trial
BackgroundPostherpetic neuralgia (PHN) is often accompanied by depression, creating a vicious cycle that exacerbates symptoms and contributes to suboptimal treatment outcomes, even with interventional therapies. Repetitive transcranial magnetic stimulation (rTMS) has demonstrated potential in alleviating both pain and mood disturbances.…
From work-related trauma to suicidal ideation: a serial mediation model of posttraumatic stress and depression in rescue workers
ObjectivesRescue workers face frequent occupational trauma, increasing their risk for posttraumatic stress symptoms (PTSS), depression, and suicidal ideation. However, pathways linking trauma to suicidality remain poorly understood. This study investigated these mechanisms by testing a serial mediation model.MethodsFrom a larger…
The efficacy and safety of transcranial direct current stimulation in patients with ADHD: a systematic review and meta-analysis
ObjectiveThis meta-analysis evaluated the efficacy and safety of transcranial direct current stimulation (tDCS) for treating Attention-Deficit/Hyperactivity Disorder (ADHD).MethodsFollowing PRISMA guidelines, we analyzed 28 randomized controlled trials (RCTs) involving 1,864 participants. Outcomes encompassed core ADHD symptoms, hot and cold executive functions…
The mediating role of parental early maladaptive schemas in the relationship between parental self-efficacy and social interest in students with learning disabilities
IntroductionThe present work is investigating the mediating role of parental early maladaptive schemas in the relationship between parental self-efficacy and social interest among students with learning disabilities.MethodsThis descriptive-analytical study employed a correlational design within a structural equation modelling framework. The…
Nonlinear relationships between fatigue, fear of COVID-19, and PTSD among mental health professionals: the findings of a multi-site survey in China
BackgroundMental health professionals (MHPs) are susceptible to fatigue, particularly during public health crises like the COVID-19 pandemic. This study examined nonlinear relationships between fatigue, post-traumatic stress disorder (PTSD), and fear of COVID-19 (FOC) among MHPs.MethodsA multi-site survey was conducted from…
Therapeutic Potential of GLP-1 Receptor Agonists for Smoking Cessation
Glucagon-like peptide-1 (GLP-1) therapies are under investigation for a growing number of neuropsychiatric conditions, including substance use disorders. Cigarette smoking accounts for the largest proportion of substance use-related morbidity and mortality, in part reflecting increased risk for cardiometabolic disease among…
Neural sequences underlying directed turning in Caenorhabditis elegans
Nature Neuroscience, Published online: 10 April 2026; doi:10.1038/s41593-026-02257-5During olfactory navigation, Caenorhabditis elegans can execute error-correcting turns. Whole-brain imaging and perturbation experiments identify an ensemble of neurons that control reorientation and turning behaviors.
Constellations
I. We had crash-landed on the planet. We were far from home. The spaceship could not be repaired, and the rescue beacon had failed. Besides me, only the astrogator, part of the captain, and the ship’s AI mind were left. …
Opinion: I’m a MAHA activist. I went into the public health lion’s den — and it changed how I think
“In my most honest of moments, what I want from the medical community is the chance to trust it again,” a MAHA advocate writes.
Opinion: What public health can learn from the MAHA movement
“What MAHA has built, in a relatively short time, is social capital,” writes Monica L. Wang.
How sports betting apps hook users
In this week's STATus Report, host Alex Hogan dives into how sports betting apps hook users — and how he himself fell for some too-good-to-be-true promotions.
Peer Mentor Training and Supervision for a Digital Adolescent Depression Treatment in South Africa and Uganda: Mixed Methods Evaluation
Background: Blended digital mental health interventions combining technology with human support are more effective than stand-alone treatments. However, limited research has examined how to train and supervise personnel delivering human support components. The Kuamsha app, a gamified digital intervention for…
In Memoriam: Edna B. Foa, PhD
Dr. Edna Foa served for decades as a professor of clinical psychology in psychiatry at the University of Pennsylvania, where she also directed the Center for the Treatment and Study... Read more » The post In Memoriam: Edna B. Foa,…
In Memoriam: Judith L. Rapoport, MD
Dr. Judith L. Rapoport has left an indelible mark on the field of obsessive compulsive disorder (OCD) — not only through her extraordinary scientific contributions, but through the compassion, curiosity,... Read more » The post In Memoriam: Judith L. Rapoport,…
The Mental Health Commission of Canada is pleased to welcome Shauna Cronin
The Mental Health Commission of Canada is pleased to welcome Shauna Cronin (she/her) as our new Vice President, Programs, effective April 27, 2026. Shauna brings nearly two decades of national leadership in mental health system transformation, program design, and policy…
Speech in noise prediction by use of cortical auditory evoked potentials in normal hearing and sensorineural hearing loss: a systematic review
IntroductionSpeech perception in noise (SPiN) is a critical challenge for individuals with sensorineural hearing loss (SNHL), and current behavioral assessments can be unreliable in populations with language barriers or cognitive impairment. Cortical auditory evoked potentials (CAEPs) can serve as a…